Digital Commons Network^™

Physiologically Based And Population Pharmacokinetic Modeling Of Midazolam In Children With Obesity Using Real-World Data, Sean Mccann, Victória E. Helfer, Stephen J. Balevic, William J. Muller, John N. Van Den Anker, Amira Al-Uzri, Marisa L. Meyer, Sarah G. Anderson, Sitora Turdalieva, Andrea N. Edginton, Daniel Gonzalez, Best Pharmaceuticals For Children Act Pediatric Trials Network Steering Committee

Department of Pediatrics Faculty Papers

Children represent a highly complex and variable population for treatment, including interindividual differences in drug dose-exposure. Midazolam has been used as a sedative for hospitalized children on- and off-label; however, factors affecting interindividual variability (IIV) in observed clearance for this population are not fully understood and can result in extreme under- or overexposure. Obesity has been described as a significant influence on midazolam in adolescents, which could potentially alter drug exposure. The goal of this study was to use two modeling strategies to evaluate dose-exposure of midazolam in children with and without obesity. Population pharmacokinetic modeling assessed whether measures of …

Investigating Undergraduate Conditioned Place Preference Utilizing Virtual Alcohol Stimuli, Nikole A. Rodriguez Torres, Robert Astur, Jeffrey Divino

Honors Scholar Theses

Alcohol use remains a major concern among college students, with binge drinking linked to serious physical and mental health problems. But how much does the environment influence these addictive behaviors? The relationship between environmental cues and alcohol related behaviors is a critical area of study, particularly understanding reward and motivation mechanisms. Binge drinking, common among college students, is associated with a range of negative outcomes such as physical harm, legal issues, poorer overall health, sleep problems, depression, anxiety, and severe thoughts of suicide. In our study, college undergraduates were exposed to two VR rooms: one with alcohol-related stimuli and one …

The Role Of Somatization In Predicting Health-Related Quality Of Life Among Racial And Ethnic Minorities: Examining The Mediating Effects Of Perceived Injustice And Symptom Catastrophizing, Kimi Han Hashimoto

Clinical Psychology Dissertations

There is a pressing need to address the significant health disparities of underrepresented groups such as racial and ethnic minorities (Mills et al., 2020). As of 2019, individuals identifying as a racial or ethnic minority make up 40% of the U.S population as of 2019, yet they fare significantly worse across many health-related measures (Hill et al., 2022). Given these disparities in healthcare and health outcomes, racial and ethnic minorities represent an important group to investigate somatization and health-related quality of life (HRQOL). Cognitive appraisals, such as perceived injustice and symptom catastrophizing, may mediate this relationship, influencing how somatization translates …

Harnessing Machine Learning For Predictive Healthcare: A Path To Efficient Health Systems In Africa, Kabiru Gulma, Zainab Saidu, Kingsley Godfrey, Abubakar Wada, Zayyanu Shitu, Auwal A. Bala, Safiya Bala Borodo, Sa’Adatu M. Julde, Mustapha Mohammed

School of Medicine Publications

Machine learning (ML) presents a transformative opportunity to strengthen African health systems through predictive healthcare. This paper explores the applications, benefits, and implementation challenges of ML in African health contexts, where resource limitations and infrastructure gaps often impede efficient healthcare delivery. By leveraging supervised and unsupervised ML models-such as decision trees, neural networks, and support vector machines-predictive healthcare can aid in early disease detection, improve patient outcomes, and optimize resource allocation. Real-world case studies across the continent, including malaria forecasting and telemedicine applications, illustrate the potential of ML to mitigate the burdens of delayed diagnosis, an underutilized workforce, and a …

From Chronic Wound To Cancer: The Transformation Into Malignant Squamous Cell Carcinoma, Omair Syed, Sheel Dalal, Samee Farooqi, Allison Isabelli, Torrie Hook, Michael Kim, Bassem Chaar

Advocate GME

No abstract provided.

Smooth Muscle Cells And Fibroblasts In The Ascending Aorta Exhibit Minor Differences Between Embryonic Origins In Angiotensin Ii-Driven Transcriptional Alterations, Sohei Ito, David B Graf, Yuriko Katsumata, Jessica J Moorleghen, Chen Zhang, Yanming Li, Scott A Lemaire, Ying H Shen, Hong S Lu, Alan Daugherty, Hisashi Sawada

Faculty, Staff and Students Publications

Thoracic aortopathy is influenced by angiotensin II (AngII) and exhibits regional heterogeneity with the ascending aorta being particularly susceptible. In this region, smooth muscle cells (SMCs) and selected fibroblasts originate from the second heart field (SHF) and cardiac neural crest (CNC). While our previous study revealed a critical role of SHF-derived cells in AngII-mediated aortopathy, the contribution of CNC-derived cells remains unclear. To investigate lineage-specific responses to AngII, Mef2c-Cre R26RmT/mG mice were infused with AngII. Ascending aortas were harvested at baseline or after 3 days of infusion, representing the prepathological phase. Cells were sorted based on their embryonic origins and …

Biochar Suppresses Growth, Pupation And Eclosion Success Of A Specialist (Manduca Sexta) And A Generalist (Spodoptera Frugiperda) Insect Herbivore, Nischal Wagle, Soumya Unnikrishnan, Satinderpal Kaur, Engil Pereira, Rupesh Kariyat

Entomology and Plant Pathology Faculty Publications and Presentations

Biochar is a charcoal-like substance made by the pyrolysis of organic material from agricultural and forestry waste. While biochar is well documented for altering soil physicochemical conditions, few studies have investigated its possible effects on the management of arthropod pests. Tobacco hornworm (Manduca sexta) and fall armyworm (Spodoptera frugiperda, FAW) are specialist and generalist insect herbivores respectively, that can cause significant defoliation in natural and agricultural ecosystems. In this study, we examined whether walnut shell biochar can affect growth and development of these herbivores. Specifically, we investigated how biochar influences parameters such as mass gain, length of pupation, pupal mass, …

On The Use Of Nonlinear Electrophoresis For Separating Particles And Cells In Insulator-Based Electrokinetic Systems, Alaleh Vaghef-Koodehi

Theses

The increasing demand for efficient separation processes of micron-sized particles, including microorganisms, highlights the importance of developing low-cost, non-labor-intensive, and time-efficient techniques. Insulator-based electrokinetic (iEK) systems have proven to be a practical alternative to bench-scale methodologies such as centrifugation and membrane filtration. Several studies have reported the separation of microparticles by employing direct current (DC) voltages. However, all of them have overlooked the phenomenon of nonlinear electrophoresis (EPNL) and its role in the electrokinetic migration of particles. This study combines mathematical modeling and experiments to extend the capabilities of iEK systems. This dissertation has four aims: (1) to separate microparticles …

Wind Shear And The Role Of Eddy Vapor Transport In Driving Water Convection On Jupiter, Ramanakumar Sankar, Michael H. Wong, Csaba Palotai, Shawn Brueshaber

Michigan Tech Publications

Recent observations of convection in the Jovian atmosphere have demonstrated that convection is strongly concentrated at specific locations on the planet. For instance, observations of lightning show that the cyclonic features (e.g., belts and folded filamentary regions) show increased convective activity compared to anticyclonic regions. Meanwhile, the distribution of ammonia and water vapor shows a large enrichment near the equator, which is also suggestive of strong upwelling and convective activity. Marrying these different observations is challenging owing to a lack of data concerning the characteristics of the deep Jovian atmosphere and a resulting inability to observe the true deep source …

Accumulation Of Nitrogen Species From Industrial Wastewater By Vetiver Grass (Chrysopogon Zizanioides), Arash Aliasghar, Zhiming Zhang, Rupali Datta, Christos Christodoulatos, Dibyendu Sarkar

Michigan Tech Publications

Industrial munition facilities are increasingly manufacturing insensitive high explosives (IHEs) to improve safety. The explosive residues in wastewater from these facilities are treated to meet regulatory standards. However, the resulting effluent contains elevated levels of mineralized nitrogen species. This study evaluated the potential of vetiver grass (Chrysopogon zizanioides), a non-invasive perennial species, to remove high concentrations of nitrate, nitrite, and ammonium from munition plant wastewater. Vetiver was grown hydroponically in synthetic wastewater containing high levels of nitrogen compounds simulating munitions plant effluents. Vetiver plants were treated with one nitrogen species at a time, with concentrations ranging from 165 to 24,700 …

A Case Study Of Pavement Construction Materials For Wet-Freeze Regions: The Application Of Waste Glass Aggregate And High-Content Rubber Modified Asphalt, Kai Xin, Meng Wu, Dongzhao Jin, Zhanping You

Michigan Tech Publications

Pavement systems in wet-freeze regions are prone to cracking, rutting, and moisture damage, making it challenging to incorporate recycled materials into asphalt mixtures in a way that enhances sustainability while maintaining performance and constructability. This study investigates and demonstrates the combined benefits of using processed waste glass in a leveling course and high-content crumb rubber in a surface course, focusing on both laboratory and full-scale field assessments in a wet-freeze region of northern Michigan. A leveling course containing 10% waste glass aggregate and a surface course using 16% crumb rubber (by binder weight) modified asphalt were designed with low air …

Normobaric And Hyperbaric Oxygen Therapy In Pediatric Dog Bite Nasal Tip Avulsion/Replantation, Paul G. Harch, Adam Shalek, Jen Karen Erbil, Brett J. King, Abigail E. Chaffin

School of Medicine Faculty Publications

A 4-year-old healthy girl sustained a composite dog bite avulsion of the tip of her nose that was intraoperatively replanted without vascular reanastomosis 2 hours and 45 minutes after the avulsion. The replanted tip initially appeared viable, but became dusky at 16 hours and cyanotic at 32 hours postreplantation. Hyperbaric oxygen therapy commenced at 40 hours postreplantation, and intermittent normobaric oxygen was added at night after the fourth hyperbaric oxygen treatment. Hyperbaric oxygen therapy was dosed according to tissue response/appearance and signs of patient oxidative stress with progressive improvement in viability. The patient received 30 hyperbaric oxygen treatments in 26 …

The Effect Of An Audio-Recorded Intervention Program On The Knowledge And Self-Reported Practices Of Menstruation And Hygiene Among Visually Impaired Young Girls In Rwanda: A Mixed Method Study, Justine Bagirisano, Marie Laetitia Ishimwe Bazakare, Aimable Nkurunziza, Jean Bosco Henri Hitayezu, Godfrey Katende

School of Nursing & Midwifery, East Africa

Background Menstrual hygiene practices among visually impaired young girls are a significant public health concern in Rwanda. Limited knowledge about menstruation leads to inadequate hygiene practices, increasing the risk of cervical cancer, urinary tract infections, and reduced quality of life. The menstrual hygiene needs of visually impaired girls who depend on daily assistance for personal hygiene have not been adequately addressed in previous studies. Objectives To assess the effect of an audio-recorded program on the knowledge and self-reported practices of menstruation hygiene among visually impaired young girls in Rwanda. Methodology A pre-post mixed intervention study was conducted involving 93 visually …

Minimal Anti-Cancer Effects Of Mushroom-Derived Compounds Hispidin And Chaga Extract On Ewing Sarcoma Cells, Jordan Cosgrove, Fiona Coulbourne, Iris Reyna, Giselle Serna-Flores, Terry Jo Shackleford

Cell and Molecular Methods

Ewing sarcoma is a rare and aggressive cancer of adolescents and young adults driven by the EWSR1–FLI1 gene fusion. Standard treatments include chemotherapy, surgery, and radiation, though survival rates remain low. Natural compounds such as hispidin, derived from fungi, and Chaga mushroom extract have shown potential anti-cancer effects by disrupting cell cycle progression and promoting apoptosis in other cancer models. In this study, we tested the effects of hispidin and Chaga extract on Ewing sarcoma cells to evaluate their ability to suppress cell growth and identify potential therapeutic benefits.

The Effects Of Panobinostat On Cellular Signaling Pathways And How It Relates To Antitumor Activities In Ewing Sarcoma Cancer Cells, Crystal Valenzuela, Andrew Martini, Hannah Navarro, Mario Flores, Terry Jo Shackleford

Cell and Molecular Methods

Ewing sarcoma is a rare and aggressive cancer that primarily affects the bones and surrounding soft tissues, most commonly in children and young adults. Although the exact etiology remains unclear, a well-documented cause involves a chromosomal translocation resulting in the fusion of the EWSR1 and FLI1 genes. This fusion produces abnormal proteins that disrupt normal gene expression, cell signaling, and RNA processing, contributing to tumorigenesis. Prognosis varies significantly depending on the extent of metastasis, with 5-year survival rates ranging from 82% in localized cases to 39% in metastatic cases. Standard treatments include chemotherapy typically involving vincristine, doxorubicin, etoposide, and cyclophosphamide—surgical …

The Effects Of Hispidin And Eribulin Mesylate On Cell Proliferation Of Ewing Sarcoma Cell Lines, Elena Mares, Angelina Juarrita, Sierra Munoz, Terry Jo Shackleford

Cell and Molecular Methods

Ewing sarcoma is a type of cancer that targets the cells within bones and soft tissue and is most prevalent in younger populations. It is important to look at this specific cancer because there is no cure yet, and the risks increase, even after a patient has completed their treatment. We hypothesize that if we treat Ewing sarcoma cell lines with natural compounds, specifically Hispidin and Eribulin Mesylate, then the cell lines will decrease in cell viability and there will be an increase in apoptosis of the cancerous cell lines. We performed a series of experiments, which included IC50 analysis, …

Efficient Eeg Epilepsy Classification And Feature Selections Based On Hellinger Distance, Muhammed Sadiq

Theses and Dissertations

Accurate and efficient detection of epileptic seizures from EEG signals remains a critical challenge due to high-dimensional data, class imbalance, and the limitations of standard classifiers. This thesis introduces two novel models to address these challenges. The first model presents a new classifier based on the Hellinger Distance, specifically designed to enhance discriminative capability and robustness against imbalanced datasets. By integrating the Hellinger Distance Classifier with Particle Swarm Optimization (PSO) for feature selection, this model significantly improves classification performance while reducing computational complexity. Experimental evaluations on the Bonn dataset demonstrate an accuracy of 96.25%, an F1-score of 97.74%, a recall …

Common Challenges Faced By Early-Career Researchers In Latin American And Small U.S. Universities, Daniela Cejas, Fatima Rodriguez Acosta, Juan Rivera-Correa

Publications and Research

Early-career researchers from Spanish-speaking Latin American countries and small U.S. universities are underrepresented in international scientific databases. They have geographical importance, infectious disease endemicity, and exceptional researchers in microbiology, but these factors do not translate to representation in high-impact scientific publications. Many reasons could be involved, including financial burdens such as the inability to pay article processing charges. Additional teaching, institutional, and service responsibilities also highly influence their research productivity. Despite this, they are expected to publish high-impact articles, and their career development highly depends on it. There is an opportunity for global peer collaboration to tackle this inequity and …

Front Matter, Editors Of Comparative Labor Law & Policy Journal

Comparative Labor Law & Policy Journal

Volume 45, Number 1

Introduction, Dalia Gesualdi-Fecteau

Comparative Labor Law & Policy Journal

Volume 45, Number 1

Preface, Valerio De Stefano, Sara Slinn

Comparative Labor Law & Policy Journal

Volume 45, Number 1

The Fragmentation And Complexity Of Labour Law, Effective Protections, And Better Work: An Analytical Framework, Dalia Gesualdi-Fecteau, Richard Johnstone, Geneviève Richard

Comparative Labor Law & Policy Journal

Labour law is a fragmented regulatory landscape bringing together multiple legal sources drawn from various areas of law, institutions, and interactions between multiple regulatory tiers and frameworks. This article offers a conceptual and analytical framework for understanding the intricate contemporary structure of labour law and its effectiveness in ensuring the protections it has historically been intended to provide. The article considers four types of legal fragmentation — temporal, vertical, horizontal, and institutional — distinguished by character and effect. The fragmented architecture of legal regulation leads, unsurprisingly, to complexity. The article puts forward an analytical approach that assesses how labour law’s …

Best Friend, False Friend: The “Favour” Rule In Comparative Labour Law, Luca Ratti

Comparative Labor Law & Policy Journal

Employment relationships can be governed by multiple legal frameworks, including statutory labour codes, collective bargaining agreements (at both enterprise and sectoral levels), and individual employment contracts. How are conflicts between these sources of law resolved? In many jurisdictions, the “favour rule” addresses such conflicts by prioritising the source that offers the greatest benefit to the employee. This rule aims to prevent employers from leveraging their superior bargaining power in individual contracts to undercut more favourable terms established through collective bargaining. However, comparative analysis reveals that the scope of the favour rule is narrowing in some jurisdictions, where it is increasingly …

Meeting Mandates In A New Labour Federalism: Opportunities And Challenges, Jake Barnes, Hana Shepherd, Janice Fine

Comparative Labor Law & Policy Journal

Worker advocates seeking to affect labour policy change in the United States have shifted their attention and energy to states and localities in a move that has been called the “new labour federalism.” new labour federalism has broadened the scope of public worker protections, while also making the enforcement of those protections even more necessary. In this article, we draw on interviews with agencies and advocates, analysis of agency enforcement data, violation estimates, and publicly available information to understand better how federalism has created both opportunities and challenges for workers, employers, and agencies tasked with enforcing employment standards. We contextualise …

The Fragmentation Of French Collective Bargaining, Nicolas Moizard

Comparative Labor Law & Policy Journal

Since the 1980s, collective bargaining in France has transitioned from a centralised model based on national labour laws and sectoral agreements to a decentralised system emphasising company-level agreements. Historically, law, and sectoral agreements provided strong, uniform worker protections, but reforms, including President Emmanuel Macron’s 2017 executive orders, have allowed company agreements to override sectoral agreements and legislation, even when less favourable to employees. This shift aims to enhance flexibility and competitiveness but has fragmented protections. Small companies increasingly use direct referendums to approve agreements without formal negotiation, leading to reduced protections such as longer hours and lower pay. Many companies …

The Legal Framework For Sexual Harassment At Work In Australia And In Québec: Case Studies Of Complexity And Its Countervailing Forces, Rachel Cox

Comparative Labor Law & Policy Journal

This paper analyses the complex legal framework for sexual harassment at work in Australia and Québec using Peter Schuck’s (1992) definition of complexity and drawing on Alejandro Camacho and Robert Glicksman’s (2019) model of the dimensions of authority and how they combine with the different functions an authority carries out.

In both Australia and Québec, overlapping institutions and approaches can improve enforcement, especially when they are coordinated. overlap is less likely to improve matters if the focus is on standard-setting, where uniformity is important to ensure the clarity, transparency, and legitimacy of the rules for duty holders and workers.

Harmonisation …

Rethinking The Concept Of The Employer In The Digital Economy: Corporate Fragmentation And Power Dynamics Through Labour Law And Competition Law Lenses, Silvia Rainone

Comparative Labor Law & Policy Journal

This article argues that the transformative dynamics brought along by the digital economy call for a normative rethinking of the allocation of employers’ obligations across the value chain, so as to better target the actual holders of labour market power. There is a growing mismatch between the role of the employer as typified in labour law frameworks — as the owner of productive assets and able to conduct its business autonomously — and the limited bargaining autonomy of the firms that gravitate in the ecosystems of digital tech corporations. This phenomenon can be attributed to two parallel trends. The first …

When Digital Platforms Intrude Into The Regulation Of Paid Domestic Work: The Case Of Formalisation In Argentina, Lorena Poblete

Comparative Labor Law & Policy Journal

Paid domestic work is governed simultaneously by several normative frameworks that have different sources. Traditionally, it has been regulated by what Adelle Blackett defines as the “law of the household workplace,” as well as by state law. Thus, the tension between these two normative frameworks makes effective access to rights uncertain for domestic workers, even those with formal labour contracts. In addition, when digital platforms intervene, their rules also apply. From a sociological perspective, and using the categories forged by historical institutionalism to study dynamics of institutional change, this article aims to understand how different normative systems — formal and …

Not All Fun And Games: Videogame Labour, Project-Based Workplaces And The New Citizenship At Work By Marie-Josée Legault And Johanna Weststar (Concordia University Press, 2024), Jelena Starcevic

Comparative Labor Law & Policy Journal

NOT ALL FUN AND GAMES by Marie-Josée Legault and Johanna Weststar offers a timely and in-depth exploration of labour dynamics in the video game industry, shedding light on the labour relations and working conditions of those who create one of the most popular entertainment mediums in the world: video game developers. Rich empirical data collected over the span of fifteen years through surveying and interviewing video game developers is structured around four pillars of citizenship at work to present a comprehensive and complicated array of the economic, contractual, and social elements shaping the industry, and a nuanced portrayal of a …

Platform Capital And The City: Governing Uber In Buenos Aires And Manchester, Mathew Johnson, Angel Martin-Caballero

Comparative Labor Law & Policy Journal

Recent literature has drawn attention to the various regulatory battles and flashpoints triggered by the entry of platform Transportation network Companies such as Uber and Lyft into cities around the world. Drawing on original case study analysis of Uber in Buenos Aires and Greater Manchester, we explore the increasingly complex and dynamic nature of local regulatory responses to platforms, and how they evolve over time. We develop a three-fold analytical framework that illustrates the important interactions between the competencies of local regulatory actors, the power of different interest groups, and the legitimacy of institutional rules. Our findings suggest that balancing …