Digital Commons Network^™

Partial Wrapping Of Single-Stranded Dna By Replication Protein A And Modulation Through Phosphorylation, Rahul Chadda, Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S Holehouse, Snorri Th Sigurdsson, Gargi Biswas, Yaakov Levy, Brian Bothner, Richard B Cooley, Ryan A Mehl, Reza Dastvan, Sofia Origanti, Edwin Antony

2020-Current year OA Pubs

Single-stranded DNA (ssDNA) intermediates which emerge during DNA metabolic processes are shielded by replication protein A (RPA). RPA binds to ssDNA and acts as a gatekeeper to direct the ssDNA towards downstream DNA metabolic pathways with exceptional specificity. Understanding the mechanistic basis for such RPA-dependent functional specificity requires knowledge of the structural conformation of ssDNA when RPA-bound. Previous studies suggested a stretching of ssDNA by RPA. However, structural investigations uncovered a partial wrapping of ssDNA around RPA. Therefore, to reconcile the models, in this study, we measured the end-to-end distances of free ssDNA and RPA-ssDNA complexes using single-molecule FRET and …

Cardiovascular Findings In Klippel-Feil Syndrome: A Systematic Review, Abbigail Niewchas, Salma Alkhatib, Christopher Stewart, Mitchell Fisher, Randall Hansen, Alex Otto, Kent Mcintire, Suporn Sukpraprut-Braaten

Student Publications

Klippel-Feil syndrome (KFS) is a congenital disease defined by an abnormal fusion between cervical vertebrae. Due to the rarity of the disorder, its prevalence, along with its pathogenesis and associated conditions, remains to be clearly defined. The aim of this review is to summarize the findings of all case reports of KFS in PubMed over the last 10 years that describe cardiovascular disease, defects, or abnormalities. A total of 43 articles containing 46 reports were included from the 157 case reports considered. Cases were reviewed for commonality in biological sex and vertebral fusion and level using the Samartzis classification system …

Evidencing The Challenges Of Care Delivery For People With Intellectual Disability And Epilepsy In England By Using The Step Together Toolkit, Rohit Shankar, Georgia Page, Bridie Kent

Peninsula Medical School

BackgroundPeople with intellectual disability (PwID) and epilepsy have increased premature and potentially preventable mortality. This is related to a lack of equitable access to appropriate care. The Step Together guidance and toolkit, developed with patient, clinical, charity and commissioning stakeholders, allows evaluation and benchmarking of essential epilepsy service provision for PwID in eight key domains, at a care system level.AimsTo evaluate care provisions for adult PwID and epilepsy at a system level in the 11 integrated care systems (ICSs) of the Midlands, the largest NHS England region (population: approximately 11 million), using the Step Together toolkitMethodPost training, each ICS undertook …

Multi-Modal Contextual Search For Enterprise Content, Adam Sabra, Rekha Gopikrishnan, Altanai Bisht, Hazim Dahir, Karthik Babu Harichandra Babu, Savita Kini

Defensive Publications Series

A multi-modal contextual search system is proposed herein that may revolutionize multimedia content retrieval in collaborative environments. Unlike traditional keyword-based searches, the proposed system employs advanced artificial intelligence (AI) techniques to directly search within audio and video files in order to retrieve content, overcoming transcription limitations. By leveraging neural-encoder inspired embedding systems and AI-powered audio search without transcription, the proposed system ensures swift and accurate access to crucial information, enhancing productivity and knowledge dissemination. With enhanced features such as audio metadata extraction and semantic matching, the innovative solution proposed herein offers a comprehensive and contextually relevant search experience tailored for …

Editor's Comments, Lawrence R. Handley

The Geographical Bulletin

Editor's Comments

Cover And Forewords, Lawrence R. Handley

The Geographical Bulletin

Cover and Forewords

Getting Started With Geographic Information Systems By Keith C. Clark, Shivaij Prasad

The Geographical Bulletin

Since its first edition, this book has been an excellent contribution to the field of Geographic Information Systems (GIS). This fourth edition is considerably improved over the previous edition in terms of both extraordinary breadth of subject matter covered and the straightforward manner in which the information is presented. In four sections and 340 pages total, Getting Started With GIS covers the core of most GIS applications needed to address fundamental spatial questions such as where, what, and why. This very readable text is logically ordered with each chapter nicely balanced between GIS concepts and its practical applications. Throughout the …

Volume 46-2 Complete Issue, Lawrence Handley

The Geographical Bulletin

Volume 46-2 Complete Issue

Urban Street Systems In Nineteenth-Century Ohio Towns: An Analysis Of Diffusion, John M. Wegner

The Geographical Bulletin

This study considers the possible “migration” of urban street patterns associated with discrete east coast culture regions to America’s trans-Appalachian interior during the 19th century. Also examined was the possibility that these street patterns became less “culturallybound,“ or more admixed, over time. Ohio, one of the first (and most culturally diverse) trans-Appalachian states, was the focus of the study. To ascertain answers to the above questions, data pertaining to town platting throughout the state (as well as for four distinct survey regions associated with discrete east coast migration) was culled from county atlases and histories. Variables were selected so as …

Human Rights Abuses On The U.S.-Mexico Border, Emily J. Salava

The Geographical Bulletin

INTRODUCTION This study examines the current human rights abuses found at the United States and Mexico border. For the purposes of this paper, human rights are defined as found in the Universal Declaration of Human Rights, adopted by the United Nations in 1948, but other agreements may be cited for reference. What one person considers an abuse, another person may coin as a reality of life. The focus of this study is on the existence of human rights abuses, but does not specifically examine the historical causes. There are many agencies working in the region and abroad to protect the …

Gtu’S Conscience, Heart, And Soul: O. Orland Maxfield, A Mentor, Leon C. Hallman

The Geographical Bulletin

A mentor is defined as a trusted advisor. One usually thinks of mentoring in the context of one person helping another. However, an institution can have a mentor—its conscience, heart, soul, and history. Gamma Theta Upsilon is such an institution and Dr. O. Orland Maxfield is such a mentor. This paper outlines and recaps the ways this mentor has aided this international geographical honor society. Mentoring: one of the oldest forms of influence. One generally thinks that mentoring began with Homer telling about the King of Ithaca asking his fiend Mentor to look after his son Telemachus while he fought …

Of Mentors And Mentoring, O. Orland Maxfield

The Geographical Bulletin

Last Sunday afternoon I was at an auction out in the Boston Mountains, standing in line to get a bidder’s number while the man in front of me quarreled about giving information. Then the man behind me said, “I know my name but I don’t know who I am.” I feel a bit like that. It’s my name in the program but am I really the person being honored. I have spoken of this momentous event in my life as being the result of a conspiracy among friends. There is no way that I can thank them adequately for their …

Mentor—Mentoree, What Is In A Relationship?, Lawrence R. Handley

The Geographical Bulletin

What is a mentor? I serve as a mentor for two groups: one, to offer advice, to give counsel, and basically to help out new employees within the U.S. Geological Survey (USGS); and the other, as an advisor for the Louisiana Environmental Education Association working with new teachers. With USGS, the mentoring is a function of being designated a leader within the Bureau. Because of the size of the USGS, many individuals are mentored by long distance telephone conversations or email communication. These individuals are mostly interested in administrative issues, personal advancement, and misunderstood situations with their supervisors and co-workers. …

In Memoriam O. Orland Maxfield: A Biographical Sketch, Virgil Holder

The Geographical Bulletin

O. Orland Maxfield, born in 1925, was raised on a farm near Robinson, Illinois, and he always referred to Robinson as his home. His father was a Methodist minister who died when Orland was eleven. His mother, who graduated from Northwestern University, raised him in a disciplined manner. This shows in the fact that he earned his Bachelor’s degree at George Peabody College for Teachers in three years with a double major in Geography and English, graduating in 1945. He earned his Master’s of Arts degree in Geography at Ohio State University in one year.

In Memoriamc. Nicholas Raphael (1937–2004), Robert M. Ward, Carl F. Ojala

The Geographical Bulletin

February 21, 2004 was a sad day for all of us acquainted with C. Nicholas Raphael. On that morning, at age 66, he passed away suddenly, leaving a community he loved and one which loved him. Nick had been our dear friend and colleague for more than three decades. He will be remembered by many in the geographical profession as the editor of Gamma Theta Upsilon’s The Geographical Bulletin, a position he proudly occupied since 1987. Nick began a productive and fruitful life as the son of R. George and Angela Raphael on September 3, 1937, in Detroit, Michigan. He …

A Note From Editor, Steven M. Schnell

The Geographical Bulletin

Note from Editor

Volume 47-2 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 47-2 Complete Issue

Cover And Forewords, Steven M. Schnell

The Geographical Bulletin

Cover and Forewords

Adapting To Drought And Floods In The Semi-Arid Landscape Of Santa Cruz County, Arizona, Cynthia L. Sorrensen

The Geographical Bulletin

This paper analyzes the actions of key interest groups and major institutional regulatory agreements that influence land use change and water demand in Santa Cruz County, Arizona, in order to better understand the capacity of residents in the county to adapt to hydroclimatic hazards (drought and flooding). We found that there are strong special interest groups working in the region to ensure their own livelihoods and interests. At times, the actions of these groups enhance the adaptive capacity of the county, but their actions can also conflict with each other, producing a less-clear outcome for adaptation. We also note that …

Geographer At Work: Frank Salmon, Gis Manager, Leon Yacher

The Geographical Bulletin

Frank Salmon remembers to the day when he decided Geography was going to be his career. Frank had just taken his seat before his first Geography final exam at Gateway Community Technical College when the professor announced to the class that “any of you who liked this course and want to pursue this as a major at Southern Connecticut State, I will guarantee that you will have a career when you graduate.” Not that Frank really needed this persuasion; he had loved Geography since he was a child. This first Geography class simply articulated for him what he now believes …

Adaptation To The Effects Of Suburbanization And Drought In Central Massachusetts, Troy Hill, Colin Polsky

The Geographical Bulletin

Central Massachusetts receives more than 1100 mm of precipitation each year on average, with little inter-annual variation. Despite this, water supply shortfalls have become increasingly common, demanding responses (adaptations) from community water systems. This paper examines the process of adapting to drought in a ten-town study area. A grounded theory approach to data collection and analysis was used. Methods consisted of archival work and interviews, which investigated how structural and agent-based forces affect adaptation to drought. Suburbanization revealed itself as a major stress on water systems, jeopardizing and complicating efforts to adjust to water shortages. Structural forces and local actors …

Water Woes: Structure And Agency Influences On Adaptive Capacity In Southwest Kansas, Rorik Ford Peterson

The Geographical Bulletin

Concerns over the continual reduction of available groundwater in southwest Kansas have been increasing. This concern is compounded by the high dependence on irrigated agriculture and the related agribusiness industry, which is a staple to the regional economy and employs a large labor force. Future climate variation may enhance the sensitivity of the region to limited water availability. Through archival research and interviews, this study examines the impact of both structural forces (such as policy makers and legal bodies) and individual agents (local farmers, ranchers, and other citizens) on the capacity of southwest Kansas to adapt to climate variation. Although …

The Hero Reu Experience: Undergraduate Research On Vulnerability To Climate Change In Local Places, Cynthia L. Sorrensen, Colin Polsky, Robert Neff

The Geographical Bulletin

Undergraduates are an integral part of many university research programs. We are very pleased to showcase the efforts of some of our undergraduate students in the papers that follow, and to introduce them within the larger context of our research, here in this introduction. The Human-Environment Regional Observatory (HERO) program is a five-year research program, funded by the National Science Foundation (through an infrastructure grant) and the National Oceanic and Atmospheric Administration (through the Office of Global Programs). Our goal is to develop a research approach to monitor ongoing human-environment relationships at the local scale as they interface with the …

A Veteran Mental Health Approach Sustaining Identity Post-Military Life: A Comprehensive Overview, Darren Sosa, Lindsay Gietzen

Pacific Journal of Health

Veterans and their mental health face readjustment challenges based on veteran identity, intersectionality, and experiences from their time serving in the military. This comprehensive overview and PRISMA analysis investigate the current evidence-based practices of veterans' identity and intersectionality. Specifically, psychoeducation and evidence-based practices for veterans readjusting back into their communities. A gap identified in this research’s findings calls for suggestions for future research on the veteran population and intersectionality. No specific psychoeducation or evidence-based practices tailored for identity readjustment or veteran intersectionality were found. This research constructs a tailored framework of suggestions for current and future evidence-based practices for the …

Preparedness For Practice Of Health Professionals In Papua New Guinea: A Cross-Sectional Survey Of Nurses And Community Health Workers., Mary Kililo, Julie Dopsie, Sulpain Passingan, Julie Kep, Nina Joseph, Russel Kitau, Mary Roroi, Chris Rossiter, Jenny Sim, Di Brown, Caroline Havery, Ali Moloney, Michele Rumsey

Pacific Journal of Health

Introduction

Papua New Guinea (PNG) experiences widespread health inequity and shortage of health professionals, exacerbated by poverty, isolation, gender-based violence and limited infrastructure, transport and accessible services. Nurses and community health workers (CHW) represent 72% of health workforce. However, health professional education programs are outdated and not aligned with national health priorities. We aimed to explore the adequacy of current curricula for nurses and CHWs by examining graduate competencies and preparedness for practice.

Methods

Cross-sectional study with four cohorts: 1) 130 new nurse graduates, 2) 75 nurses who supervised them, 3) 105 new CHW graduates and 4) 65 CHW supervisors. …

Social Determinants Of Health And How They Affect A Small Rural Community (Case Study) Eastern Shore Of Maryland, Kristopher S. Durham, Lindsay Gietzen

Pacific Journal of Health

The Eastern Shore of Maryland is rural and is characterized by prevalent poverty, housing instability, lack of access to healthcare, chronic diseases, substance abuse, and issues with transportation to access healthcare services. The same problems exist for the population in Maryland and the United States. Understanding the challenges experienced by rural communities in Maryland is critical to addressing the vulnerable population. This study is an explanatory case study that examines the social determinants of health and how those affect small rural communities on the Eastern Shore of Maryland by examining literature published between 2016 and 2024. The literature reviewed resulted …

The Efficacy Of The G.R.A.C.E Matrix® In Ptsd Treatment”, Maria Grace G. Wolk, Lindsay Gietzen

Pacific Journal of Health

The purpose of this study is to explore the efficacy of the G.R.A.C.E Matrix®, a step-by-step technique of treatment for post-traumatic stress disorder (PTSD). This study uses case studies that serve as portrayals of adults who struggle with PTSD. The three cases, referred to as "Jamal," "Isabel," and "Joel," are based on disguised aspects of real psychotherapy patients from a psychotherapy clinic. By detailing the treatment courses of these patients, the study highlights critical clinical issues in engaging patients with evidence-based therapy. The cases illustrate how the G.R.A.C.E Matrix® treatment, beginning with written assessments and culminating in trauma-informed interventions, has …

Clcweb Special Issue: The Peripheral Jameson

CLCWeb Calls for Papers

CLCWeb Special Issue: The Peripheral Jameson

“Always Totalize,” as Clint Burnham notes, could be one of the mottos of Fredric Jameson’s work: a commitment to drawing—always partial—connections between seemingly disparate fragments of reality into a contradictory unity, one that is never fully present. But how are we to make sense of totalization in the periphery of capitalism? This periphery is where the totality of global capitalism is more readily intuited, to draw on another argument by Jameson. Thus, one could argue that peripheral contexts are where the act of totalization more directly confronts totality itself.

This issue seeks to interrogate …

Strategies To Enhance Employee Knowledge Retention In Public And Private Universities, Funmilola Adebunmi Iyiola

Walden Dissertations and Doctoral Studies

Retaining an employee's knowledge becomes a significant challenge when skilled and experienced employees leave an organization. Human resources (HR) professionals/leaders at public and private universities are particularly concerned about the detrimental impact of knowledge loss in such cases. Grounded in the knowledge management cycle (KMC) model, the purpose of this qualitative multiple case study was to explore strategies that HR professionals/leaders of public and private universities use to enhance employee knowledge retention. The participants were nine HR professionals/leaders in public and private universities who successfully enhanced employee knowledge retention. Data were collected using semistructured interviews and a review of publicly …

Relationship Between Enrollment, Retention, Alumni Giving, And Financial Health At Historically Black Colleges And Universities, Kenneth Mercury

Walden Dissertations and Doctoral Studies

Decreasing financial health damages an organization’s reputation and economic viability to survive. Historically Black Colleges and Universities (HBCUs) leaders must strive to improve their financial health to protect their institution’s reputation and risk of closure. Grounded in strategic enrollment management theory, the purpose of this quantitative ex-post facto study was to examine the relationship between student enrollment, student retention, alumni giving, and financial health of HBCUs. The participants were 101 HBCUs collected from the National Center for Education Statistics and the Voluntary Support of Education databases, from 2020 to 2022. The results of the multiple linear regression analysis showed that …