Digital Commons Network^™

Expert Opinion: Management Of Intraocular Inflammation And Vasculitis After Intravitreal Pegcetacoplan For Geographic Atrophy, Thomas Albini, Steven Yeh, Carl Regillo, Roy Schwartz, Philip Ferrone, Caroline Baumal, Charles Wykoff

Wills Eye Hospital Papers

BACKGROUND AND OBJECTIVE: This expert opinion review is intended to provide guidelines for diagnosis and management of intraocular inflammation (IOI) and vasculitis following pegcetacoplan.

PATIENTS AND METHODS: A case series of all post-marketing reports classified by experts as definite or suspected vasculitis over an 18-month period was assessed.

RESULTS: A total of 306,000 pegcetacoplan intravit real injections were given in the real world between March 1, 2023, and August 31, 2024. Twenty-four eyes from 22 patients (mean age 76 years, 59% female) with definite or suspected vasculitis were evaluated. Comorbidities included hypertension (55%), hypo thyroidism (27%), and recent COVID-19 infection …

Longitudinal Patterns In Stygobiont Distribution In The Hyporheic Zone Of The Karst Spring-Fed San Marcos River, Texas, Usa, Kenneth Sparks, Benjamin F. Schwartz, Safra Altman, Kathryn E. Perez, Zoey B. Chanin, Caroline Mierzejewski, Benjamin T. Hutchins

School of Integrative Biological & Chemical Sciences Faculty Publications

Groundwater-obligate taxa (stygobionts) exhibit variable degrees of habitat specialization, ranging from those restricted to single micro-habitats to generalists occurring in a broad range of habitat types. The karstic Edwards Aquifer is the most biodiverse and well-studied groundwater habitat in the continental United States, but some Edwards Aquifer-associated species also occupy the hyporheic zone of rivers downstream from karst. The goals of this research were to 1) assess the potential of the off-karst hyporheic zone as habitat for ‘karst’ species and 2) to determine how stygobiont richness, diversity, and abundance related to distance from karst in the hyporheic zone of a …

Advancing Data-Driven Health Research From The All Of Us Data Training And Engagement Program, Maletta Payne, Kristi Sadowski, Debran Tarver, Jennifer Burnette, Allissa Dillman, Regina Renfro, Lafrancis Gibson, Kelli Bursey, Laura Bartlett, Nadine Bonds-Bishop, Lisa Connor, Efrain Flores-Rivera, Sarah Joseph, Yugi He, Margaret Henderson, Savannah Kelley, Brett Porter, Kimberly Prosper, Melissa Rethlefsen, Deborah Rhue, Dede Rios, Anna Simonson, Jocelyn Swick-Jemison, Linda Todd, Shelby Watson, Semhar Yohannes

Southern University and A&M College: John B. Cade Library Publications

Fulfilling a recognized need in data skills training for academic librarians, the National Library of Medicine and the National Institutes of Health All of Us Research Program collaborated to enhance academic library workers& skills in biomedical and public health data, as well as their library's research capacity, through the awareness and use of the All of Us Researcher Workbench.

Lightning Safety Tips Everyone Should Know, From A Unh Expert, Scott Ripley

UNH Today Archive

No abstract provided.

The Nsf Seafood Engine In New England Wins $15m Award To Strengthen Fisheries And Aquaculture, Tania Deluzuriaga

UNH Today Archive

No abstract provided.

Vamorolone For Duchenne Muscular Dystrophy A Cross-Trial Efficacy Comparison With Classic Corticosteroids From The For-Dmd Trial, Paula R. Clemens, Anders Berglund, Marianela Schiava, Meredith K. James, Michael P. Mcdermott, Katherine Bushby, Erik Lampa, Edward Thomas James Rochford, Leanne M. Ward, Robert C. Griggs, Eric P. Hoffman, Michela Guglieri

Pharmacy Faculty Scholarship

Background and Objectives: Vamorolone demonstrated similar efficacy for Duchenne muscular dystrophy (DMD) compared with prednisone in a 24-week exploratory analysis and may reduce key side effects compared with classic corticosteroids. In this study, we compare the efficacy and anthropometric effect of vamorolone 6 mg/kg/d with prednisone 0.75 mg/kg/d and deflazacort 0.9 mg/kg/d in steroid-naïve boys aged 4 to < 7 years using data from 2 trials. Methods: VISION-DMD was a phase 2b, 48-week randomized, double-blind trial assessing vamorolone 2 and 6 mg/kg/d vs placebo and prednisone 0.75 mg/kg/d to 24 weeks. Finding the Optimum Steroid Regimen for DMD (FOR-DMD) was a double-blind, parallel-group randomized trial comparing daily prednisone 0.75 mg/kg/d, daily deflazacort 0.9 mg/kg/d, and intermittent prednisone 0.75 mg/kg (10/10 days on/off). Entropy balancing generated weighted data for mixed model for repeated measures analyses that compared VISION-DMD vamorolone 6 mg/kg/d efficacy and anthropometric outcomes with FOR-DMD prednisone and deflazacort outcomes at 6 and 12 months. Inclusion criteria were boys with genetically confirmed DMD, age 4 to < 7 years, ambulatory, and able to complete a time-to-stand (TTSTAND) assessment in < 10 seconds at baseline. Results: All interventions showed motor improvements relative to baseline at 6 and 12 months. Using the weighted cohorts and at 12 months, vamorolone 6 mg/kg/d (n = 28) had similar changes in TTSTAND velocity, the primary motor endpoint component in both trials, vs daily prednisone (n = 50) or deflazacort (n = 55; mean baseline age 5.42 years all groups), but with CIs overlapping minimal clinically important thresholds of 0.023 rises per second (TTSTAND velocity least squares mean [LSM] difference [95% CI]: vamorolone 6 mg/kg/d vs prednisone 0.75 mg/kg/d, 0.004 rises per second [−0.025 to 0.032] and vs deflazacort 0.9 mg/kg/d, 0.001 rises per second [−0.027 to 0.028]). Body mass index (BMI) Z-scores increased in all groups, greatest with vamorolone (12-month LSM difference [95% CI]: vamorolone vs prednisone 0.57 [0.24–0.90]; vamorolone vs deflazacort 0.29 [0.03–0.56]), whereas growth slowdown occurred in prednisone- and deflazacort-treated boys but not vamorolone (12-month LSM difference in height Z-scores [95% CI]: vamorolone vs prednisone 0.57 [0.24–0.90]; vamorolone vs deflazacort 0.72 [0.53–0.91]). Discussion: Vamorolone demonstrated numerically similar TTSTAND velocity changes to prednisone and deflazacort at 1 year; however, interpretations of differences are limited by 95% CIs crossing minimally important difference thresholds. Further evidence of the growth-protective effect of vamorolone was observed; however, all treatments increased BMI. Vamorolone provides a linear growth-protective classic corticosteroid alternative.

Cover And Content

Turkish Journal of Electrical Engineering and Computer Sciences

No abstract provided.

Swindeitvit: A Soft Voting Vision Transformer Ensemble For Accurate And Explainable Solar Panel Fault Detection, Mahe Zabin

Turkish Journal of Electrical Engineering and Computer Sciences

Solar panels are becoming very essential in providing sustainable energy but they are usually affected by defects on the surface like dust, snow, bird droppings, physical damages and electrical faults which interfere with their performance. These faults must be identified accurately and in a timely manner to enhance energy efficiency, lower the maintenance cost, and supplement the traditional manual methods of inspection which are labor-intensive, time-consuming and subject to human errors in judgment. The most common methods, such as traditional CNNs and hybrid architectures tend to be less accurate, less explainable and cannot be properly evaluated to be deployed in …

Optimizing Orthopedic Outcomes: Correlation Between Postoperative Disposition Planning And Quality Outcomes In Joint Reconstruction Patients, Mahdi Ali, Teresa Latvis Ma, Bsn, Rn, Carissa Hrichak Mba, Bsn, Rn, Ashleigh Solomon, Hannah Fortune Mha

Research Scholars

No abstract provided.

Association Of Calcium-Sensing Receptor (Casr) Gene Polymorphisms With Calcium Stone Disease In Babylon Province, Iraq., Hadi Sajid Abdulabbas, Yasir Haider Al-Mawlah, Aamal Muhsen Kadhum

Baghdad Science Journal

In an effort to identify the polymorphism's ultimate function in calcium stone development, an evaluation of the link between calcium stone disease and CaSR polymorphism in the population of Babylon Province, Iraq, was performed. 60 patients were hospitalized at Hillah Hospital in the province of Babylon. Blood samples were collected between January and December 2020. Sixty patients diagnosed with renal stones and forty healthy controls were included in the study. CaSR single-nucleotide polymorphisms (SNPs) were genotyped using the single-strand conformation polymorphism technique after a polymerase chain reaction. In order to confirm these DNA polymorphisms, DNA sequencing was employed. The findings …

Evaluation Of Cytotoxic Effect From Clinacanthus Nutans Leaf Extract On Mda-Mb231 Cells Expressing Cd44+/Cd24–, Siti Syarifah, Tri Widyawati, Sri Melinda Kaban, Nor Adlin Md Yusoff

Baghdad Science Journal

Breast cancer prevalence and incidence are increasing globally every year. Medication resistance and recurrence are more likely in breast cancer cells that express CD44⁺/CD24^–. C.nutans leaves are a traditional medicinal herb with numerous pharmacological benefits, including antioxidant and antiproliferation properties, although the activity against breast cancer stem cells is still unclear. Method: In this study, C.nutans leaves were extracted using ethanol solvent with graded concentrations of 100%, 80%, 60%, 40%, 20%, and 0% (water), respectively, by maceration. We used isolated MDA-MB231 cells with high expression of CD44⁺/CD24^– by using magnetic-activated cell sorting …

Effects Of Modified Cryoprotectants On The Expression Of Heat Shock Protein 90 (Hsp90) And Zona Pellucida Ii (Zpii) Of Post-Thawing Sperm Quality, Silvia Werdhy Lestari, Manggiasih Dwiayu Larasati, Gita Pratama, Mulyoto Pangestu, Muhammad Thoriq, Dantha Rafael Sitompul

Baghdad Science Journal

Sperm cryopreservation is a basic element of assisted reproductive technology, yet it often compromises cell viability through thermal and osmotic stress. The cellular response involves HSP90, a stress marker and ZPII, which is essential for sperm-oocyte interaction and preventing polyspermy. In addition, this modified cryoprotectant combines glycerol and raffinose is expected to reduce damage and increase spermatozoa's recovery rate after cryopreservation. To address these challenges, we investigated the expression levels of HSP90 and ZPII to assess the protective capacity of modified cryoprotectant formulations. These parameters were analyzed pre- and post-cryopreservation to establish whether these novel mediums superiorly preserve sperm integrity …

Rethinking Vaginal Microbiome Resilience: A Conceptual Multi-Omic Framework, Brittnee Cagle-White, Rob E. Carpenter, Alaina Vincent, Ellen Kominek, Andrew Krouse

Human Resource Development Faculty Publications and Presentations

The vaginal microbiome is often interpreted through static taxonomic patterns. Yet microbial composition alone does not explain why some communities resist perturbation, recover after disruption, or transition toward dysbiosis. This narrative review synthesizes evidence that vaginal microbiome stability is shaped by endocrine phase, epithelial substrate availability, microbial functional capacity, mucosal tone and candidate host modifiers. High-estrogen states, particularly pregnancy, are associated with epithelial maturation, glycogen accumulation, low vaginal pH, and Lactobacillus-dominant communities, whereas postpartum, lactational, menopausal, and other hypoestrogenic states are associated with reduced epithelial support and increased vulnerability to diverse anaerobe-rich configurations. We review the linking of the estrogen–glycogen–Lactobacillus …

Enhancing Resonance Wave–Matter Interaction In Finite-Size Dielectric Metasurfaces, Varsha Vijay Kumar, Elena Semouchkina

Michigan Tech Publications

We investigate the dramatic effects produced by the presence of physical boundaries of finite-size metasurfaces (MSs), composed of identical cylindrical dielectric resonators without broken symmetry, on the complexity of their responses, observed at normal plane wave incidence, when constituent particles can support only dipolar Mie resonances. We demonstrate the possibility to excite extra high-quality resonance modes in these finite structures, which are quite distinct from the modes in infinite structures. We explore the formation of different types of high-quality modes in MS fragments of different configurations and sizes, which makes it possible to provide guidance for configuring their optimal designs. …

Distributed Impressions: How Multiple Minds Come Together To Shape Person Perception, Lindsey J. Tepfer

Dartmouth College Ph.D Dissertations

Moments after perceiving another person, we immediately infer a wealth of information about them. Despite the complexities within our social environments, we distill an incredible magnitude of details available to us into compressed representations of other people’s minds and mannerisms. Yet research has focused largely on mapping isolated stimuli—divorced from its messy context—to the spontaneous impressions they provoke. As a result, there are many unanswered questions about how our judgments are influenced by the rich and noisy social world we inhabit. Here, I’ve leveraged two paradigms to investigate how impression formation and updating may operate when the constraints of the …

Scientific Advances In Ecology Through The Lens Of Ecological Processes, Jiquan Chen, De Hui Zeng, Guillermo Martínez Pastur, João C. Azevedo, James A. Lutz, Raffaele Lafortezza, Andrew Burton, Et Al.

Michigan Tech Publications

In this perspective editorial, we analyzed publication trends and author-provided keywords across ten leading ecology journals from 2012 to 2025 to synthesize recent developments in ecological research. We identified six major trends that have shaped the field: (1) the shift from descriptive to mechanistic investigations, (2) the relevance of climate change and ecosystem feedbacks, (3) the growing integration of the human dimension into ecological research, (4) the application of advanced technologies and analytical methods, (5) the increasingly diverse contributions from the global scientific community, and (6) the rise of issue-focused research. Building on this synoptic overview, we discuss emerging frontiers …

Assessing The Role Of Model Complexity In Virtual Clinical Trial Outcomes, Jana L. Gevertz, Joanna R. Wares

Department of Math & Statistics Faculty Publications

Virtual clinical trials (VCTs) hold significant promise for improving the drug development process, yet their predictive reliability depends critically on design decisions that remain poorly understood. This study examines how model complexity influences VCT outcomes, as well as how the choice of prior parameter distributions and virtual patient inclusion criteria affects those outcomes. Using oncolytic virotherapy treatment of murine tumors as a case study, we compared a relative hierarchy of three mathematical models of increasing complexity under different parameter priors (uniform and normal distributions) and two inclusion methods (accept-or-reject and accept-or-perturb). Our results demonstrate that the simplest model produces a …

The Exploration Of The Antidiabetic Potentialities Of Bottle Gourd (Lagenaria Siceraria) Fruits Through In Vivo, In Vitro And In Silico Approaches, Arifa Sultana, Fahima Aktar, Fabiha Noushin, Mariam Wahed, Jakir Ahmed Chowdhury, Abu Asad Chowdhury, Shaila Kabir, Md. Shah Amran

Pharmaceutical Sciences and Research

Due to the ineffectiveness, side effects, and high cost of conventional drugs, medicinal plants grabbed the attention to treat diabetes, which has been a global health concern nowadays. Therefore, this study aims to investigate the antidiabetic potentialities of bottle gourd (Lagenaria siceraria) fruits in in vivo, in vitro, and in silico methods. For the in vivo assessment, alloxan-induced diabetic rats were fed food mixed with bottle gourd powder for 21 days. For the in vitro assessment, the alpha-amylase inhibitory assay was used to determine the antidiabetic properties of an ethanolic extract of L. siceraria. For the …

Resource Constraint Evacuation Route Planning A Capacity-Aware Charge-Encoded State-Space Approach, Praveen Borra

Electronic Theses and Dissertations 2020 - Present

Emergency Management Information Systems (EMIS) are defined as a set of tools that assist decision-makers in risk assessment and disaster response for significant multi-hazard threats and disasters. Over the past several decades, EMIS have become increasingly important for understanding, managing, and governing transportation systems during large-scale emergency events. One of the primary objectives of EMIS is to efficiently utilize spatial and network datasets to support evacuation planning, identify critical transportation patterns during emergencies, and allocate resources effectively. However, the increasing complexity and scale of modern transportation systems present significant challenges in developing reliable evacuation planning solutions.

One of the most …

Illinois Wesleyan Launches New Podcast To Share Campus Stories, Emily Bollinger

Press Releases 2020-2029

No abstract provided.

Combining Menin And Mek Inhibition To Target Poor Prognosis Kmt2a-Rearranged Ras Pathway-Mutant Acute Myeloid Leukemia., Nastassja Scheidegger, Constanze Schneider, Gabriela Alexe, Yi-Cheng Wang, Todd A. Alonzo, Allen Basanthakumar, Wallace A. Bourgeois, Julia Dudkiewicz-Garbicz, Delan Khalid, Lucy A. Merickel, Jennifer A. Perry, Rhonda E. Ries, Silvi Salhotra, Audrey Taillon, Alan S. Gamis, Richard Aplenc, Marian H. Harris, Mark Wunderlich, Scott A. Armstrong, Jessica A. Pollard, Soheil Meshinchi, Yana Pikman, Kimberly Stegmaier

Manuscripts, Articles, Book Chapters and Other Papers

KMT2A-rearranged (KMT2A-r) acute leukemias are especially prevalent in the pediatric population. KMT2A-fusion proteins drive leukemogenic gene expression through an interaction with a chromatin complex that includes the scaffold protein menin, giving rise to aggressive acute leukemias. RAS pathway mutations are also common in pediatric leukemia. In a cohort of 1750 patients enrolled on Children's Oncology Group (COG) trials, we identified RAS pathway mutations in 43% of acute myeloid leukemia (AML) cases. The presence of RAS pathway mutations in KMT2A-r AML was associated with a lower complete remission rate, poor event-free survival and overall survival (OS), and early relapses. Given the …

Prevalence Of Torovirus, Rotavirus, And Adenovirus Infection Among Iraqi Pediatric Patients With Gastroenteritis, Eman A. Mahmood, Nadira S. Mohamed, Safaa Al-Deen A. S. Al-Qaysi

Baghdad Science Journal

Gastroenteritis is a major cause of morbidity and mortality among children, particularly in developing countries. Rotavirus, adenovirus, and torovirus are among the common viral agents associated with pediatric gastroenteritis. This study aimed to determine the prevalence of these viruses and to evaluate diagnostic methods for torovirus infection among Iraqi children. A total of 250 stool samples were collected from pediatric patients aged from 2 weeks to over 10 years who attended Children's Protection Teaching Hospital, Baghdad, Iraq, between December 2023 and August 2024. The samples were screened for the presence of rotavirus, enteric adenovirus, and torovirus antigens using the Hemagglutination …

An Anthropological Lens Into Human Milk Mirnas: Roles In Evolution And Epigenetic Programming Of Infant Health, Samantha Wu, Erika Yu, Allison Oh, Chantal Rabay, Amy L. Non

Human Biology Open Access Pre-Prints

MicroRNAs (miRNAs) represent an understudied bioactive component of human milk with an important epigenetic role in regulating infant gene expression. Most anthropological studies of human milk have focused on the evolutionary and biocultural significance of milk macronutrient content for infant development. This review will focus specifically on the value of studying milk miRNAs, a critical bioactive component of milk that may transmit cues to offspring about maternal environments. These cues could epigenetically program infant development and shape health trajectories throughout the life course. MiRNAs are short, single stranded, ribonucleic acids that serve as post-transcriptional regulators of gene expression which can …

Blood Biomarkers Predict Conversion From Cognitively Stable To Mild Cognitive Impairment Or Alzheimer's Disease In Down Syndrome At 16-Month Follow-Up In Abc-Ds, Fan Zhang, Melissa Petersen, Mark Mapstone, James Hall, Benjamin Handen, Brad Christian, Elizabeth Head, Herminia Diana Rosas, Florence Lai, Joseph H. Lee, Sharon J. Krinsky-Mchale, Frederick A. Schmitt, Jordan Harp, Christy Hom, Ira T. Lott, Sigan Hartley, Shahid Zaman, Beau M. Ances, Lauren Ptomey, Jeffrey M. Burns, Ann D. Cohen, Adam M. Brickman, Sid E.O’ Bryant

Psychology Faculty Publications

INTRODUCTION: Individuals with Down syndrome (DS) face high risk for Alzheimer's disease (AD), yet presymptomatic detection of cognitive decline is hindered by lifelong intellectual disability. METHODS: Using data from the Alzheimer's Biomarker Consortium–Down Syndrome (ABC-DS), blood samples from 246 participants were analyzed, yielding 404 longitudinal observations (45 Converters, 359 Stable) collected at 0, 16, and 32 months were analyzed. A Support Vector Machine was trained on 25 plasma biomarkers spanning neurodegeneration, inflammation, and vascular health, along with demographic factors (age, sex, ethnicity, karyotype, apolipoprotein E [APOE ε4]). Batch-effect correction and feature selection were applied, resulting in 13 key markers. RESULTS: …

Turning Policy Implications Into Policy Impact, Alycia Chin, Katherine G. Carman, Adam W. Craig, Jonathan A. Cook, David B. Zimmerman

Psychology Faculty Publications

We describe how research can inform policymaking. We begin by summarizing the policy formation process, offering a framework illustrating how interactions between scientists and policymakers can provide mutual benefits. We then describe four research initiatives from the Securities and Exchange Commission’s Office of Investor Research (OIR) as examples of how behavioral sciences can help inform policymakers. The first initiative established a probability-based nationally representative survey panel focused on US investor behavior. The remaining three examined investor communications for mutual fund benchmarks, emerging annuities (known as registered index-linked annuities), and mutual fund fee visuals. We conclude by synthesizing our work and …

2026-07-14 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from July 14, 2026.

Pengembangan Diorama Dunia Mini Kita Sebagai Media Pembelajaran Ipas Pada Materi Denah Lingkungan Di Kelas Iii Sekolah Dasar, Sunya Tiara Putri, Aditya Pringga Satria, Leny Suryaning Astutik

Journal of Innovation and Teacher Professionalism

The present study aimed to develop the Dunia Mini Kita Diorama as a learning medium for the topic of neighborhood maps in Grade III Natural and Social Sciences (IPAS) and to determine its validity and practicality. This study employed the Research and Development (R&D) method using the ADDIE model, which consists of five stages: Analysis, Design, Development, Implementation, and Evaluation. The participants included two media experts, two subject matter experts, one Grade III teacher, and 28 Grade III students of SD Negeri 1 Kalidawir. Data were collected through observations, interviews, documentation, expert validation sheets, and teacher and student response questionnaires. …

Enhancing Patient Safety: The Impact Of Ehr Modifications On Medication Administration, Ellie Foral, Sarah Kiser, Regine Collier, Courtney Schleder, Cynthia Gamino, Morgan Garrison, Samantha Higdon, Bao Khuat

2025

No abstract provided.

20260714: Schedule Of Courses, 1999-2005, Registrar

Guides to University Archives

These items include materials from the Office of the Registrar. Items were received in 2008 most likely, but were not processed until 2026. Items include the Schedule of Courses from 1999-2005 on a semester by semester basis. Please download the finding aid for a full list of contents.

Mxene-Based Optical Fiber Sensors For Chemical And Biosensing: Review And Perspectives, Chen Zhu, Huaijun Guan, Chenxi Huang, Rex E. Gerald, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

No abstract provided.