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Fluorescence-Guided Resection Of Gl261 Red-Fluc And Trp-Mcherry-Fluc Mouse Glioblastoma Tumors, Louis T. Rodgers, Bryan J. Maloney, Anika M. S. Hartz, Björn Bauer

Pharmaceutical Sciences Faculty Publications

Background: Most preclinical studies on glioblastoma (GBM) fail to provide translational utility in the clinic. Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) improves tumor resection, disease prognosis, and, thus, patient outcomes. Given the critical role of surgery in managing recurrent GBM, it is essential to incorporate surgical elements into preclinical models to accurately reflect clinical scenarios and enhance translational success. However, existing protocols for 5-ALA-guided resection in preclinical models are limited and often lack clinical relevance.

Methods: To address this gap, we developed a novel protocol for the 5-ALA-guided resection in two mouse GBM models: TRP-mCherry-FLuc and GL261 Red-FLuc.

Results: The …

Development Of Zafirlukast Analogues For Improved Antithrombotic Activity Through Thiol Isomerase Inhibition, Justine A. Keovilay, Kaitlind C. Howard, Kirk A. Taylor, Sabeeya Khan, Sienna E. Wurl, Melanie K. Szahaj, Tanya Sage, Nishad Thamban Chandrika, Caixia Hou, Oleg V. Tsodikov, Jonathan M. Gibbins, Sylvie Garneau-Tsodikova, Daniel R. Kennedy

Pharmaceutical Sciences Faculty Publications

Background:   Thiol isomerases play essential and nonredundant roles in platelet activation, aggregation, and thrombus formation. Thiol isomerase inhibitors have the potential to overcome the 2 major drawbacks of current antithrombotic therapies, as they target both arterial and venous thrombosis without enhancing bleeding risks. Recently, a Food and Drug Administration–approved drug, zafirlukast (ZAF), was shown to be a promising pan-thiol isomerase inhibitor. The objective of this study is to develop analogues of ZAF with optimized thiol isomerase inhibition and antithrombotic activity.   Methods:   Thirty-five ZAF analogues were tested in an insulin turbidometric assay for thiol isomerase inhibition. Analogues were tested for platelet …

Functional And Structural Studies On The Esperamicin Thioesterase And Progress Toward Understanding Enediyne Core Biosynthesis, Erome D. Hankore, Mitchell D. Miller, Abigael J. Kosgei, Weijun Xu, Kemin Tan, Michael Endres, Minakshi Bhardwaj, Grazyna Joachimiak, Andrzej Joachimiak, George N. Phillips Jr., Jon S. Thorson, Steven G. Van Lanen

Pharmaceutical Sciences Faculty Publications

Enediynes are among the most potent antitumor and antibacterial natural products. Studies on their biosynthetic pathways have identified a shared, linear polyene precursor generated from an iterative type I polyketide synthase (PKSE) as the source of the enediyne warhead. A key step is the release of this polyene from the PKSE by a discrete thioesterase (TE). Here, we used X-ray crystallography, site-directed mutagenesis, and heterologous coexpression of PKSEs and TEs to elucidate how enediyne TEs mediate the production of the polyene. We solved the structure of wild-type EspE7 from esperamicin producer Actinomodura verrucosospora. The substrate binding pocket was also …

Brigham Young Unfiltered His Life, Conversion, And Faith In His Own Words, Lajean Purcell Carruth

BYU Studies

On October 6, 1867, the Saints met in the new Salt Lake Tabernacle for the first time. Brigham Young rose, made some remarks about the still unfinished state of the organ, and then dedicated the tabernacle to the Lord. This dedicatory prayer was completely unknown until I found the original shorthand record of it several years ago and transcribed it; prior to that time, the earliest known dedication of the tabernacle was 1875. He prayed, “O God our Heavenly Father who dwells in the heavens, in the name of thy Son Jesus Christ we come before thee at this time …

Full Issue

BYU Studies

No abstract provided.

Artist’S Note On This Is . . ., Eli Peterson

BYU Studies

The First Vision has always been an inspiration to me—the opening of heaven, the burst of such a powerful presence that our Father in Heaven and Savior brought to the earth after nearly two thousand years.

The Wonder Is Scripture, Jared Halverson

BYU Studies

It’s an honor to be associated in any way with this institute, as it’s my second-favorite thing named after Elder Neal A. Maxwell. The first is my eldest son, whose middle name was an obvious choice, largely because my wife loves Elder Maxwell even more than she loves me, which might be a problem were it not for the fact that I agree with her. I once spent so much time in this library creating a compilation of Elder Maxwell’s talks that by the time I was finished, my wife had called the police to report a missing person. When …

A Moderated Mediation Model Of Perceived Control, Fairness, And Leader–Member Exchange In The United States And South Korea, Nari Kim

Publications and Research

Drawing on the two-factor model of organizational justice and social exchange theory, this study investigates the mediating roles of procedural and distributive justice in the relationship between work locus of control (WLOC) and leader–member exchange (LMX). Using data collected from two cultural contexts – the United States and South Korea – this research further examines whether culture moderates the indirect relationship between WLOC and LMX through perceived justice. The findings indicate that subordinates with an internal WLOC tend to report higher-quality LMX relationships, and that both procedural and distributive justice partially mediate this relationship. Moderated mediation analyses reveal that the …

James Walks Home From Nain, Robbie Taggart

BYU Studies

A pleasant place, he thinks as they descend the steep hill where sparrows dance, making their way among the tombs that line their narrow path. He imagines the lives and dreams of the inhabitants of these stone rooms. The way their voices have flown like leaves, the way they abide like trees.

“Struck With Wonder And Amazement” On Reading The Book Of Mosiah, Joseph M. Spencer

BYU Studies

The Wonder of Scripture”: that’s the title of this lecture series.1 Book of Mormon scholar that I am, that title draws my mind to a passage in our keystone scripture. It’s a passage where the word “wonder” is used in connection with people’s responses to sacred records—to scripture. Tucked away somewhere most of us wouldn’t think to look, the Book of Mormon stages a remarkable scene that’s precisely about the wonder of scripture. I can’t help seeing that as just a little too appropriate, so I’d like to examine that scene. I’m going to argue that Mormon, serving simultaneously in …

Seam Allowance, Sarah Hafen D’Evegnée

BYU Studies

The shirts hang like a battalion of cotton soldiers on the large metal rack sticking out of the wall. I remove them from the hangers one by one, letting my fingers linger over the stripes, checks, and plaids. Some of them still feel new. The laundry room mingles the freshness of laundry soap with the odor of aging linoleum and tangy, rusty overtones— the same way it has for the past twenty-five years. My children’s younger faces, their grins all gaps and crowded teeth, peer out at me from an assortment of paper flowers glued to a frame on the …

Front Matter

BYU Studies

No abstract provided.

Words Never To Be Forgotten The Thoughtful Legacy Of Neal A. Maxwell, John W. Welch

BYU Studies

Many people in the world today cherish precious memories of times when Elder Maxwell (1926–2004) indelibly touched their lives. In so many cases, the thoughtful and thought-filled legacy of Neal A. Maxwell has left us all with a trove of words never to be forgotten.1 In subtitling this article “The Thoughtful Legacy of Neal A. Maxwell,” the ambiguity embedded there is intentional. His legacy is not only full of thought but also thoughtful. Everything he said and did was perfectly framed and eloquently stated; and, more than that, it was also perfectly thoughtful, kind, and concerned about other people. I …

“There Is Law” Joseph Smith’S Use Of Arbitration To Protect The Book Of Mormon, Jeffrey N. Walker, Andrew H. Hedges, Gerrit J. Dirkmaat

BYU Studies

This case marks the first time Joseph Smith invoked his legal rights to safeguard work connected with his prophetic calling from abuse or exploitation. The case arose from Abner Cole’s1 January 1830 efforts to publish Book of Mormon excerpts in his newspaper The Reflector, which he printed on the same Palmyra, New York, press that the Book of Mormon was being printed on. The case was evidently settled in Joseph Smith’s favor through arbitration, an out-of- court option for adjudication that New York law considered legally binding.2

This Branch Of The Church The Early Development Of Local Administration In The Church Of Jesus Christ Of Latter-Day Saints, Part 2, The Church In Flux, 1846–1851, Brandon Plewe

BYU Studies

A primary concern of The Church of Jesus Christ of Latter-day Saints is the spiritual and physical welfare of its members, and local congregations have always been the primary mechanism for that ministry. However, the structure and leadership of local administrative organizations has changed significantly over the history of the Church, most significantly under its first two presidents, Joseph Smith and Brigham Young. During these years, the terms and structures that are familiar to us—wards, presidents, bishops, stakes, and so on—emerged, but so did many practices that did not survive the 1877 Priesthood Reorganization.

Enhancing Topical Delivery Of N-Acetylcysteine And Collagen Via A Novel Electrospun Collagen/Pmma Nanofibrous Mats As Facial Mask Development: Nanofibers Optimization And In Vitro Experiments, Abdullah Elbadry, Elbadawy Kamoun, Mahmoud Sabahy, Mohamed Helmy, Mahmoud Khaled, Shahira Elmosalamy, Noura Eissa

Nanotechnology Research Centre

No abstract provided.

Academic Proficiency In Ugandan Children With Sickle Cell Anemia: A Cross-Sectional Study, Robert Opoka, Shubaya Kasule Naggayi, Paul Bangirana, Simple Ouma, Betty Nyangoma, Annet Birabwa, Grace Nambatya, Maxencia Kabatabaazi, Ann Jacqueline Nakitende, Dennis Kalibbala

Paediatrics and Child Health, East Africa

Introduction: Academic proficiency is crucial for advancing learning goals, school advancement, and future economic security. Children with sickle cell anemia (SCA) in sub-Saharan Africa (SSA) may be at risk of disease-associated learning difficulties. Limited data exist on this topic among school-age children in the region. We aimed to assess academic proficiency in a sample of children with SCA in Uganda compared with unaffected controls.

Methods: This cross-sectional study was conducted in Kampala, Uganda. Participants were school-going children with SCA, aged 6–12 years, attending Mulago Hospital SCA Clinic, and age-matched sibling controls without SCA. Academic proficiency was assessed by the Wide …

Hypertensive Hijinks: Implementation Of An Emergency Department Hypertensive Emergency Order Panel, Caleb Hoppe Pharmd Candidate

Pharmacy Residency

This evaluation found that the order panel was effective in promoting rapid blood pressure attainment and appropriate antihypertensive dosing.

This was presented at the OHIO PRC.

Daratumumab Monotherapy: Reconsidering Relapsed And Refractory Multiple Myeloma Maintenance Therapy, Gabrielle O. Carreon Pharmd, Ms

Pharmacy Residency

Results from this study support the continued use of daratumumab monotherapy in carefully selected patients who may not be candidates for more intensive combination therapies due to age, comorbidities, or prior toxicities. However, further research is needed to confirm these early observations.

Presented at Great Lakes PRC

Silent Pressure: Outcomes Of As-Needed Antihypertensives In Hospitalized Adults*, Corey Uetrecht Pharmd Candidate

Pharmacy Residency

Presented at ACCP

This study found that PRN antihypertensives are frequently used for AEBP in hospitalized patients, despite limited benefit and potential risk of hypotension-related adverse events.

Development And Implementation Of An Analgesia, Sedation, And Paralysis Order Panel For Mechanically Ventilated Pediatric Patients At A Large Community Health System, Kristin Lytal Pharmd, Mspgx

Pharmacy Residency

This project describes best practices and steps taken in development of a protocol for analgesia, sedation, and paralysis in pediatric patients.

This was presented at OHIO PRC.

Identification Of Host-Pathogen Protein Interactions: Yeast Two-Hybrid Analysis Of Sars-Cov-2 Nsp10 And Human Cellular Proteins, Antonios Argyriou

Selected Full-Text Master Theses 2021-

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has resulted in over 774 million cases and 7 million deaths worldwide, establishing it as one of the most devastating pandemics in recorded history. While current therapeutic approaches primarily target viral entry mechanisms and specific enzymes, the limited understanding of non-structural protein functions hinders the development of comprehensive antiviral strategies. This research focuses on Nsp10 (non-structural protein 10), a highly conserved 139-amino acid protein essential for viral mRNA capping and replication. Nsp10 serves as a critical cofactor in the formation of methyltransferase complexes with Nsp14 and Nsp16, playing a vital role in viral …

Coordinating The Energetic Strategy Of Glia And Neurons For Memory, Hannah Shoenhard, Amita Sehgal

Biology Faculty Research and Scholarship

Memory consolidation requires rapid energy supply to neurons. In a recent study, Francés et al revealed the signal by which a neuron commands glia to limit fatty acid synthesis in favor of metabolite export during memory formation in Drosophila melanogaster. This mechanism coordinates just-in-time glial energy delivery in response to dynamic neuronal needs.

Association Between Lifetime Interpersonal Violence And Post– Covid-19 Condition Among Women In Kentucky, 2020-2022, Ayşe Güler, Heather M. Bush, Katie Schill, Nurlan Kussainov, Ann L. Coker

Biostatistics Faculty Publications

Objective: The COVID-19 pandemic increased the risk of interpersonal violence. We investigated the association between lifetime interpersonal violence experience and risk of post–COVID-19 condition (the persistence of symptoms of COVID-19 and severity of health problems associated with COVID-19 that last a few weeks, months, or years) among women with lifetime interpersonal violence experience.   Methods: Women participants aged ≥18 years in Kentucky’s Wellness, Health & You—COVID-19 study completed online quantitative surveys about the impacts of the pandemic, developing COVID-19, and symptoms of post–COVID-19 condition. We conducted cross-sectional analyses estimating rate ratios of developing COVID-19 and symptoms of post–COVID-19 condition during the …

Saa 6173: Career Advising, Dana J. Tribble

ATU Faculty OER Books and Materials

Course Description:

This elective course provides an overview of the foundations of career advising. Students will learn career development theories, career advising interventions and practices, career assessment and planning tools, and sources of career information and technology designed to assist individuals and groups in lifelong career and lifestyle planning.

Edmd 6163: Internet Resources, Mohamed Ibrahim

ATU Faculty OER Books and Materials

No abstract provided.

Semi Analytical Solution Ofmhd And Heat Transfer Of Couple Stress Fluid Over A Stretching Sheet With Radiation In Porousmedium, Sara Abdelsalam, M. Khairy, W. Abbas, A.M. Megahed, M.S. Emam

Basic Science Engineering

This comprehensive research examines the dynamics of magnetohydrodynamic (MHD) flow and heat transfer within a couple stress fluid. The investigation specifically focuses on the fluid’s behavior over a vertical stretching sheet embedded within a porous medium, providing valuable insights into the complex interactions between fluid mechanics, thermal transport, and magnetic fields. This study accounts for the significant impact of heat generation and thermal radiation, crucial factors for enhancing heat transfer efficiency in various industrial and technological contexts. The research employs mathematical techniques to simplify complex partial differential equations (PDEs) governing fluid flow and heat transfer. Specifically, suitable similarity transformations are …

Numerical Simulation Via Homotopy Perturbation Approach Of A Dissipative Squeezed Carreau Fluid Flow Due To A Sensor Surface, Sara Abdelsalam, W. Abbas, A.M. Megahed, H. M.H. Sadek, M.S. Emam

Basic Science Engineering

This study rigorously examines the interplay between viscous dissipation, magnetic effects, and thermal radiation on the flow behavior of a non-Newtonian Carreau squeezed fluid passing by a sensor surface within a micro cantilever channel, aiming to deepen our understanding of heat transport processes in complex fluid dynamics scenarios. The primary objective is to elucidate how physical operational parameters influence both the velocity of fluid flow and its temperature distribution, utilizing a comprehensive numerical approach. Employing a combination of mathematical modeling techniques, including similarity transformation, this investigation transforms complex partial differential equations into more manageable ordinary ones, subsequently solving them using …

Experimental Investigation Of The Effect Of The Offset Ratio On The Flow Characteristics And Heat Transfer Behaviour Of A Wall-Bounded Dual Jet Flow, P. J. Murphy, S. Alimohammadi, S. M. O'Shaughnessy

Articles

A wall-bounded dual jet is formed through combining a wall jet, flowing directly adjacent to a solid wall, with a parallel, co-flowing offset jet. The combination of a wall and offset jet in this manner is commonly encountered across many industrial applications, such as electronics cooling, wastewater evacuation, and noise suppression technologies, despite remaining relatively misunderstood across the published literature. This study aims to contribute to the available dual jet experimental data and further fundamental knowledge of dual jet flows and their accompanying heat transfer characteristics. The primary objective of this experimental investigation is to analyse the effect of varying …

An Analysis Of Possession Outcomes Following Turnovers And Throw-Ups In Sub-Elite Gaelic Football, Kate Emma Timmons, Kieran Collins, Shane Mangan

Other resources

This study investigated possessions following turnovers and throw-ups in sub-elite Gaelic football, an area only explored at elite level. A total of 1,735 possessions from 48 championship matches involving 67 teams from the 2023 and 2024 seasons were analysed. Binary logistic regression was employed to model the key predictors of successful possessions following turnovers. Turnovers won in contact significantly increased the likelihood of a score (p=.012), while possession duration between 31–90 seconds was associated with higher scoring rates (p < . 001). Although descriptive statistics indicated that more passes led to more scores, the regression analysis revealed possession sequences of 1-10 passes were more likely to lead to successful possessions (p = .004). The first action following a turnover significantly predicted possession success. Periods of 1-90 seconds ball out of play increased scoring odds (p < .001). The findings of the current study provide novel insights into transition play and possession effectiveness in sub-elite Gaelic football, with practical implications for coaching and analysis.