Digital Commons Network^™

Mitochondrial Memory: Transgenerational Trauma, Functional Medicine, And Quantum Physics, Rosalynn A. Vega

Anthropology Faculty Publications

Building from Karen Barad’s “diffractive methodological approach” (2007, 71), this article combines Mariella Pandolfi’s notion of the female body as a transgenerational “physiological memoir” (1990, 255) with functional medicine perspectives on mitochondria and advances in quantum physics around “entanglement” to explore a new concept—“mitochondrial memory.” Recent findings in biological research depict a communicating collective of mitochondria distributed across different “human” organs and describe how this collective controls many aspects of human health through epigenetic mechanisms. Since exact copies of mitochondria are inherited through the maternal line, I draw from anthropological theory, functional medicine research, and recent discoveries in physics to …

Prakash ‘24, Mcmillan ‘25 Attend Forbes Under 30 Summit, Jeffery Woodard

News and Events (Discontinued Series)

No abstract provided.

Exploitation, Gentrification, And Commercialization: The Evolution Of Third Spaces For Marginalized People In Post-Democratization Cape Town, Nicole Overbay

Armstrong Undergraduate Journal of History

This paper explores the impact of high-cost leisure spaces that are emerging in low-income marginalized communities within the Cape Town metropolitan area of South Africa after democratization. The resilience and cultural significance of unregulated third spaces, like shebeens, despite governmental suppression demonstrates the importance of these venues to marginalized South Africans. Through the examination of the gentrification of Bo Kaap and Khayelitsha, this paper argues that the pervasive trend of commercialization (which is supposedly for economic empowerment of said areas), can exclude non-White residents and corrode the generations-long cultural significance created in third spaces. This barrier disproportionately harms Black and …

Review Of The Byzantine Republic: People And Power In New Rome, Cemre Yordamlı

Armstrong Undergraduate Journal of History

No abstract provided.

Selective Pericyte Recruitment To Ec-Lined Tubes, Vessel Assembly Enhancement Through Pericyte Timp-3 Induction, And Pericyte Tbx2 In Capillary Formation And Maturation, Ksenia Marilyn Yrigoin Kaluguina

USF Tampa Graduate Theses and Dissertations

Capillaries, the smallest blood vascular networks, are formed by narrow and elongated endothelial cell (EC)-lined tubes with associated pericytes anchored to the abluminal tube surface. Our laboratory demonstrated that dynamic interactions between ECs and pericytes during capillary tube network assembly are required for basement membrane matrix deposition and maturation. We have also shown that key EC-derived factors promote pericyte recruitment, proliferation, and pericyte-induced basement membrane formation during capillary assembly. In the first section, we aim to identify if vascular smooth muscle cells (VSMCs) respond to the same factors and have the same invasive ability as pericytes since they are both …

Rictor, A Mtorc2 Protein, Regulates Lymphatic Valve Formation And Maintenance Through The Akt-Foxo1 Signaling Axis, Richa Banerjee

USF Tampa Graduate Theses and Dissertations

The lymphatic vasculature maintains tissue fluid homeostasis by absorbing interstitial fluid to form lymph and transporting it back to the bloodstream. Collecting lymphatic vessels have lymphatic valves (LVs) that prevent the retrograde flow of lymph generated by hydrostatic pressure from the blood vasculature. Backflow and accumulation of lymph leads to a lymphatic pathology called lymphedema. This implicates the involvement of defective LVs in the pathogenesis of lymphedema and warrants the study of lymphatic valve development and maintenance. The LVs are formed through a process called mechanotransduction which signals through the intracellular PI3K-AKT pathway in lymphatic endothelial cells. However, the activation …

What Do We Know About Hugging Face? A Systematic Literature Review And Quantitative Validation Of Qualitative Claims, Jason Jones, Wenxin Jiang, Nicholas Synovic, George K. Thiruvathukal, James C. Davis

Computer Science: Faculty Publications and Other Works

Background: Collaborative Software Package Registries (SPRs) are an integral part of the software supply chain. Much engineering work synthesizes SPR package into applications. Prior research has examined SPRs for traditional software, such as NPM (JavaScript) and PyPI (Python). Pre-Trained Model (PTM) Registries are an emerging class of SPR of increasing importance, because they support the deep learning supply chain.
Aims: Recent empirical research has examined PTM registries in ways such as vulnerabilities, reuse processes, and evolution. However, no existing research synthesizes them to provide a systematic understanding of the current knowledge. Some of the existing research includes qualitative …

Salvage Reirradiation With Proton Beam Therapy For Locoregionally Recurrent Non-Small Cell Lung Cancer, Matthew S Ning, Abigael Odwuor, Joe Y Chang, Saumil Gandhi, Zhongxing Liao, Steven H Lin, Aileen Chen, James W Welsh, Quynh-Nhu Nguyen, Michael S O'Reilly, Stephen G Chun, Julianna Bronk, David Qian, Percy Lee

Faculty, Staff and Student Publications

Background/objectives: This retrospective study evaluates outcomes of 66 patients who underwent reirradiation (re-RT) with proton beam therapy (PBT) for recurrent non-small cell lung cancer.

Methods: Toxicity was scored via the CTCAE v5.0, and outcomes estimated using the Kaplan-Meier method, with associations evaluated via Cox proportional hazards and logistic regression analyses.

Results: Patients were treated to a median re-RT prescription of 66 Gy/33 fxs (BED10 = 79 Gy; IQR: 71-84 Gy) at an interval of 1.4 years from prior RT. Half (50%) received concurrent chemotherapy. At 14 months follow-up, the median OS and PFS were 5 months (95%CI: 13-17) and 12.5 …

Aromatase, Testosterone, Tmprss2: Determinants Of Covid-19 Severity, Eric C Mohan, Jude P J Savarraj, Gabriela D Colpo, Diego Morales, Carson E Finger, Alexis Mcalister, Hilda Ahnstedt, Huimahn Choi, Louise D Mccullough, Bharti Manwani

Faculty, Staff and Student Publications

Background: Male sex has been identified as a risk factor for worse COVID-19 outcomes. This sex difference has been mostly attributed to the complex role of sex hormones. Cell surface entry of SARS-CoV-2 is mediated by the transmembrane protease serine 2 (TMPRSS2) which is under transcriptional regulation by androgens. P450 aromatase enzyme converts androgens to estrogens. This study measured concentrations of aromatase enzyme, testosterone, estradiol, and TMPRSS-2 in plasma of hospitalized COVID-19 patients to elucidate the dynamics of sex-linked disparity in COVID-19 and correlate them with disease severity and mortality.

Methods: In this prospective cohort study, a total of 265 …

Optimizing Allocation To Telehealth And In-Person Prolonged Exposure For Women Veterans With Military Sexual Trauma: A Precision Medicine Approach., Evangelia Argyriou, Daniel F Gros, Melba A Hernandez Tejada, Wendy A Muzzy, Ron Acierno

Faculty, Staff and Student Publications

Military sexual trauma-related post-traumatic stress disorder (PTSD) is highly prevalent and costly among women veterans, making the need for effective and accessible treatment of critical importance. Access to care is a key mechanism of mental health disparities and might affect differential response to treatment. The goal of this study was to estimate an individualized treatment rule based on readily available individual characteristics related to access to care to optimize allocation to in-person vs. telehealth delivery of prolonged exposure for PTSD in military sexual trauma survivors. The following variables were used as prescriptive factors: age, race, disability status, socioeconomic status, rural …

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …

Childhood Neglect Is Associated With Alterations In Neural Prediction Error Signaling And The Response To Novelty, Joseph Aloi, Kathleen I Crum, Karina S Blair, Ru Zhang, Johannah Bashford-Largo, Sahil Bajaj, Soonjo Hwang, Bruno B Averbeck, Nim Tottenham, Matthew Dobbertin, R James R Blair

Faculty, Staff and Student Publications

Background: One in eight children experience early life stress (ELS), which increases risk for psychopathology. ELS, particularly neglect, has been associated with reduced responsivity to reward. However, little work has investigated the computational specifics of this disrupted reward response - particularly with respect to the neural response to Reward Prediction Errors (RPE) - a critical signal for successful instrumental learning - and the extent to which they are augmented to novel stimuli. The goal of the current study was to investigate the associations of abuse and neglect, and neural representation of RPE to novel and non-novel stimuli.

Methods: One hundred …

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …

Shade, Height Of Cut, And Plant Growth Regulator Effects On Bermudagrass And Zoysiagrass Putting Greens, Thomas E. Walton, John Mccalla, Douglas E. Karcher, W. J. Hutchens, Ambika Chandra, Michael D. Richardson

Horticulture Faculty Publications and Presentations

Warm-season turfgrasses, especially hybrid bermudagrass (Cynodon dactylon (L.) Pers × Cynodon transvaalensis Burtt-Davy), continue to be widely used on golf course putting greens in tropical and subtropical climates globally and are also gaining popularity in the transition zone region of the United States. Hybrid bermudagrass produces a high-quality putting green surface; however, it has relatively poor shade and cold tolerance. Recently, fine-textured zoysiagrass (Zoysia spp.) cultivars have been released and may be another potential option for golf course putting greens, especially since zoysiagrass is generally considered more shade tolerant than bermudagrass. “Lazer (DALZ 1308)” zoysiagrass (Zoysia …

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …

Quaker Campus, October 24, 2024 (Vol. 23, Issue 5), Whittier College

Quaker Campus

No abstract provided.

Kenyon Collegian - October 24, 2024

The Kenyon Collegian

No abstract provided.

2024-10-24 Faculty Welfare & Concerns Committee Meeting Minutes, Morehead State University. Faculty Senate., Faculty Welfare & Concerns Committee.

Faculty Senate Records

Meeting minutes from the Faculty Welfare & Concerns Committee for October 24, 2024.

2024-10-24 Governance Committee Report, Morehead State University. Faculty Senate., Academic Issues Committee.

Faculty Senate Records

The Governance Committee report submitted to the Faculty Senate on November 7, 2024.

Troubleshooting And Diagnostics Of Electronic Computing Devices Using The Object Model Creation Method, Gulmira Shuxratovna Abidova, Asad Xolboy O’Gli Shosalmanov

Chemical Technology, Control and Management

This paper presents a major challenge in fault diagnosis for electronic computing equipment is developing an object model tailored to support diagnostic tasks. Effective fault localization requires establishing a link between the diagnostic process and the object model. This connection should enable direct observation of diagnostic points and organize all potential defect and fault sources to clearly show their impact on each diagnostic point and the relevant parameters. Achieving this necessitates comprehensive information about parameter values, expected variations, and the permissible relationships between network elements that generate these parameters. Therefore, building a robust model is essential to facilitate accurate fault …

Algorithms For Minimizing The Boundary Values Of The Quadratic Quality Criterion Based On Approximation Methods, Yulduz Mukhtarkhodzhaevna Abdurakhmanova

Chemical Technology, Control and Management

This paper considers approximation methods for solving optimization problems while discussing the possibility to reduce the large amount of calculations. Hence, the approximation range is selected in accordance with the optimal value of the quality indicator. To do this, the upper and lower boundaries are being calculated followed by generating the control sequences that minimize the specified boundaries. The next step is to find an approximate solution. An approximate solution to the dual control problem comes from the problem of optimal control of a linear Gaussian system with a quadratic quality criterion and unknown parameters. For the dual control problem, …

Neural Network Models Of Adaptive Position-Trajectory Control Systems Of Moving Objects, Dildora Usmonovna Sevinova

Chemical Technology, Control and Management

This article is devoted to neural network models of adaptive position-trajectory control systems of moving objects. Neural network models of adaptive positional-trajectory control systems of moving objects have been developed on the basis of proportional-differential adjusters, which allow for quick calculation and determination of nonlinear characteristics of the system. Also, the kinematic scheme of the multi-link industrial robot is presented for describing the motion of the multi-link industrial robot according to the specified traction and positions, and for representing the input forces and training in the neural network. Mathematical models for calculating the linear and rotational movements of the manipulator …

System Of Monitoring And Control Of Thermal Regime In Gas-Fired Furnaces, U.U. Kholmanov

Chemical Technology, Control and Management

The system of monitoring and control of thermal regime in gas furnaces is considered, the description of which includes temperature sensors, control systems and optimization algorithms. Attention is paid to monitoring, which allows to ensure stability and efficiency of furnace operation. The existing approaches to thermal regime control are analyzed. Examples of implementation of these systems are given, as well as the prospects for their development with regard to modern trends in automation and digitalization.

Development Of Structures Of Intellectual Control Systems Of The Rectification Process, Shodievich Avazov Yusuf

Chemical Technology, Control and Management

Rectification processes, which are considered complex technological processes, and the development of structures of intelligent systems for controling the work of rectification devices and columns, which serve to organize them, were considered. The need to build intelligent control systems is based on the fact that the progress of the rectification process is affected by a large number of factors, including temperature, pressure, consumption, temperature difference, concentration of mixtures, properties of light and heavy volatile components. The structure of an intelligent control system based on the situational control method for rectification devices is proposed. The architecture of the proposed intelligent control …

Self-Calibration Of Smart Sensors Based On Fuzzy Logic, U.A. Ruziev, M.K. Shodiev

Chemical Technology, Control and Management

The paper discusses and analyzes the application of fuzzy logic methods for self-calibration of measuring devices. In particular, the principles of constructing measurement devices based on fuzzy logic, based on linguistic variables and rules, are considered, which makes it possible to take into account various conditions and requirements of production processes. To illustrate the effectiveness of the proposed methods, the results of experiments on measuring and classifying process parameters using fuzzy logic algorithms are presented. The study also covered fuzzy rule methods for evaluating and processing measurement data based on expert knowledge and linguistic variables. Fuzzy rule-based systems are shown …

Implementation Of The Method Of Fuzzy Control Of The Rectification Process Based On Fuzzy Logic, Yusuf Shodievich Avazov, Kamola Rustamovna Abdullaeva

Chemical Technology, Control and Management

The method of controlling the rectification process using fuzzy control based on fuzzy logic is studied. The structural scheme of the rectification process control system based on fuzzy logic is proposed. The analysis of the operation of the fuzzy rectifier is also carried out by comparing the human with the elements of fuzzy thinking. It is shown that the logical thinking of the human is similar to the functions performed by the fuzzy rectifier and the work of the components of the intellectual control system. The terms of linguistic variables are presented to reflect the rectification process of multi-component mixtures. …

Numerical Simulation Of Gas Flow In A Direct-Flow Cyclone, V.S. Toptalov, S.U. Ganieva, O.M. Flisyuk, Kh.S. Nurmukhamedov

Chemical Technology, Control and Management

A numerical model of gas flow in a direct-flow cyclone of two different configurations is presented. The main task of the simulation was to determine the gas velocity field in the apparatus and analyze the presence of a turbulent wake of the stabilizer swirled, which can have a negative impact on the efficiency of the apparatus. During the study, it was found that when the gas flow is disrupted by the stabilizer of the swirler, a turbulent wake is formed, into which trapped particles can fall. The solution to this problem is to lengthen the stabilizer and increase its diameter. …

Research And Justification Of The Optimal Optical And Design Parameters Of The Activated Sludge Concentration Measuring Device For Biological Wastewater Treatment, Siroj Sobirovich Nurov, Makhsud Idrisovich Makhmudov, Uktam Farxodovich Mamirov

Chemical Technology, Control and Management

This article discusses the optimization of the design and optical parameters of an activated sludge concentration measuring device through experimental studies in laboratory conditions in order to improve the metrological characteristics of the meter. In particular, based on the optimality criteria, a more suitable type of photodetector for the meter is compared and selected; for the selected photodetector, the optimal distance with the emitter is determined, which is modern LEDs that emit light of a selective wavelength of radiation and under a certain degree of illumination. Based on the experiments conducted, it was determined that the optimal thickness between the …