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Racial Health Disparities Among Pregnant Women Of Color In New York City: Biological And Systemic Impacts, Kaylin Peña

Pitzer Senior Theses

Racial Health Disparities Among Pregnant Women of Color in New York City: Biological and Systemic Impacts

Abstract

This thesis aims to explore how racial health disparities, underrepresentation in gynecology, and socioeconomic barriers contribute to adverse pregnancy outcomes among women of color in New York City. Through an interdisciplinary approach that combines resources from medical anthropology and human biology, this research will examine the biological implications of chronic stress, specifically HPA axis dysregulation, and its role in maternal health outcomes. With the idea of intersectionality, as conceptualized by Kimberlé Crenshaw, the study analyzes the various effects of systemic inequities and social …

Technology Competency Road Map In Rhode Island: Reforming Professional Rules And Continuing Legal Education With Modern Educational Frameworks And Instructional Design Principles To Protect Clients, Myrta L. Ventura

Roger Williams University Law Review

No abstract provided.

2024 Survey Of Rhode Island Law, Table Of Contents

Roger Williams University Law Review

No abstract provided.

Understanding The Pathogenesis Of Uveitis In Ebola Virus Disease Survivors: An Observational Cohort And Cross-Sectional Study Protocol For Clinical, Molecular Virologic And Immunologic Characterisation, Caleb D. Hartley, Susanne Linderman, Tolulope Fashina, Laura Ward, Carolyn Drews-Botsch, Catherine Pratt, Sanjana Kuthyar, Alcides Filho Fernandes, Ye Huang, Charlene Choo, Nam Nguyen, Jessica Carag, Jill Morgan, Colleen S. Kraft, Angela L. Hewlett, David Brett-Major, John S. Schieffelin, Robert F. Garry, Donald Grant, Grant A. Justin, Christopher D. Conrady, Justine R. Smith, Brent R. Hayek, Shiama Balendra, Nisha Acharya, Thuy Doan, Anais Legand, Pierre Formenty, Xiankun Zeng, Ibrahim Conteh, Matthew Jusu Vandy, Lloyd Harrison-Williams, Jalikatu Mustapha, Zikan Koroma, Michael R. Wiley, Ian Crozier, Jean-Claude Mwanza, Jessica G. Shantha, Rafi Ahmed, Steven Yeh, Smile And Evict-Vr Investigator Study Groups

Journal Articles: Epidemiology

INTRODUCTION: The 2013-2016 Western African outbreak of the Ebola virus disease (EVD), the largest recorded outbreak since the discovery of Ebola virus (EBOV) in 1976, destabilised local health systems and left thousands of survivors at risk for postacute sequelae, including vision-threatening uveitis. In an EVD survivor with severe panuveitis, the detection of persistent EBOV in the aqueous humour, long after clearance of acute viremia, focused clinical and research attention on the host-EBOV interaction in the unique terrain of ocular immune privilege. Despite the recognition that uveitis is common and consequential in EVD survivors, our understanding of pathogenesis is extremely limited, …

Bridging The Green Divide: Sustainable Community Development And Climate Resilience In Altadena, Ca, Katie Brosnan

Pitzer Senior Theses

Sustainable Community Development (SCD) is widely debated as a climate mitigation strategy, with recognized benefits such as reducing carbon footprints, enhancing public health, and fostering economic resilience. However, a major critique is its limited accessibility to marginalized communities. In particular, the resilience embedded in rebuilding plans does not necessarily translate to real access for those whose insurance coverage may not be sufficient to afford conventional design services or reconstruction costs. This thesis argues that while SCD is an effective tool for climate mitigation, its success depends on equitable access—not just in principle, but in the material capacity to participate in …

Mapping The Tren Maya’S Mark On Mérida, Diego Tamayo

Pitzer Senior Theses

Mapping the Tren Maya’s Mark on Mérida investigates whether the Tren Maya railway is ushering in new sustainable development which provides economic and social benefits for the residents of Mérida, Mexico. The Mexican government has spearheaded the megaproject’s construction in a mere four years with the goal of boosting economic growth in an environmentally and socially conscious manner. The following investigation highlights where this vision, articulated in technocratically-constructed public documents and amplified in reporting, has been fulfilled in Mérida. Through geospatial, physical, and journalistic investigations and analysis, it is revealed the Tren Maya has brought a host of impacts upon …

Feeding The System: A Political Ecology Of Stakeholders In The Soy Value Chain, Calli E. Oneal

Pitzer Senior Theses

This thesis presents a holistic analysis of power dynamics within the global soybean value chain, through the evaluation of the trade relationship between Brazil and the European Union. In order to identify how critical decisions regarding sustainability are concentrated among a few dominant actors. Eight core stakeholder groups are mapped: land-use conversion actors, producers, traders, agro-input providers, financial institutions, regulatory bodies, NGOs, and key consumers, including meatpacking and animal feed companies. Multinational traders, who control approximately 80% of global soy trade, act as sustainability gatekeepers through their lobbying influence and control over supply chain narratives and are disincentivized from human …

The Landscape Of Cyclin‑Dependent Kinase 4/6 Inhibitors In Solid Malignancies: Emphasis On Immunotherapy Combinatorial Strategies, Maha R.A. Abdollah, Sara A. Hussein, Ahmed H. Saadawy, Eman Badr, Neamtullah Wael, Rasha M. Allam, Ahmed M. Al‑Abd, Ana Maria Roncero Sanchez, Mai Tolba

Pharmacy

Given the pivotal role of CDK4/6 deregulation in the pathogenesis of various malignancies, CDK4/6 inhibitors have been incorporated into cancer treatment protocols. Beyond their antiproliferative effects, these inhibitors exhibit prominent immunomodulatory properties. Preclinical data indicated that CDK4/6 inhibitors enhance the tumor cell antigen presentation capacity and restrict the proliferation of immunosuppressive regulatory T-cells. Furthermore, studies showed that CDK4/6 inhibitors could enhance the development of memory T-cell in vivo in melanoma mouse models and in the clinical setting in breast cancer (BC) patients. In silico analysis identified 225 protein targets for CDK4/6 inhibitors involved in 57 immune-related pathways which further supported …

Corchorus Olitorius Exhibits Antiproliferative Potential Supported By Metabolic Profiling And Integrative Biological Analyses, Maha R.A. Abdollah, Salma Sameh, Ahmed Elissawy, Eman Al-Sayed, Rola Labib, Lan Ye, Fang-Rong Chang, Abdel Nasser B. Singab

Pharmacy

Herbal nutraceuticals could be employed as alternative or complementary routes for alleviating cancer. Corchorus olitorius (Malvaceae) was employed traditionally in the management of tumors. The study aimed to investigate the antiproliferative activity of C. olitorius leaves. In vitro cytotoxic and anti-angiogenic activities of C. olitorius were estimated. The bioactive fraction was subjected to in vivo study on BALB/ c female mice using Ehrlich Ascites Carcinoma model. UPLC-ESI-MS/MS analysis was done to determine the phytometabolites followed by in silico studies on the major identified compounds. The bioactive fraction possessed potent in vitro activity against A549 cells with IC50 = 7.8 µg/mL …

Uni Men's Golf Season Statistics 2024-25, University Of Northern Iowa

Athletics Media Guides

Contents:

--- 2024-25 Team Results
--- Round-by-Round Results

2025 University Of Northern Iowa Softball Overall Statistics, University Of Northern Iowa

Athletics Media Guides

Contents:

--- Batting Statistics
--- Pitching Statistics
--- Fielding Statistics

Effective Treatments For Veterans With Post Traumatic Stress Disorder From Military Sexual Trauma: A Literature Review, Lisa Wipf

Schultz-Werth Award Papers

Background: Military sexual trauma (MST) is a pervasive issue within the armed forces, leading to profound psychological and physical consequences, including post-traumatic stress disorder (PTSD). Purpose: The purpose of this literature review was to examine the effectiveness of pharmacologic and non-pharmacologic therapies in reducing PTSD symptoms in military veterans who have experienced MST. Method: A comprehensive review of literature from PubMed and CINAHL yielded 488 articles, which were filtered to 14 peer-reviewed studies published within the last two decades. Results: The study yielded articles that focused on pharmacologic treatments such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), …

Marijuana Use And The Health Of The Mother: Factors Relating To Marijuana Use Around Pregnancy, Grace Schroeder

Schultz-Werth Award Papers

This study examines data reported from SD PRAMS during the years 2018 to 2022 to understand the relationship between demographic and health factors and marijuana use before and during pregnancy. As the use of marijuana increased in the general population within the last few years, it also increased among women of childbearing age, both pregnant and not pregnant (Alshaarawy & Anthony 2019) (NIDA, 2023). The SD PRAMS questionnaire included questions on health care utilization, substance use, mental health, pregnancy-related care, and other related topics. We controlled for responses relating to demographic factors such as race, age, marital status, living in …

Reducing Food Waste Among College Students Through Educational Messaging, Olivia Husmann

Schultz-Werth Award Papers

The environmental and societal impacts of food waste continue to be demonstrated in reports, governmental documents, and independent research. While it is not the leading source of food waste, the foodservice industry has an important role in bringing awareness of the detriments of waste to its consumers. The following paper offers observations on food waste behaviors in college students at South Dakota State University (SDSU), specifically at Larson’s Commons dining hall during the 2024 spring semester. The study explores whether advocating for decreased food waste through infographics at dining tables changes the amount of food and drink wasted during the …

Harvesting Hope Creative Works : Art Of Storytelling Proposal A Chickadee’S Guidance, Carol Glaus

Schultz-Werth Award Papers

No abstract provided.

The Local Deep Galerkin Method Applied To The (2+1)-D Cahn-Hilliard Equation, Caden Fischer

Schultz-Werth Award Papers

Physics-informed Neural Networks (PINNs) are an alternative approach to solving Partial Differential Equations. This study examines the Local Deep Galerkin Method (LDGM), and its application to the (2+1)-Dimensional Cahn-Hilliard Equation (2D-CH). The 2D-CH models phase separation. One application of this is to modeling biofilm. The LDGM is trained on a loss function that minimizes the sum of the squares of the residuals of the system of equations. The LDGM is compared to a numerical simulation based on the Finite Element Method. The results of this study show that LDGM does not produce accurate results for the 2D-CH equation for large …

A Bioethical Analysis On The Allowance Of Physician-Assisted Death In Cases Of Mentally Declined Patients, Megan Nelson

Schultz-Werth Award Papers

As advancements are continually made in science, there is an increase in ethical issues that the world needs to address. When deciding where the law should fall on these new issues, it is important to use different ethical theories to view the issues from all sides. This is where the growing field of bioethics comes into play. “Bioethics is the study of ethical, social, and legal issues that arise in biomedicine and biomedical research” (Resnik, 2023). One of these bioethical issues that has become increasingly prevalent in society is physician-assisted death, which is sometimes referred to as euthanasia. This paper …

Capstone Ii Project : Mlb, Tayven Badger

Schultz-Werth Award Papers

Clustering player statistics provides new perspectives on identifying elite Major League Baseball (MLB) players. This paper explores the use of k-means clustering combined with principal component analysis (PCA) to segment players based on various performance metrics such as batting average, on-base percentage, wins above replacement, and many others. The analysis examines over a century of MLB data, dating from 1900 to 2023, to uncover meaningful groups and highlight key differences between elite and non-elite players. Results demonstrate how modern statistical techniques can go beyond traditional metrics to provide insights into player performance. These findings have implications for player evaluation, team …

Alexander Glazunov: Patriarch Of Students, Levi Gebhard

Schultz-Werth Award Papers

Amid shifting empires, political turmoil, cultural reform, famine, and immense poverty, few individuals have asserted themselves as boldly as Alexander Konstantinovich Glazunov. Glazunov lived through the end of the Tsarist Russia era and the uprising of the Soviet Union. The transition between those two powers consisted of hostile political pressure, brutal winters, revolts, and famine. What ultimately kept Glazunov from succumbing to the darkness of his times were his students and his compositions. As a teacher he was protective of his students’ academic success and their physical wellbeing. Not only did Glazunov live during the transition of one great political …

Comparison Of Hypertension Outcomes In Pharmacist Managed Patients Versus Cardiology Provider-Only Care Models, Alexis Clarke Pharmd

Pharmacy Residency

Presented at Midyear Clinical Meeting.

In this study, pharmacist-managed patients achieved BP goal 80 days faster than provider-only patients. Integrating pharmacists into care teams helps patients achieve their BP goal faster through increased visits and closer follow-up. Pharmacist managed groups had less therapeutic inertia regarding drug class changes.

No Cap! Evaluation Of Empiric Antibiotic Duration For Community Acquired Pneumonia, Bailey Castato Pharmd

Pharmacy Residency

Presented at the Midyear Clinical Meeting.

This evaluation found that patients hospitalized for CAP (including severe) without culture data or with negative respiratory cultures met clinical stability criteria early in admission. The maximum time to clinical stability was approximately 5 days. However, total median antibiotic duration was 7 days (IQR 6.0- 8.7), resulting in 2 days (IQR 1.5-3.9) of excess antibiotics.

Evaluation Of A Pharmacist-Driven Electrolyte Replacement Protocol In A Community Health System, Corey Uetrecht Pharmd Candidate

Pharmacy Residency

This evaluation found a higher rate of pharmacist consults for electrolyte management, though these were not always indicated. Repletion via oral route was not optimized and there were opportunities for improvement in protocol alignment.

Presented at Great Lakes PRC

Implementation Of An Evidence Based Skin And Soft Tissue Infection Algorithm At A Large Community Health System, Jennifer Mccarthy Pharmd, Ms

Pharmacy Residency

This study found a continued need for an updated skin and soft tissue infection algorithm. Ongoing reliance on IV antibiotics suggests underutilization of oral options. Promoting oral antibiotic use may reduce inpatient admissions and length of stay.

Presented at OHIO PRC

Evaluating The Impact Of A Pharmacist-Led Wellness And Weight Management (Wwm) Service In The Primary Care Setting, Nicholas Buttermore Pharmd

Pharmacy Residency

This evaluation found superior weight loss from baseline with pharmacist management, along with comparable GLP-1 and non-GLP-1 use and considerable financial benefits.

Aluminum In Beverages And Foods: A Comprehensive Compilation Of Regulations; Concentrations In Raw, Prepared, And Stored Beverages And Foods; And Intake, Robert Yokel

Pharmaceutical Sciences Faculty Publications

The history and controversy concerning aluminum use in beverage and food preparation and storage are reviewed. This review on aluminum in drinking water, foods, and beverages updates and exceeds prior reviews. Country and international organization regulations that permit incorporation of aluminum containing food additives, their use limit, and purposes are presented. The aluminum concentration in beverages and foods consumed worldwide was gleaned from approximately 2100 sources available to the author. The approximately 17700 values are compiled in 175 tables by beverage or food category that include the analytical method used, sample source, and reference. The tables are posted on the …

A Cocaine Hydrolase Engineered From Human Butyrylcholinesterase As A Medical Countermeasure For Aldicarb Poisoning, Johnathan E. Lesaint, Nellore Bhanu Chandar, Annet Kyomuhangi, Huimei Wei, Fang Zheng, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Publications

Aldicarb is known to be the most toxic carbamate pesticide and could be used easily by terrorists to cause a mass casualty incident. It is highly desired to discover a medical countermeasure for aldicarb poisoning. Based on structural insights from molecular modeling and in vitro experimental validation, CocH3-Fc(M3), a potent cocaine hydrolase engineered from human butyrylcholinesterase (BChE), has a ~4-fold improved binding affinity with aldicarb compared to wild-type human acetylcholinesterase (AChE) and BChE and a 9-28-fold improved bimolecular rate constant for the carbamylation with aldicarb compared to AChE. CocH3-Fc(M3) also has significant catalytic activity for aldicarb hydrolysis and, hence, is …

Development Of A Ghrelin Deacylase To Attenuate Drug Reward And Associated Effects Of Methamphetamine, Madeline J. Stewart, Huimei Wei, Nellore Bhanu Chandar, Fang Zheng, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Publications

All addictive substances directly or indirectly interact with the dopamine reward system to alter the brain’s dopamine receptor activities. It is essential for a truly effective addiction medication to attenuate substance reward and normalize the brain’s physiological functions. Conventional pharmacological intervention approaches to the treatment of substance addiction usually aim to develop and deliver a potential therapeutic agent to the brain to directly block or decrease actions of the substance or its therapeutic target in the brain. However, it is a grand challenge to attenuate the substance reward without affecting the normal physiological functions of brain receptors or transporters. Here, …

Effects Of Biased Analogues Of The Kappa Opioid Receptor Agonist, U50,488, In Preclinical Models Of Pain And Side Effects, Ross Van De Wetering, Loan Y. Vu, Lindsay D. Kornberger, Dan Luo, Brittany Scouller, Sheein Hong, Kelly F. Paton, Thomas E. Prisinzano, Bronwyn M. Kivell

Pharmaceutical Sciences Faculty Publications

Kappa opioid receptor (KOR) agonists have well-established antinociceptive effects. However, many KOR agonists have negative side effects, which limit their therapeutic potential. Some researchers have suggested that the development of biased agonists that preferentially stimulate KOR G-protein pathways over β-arrestin pathways may yield drugs with fewer adverse side effects. This was investigated in the current study. We describe the synthesis and characterization of three U50,488 analogues, 1, 2, and 3. We evaluated the acute and chronic antinociceptive effects of these compounds in mice using the warm-water tail flick assay and in a paclitaxel-induced neuropathic pain model. Side …

Effects Of Fentanyl-Adulterated Methamphetamine On Circulating Ghrelin In Rats, Huimei Wei, Elise C. Maul, Shawn Park, Kaniz Fatema, Daniel J. Peter, Chang-Guo Zhan, Fang Zheng

Pharmaceutical Sciences Faculty Publications

The appetite hormone ghrelin influences biological processes that are responsible for substance use disorder, which is related to alcohol and most abused drugs including cocaine, methamphetamine, nicotine, etc. In general, upregulation of the ghrelin system enhances drug cravings and substance use. Studies reported in the literature consistently demonstrated that the ghrelin system is associated with stimulants. However, research on opioids in combination with methamphetamine has not been reported. In this study, we examined the relationship of circulating ghrelin with the polydrug use of fentanyl and methamphetamine in male Sprague-Dawley rats, demonstrating for the first time that concurrent use of fentanyl …

Effects Of Fentanyl-Laced Cocaine On Circulating Ghrelin, Insulin, And Glucose Levels In Rats, Huimei Wei, Elise C. Maul, Annet Kyomuhangi, Shawn Park, Maddilynn L. Mutchler, Chang-Guo Zhan, Fang Zheng

Pharmaceutical Sciences Faculty Publications

Opioid mixed with cocaine has been increasingly implicated in overdose deaths, including both intentional co-use of opioid and cocaine and fentanyl-adulterated drug supply. As ghrelin plays an important role in drug reward and can also influence insulin, this study aimed to assess responses of the circulating ghrelin, insulin, and glucose levels to the combined use of fentanyl and cocaine (a polydrug) in rats by performing combined animal behavioral experiments and biochemical analysis. The experimental data consistently revealed that the fentanyl and cocaine co-use can significantly elevate both the acyl-ghrelin and desacyl-ghrelin levels and significantly decrease the insulin level without significant …