Digital Commons Network^™

South Carolina Administrator Workforce Profile For 2023–24, Brian Cartiff, Svetlana Dmitrieva, Angela Starrett

Reports

This report details South Carolina’s public school administrator workforce for the 2023–24 academic year. SC TEACHER publishes educator workforce profiles each year, covering public school teacher and administrator populations. Alongside the full breadth of SC TEACHER’s research, these profiles share information and insights with educators, policymakers, community members, and other stakeholders.

The analysis in this report draws on statewide data to examine the demographic characteristics of South Carolina’s principal and assistant principal workforce. Findings are based on data from 1,380 principals and 2,280 assistant principals employed in South Carolina public schools during 2023–24. The report also incorporates data from recent …

Law School News: Destined For Law: From Legal Dream To Valedictorian 05-13-2025, Jane Govednik

Life of the Law School (1993- )

No abstract provided.

Phage Therapy For Urinary Tract Infections: Progress And Challenges Ahead, Chase J. Morgan, Haley Atkins, Alan J. Wolfe, Linda Brubaker, Saima Aslam, Catherine Putonti, Michael B. Doud, Lindsey A. Burnett

Biology: Faculty Publications and Other Works

Introduction and Hypothesis: Urinary tract infection (UTI) treatment is a growing public health concern owing to increasing antimicrobial resistance. Phage therapy, an alternative or adjunctive treatment to antibiotics, has the potential to address this challenge. However, clinical use of phage therapy is hindered by knowledge gaps and inconsistent reporting. The objective was to review the current state of phage therapy for UTIs and highlight research priorities that can optimize phage clinical efficacy. Methods: Current literature on UTI phage therapy was examined, focusing on the lack of standardized phage susceptibility testing, phage characterization, and microbiological assessments during and after treatment. Results: …

Ogg1s326c Variant Frequent In Human Populations Facilitates Inflammatory Responses Due To Its Extended Interaction With Dna Substrate, Jinling Han, Meichen Zhang, Jiakun Ge, Zhihua Ji, Jianyi Zhao, Yinchao Hu, Chunshuang Li, Yaoyao Xue, Xining Li, Haiwang Zhao, Zixu Cui, Miaomiao Tian, Xu Zheng, Dapeng Wang, Jing Wang, Min Wei, Zsolt Radak, Yusaku Nakabeppu, Istvan Boldogh, Xueqing Ba

Faculty, Staff and Student Publications

8-oxoguanine (8-oxoGua) is one of the most frequent forms of oxidative DNA base lesions, repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) via base excision repair (BER) pathway to maintain genome fidelity. The human allelic variant hOGG1^S326C, prevalent in Caucasians and Asians, has been regarded as a susceptibility factor for various diseases, yet its pathogenic mechanism remains elusive. In this study, we demonstrate that Ogg1^S326C/S326C mice exhibit increased and sustained airway inflammation compared with wild-type (WT) Ogg1^S326/S326 mice. Mechanistically, in response to inflammatory stimulation, OGG1S326C undergoes reactive oxygen species-induced dimerization, which impairs its base excision function, but …

A Pharmacokinetic And Safety Study Of Oral Arsenic Trioxide In Patients With Acute Promyelocytic Leukemia, Farhad Ravandi, Sravanti Rangaraju, Hagop Kantarjian, Guillermo Garcia-Manero, Musa Yilmaz, Kristen Baker, Terence Hall, Joy Grabenstein, Pourab Roy, Beth A Zamboni, William C Zamboni, Erica Warlick, Michael Kelly, David A Roth, Gabriel Ghiaur

Faculty, Staff and Student Publications

SY-2101 is a novel oral formulation of arsenic trioxide (ATO). Although IV ATO in combination with all trans retinoic acid is highly efficacious in treating acute promyelocytic leukemia (APL), there remains a significant unmet need due to the treatment burden associated with receiving daily ATO infusions for nearly a year and the risk of complications associated with indwelling central catheters. The pharmacokinetics (PK), safety, and tolerability of SY-2101 and ATO IV after single- and multiple-dose administration and the impact of food on PK for SY-2101 were evaluated in this phase 1 study in 15 participants with APL. SY-2101 in the …

Genetic, Transcriptomic, And Epigenomic Insights Into Sjögren's Disease: An Integrative Network Investigation And Immune Diseases Comparison, Nitesh Enduru, Astrid M Manuel, Zhongming Zhao

Faculty, Staff and Student Publications

Sjögren's disease (SjD) is a systemic autoimmune disorder primarily causing dry eyes and mouth. It frequently overlaps with other autoimmune diseases (AIDs), including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). However, the genetic basis of SjD remains underexplored, limiting our understanding of its connections to other immune-mediated conditions. In this study, we aimed to identify gene networks associated with SjD through the integration of genetic, transcriptomic, and epigenomic data. We further compared the genetic factors of SjD with other immune-mediated diseases. We analyzed genome-wide association studies (GWAS) summary statistics, DNA methylation, and transcriptomic data using our in-house network-based methods, …

Phase I Study Of Pomalidomide In Relapsed Or Refractory Waldenström Macroglobulinaemia, Karan L Chohan, Donna M Weber, Lei Feng, L Michael Wang, Sattva S Neelapu, Jasper Olsem, Ralph J Johnson, Claudia Morales De Partovi, Robert Z Orlowski, Sheeba K Thomas

Faculty, Staff and Student Publications

No abstract provided.

Faculty And Administrator Perceptions Of The Implementation Of The International Baccalaureate Diploma Program In Relation To Roger’S Theory Of Diffusion Of Innovation, Kyle Roddey

Seton Hall University Dissertations and Theses (ETDs)

This study examined the perceptions of both teachers and school administrators of the implementation of the International Baccalaureate Diploma Program in High Schools in the northeastern United States. Using a qualitative design, data was collected through an anonymous survey of teachers who presently teach International Baccalaureate Diploma Program courses. Additional data was collected through conducting semi-structured interviews of acting principals of schools that offer the International Baccalaureate Diploma Programme. Results of this data collection was reviewed through the lens of Roger’s Theory of Diffusion of Innovation. Qualitative results indicated that both teachers and administrators alike viewed teacher leadership and teacher …

Perceptions Of Bullying In A Public Charter School, Ana I. Perea

Teacher Education, Educational Leadership & Policy ETDs

ABSTRACT

Bullying is perceived in different ways according to the experience or training of individuals. In my practice, adults often misidentify disputes or incidents as bullying due to a lack of evidence or varying perceptions. This problem must be a theme of reflection for all stakeholders in traditional or charter schools. My study aimed to understand how teachers and parents perceive bullying in terms of social implications, cultural factors, and professional training. In my research, I provided insight into how the stakeholders in a public charter school perceive this phenomenon. The participants highlighted their perceptions and topics of communication, exclusion, …

Assessment Of The Risk Factors Affecting Diabetes Outcome In Kumasi Metropolis Of Ghana, Audrey Jacobs

Honors College Theses

This paper examines Kumasi Metropolis, Ghana risk factors for diabetes outcomes, considering the prominent determinants such as geographic location, income, and educational level. Such determinants play a role when it comes to shaping health outcomes, with research indicating positive correlation between per capita expenditure on healthcare and life expectancy. In spite of that, inequalities do occur, even in developing nations such as Ghana, where minimal health care investment impacts poor health outcomes. Socioeconomic factors, including low living conditions, poor access to healthcare, and illiteracy, reinforce health disparities, especially in rural areas. Informed by a review of past research, we hypothesized …

Invasion As A Structure: Carceral Capitalism, Necropolitics, And The Persistence Of Settler-Colonialism, Ethan Peacock

Honors College Theses

In the United States, settler-colonialism is often dismissed as a "bad chapter" of the past, an embarrassing episode of the nation's history, considered irrelevant to contemporary socio-political discussions. In contrast, while ongoing, Canada's reconciliation efforts remain performative, failing to address underlying colonial power structures. This project argues that settler-colonialism is not merely a historical phenomenon but a pervasive socio-political and cultural structure shaping the contemporary world. Capitalism depends on racialized and gendered hierarchies, continually produced through dispossession, marginalization, and exploitation. The prison-industrial complex (PIC) exemplifies this dynamic by industrializing dehumanization and weaponizing state violence against marginalized communities through mass incarceration, …

The Impact Of Large Language Models On Graduate Students: Development, Usage, And Ethical Considerations, Bahaaldeen Alzubi

Masters Theses (Archived)

The rapid integration of Large Language Models (LLMs) into academic settings is transforming how graduate students conduct research, organize information, and refine their writing. This study explores the role of four AI tools—ChatGPT, Grammarly, Research Rabbit, and Zotero—in supporting scholarly practices while examining their implications for academic integrity, linguistic diversity, and research efficiency. Using an autoethnographic approach, this research documents personal interactions with these technologies, highlighting both their advantages and limitations. Findings suggest that while AI tools enhance productivity and accessibility, they also raise concerns about reliance, originality, and ethical usage. The study underscores the need for a balanced approach …

Identity And The Russian-Ukrainian War: Evidence From The American Community Survey, Matthew Holian, Oleh Wolowyna

Faculty Research, Scholarly, and Creative Activity

The Russian invasion of Ukraine in 2022 led to significant changes in ethnic identity and language preferences among U.S. residents. We observe an 18.9% increase in U.S.-born individuals identifying as ethnic Ukrainian from 2021 to 2022 and a 6.8% decrease for U.S.-born ethnic Russians, which cannot be attributed to prior trends or sampling variation. The changes among Ukrainians were more pronounced among college graduates and those living in Democratic-leaning counties. We document an increase in the use of the Ukrainian language among Ukrainian immigrants, which cannot be explained by prior trends or immigration patterns. We test for labor market discrimination, …

4-H Schedule At The 2025 North Haverhill Fair, Extension

UNH Cooperative Extension

No abstract provided.

2025 4-H Pint-Size Pet Showcase, Extension

UNH Cooperative Extension

No abstract provided.

2025 North Haverhill Fair 4-H Exhibit Hall Packet, Extension

UNH Cooperative Extension

No abstract provided.

Can Flywheel Training Serve As A Viable Intervention For Dynamic Strength Index Based Programs?, Jeffrey Ruiz

Doctorate in Kinesiology

The purpose of this case series was to examine the effects that flywheel training had on a person’s dynamic strength index in comparison to concurrent training (DSI). It has been shown that with strength training alone there can be an overall decrease in the DSI, due to an increase the IMTP peak force and no significant change in the CMJ performance (Comfort et al., 2018). Flywheel training’s effect on the DSI specifically have not been previously examined. It was hypothesized that a regimented flywheel training intervention will demonstrate an

improvement in the peak force for the countermovement jumps as well …

Staff Education To Improve Patient Follow Through And Continuity Of Care, Aitenobhan Cynthia Ofeinmun

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) staff education project was conducted in the adult inpatient psychiatric unit of a behavioral health facility in Texas over 4 weeks. The project involved addressing the absence of standardized staff practices related to patient follow through after discharge. This practice gap contributed to fragmented continuity of care and inconsistent discharge planning. The project’s practice-focused question was: How does staff education on patient follow through impact staff knowledge? The goal was to determine whether an evidence-based staff education program could improve staff knowledge and promote efficiency in terms of discharge practices. Education was delivered through …

Strategies For Intimate Partner And Domestic Violence Survivorship, Kimberly Renee Best

Walden Dissertations and Doctoral Studies

Domestic violence victims suffer not only physical abuse but also emotional, psychological, and economic violence, leading to long-term trauma, poverty, and recovery barriers. At least 40% of victims of abuse and their children have experienced some form of violence. The lack of shelters, counseling, and legal support deepens the sense of hopelessness victims often feel. In this study, the gap in literature was addressed by exploring coping strategies of survivors of intimate partner and domestic violence in rural North Carolina. The social and economic effects of survivorship were explored in this study, especially the disruptions caused by the COVID-19 pandemic, …

Avoiding Recidivism Of Recently Released Offenders In North Carolina, Josue Genaro Galvez

Walden Dissertations and Doctoral Studies

There is a problem with recidivism in the North Carolina prison system and the United States. This study fills the gap in the literature by focusing on what life experiences contribute to behaviors in recently released offenders not to reoffend in North Carolina. Edmund Husserl's (1913) Transcendental Phenomenology used several angles of perception and a thematic analysis of the participant’s lived experiences. This study employed a purposive sampling method by targeting 17 participants who may have represented characteristics of the intended population. Researchers do not know what kept these released offenders from avoiding prison. This phenomenological design focused on the …

Lived Experiences Of Hispanic Parents Considering Early Intervention Services For Developmentally Delayed Children, Karina Proffer

Walden Dissertations and Doctoral Studies

Studies have demonstrated that children benefit significantly from Early Intervention (EI) services due to brain plasticity and rapid early development. EI supports growth and establishes foundational skills in cognitive, social, emotional, motor, language, and daily living domains. Research indicates that children who participate in EI programs experience positive outcomes in their academic trajectories. However, limited studies examine the lived experiences of Hispanic parents with children diagnosed with autism or intellectual disabilities who did not utilize EI services. This study explores the factors influencing these parents' decisions and experiences that hinder their children’s participation in the program. The Theory of Planned …

How School Professionals Perceive They Can Engage Parents In Helping Children In Fifth Grade Cope Adaptively With Stress, Hector Alejandro Soto

Walden Dissertations and Doctoral Studies

National education statistics indicate issues of aggressive behaviors in middle schools, such as bullying and disrespecting teachers. This suggests that fifth-grade students could benefit from parental intervention to manage stress and reduce such behaviors. However, there is limited information on effectively engaging parents in this process. The study involved a purposive sample of 20 school professionals from four schools in a large southwestern U.S. school district who were invited to address this gap. Nine professionals completed the online survey of six qualitative, open-ended questions regarding engaging parents in helping fifth graders cope with stress. The questions focused on establishing meaningful …

Dnmt3a Regulates Murine Megakaryocyte-Biased Hematopoietic Stem Cell Fate Decisions, Sarah M Waldvogel, Virginia Camacho, Dandan Fan, Anna G Guzman, Alejandra Garcia-Martell, Elmira Khabusheva, Jacey Rodriguez Pridgen, Josephine De La Fuente, Rachel Rau, Ashlyn G Laidman, Maria N Barrachina, Estelle Carminita, Justin A Courson, Michael R Williamson, Joanne I Hsu, Chun-Wei Chen, Jaime Reyes, Subhashree Pradhan, Rolando E Rumbaut, Alan R Burns, Benjamin Deneen, Jianzhong Su, Kellie R Machlus, Margaret A Goodell

Center on Aging Staff Publications

Hematopoietic stem cells (HSCs) are defined by their capacity to regenerate all main components of peripheral blood, but individual HSCs exhibit a range of preferences for generating downstream cell types. Their propensities are thought to be epigenetically encoded, but few differential regulatory mechanisms have been identified. In this work, we explored the role of DNA methyltransferase 3A (DNMT3A) in the megakaryocyte-biased HSC population, which is thought to reside at the top of the hematopoietic hierarchy. We demonstrate that heterozygous loss of DNMT3A (Dnmt3a+/-) in these megakaryocyte-biased HSCs has distinct consequences compared with the rest of the HSC pool. These megakaryocyte-biased …

White Matter Connections Within The Central Sulcus Subserving The Somato-Cognitive Action Network, Georgios P Skandalakis, Evan M Gordon, Nico U F Dosenbach, Et Al.

2020-Current year OA Pubs

The somato-cognitive action network (SCAN) consists of three nodes interspersed within Penfield's motor effector regions. The configuration of the somato-cognitive action network nodes resembles the one of the 'plis de passage' of the central sulcus: small gyri bridging the precentral and postcentral gyri. Thus, we hypothesize that these may provide a structural substrate of the somato-cognitive action network. Using microdissections of 16 human hemispheres, we consistently identified a chain of three distinct plis de passage with increased underlying white matter in locations analogous to the somato-cognitive action network nodes. We mapped localizations of plis de passage into standard stereotactic space …

Novel Treatment Approaches Utilizing Antibody-Drug Conjugates In Breast Cancer, Andrew A Davis, Jennifer Hesse, Patrícia M R Pereira, Cynthia X Ma

2020-Current year OA Pubs

Antibody-drug conjugates (ADCs) are rapidly changing the way we treat patients with breast cancer. Despite this progress, many unanswered questions remain regarding the sequencing of different ADCs with similar payloads, optimal combinations, drug design strategies to limit off-target toxicities, biomarkers to define antigen positivity, and the use of ADCs in the neoadjuvant and adjuvant settings. In this review, we summarize novel ADC approaches in breast cancer treatment, including potential improvements in ADC payloads, linkers, targets, and drug delivery. We also evaluate novel strategies to combine ADCs with other agents, such as targeted drugs and immune checkpoint inhibitors. To improve patient …

International Multi-Center Study Of Middle Meningeal Artery Embolization For Chronic Subdural Hematoma In Cancer Patients: Efficacy, Safety, And Outcomes In A High-Risk Population, Avi A Gajjar, Mohamed M Salem, Georgios S Sioutas, Rashad Jabarkheel, Okkes Kuybu, Jane Khalife, Daniel A Tonetti, Gustavo Cortez, Adam A Dmytriw, Diego Alejandro Ortega Moreno, William Smith, Robert W Regenhardt, Kate T Carroll, Zachary A Abecassis, Juan Francisco Ruiz Rodriguez, Oleg Shekhtman, Alex Nguyen Hoang, Alexander A Khalessi, Cordell Baker, Matthias Matejka, Nicole M Cancelliere, Christoph J Griessenauer, Ramesh Grandhi, Peter Kan, Omar Tanweer, Michael R Levitt, Christopher J Stapleton, Vitor Mendes Pereira, Brian Jankowitz, Howard A Riina, Aman B Patel, Ricardo Hanel, Ajith J Thomas, Michael J Lang, Bradley A Gross, Jan-Karl Burkhardt, Visish M Srinivasan

Faculty, Staff and Students Publications

Background

Middle meningeal artery embolization (MMAE) is a promising treatment for chronic subdural hematoma (cSDH). Cancer patients are at risk for cSDH due to thrombocytopenia. The efficacy of MMAE in this population has not been studied.

Methods

We conducted a retrospective analysis of 76 patients who underwent 94 MMAEs for cSDH at 12 tertiary centers across North America and Europe between February 2018 and January 2023. We analyzed patient demographics, clinical profiles, procedural details, and outcomes. The primary outcome was cSDH progression, while secondary outcomes included radiographic resolution, mortality, 90-day functional outcomes, functional improvement, and procedural complications.

Results

Radiographic improvement …

Long-Term Outcomes Of Resolute Onyx Zotarolimus-Eluting Stents For Symptomatic Intracranial Stenosis: A Multicenter Propensity Score-Matched Comparison With Stenting Versus Aggressive Medical Management For Preventing Recurrent Stroke In Intracranial Stenosis Trial, Omid Shoraka, Ramesh Grandhi, Samantha Miller, Joanna Roy, Vinay Jaikumar, Basel Musmar, Omar Tanweer, Jan-Karl Burkhardt, Pascal M Jabbour, Adnan H Siddiqui, Farhan Siddiq, Ameer E Hassan

Faculty, Staff and Students Publications

Background

Intracranial atherosclerotic disease (ICAD) is a leading cause of ischemic stroke. The Medtronic Resolute Onyx Zotarolimus-eluting stents (RO-ZES) are promising in preventing stroke recurrence compared with medical management (MM) and percutaneous angioplasty and stenting (PTAS) at both 30-day and one-year follow-ups. We evaluated long-term outcomes for patients treated with RO-ZES, PTAS, or MM.

Methods

A retrospective multicenter study was conducted including patients who underwent RO-ZES stenting for symptomatic ICAD between March 2018 and May 2023, with follow-up through October 2024. Propensity score-matched control groups, representing MM and PTAS, were derived from the SAMMPRIS trial. Primary outcomes included recurrence rates …

Effect Of Race On Procedural And Clinical Outcomes In Middle Meningeal Artery Embolization For Primary And Adjunctive Treatment Of Chronic Subdural Hematoma, Santiago Gomez-Paz, Mohamed M Salem, Cordell Baker, Okkes Kuybu, Georgios S Sioutas, Kate T Carroll, Mira Salih, Adam A Dmytriw, Jane Khalife, William Smith, Diego Alejandro Ortega Moreno, Robert W Regenhardt, Nicole M Cancelliere, Alejandro M Spiotta, Omar Tanweer, Christopher J Stapleton, Michael Lang, Vitor M Pereira, Aman B Patel, Adnan H Siddiqui, Elad I Levy, Christopher S Ogilvy, Daniel Tonetti, Ajith J Thomas, Visish M Srinivasan, Brian T Jankowitz, Michael R Levitt, Bradley A Gross, Jan-Karl Burkhardt, Ramesh Grandhi

Faculty, Staff and Students Publications

Background

We investigated racial disparities in radiologic and clinical outcomes of patients after middle meningeal artery embolization (MMAE) for chronic subdural hematoma (CSDH) with or without evacuation surgery.

Methods

This multicenter retrospective study includes consecutive patients who underwent MMAE across 11 institutions in North America (10 in the United States and 1 in Canada). Patients were stratified using self-reported racial data. Outcomes of interest were complications, treatment failure/reoperations, resolution of hematoma, and functional independence at last follow-up. Multivariable regression models were used to assess and adjust for relevant confounders.

Results

A total of 557 patients underwent 663 MMAEs, including 323 …

Loss Of Progesterone Receptor In Smooth Muscle Cells Has No Impact On Oviductal Contractions And Preimplantation Embryo Development†, Emily A Mcglade, Jiude Mao, Kalli K Stephens, Cayce N Rose, John P Lydon, Wipawee Winuthayanon

Faculty, Staff and Students Publications

No abstract provided.

Disruption Of Oocyte Sumoylation Impacts Critical Regulatory Processes During Folliculogenesis In Mice, Zian Liao, Tessa E Steenwinkel, Bruno Moscoso, Ernesto Salas, Bethany K Patton, Amanda Rodriguez, Anna Malovannaya, Stephanie A Pangas

Faculty, Staff and Students Publications

The conjugation of small ubiquitin-like modifiers (SUMO) to target proteins, known as SUMOylation, plays a crucial role in regulating protein homeostasis, activity, interaction with other proteins, and subcellular localization. Loss of SUMOylation in nongrowing oocytes by conditional deletion of the E2 SUMO conjugating enzyme, Ube2i, at the primordial follicle stage leads to female sterility due to complex changes in oocyte development, including altered folliculogenesis, defective meiotic progression, and premature loss of the ovarian reserve. In this study, proteomics was used to compare control and Ube2i conditional knockout ovaries during the first wave of folliculogenesis to identify key differences that may …