Digital Commons Network^™

Chimes: November 11, 2024, Calvin University

Chimes

“There for a reason”: How the search committee chose Elzinga by Ethan Meyers

Student organizations across campus adjust to decreasing budgets by Elisabeth Stevens

Calvin Theatre Company’s Millennial Adaptation of Shakespeare’s Much Ado About Nothing by Natasha Jayaputra

The Freshman 15: Fact or Fiction? by McKenna Wilkinson

Knights Sweep Conference Cross Country Titles by Dillion Baumchen

A Retreat for Calvin Students: The Ecosystem Preserve and Native Gardens by Sarah Sparling

Trump does not (and should not) represent Christian values by Marcail Schuurmann

Characteristics Of Exacerbators In The Us Bronchiectasis And Ntm Research Registry: A Cross-Sectional Study, Nicole C. Lapinel, Radmila Choate, Timothy R. Aksamit, Joseph Feliciano, Kevin L. Winthrop, Andreas Schmid, Sebastian Fucile, Mark L. Metersky

School of Medicine Faculty Publications

BACKGROUND: Exacerbations of noncystic fibrosis bronchiectasis (bronchiectasis) are associated with reduced health-related quality of life and increased mortality, likelihood of hospitalisation and lung function decline. This study investigated patient clinical characteristics associated with exacerbation frequency. METHODS: A cross-sectional cohort study of patients ≥ 18 years with bronchiectasis enrolled in the US Bronchiectasis and Nontuberculous Mycobacteria (NTM) Research Registry (BRR) September 2008-March 2020. Patients were stratified by exacerbation frequency in their 2 years before enrolment. Patient demographics, respiratory symptoms, healthcare resource utilisation, microbiology, modified bronchiectasis severity index (mBSI) and select comorbidities were collected at enrolment. Patient characteristics associated with exacerbation frequency …

Understanding Faculty Perspectives On Health Equity Curriculum Implementation In Graduate Medical Education: A Qualitative Study, Krys Foster, Dhruvi Shah, Quinn Plunkett, Randa Sifri

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Despite increased awareness of persistent healthcare disparities, integrating health equity education into medical residency curricula needs urgent expansion. The Accreditation Council for Graduate Medical Education (ACGME) mandates addressing healthcare disparities and social determinants of health, but implementation remains insufficient due to pervasive barriers.

OBJECTIVE: To explore residency faculty perspectives at one institution surrounding implementing a health equity curriculum within their programs.

METHODS: Between November 2022 and April 2023, qualitative interviews and focus groups were conducted with residency faculty participants (n = 13) from a large academic medical institution. Participants were recruited via an internal email list directory of program …

Serca Modulators Reveal Distinct Signaling And Functional Roles Of T Lymphocyte Ca2+ Stores, Md N. Uddin, David W. Thomas

Pacific Faculty Work

The allosteric SERCA (Sarcoplasmic/Endoplasmic Reticulum Ca²⁺-ATPase) activator CDN1163 has been recently added to the group of pharmacological tools for probing SERCA function. We chose to investigate the effects of the compound on T lymphocyte Ca²⁺ stores, using the well-described Jurkat T lymphocyte as a reliable cell system for Ca²⁺ signaling pathways. Our study identified the lowest concentrations of the SERCA inhibitors thapsigargin (TG) and 2,5-di-(tert butyl)-1,4-benzohydroquinone (tBHQ) capable of releasing Ca²⁺, permitting the differentiation of the TG-sensitive SERCA 2b Ca²⁺ store from the tBHQ-sensitive SERCA 3 Ca²⁺ store. We proceeded to test …

Vista: November 11, 2024, University Of San Diego

USD Vista (1965-)

No abstract provided.

Hypothermia In Patients With Traumatic Injuries: An Integrative Review, Andrew P. Gribble, David J. Saucedo

Master's Projects

Abstract

Background: An estimated 30-50% of severely injured patients with traumatic injuries will experience hypothermia. As a result of hypothermia, several clinical manifestations such as impaired coagulation, dissociation of the oxygen curve, cardiac arrhythmias, reduced cardiac output and death. Little evidence has been published promoting specific patient re-warming protocols and the best rewarming methods, active versus passive. Few studies have focused on the pre-hospitalization treatment for hypothermia and the overall effectiveness of interventions to mitigate hypothermia to reduce morbidity and mortality. Given this knowledge, the aim of this integrative review (IR) is to research and evaluate current practices regarding hypothermia …

Human Hnrnpa1 Reorganizes Telomere-Bound Replication Protein A, Sophie L. Granger, Richa Sharma, Vikas Kaushik, Mortezaali Razzaghi, Masayoshi Honda, Paras Gaur, Divya S. Bhat, Sabryn M. Labenz, Jenna E. Heinen, Blaine A. Williams, S. M. Ali Tabei, Marcin W. Wlodarski

Faculty Publications

Human replication protein A (RPA) is a heterotrimeric ssDNA binding protein responsible for many aspects of cellular DNA metabolism. Dynamic interactions of the four RPA DNA binding domains (DBDs) with DNA control replacement of RPA by downstream proteins in various cellular metabolic pathways. RPA plays several important functions at telomeres where it binds to and melts telomeric G-quadruplexes, non-canonical DNA structures formed at the G-rich telomeric ssDNA overhangs. Here, we combine single-molecule total internal reflection fluorescence microscopy (smTIRFM) and mass photometry (MP) with biophysical and biochemical analyses to demonstrate that heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) specifically remodels RPA bound to …

Ndls Communicator: Week Of 11.11.24, Notre Dame Law School

NDLS Communicator

The Latest News

• Veterans Day 2024: Honoring our ND Law student veterans and reflecting on God, Country, Notre Dame
• Notre Dame Law Professor Avishalom Tor awarded Honorary Doctorate by University of Lucerne for pioneering behavioral legal research
• Notre Dame Law School hosts annual Rev. David T. Link Public Interest Banquet
• Notre Dame Law School’s Religious Liberty Clinic Provides Legal Support to Faith-Based Nonprofits
• Trailblazing Judge Michael Fitzgerald reflects on his career and advocacy for LGBTQ+ rights at ND Law LGBT Law Forum event

Faculty News and Briefs

• Diane Desierto's chapter about the UNHRC's jurisprudence from 2022-23 surrounding authoritarian regimes and …

The Rise And Fall Of An Aryanization Bank: The Romanian Credit Institute, 1941–1951, Stefan Cristian Ionescu

History Faculty Books and Book Chapters

Probably the most important domestic project of the pro-Nazi Antonescu regime, the policy of Romanianization of the economy had ambitious goals. It aimed to seize Jewish-owned real estate and to redistribute it to “deserving” Romanians, state agencies, and welfare organizations and to increase the share of ethnic Romanian entrepreneurs and skilled employees through purchasing Jewish companies, adopting business and labour restrictions against Jews and “foreigners,” training and funding ethnic Romanian professionals and would-be entrepreneurs, and establishing new companies to displace minority and foreign competitors. While this project looked feasible on paper, in practice, it faced major obstacles, including a lack …

Wellbeing And Working Conditions In The Arkansas Teacher Workforce, Gema Zamarro, Josh B. Mcgee, Meredith Schellhase

Education Reform Faculty and Graduate Students Publications

• To better support a healthy teacher workforce, it is crucial to understand their job satisfaction, stress, and intentions to leave the profession.
• While most Arkansas teachers (86%) report being satisfied being an educator, we identify several potential areas for improvement.
• Teachers report that managing student behavior is their primary source of stress.
• Thirteen percent (13%) of teachers reported they plan to leave their current school.
• When asked why they were considering leaving their current school, teachers reported feeling unsupported, lacking influence over school policies, and insufficient planning time.
• Regular assessments of teacher well-being and job satisfaction can help us identify …

Modern Tools, Ancient Skills: An Attempted Dialogue Between Ai, Design And Traditional Craft, Paolo Cardini, Juan C. Noguera

Tradition Innovations in Arts, Design, and Media Higher Education

This study explores the integration of artificial intelligence (AI) tools in traditional craft practices, focusing on Guatemalan artisans. The research investigates how machine learning, specifically generative AI platforms like OpenAI’s DALL-E and Midjourney, can bridge the gap between traditional craftsmanship and contemporary design methods. Guatemalan artisans were trained to use these AI tools to generate design ideas, which were then translated into three-dimensional bronze door knockers. The study analyzes the impact of AI on the artisans' workflow, creativity, and business, highlighting both the challenges and benefits. Results indicate that AI can streamline the design process and inspire new creative directions, …

Genetically Determined Telomere Length In Monoclonal Gammopathy Of Undetermined Significance, Multiple Myeloma Risk And Outcome, Matteo Giaccherini, Alyssa I Clay-Gilmour, Romano Liotti, Angelica Macauda, Manuel Gentiluomo, Elizabeth E Brown, Mitchell J Machiela, Stephen J Chanock, Michelle A T Hildebrandt, Aaron D Norman, Elisabet Manasanch, S Vincent Rajkumar, Jonathan N Hofmann, Sonja I Berndt, Parveen Bhatti, Graham G Giles, Elad Ziv, Shaji K Kumar, Nicola J Camp, Wendy Cozen, Susan L Slager, Federico Canzian, Federica Gemignani, Celine M Vachon, Daniele Campa

Faculty, Staff and Student Publications

No abstract provided.

Beta-Blocker Use In Patients Undergoing Non-Cardiac Surgery: A Systematic Review And Meta-Analysis, Doménica Herrera Hernández, Bárbara Abreu, Tania S. Xiao, Andreina Rojas, Kevin López Romero, Valentina Contreras, Sol Villa Nogueyra, Zulma Sosa, Samantha M. Alvarez, Camila Sánchez Cruz, Ernesto Calderón Martinez

Department of Radiology Faculty Papers

BACKGROUND: The use of beta-blockers in the perioperative period has been widely investigated due to their potential to reduce the risk of major adverse cardiovascular and cerebrovascular events (MACCE) and mortality; yet their overall impact on various postoperative outcomes remains debated. This study constitutes a systematic review and meta-analysis of the impact of beta-blockers on mortality, MI, stroke, and other adverse effects such as hypotension and bradycardia in patients undergoing non-cardiac surgery.

METHODS: A comprehensive systematic review and meta-analysis were conducted according to PRISMA 2020 guidelines. Searches were performed across PubMed, Cochrane, Web of Science, Scopus, EMBASE, and CINAHL databases; …

Staff Education To Increase Staff Awareness On How Personal Trauma Affects Responses During Restraints, Marygoretti Kibe

Walden Dissertations and Doctoral Studies

The emotional and or physical trauma that individuals sustained while growing up may continue to adversely affect their health as adults, leading to mental health issues, depression, substance use, anxiety and secondary trauma. The prevalence of this trauma widely unacknowledged among mental healthcare staff. Trauma prevention is crucial and can be achieved through educational interventions. In clinical settings, this can prevent staff high turnover, leaving the profession, disengagement, hypervigilance, and overinvolvement. In a mental health clinical setting, this trauma can lead to overuse or misuse of restraints as the trauma staff bring to these situations drives their reactions.

Spanish-Speaking Students’ Perceptions Of Presences In Digital Technology-Enabled High Schools, Deb Ogburn

Walden Dissertations and Doctoral Studies

Spanish-speaking students, also identified as Hispanic or Latino/a/x, have been reported to have lower high school graduation rates, and lower enrollment and retention rates in higher education than their peers. Research exists describing technology and emergency remote teaching (ERT) as widening the achievement gap, however Spanish-speaking students’ perspectives of their high school experiences in digital technology-enabled learning environments (DTELEs) are missing in the literature. To fill this gap this qualitative study explored six Spanish-speaking students’ perceptions of Garrison’s social, teaching, and cognitive presences with the addition of Cleveland-Innes and Campbell’s emotional presence in public high schools in the northwestern United …

Executive Summary: Staff Education Improving Cultural Competence In Mental Health Providers, Mary Osagie

Walden Dissertations and Doctoral Studies

In the current healthcare environment, providers care for an increasingly diverse patient population and are challenged with the need for cultural competency skills. Evidence indicates that there are gaps related to cultural competency among healthcare providers across all specialties and settings. This paper describes a staff education project that addressed limited cultural competence skills among nurses and staff at an ambulatory mental health clinic on the East Coast. The purpose of the project was to develop, implement, and evaluate a staff education program on cultural competency. The goal was for participants to become more culturally aware and gain knowledge in …

Differences Between The Reintegration Of Combat Veterans And Noncombat Veterans While Controlling For Stigma, Caroline Ramos

Walden Dissertations and Doctoral Studies

Veterans face challenges in reintegrating into civilian life. Experiences of public stigma arise from socially learned stereotypes about military service and mental health issues, which can impact veterans' ability to reintegrate following military deployment successfully. Goffman’s theory of stigma details its influences on personal adjustment. The purpose of this quantitative research study utilizing a survey design was to assess the role of public stigma as a mediator between the type of deployment and veterans’ reintegration experiences. A snowball sample of 85 recently discharged veteran volunteers representing combat zone deployed or non-combat zone deployed completed the Military Stigma Scale and the …

Childhood Trauma As An Influencing Factor On Obesity Among Black Women, Andréa Autum Michel

Walden Dissertations and Doctoral Studies

Childhood trauma and obesity have a significant impact on development throughout the lifespan. Black women have the highest prevalence of obesity and experience more severe and a greater number of traumatic events than their White peers. The purpose of this phenomenological study was to explore how Black women perceived the role of childhood trauma in their struggles with obesity. Bronfenbrenner’s ecological systems theory served as the theoretical framework for this study. The central research question explored the experiences of Black women who experienced childhood trauma and were struggling with obesity as adults. A secondary question explored coping mechanisms developed to …

Develop An Education Program Related To Evidence-Based Strategies Nurses Can Use To Decrease Medication Errors In A Nursing Home, Ann N. Akwaraonwu

Walden Dissertations and Doctoral Studies

These medication errors have posed an immense threat to patient safety, regulatory compliance, and staff confidence in healthcare. Therefore, the improved understanding of nursing staff and reduction in medication error rates required targeted education of nursing staff, thus the basis upon which this quality improvement project was implemented at a nursing home facility located in the Northeastern United States. This evidence-based intervention was developed from feedback that indicated a gap in knowledge on best practices related to the administration of medication among nursing staff. These were eight in number: registered nurses, licensed practical nurses, and certified nursing assistants, who had …

Students Manage Nearby Vacation Rental Through Internship With Talluto '94, Jeffery Woodard

News and Events (Discontinued Series)

No abstract provided.

Shehbaz Govt Considering For Bureaucracy What Ik Regime Prepared But Never Implemented, Ansar Abbasi

Faculty Research - Newspaper and Magazine Articles

ISLAMABAD: Imran Khan government’s Task Force on Civil Service Reform, after two years consultations with more than 3,000 participants from all walks of life holding 68 sessions throughout the country, had developed a comprehensive set of recommendations for modernising the civil service structure, processes and incentives.

Tmic-58. Leveraging Viro-Immunotherapy By Targeting Igf2-Igf1r Signaling, Minhye Noh, Jin Muk Kang, Grace Nguyen, Ji Seon Shim, Alberto J. Bueso-Perez, Sara Murphy, Kimberly A. Rivera-Caraballo, Yoshihiro Otani, Eun Ju Kim, Seung-Hee Yoo, Yuanqing Yan, Yeshavanth Banasavadi-Siddegowda, Hiroshi Nakashima, E Antonio Chiocca, Balveen Kaur, Zhongming Zhao, Tae Jin Lee, Ji Young Yoo

Faculty, Staff and Student Publications

While an FDA-approved oncolytic herpes simplex-1 virus (oHSV) has shown therapeutic promise with superior safety, accumulating clinical data revealed that its therapeutic efficacy is observed in a small subset of patients. Here, we show that NFκB-mediated Insulin-like Growth Factor 2 (IGF2)/Insulin-like Growth Factor-1 Receptor (IGF1R) signaling pathway as a key modulator for oHSV therapy-mediated tumor resistance. RNA sequencing on the oHSV-infected primary glioblastoma (GBM) and breast cancer (BC) cells identified IGF2 as one of the top 10 upregulated secretomes. Transcriptomic analysis also revealed significant upregulation/enrichment of genes related to IGF2-IGF1R-MAPK pathway in oHSV-treated tumor cells. Infection with oHSV in GBM …

Lanthorn, Vol. 59, No. 07, November 11, 2024, Grand Valley State University

Volume 59, August 5, 2024 – April 14, 2025

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Fraud Detection And Prevention In The Nigerian Financial Industry, Ibukunoluwa Adetola Ayodeji

Walden Dissertations and Doctoral Studies

The emergence of digital banking has led to an increase in transaction volume in Nigeria's financial industry, resulting in a rise in fraud cases. This is gradually eroding trust in the economic system and posing a major challenge to the Central Bank's goal of financial inclusion. Fraud detection and prevention strategies must be put in place by IT leaders of Nigerian financial institutions, as fraud in the country can undermine the integrity and trust that are essential to maintaining the integrity of the country's financial system. Grounded in the unified theory of acceptance and use of technology 2 (UTAUT 2) …

Coach Norm Eash Is Retiring From Iwu, Eric Stock

Interviews for WGLT

Retiring IWU coach Norm Eash says relationships and 'tough love' kept him going all these years.

Impact Of Socioeconomic Deprivation On Care Quality And Surgical Outcomes For Early-Stage Non-Small Cell Lung Cancer In United States Veterans, Steven Tohmasi, Brendan T Heiden, Nikki E Rossetti, Ana A Baumann, Theodore S Thomas, Su-Hsin Chang, Nahom Seyoum, Yan Yan, Whitney S Brandt, Bryan F Meyers, Benjamin D Kozower, Varun Puri, Et Al.

2020-Current year OA Pubs

No abstract provided.

Epidemiology Of Β-Blocker Use Among Critically Iii Patients During And After Septic Shock, Stuthi Iyer, Jason N Kennedy, Peter C Nauka, Mourad H Senussi, Christopher W Seymour

Faculty, Staff and Students Publications

No abstract provided.

Immunofluorescence Use And Techniques In Glomerular Diseases: A Review, Nidia Messias

2020-Current year OA Pubs

BACKGROUND: Immunofluorescence (IF) studies play an essential role in the evaluation of medical renal biopsies. Particularly, in the study of renal glomerular diseases, where it provides fundamental data for the diagnosis, classification, and etiology of the glomerular pathologies. Diverse techniques may be used to optimize the utilization of IF studies, from variations on the test methodologies to expertise on the interpretation of the results and knowledge of potential pitfalls.

SUMMARY: This manuscript presents a brief review on the history of IF and its utilization in kidney pathology, followed by a description of the IF methods, including the use of IF …

Effectiveness Of Mailed Outreach And Patient Navigation To Promote Hcc Screening Process Completion: A Multicentre Pragmatic Randomised Clinical Trial, Amit G Singal, Manasa Narasimman, Darine Daher, Sruthi Yekkaluri, Yan Liu, Minjae Lee, Vanessa Cerda, Aisha Khan, Karim Seif El Dahan, Jennifer Kramer, Purva Gopal, Caitlin Murphy, Ruben Hernaez

Faculty, Staff and Students Publications

Background: Hepatocellular carcinoma (HCC) is plagued by failures across the cancer care continuum, leading to frequent late-stage diagnoses and high mortality. We evaluated the effectiveness of mailed outreach invitations plus patient navigation to promote HCC screening process completion in patients with cirrhosis.

Methods: Between April 2018 and September 2021, we conducted a multicentre pragmatic randomised clinical trial comparing mailed outreach plus patient navigation for HCC screening (n=1436) versus usual care with visit-based screening (n=1436) among patients with cirrhosis at three US health systems. Our primary outcome was screening process completion over a 36-month period, and our secondary outcome was the …

Examining Ptsd Prevalence Among Underserved Populations In The Integrated Community Mental Health Setting 2019 To 2022, Siran Koroukian, Stephen Zyzanski, Kurt C. Stange

Faculty Scholarship

Background: The prevalence of Post Traumatic Stress Disorder (PTSD) has been rising since the start of the COVID-19 pandemic, and affects females, sexual and gender minorities, and individuals with social risks at higher rates. Objective: This study examines if the prevalence of PTSD increased from 2019 to 2022 among patients who received care in a national network of safety-net, community-based health centers with integrated behavioral health programs that serve patients at high risk for PTSD. Methods: We analyzed electronic health record data from patients with 1 or more behavioral health visits during 2019 to 2022 using repeated cross-sectional data to …