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Articles 25381 - 25410 of 5206364
Full-Text Articles in Entire DC Network
Integrative Data Inform The Taxonomy Of Salix: A Case Study Of S. Purpurea L. Subsp. Leucodermis Yalt. (Salicaceae) From Türkiye, Peli̇n Acar, Yasi̇n Kaya, Dudu Özlem Mavi̇ İdman, Irina V. Belyaeva
Integrative Data Inform The Taxonomy Of Salix: A Case Study Of S. Purpurea L. Subsp. Leucodermis Yalt. (Salicaceae) From Türkiye, Peli̇n Acar, Yasi̇n Kaya, Dudu Özlem Mavi̇ İdman, Irina V. Belyaeva
Turkish Journal of Botany
The study of endemic species provides valuable perspectives on evolutionary history and future targets for their conservation. Salix purpurea L. subsp. leucodermis Yalt., which is endemic to Sandras Mountain in Türkiye, was analysed using morphological, anatomical, and genomic methods. This study presents the first draft short-read sequence of S. purpurea subsp. leucodermis, providing preliminary genomic evidence of differentiation from related taxa. This study also revealed a specific combination of anatomical features (prominent calcium oxalate crystals and amphistomatous leaves) and morphological characteristics (striated wood, glabrous buds, absence of stipules) that differentiate the taxon in question from the closely related species S. …
How To Authenticate An Orcid On Your Experts Profile, Kimberly Holling
How To Authenticate An Orcid On Your Experts Profile, Kimberly Holling
ScholarWorks Publications
This document provides step-by-step instructions for researchers to authenticate their unique ORCID number on the Experts Portal profile. This allows for the two systems to update researcher profiles for either one or both systems, as preferred.
Influence Of Supermassive Black Holes On The Star Formation Activities Of Their Host Active Galaxies, Ananthamoorthy Bannanje
Influence Of Supermassive Black Holes On The Star Formation Activities Of Their Host Active Galaxies, Ananthamoorthy Bannanje
University Departments
Active galactic nuclei (AGN) release substantial energy into their surrounding environn1ent, influencing the physical properties of the host galaxy and regulating the accretion of matter onto the central 'supermassive black hole (SMBI-D.' This process is known as ?GN feedback.' While AGN feedback is consideied an essential component in simulations to reproduce several observed properties of galaxies and clusters" direct observational evidence for its immediate and long-term impact on 'star formation' (SF) in both strong- and weak-jetted systems remains sparse and often contrasting. The primary limitation arises from the lack of high-resolution observations required for spatially resolved investigations of SF down …
Influence Of A New Nanoensemble Of Graphene Oxide And Indole-3-Acetic Acid On The Morphophysiological, Biochemical, And Ultrastructural Characteristics Of Upland Cotton (Gossypium Hirsutum L.), Nurlan Amrahov, Ulviyya Hasanova, Aliyeva Gunel, Aghazada Goncha, Fuad Rzayev, Eldar Gasimov, Aliyeva Solmaz, Lala Gahramanli, Elvin Ibrahimli, Ruhangiz Mammadova, Zarema Gakhramanova, Cem Bayram, Goncha Eyvazova, Si̇bel Hasanova, Ziyaddin Mammadov
Influence Of A New Nanoensemble Of Graphene Oxide And Indole-3-Acetic Acid On The Morphophysiological, Biochemical, And Ultrastructural Characteristics Of Upland Cotton (Gossypium Hirsutum L.), Nurlan Amrahov, Ulviyya Hasanova, Aliyeva Gunel, Aghazada Goncha, Fuad Rzayev, Eldar Gasimov, Aliyeva Solmaz, Lala Gahramanli, Elvin Ibrahimli, Ruhangiz Mammadova, Zarema Gakhramanova, Cem Bayram, Goncha Eyvazova, Si̇bel Hasanova, Ziyaddin Mammadov
Turkish Journal of Botany
The exogenous application of phytohormones plays a crucial role in the activation of adaptive mechanisms in plants under both normal and stress conditions. Therefore, the present study investigates the synthesis, characterization, and application of nanoensembles based on indole-3-acetic acid (IAA) and graphene oxide (GO) nanolayers. The surface of GO synthesized by the modified Hummer method was noncovalently functionalized with IAA molecules. The structure and morphological properties of the prepared materials were analyzed by Fourier transform infrared spectroscopy, X-ray diffraction, UV-Vis spectroscopy, and transmission electron microscopy. The IAA and IAA+GO nanoensemble enhanced the morphological parameters, lateral root formation, catalase and peroxidase …
Effects Of Calcium And Magnesium Ions On Wheat (Triticum Aestivum) Chromosome Structure Visualized Using Light And Scanning ElecTron Microscopes, Andi Salamah, Fitri Amalia Nurchasanah, Vycka Fikriyani Fairuz, Astari Dwiranti
Effects Of Calcium And Magnesium Ions On Wheat (Triticum Aestivum) Chromosome Structure Visualized Using Light And Scanning ElecTron Microscopes, Andi Salamah, Fitri Amalia Nurchasanah, Vycka Fikriyani Fairuz, Astari Dwiranti
Turkish Journal of Botany
Divalent cations, particularly calcium (Ca2+) and magnesium (Mg2+), are essential for maintaining chromosomal architecture, yet their roles in plants remain poorly characterized. This study investigated the effects of Ca2+ and Mg2+ on the chromosomal structure of wheat (Triticum aestivum, 2n = 6x = 42), a widely used model in plant cytogenetics. Root-tip chromosomes were isolated enzymatically and treated with BAPTA (a Ca2+-specific chelator), EDTA (a broad cation chelator), and buffer solutions containing either 5 mM Mg2+ (XBE5) or no Mg2+ (XBE). Chromosomes were stained with aceto-orcein for light microscopy and processed for scanning electron microscopy (SEM). Microscopic observations revealed that …
Systematic Implications Of Seed Morphology In Oxytropis (Galegeae: Fabaceae) From Pakistan, Amjad Khan, Amir Sultan, Raees Khan, Rozina Rozina, Shahab Ali, Ali Bagheri, Rifat Ullah Khan, Abdul Samad Mumtaz, Tariq Ullah, Ghalia Saleem Aljeddani, Hasil Khan
Systematic Implications Of Seed Morphology In Oxytropis (Galegeae: Fabaceae) From Pakistan, Amjad Khan, Amir Sultan, Raees Khan, Rozina Rozina, Shahab Ali, Ali Bagheri, Rifat Ullah Khan, Abdul Samad Mumtaz, Tariq Ullah, Ghalia Saleem Aljeddani, Hasil Khan
Turkish Journal of Botany
Oxytropis is a taxonomically challenging genus within the tribe Galegeae of the family Fabaceae. Despite its systematic importance, the seed morphology of Oxytropis has been poorly investigated. In the present study, we examined the seed morphology of 18 Oxytropis species representing 10 sections from the Pakistan, with the aim of evaluating the diagnostic value of seed traits using both light and scanning electron microscopy. The current investigation revealed two distinct seed shapes, namely cordiform and prolonged reniform, across the studied taxa. Seed length ranged from 1.75 mm in O. crassiuscula to 2.3 mm in O. duthieana, while seed width varied …
A Revenue-Driven Approach For Enhanced Task Utilization In Vehicular Cloud Computing, Ashish Singh Saluja, Satyabrata Das, Sanjib Kumar Nayak, Sohan Kumar Pande
A Revenue-Driven Approach For Enhanced Task Utilization In Vehicular Cloud Computing, Ashish Singh Saluja, Satyabrata Das, Sanjib Kumar Nayak, Sohan Kumar Pande
Turkish Journal of Electrical Engineering and Computer Sciences
Vehicular networks support intelligent transportation through vehicle-to-roadside Units (V2R) and vehicle-to-vehicle (V2V) communication but face challenges from dynamic topologies, limited RSU coverage, and bandwidth scarcity, which impact service delivery and revenue. RDA-ITU addresses these challenges by integrating V2R and V2V paradigms to maximize RSU revenue, enhance service availability, and improve system efficiency. It dynamically allocates services based on real-time network conditions and vehicle mobility, leveraging V2V relays to optimize both RSU-direct and cooperative communication. Through extensive simulations, RDA-ITU significantly outperforms four baselines: RBSM, VVMM-U, VVMM-LW, and VVMM-MA. It achieves 81.1% higher total revenue, 154.8% more completed requests, and 103.6% higher …
Class-Aligned Frequency Augmentation Using Variational Mode Decomposition Forfew-Shot Image Classification, Leila Boussaad
Class-Aligned Frequency Augmentation Using Variational Mode Decomposition Forfew-Shot Image Classification, Leila Boussaad
Turkish Journal of Electrical Engineering and Computer Sciences
Few-shot image classification benefits from data augmentation, yet most existing methods operate in pixel space with limited control over spectral semantics. We introduce a lightweight, frequency-guided augmentation strategy based on Variational Mode Decomposition (VMD). Our method constructs an offline, per-class ModeBank by decomposing downsampled luminance patches and retaining midband modes that encode class-specific texture patterns. During episodic training, VMD is never executed online: instead, for each support image, a same-class midband mode is selected and blended using PSNR-targeted scaling with a luminance energy cap, ensuring perceptual consistency. The augmentation is fast, reproducible, class-consistent, and integrates seamlessly into standard metric-based pipelines …
Scalefusion: Hierarchical Feature Aggregation For Unified Multiscale Object Detection, Ayşenur Yaylaci, Berru Kaya, Mehmet Kiliçarslan
Scalefusion: Hierarchical Feature Aggregation For Unified Multiscale Object Detection, Ayşenur Yaylaci, Berru Kaya, Mehmet Kiliçarslan
Turkish Journal of Electrical Engineering and Computer Sciences
Detecting objects across a wide range of scales, particularly small ones, remains a significant challenge in computer vision. Existing methods often improve small object detection at the cost of performance on larger objects or introduce significant computational overhead through external techniques like image slicing. This paper introduces ScaleFusion, a novel, unified, end-to-end object detection architecture designed to provide robust performance across all scales within a single model. The core of our approach is a hierarchical feature aggregation strategy structured like a tree. ScaleFusion processes an image by running a shared backbone network only on fine-grained patches at the lowest level …
Beyond Static Measures: The Predictive Validity And Classification Accuracy Of A Dynamic Assessment Of Decoding For Early Elementary, Bridgett Bakula
Beyond Static Measures: The Predictive Validity And Classification Accuracy Of A Dynamic Assessment Of Decoding For Early Elementary, Bridgett Bakula
Theses and Dissertations
Early and accurate identification of children at risk for reading difficulty is essential to prevent long-term academic failure, yet traditional static assessments often struggle to distinguish between a true reading disorder and a lack of prior instruction. This is particularly evident in the early grades, where floor effects and cultural/linguistic biases limit the classification accuracy of traditional screeners. This study investigated the predictive validity and structural utility of the modifiability index of a dynamic assessment (DA) of decoding, administered in kindergarten. Unlike static measures that evaluate "already actualized" knowledge, DA measures a student's learning potential and modifiability, or the capacity …
The Primary Care Brief Intervention Competency Assessment Tool (Bi-Cat): Examining Reliability And Validity, Arielle Guillod
The Primary Care Brief Intervention Competency Assessment Tool (Bi-Cat): Examining Reliability And Validity, Arielle Guillod
Dissertations
Within primary care, the Primary Care Behavioral Health (PCBH) model integrates behavioral health services into medical settings through brief, population‑based interventions delivered by behavioral health consultants (BHCs). Although effective performance in this role requires competencies distinct from traditional mental health practice, few psychometrically sound tools exist to assess clinical skills in primary care. The Brief Intervention Competency Assessment Tool (BICAT) is commonly used for this purpose but lacks published evidence supporting its reliability and validity. This dissertation examined the psychometric properties of the BICAT across two studies. Study 1 evaluated factor structure, internal consistency, and construct validity in a heterogeneous …
Optimized Immunoprecipitation Identifies Candidate Proteins Associated With Eyespot Protein Eye2 In Chlamydomonas Reinhardtii , Esra Öztürk, Telsa Mittelmeier, Carol Dieckmann, Atakan Sukatar
Optimized Immunoprecipitation Identifies Candidate Proteins Associated With Eyespot Protein Eye2 In Chlamydomonas Reinhardtii , Esra Öztürk, Telsa Mittelmeier, Carol Dieckmann, Atakan Sukatar
Turkish Journal of Botany
The EYE2 protein is essential for eyespot assembly and localization in Chlamydomonas reinhardtii, yet the molecular mechanisms underlying its function remain poorly understood. In this study, we present a systematic evaluation and optimization of an immunoprecipitation (IP)-based workflow for isolating EYE2 and its associated protein complexes. Key methodological variables including strain selection, flagella removal, and detergent concentration were compared using western blotting to determine optimal extraction conditions. The combination of the cell wall-deficient cw15 strain, 4% digitonin extraction, and pH shock-mediated deflagellation significantly enhanced IP specificity and reproducibility. Using this optimized protocol, EYE2 and its potential interaction partners were isolated …
A Scoping Review Of The Role, Challenges, And Opportunities Of Academic Librarians In Research Data Management And Open Science In Africa, Aminu Umar Musa, Usman Hassan, Abubakar Mohammed Musa
A Scoping Review Of The Role, Challenges, And Opportunities Of Academic Librarians In Research Data Management And Open Science In Africa, Aminu Umar Musa, Usman Hassan, Abubakar Mohammed Musa
Library Philosophy and Practice (e-journal)
Objective: The increased data density of research has made research data management a critical service within university libraries. This paper provides a scoping analysis of the literature on academic librarians' roles, difficulties, and possibilities in research data management (RDM) and open science (OS) in Africa.
Methods: The review, which followed the Arksey and O'Malley scoping review framework and was presented in accordance with PRISMA-ScR principles, methodically mapped existing evidence from peer-reviewed literature published between 2010 and 2024. Scopus, Web of Science, Library and Information Science Source, and Google Scholar were all used for searches. Following screening and eligibility assessment, 43 …
Oregon State Rank Assessment For Steens Mountain Cushion Buckwheat (Eriogonum Ovalifolium Var. Rubidum), Lindsey K. Wise
Oregon State Rank Assessment For Steens Mountain Cushion Buckwheat (Eriogonum Ovalifolium Var. Rubidum), Lindsey K. Wise
Institute for Natural Resources Publications
Oregon state conservation status assessment for Steens Mountain Cushion Buckwheat (Eriogonum ovalifolium var. rubidum) using NatureServe methodology, 2026.
Investigating The Links Between Parent Math Anxiety, Parenting Behaviors, And Child Math Achievement And Math Anxiety In Middle Childhood, Kimia Akhavein
Investigating The Links Between Parent Math Anxiety, Parenting Behaviors, And Child Math Achievement And Math Anxiety In Middle Childhood, Kimia Akhavein
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Existing research indicates that parents’ math anxiety is a robust predictor of children’s math achievement and math anxiety. The current dissertation study moved the literature forward by examining the transmission of parents’ math anxiety to children’s math achievement and math anxiety via autonomy-supportive and controlling parenting behaviors using an observational coding scheme during a homework help task when children were in second grade. The first research aim examined if parents’ autonomy supportive and controlling behaviors mediated the link between parents’ math anxiety and children’s math achievement and math anxiety one year later. The second research aim examined whether parents’ emotion …
Analysis Of The Fracture Toughness Of Ercual A2 Cladding On Api X70 Using The Instrumented Charpy Impact Test, Martín Aguirre-Pulido, Francisco Fernando Curiel-López, Jose Jaime Taha-Tijerina, Jorge Alejandro Verduzco-Martínez, Víctor Hugo López-Morelos, Heriberto Granados-Becerra, Ariosto Medina-Flores
Analysis Of The Fracture Toughness Of Ercual A2 Cladding On Api X70 Using The Instrumented Charpy Impact Test, Martín Aguirre-Pulido, Francisco Fernando Curiel-López, Jose Jaime Taha-Tijerina, Jorge Alejandro Verduzco-Martínez, Víctor Hugo López-Morelos, Heriberto Granados-Becerra, Ariosto Medina-Flores
Mechanical Engineering Faculty Publications
The degradation of steel used in the oil industry has become a serious problem due to the high costs associated with material loss from corrosion. Applying thin layers of corrosion-resistant material promises to be a viable alternative for extending the service life of pipelines. ERCuAl-A2 electrode claddings were applied to API X70 carbon steel using the MIG brazing process with direct current (DC) and pulsed current (P). The cladding was applied under three conditions: base material (BM) at room temperature, BM preheated to 120 °C, and Ni-buttered BM. Microhardness profiles and Charpy impact tests were performed on the MB and …
Beyond Sticky Floors: Executive Gender Diversity And Firm-Level Gender Pay Inequality In Uk Firms, Yasser Eliwa, Sally Ahmed, Ahmed Saleh
Beyond Sticky Floors: Executive Gender Diversity And Firm-Level Gender Pay Inequality In Uk Firms, Yasser Eliwa, Sally Ahmed, Ahmed Saleh
All Works
This study examines whether executive gender diversity is associated with gender pay inequality in UK firms. Although prior research has extensively examined board diversity, less is known about whether gender diversity within executive leadership teams is linked to differences in pay inequality across firms. Using a panel of FTSE 350 non-financial firms from 2017 to 2023 and mandatory UK gender pay gap disclosures, we estimate regression models to examine the relationship between the proportion of female executives and the gender pay gap. The findings show that greater executive gender diversity is significantly associated with lower gender pay inequality. In contrast, …
Water-Driven Reactivation Of Photosystem Ii In Plagiochasma Appendiculatum, Vineet Soni, Upma Bhatt, Yashwant Sompura
Water-Driven Reactivation Of Photosystem Ii In Plagiochasma Appendiculatum, Vineet Soni, Upma Bhatt, Yashwant Sompura
Turkish Journal of Botany
Plagiochasma appendiculatum, a desiccation-tolerant liverwort, offers a unique system for unraveling the biophysical dynamics of photosynthetic recovery upon rehydration. This study employed high-resolution chlorophyll a fluorescence (ChlF) kinetics to clarify the sequential reactivation of photosystem II (PSII) during the desiccation-to-rehydration transition. Upon desiccation, the OJIP transient collapsed into a linear trace, indicating complete photochemical arrest and inactivation of PSII reaction centers (RCs). Rehydration triggered a biphasic recovery, including an initial rapid phase (0–30 min) marked by sharp increases in F0 and Fm , indicative of PSII–LHCII supercomplex reassembly and thylakoid membrane restoration, followed by a stabilization phase (30–125 min) wherein …
Application Of Virtual Reality To Alter Sweetness Perception, Serena Wellbelove, John Gieng, Valerie A. Carr, Kate Mcleod, Xi Feng
Application Of Virtual Reality To Alter Sweetness Perception, Serena Wellbelove, John Gieng, Valerie A. Carr, Kate Mcleod, Xi Feng
Faculty Research, Scholarly, and Creative Activity
Regular consumption of excess sugar is linked to nutrition-based diseases, including gut problems, Non-Alcoholic Fatty Liver Disease, and Type 2 Diabetes Mellitus. Increasing sweetness perception is a novel technique to decrease sugar consumption. This experiment compared the sweetness perception of sweetened and unsweetened almond milk in response to different virtual environments with music and visuals. Two music types, the classical song Goldberg Variations, BMV. 998-Variation 13 and a jazz song generated by AI were used. Additionally, fall and spring forest backgrounds were generated by the Blockade Labs 3D image generator. Each participant tasted sweetened and unsweetened almond milk in music-only, …
Fostering Collaboration Through Learning Communities: A Case Report On Engaging With All Of Us Data Among Library Professionals, Faculty, And Students, Zachary Mcniece, Dawn Hackman, Nick Szydlowski, Yuqi He
Fostering Collaboration Through Learning Communities: A Case Report On Engaging With All Of Us Data Among Library Professionals, Faculty, And Students, Zachary Mcniece, Dawn Hackman, Nick Szydlowski, Yuqi He
Faculty Research, Scholarly, and Creative Activity
Background: Research data services (RDS) have expanded in academic libraries but can be challenging to develop, particularly in teaching-intensive and less-resourced institutions. Learning communities offer a promising model for building skills, fostering collaboration, and aligning services with local needs. Case Presentation: This case report describes the development and implementation of three learning communities—a library group, a faculty group, and a student group—at a teaching-focused institution. These communities brought together library professionals, faculty, and students from diverse disciplines—including health sciences, education, data science, and engineering—to collaboratively explore the All of Us dataset. By working with the same dataset, participants were able …
577 Vanderbilt Llc V. Hassell
All Decisions
Landlord commenced a nonpayment proceeding demanding the legal regulated rent. In 2018, landlord's predecessor-in-interest settled a prior nonpayment proceeding by two-attorney stipulation, granting tenant a preferential rent of $1,750 set to expire August 14, 2024. After HSTPA's enactment on June 14, 2019, RSL §26-511(c)(14) and RSC §2521.2(d) were amended to require that any tenant paying a preferential rent as of HSTPA's effective date be charged no more than that preferential rent for the lifetime of the tenancy. Tenant moved for summary judgment. The court granted the motion, holding that the 2018 stipulation's expiration date became unenforceable after HSTPA, that applying …
Hill Plaza Enters. Ny Llc V. Terris
Hill Plaza Enters. Ny Llc V. Terris
All Decisions
Court granted tenant's motion for a discretionary stay of the proceeding pending appeal under CPLR 5519(c), allowing tenant to challenge a prior decision denying summary judgment on her rent overcharge and fraudulent deregulation counterclaims. Court found minimal prejudice to landlord because the underlying nonpayment petition had already been dismissed, while potential prejudice to tenant from proceeding without resolution of the appeal was manifest.
Expert Opinion: Management Of Intraocular Inflammation And Vasculitis After Intravitreal Pegcetacoplan For Geographic Atrophy, Thomas Albini, Steven Yeh, Carl Regillo, Roy Schwartz, Philip Ferrone, Caroline Baumal, Charles Wykoff
Expert Opinion: Management Of Intraocular Inflammation And Vasculitis After Intravitreal Pegcetacoplan For Geographic Atrophy, Thomas Albini, Steven Yeh, Carl Regillo, Roy Schwartz, Philip Ferrone, Caroline Baumal, Charles Wykoff
Wills Eye Hospital Papers
BACKGROUND AND OBJECTIVE: This expert opinion review is intended to provide guidelines for diagnosis and management of intraocular inflammation (IOI) and vasculitis following pegcetacoplan.
PATIENTS AND METHODS: A case series of all post-marketing reports classified by experts as definite or suspected vasculitis over an 18-month period was assessed.
RESULTS: A total of 306,000 pegcetacoplan intravit real injections were given in the real world between March 1, 2023, and August 31, 2024. Twenty-four eyes from 22 patients (mean age 76 years, 59% female) with definite or suspected vasculitis were evaluated. Comorbidities included hypertension (55%), hypo thyroidism (27%), and recent COVID-19 infection …
Longitudinal Patterns In Stygobiont Distribution In The Hyporheic Zone Of The Karst Spring-Fed San Marcos River, Texas, Usa, Kenneth Sparks, Benjamin F. Schwartz, Safra Altman, Kathryn E. Perez, Zoey B. Chanin, Caroline Mierzejewski, Benjamin T. Hutchins
Longitudinal Patterns In Stygobiont Distribution In The Hyporheic Zone Of The Karst Spring-Fed San Marcos River, Texas, Usa, Kenneth Sparks, Benjamin F. Schwartz, Safra Altman, Kathryn E. Perez, Zoey B. Chanin, Caroline Mierzejewski, Benjamin T. Hutchins
School of Integrative Biological & Chemical Sciences Faculty Publications
Groundwater-obligate taxa (stygobionts) exhibit variable degrees of habitat specialization, ranging from those restricted to single micro-habitats to generalists occurring in a broad range of habitat types. The karstic Edwards Aquifer is the most biodiverse and well-studied groundwater habitat in the continental United States, but some Edwards Aquifer-associated species also occupy the hyporheic zone of rivers downstream from karst. The goals of this research were to 1) assess the potential of the off-karst hyporheic zone as habitat for ‘karst’ species and 2) to determine how stygobiont richness, diversity, and abundance related to distance from karst in the hyporheic zone of a …
Advancing Data-Driven Health Research From The All Of Us Data Training And Engagement Program, Maletta Payne, Kristi Sadowski, Debran Tarver, Jennifer Burnette, Allissa Dillman, Regina Renfro, Lafrancis Gibson, Kelli Bursey, Laura Bartlett, Nadine Bonds-Bishop, Lisa Connor, Efrain Flores-Rivera, Sarah Joseph, Yugi He, Margaret Henderson, Savannah Kelley, Brett Porter, Kimberly Prosper, Melissa Rethlefsen, Deborah Rhue, Dede Rios, Anna Simonson, Jocelyn Swick-Jemison, Linda Todd, Shelby Watson, Semhar Yohannes
Advancing Data-Driven Health Research From The All Of Us Data Training And Engagement Program, Maletta Payne, Kristi Sadowski, Debran Tarver, Jennifer Burnette, Allissa Dillman, Regina Renfro, Lafrancis Gibson, Kelli Bursey, Laura Bartlett, Nadine Bonds-Bishop, Lisa Connor, Efrain Flores-Rivera, Sarah Joseph, Yugi He, Margaret Henderson, Savannah Kelley, Brett Porter, Kimberly Prosper, Melissa Rethlefsen, Deborah Rhue, Dede Rios, Anna Simonson, Jocelyn Swick-Jemison, Linda Todd, Shelby Watson, Semhar Yohannes
Southern University and A&M College: John B. Cade Library Publications
Fulfilling a recognized need in data skills training for academic librarians, the National Library of Medicine and the National Institutes of Health All of Us Research Program collaborated to enhance academic library workers& skills in biomedical and public health data, as well as their library's research capacity, through the awareness and use of the All of Us Researcher Workbench.
Lightning Safety Tips Everyone Should Know, From A Unh Expert, Scott Ripley
Lightning Safety Tips Everyone Should Know, From A Unh Expert, Scott Ripley
UNH Today Archive
No abstract provided.
The Nsf Seafood Engine In New England Wins $15m Award To Strengthen Fisheries And Aquaculture, Tania Deluzuriaga
The Nsf Seafood Engine In New England Wins $15m Award To Strengthen Fisheries And Aquaculture, Tania Deluzuriaga
UNH Today Archive
No abstract provided.
Vamorolone For Duchenne Muscular Dystrophy A Cross-Trial Efficacy Comparison With Classic Corticosteroids From The For-Dmd Trial, Paula R. Clemens, Anders Berglund, Marianela Schiava, Meredith K. James, Michael P. Mcdermott, Katherine Bushby, Erik Lampa, Edward Thomas James Rochford, Leanne M. Ward, Robert C. Griggs, Eric P. Hoffman, Michela Guglieri
Vamorolone For Duchenne Muscular Dystrophy A Cross-Trial Efficacy Comparison With Classic Corticosteroids From The For-Dmd Trial, Paula R. Clemens, Anders Berglund, Marianela Schiava, Meredith K. James, Michael P. Mcdermott, Katherine Bushby, Erik Lampa, Edward Thomas James Rochford, Leanne M. Ward, Robert C. Griggs, Eric P. Hoffman, Michela Guglieri
Pharmacy Faculty Scholarship
Background and Objectives: Vamorolone demonstrated similar efficacy for Duchenne muscular dystrophy (DMD) compared with prednisone in a 24-week exploratory analysis and may reduce key side effects compared with classic corticosteroids. In this study, we compare the efficacy and anthropometric effect of vamorolone 6 mg/kg/d with prednisone 0.75 mg/kg/d and deflazacort 0.9 mg/kg/d in steroid-naïve boys aged 4 to < 7 years using data from 2 trials. Methods: VISION-DMD was a phase 2b, 48-week randomized, double-blind trial assessing vamorolone 2 and 6 mg/kg/d vs placebo and prednisone 0.75 mg/kg/d to 24 weeks. Finding the Optimum Steroid Regimen for DMD (FOR-DMD) was a double-blind, parallel-group randomized trial comparing daily prednisone 0.75 mg/kg/d, daily deflazacort 0.9 mg/kg/d, and intermittent prednisone 0.75 mg/kg (10/10 days on/off). Entropy balancing generated weighted data for mixed model for repeated measures analyses that compared VISION-DMD vamorolone 6 mg/kg/d efficacy and anthropometric outcomes with FOR-DMD prednisone and deflazacort outcomes at 6 and 12 months. Inclusion criteria were boys with genetically confirmed DMD, age 4 to < 7 years, ambulatory, and able to complete a time-to-stand (TTSTAND) assessment in < 10 seconds at baseline. Results: All interventions showed motor improvements relative to baseline at 6 and 12 months. Using the weighted cohorts and at 12 months, vamorolone 6 mg/kg/d (n = 28) had similar changes in TTSTAND velocity, the primary motor endpoint component in both trials, vs daily prednisone (n = 50) or deflazacort (n = 55; mean baseline age 5.42 years all groups), but with CIs overlapping minimal clinically important thresholds of 0.023 rises per second (TTSTAND velocity least squares mean [LSM] difference [95% CI]: vamorolone 6 mg/kg/d vs prednisone 0.75 mg/kg/d, 0.004 rises per second [−0.025 to 0.032] and vs deflazacort 0.9 mg/kg/d, 0.001 rises per second [−0.027 to 0.028]). Body mass index (BMI) Z-scores increased in all groups, greatest with vamorolone (12-month LSM difference [95% CI]: vamorolone vs prednisone 0.57 [0.24–0.90]; vamorolone vs deflazacort 0.29 [0.03–0.56]), whereas growth slowdown occurred in prednisone- and deflazacort-treated boys but not vamorolone (12-month LSM difference in height Z-scores [95% CI]: vamorolone vs prednisone 0.57 [0.24–0.90]; vamorolone vs deflazacort 0.72 [0.53–0.91]). Discussion: Vamorolone demonstrated numerically similar TTSTAND velocity changes to prednisone and deflazacort at 1 year; however, interpretations of differences are limited by 95% CIs crossing minimally important difference thresholds. Further evidence of the growth-protective effect of vamorolone was observed; however, all treatments increased BMI. Vamorolone provides a linear growth-protective classic corticosteroid alternative.
Cover And Content
Turkish Journal of Electrical Engineering and Computer Sciences
No abstract provided.