Digital Commons Network^™

A Phase I Dose-Escalation Study Of The Hif-2 Alpha Inhibitor Dff332 In Patients With Advanced Clear-Cell Renal Cell Carcinoma, Sumanta K Pal, Joel Picus, Et Al.

2020-Current year OA Pubs

PURPOSE: Mutations or silencing of the von Hippel-Lindau tumor suppressor gene accumulate hypoxia-inducible factors (HIF). HIF-2α is implicated in the oncogenesis of ∼50% of patients with clear-cell renal cell carcinoma (ccRCC) but has been considered "undruggable." DFF332, an orally administered novel allosteric inhibitor of HIF-2α, showed dose-dependent antitumor efficacy in preclinical models of ccRCC.

PATIENTS AND METHODS: This first-in-human study evaluated the safety, tolerability, antitumor activity, pharmacokinetics, and pharmacodynamics of DFF332 in patients with heavily pretreated advanced ccRCC. Preliminary data from the dose escalation of DFF332 monotherapy, administered orally at 50 or 100 mg weekly or 25, 50, 100, or …

Acute Kidney Injury Triggers Hypoxemia By Lung Intravascular Neutrophil Retention That Reduces Capillary Blood Flow, Yohei Komaru, Liang Ning, Carine Lama, Anusha Suresh, Eirini Kefaloyianni, Mark J. Miller, Shinichi Kawana, Hailey M Shepherd, Wenjun Li, Daniel Kreisel, Andreas Herrlich

2020-Current year OA Pubs

Sterile acute kidney injury (AKI) is common in the clinic and frequently associated with unexplained hypoxemia that does not improve with dialysis. AKI induces remote lung inflammation with neutrophil recruitment in mice and humans, but which cellular cues establish neutrophilic inflammation and how it contributes to hypoxemia is not known. Here we report that AKI induced rapid intravascular neutrophil retention in lung alveolar capillaries without extravasation into tissue or alveoli, causing hypoxemia by reducing lung capillary blood flow in the absence of substantial lung interstitial or alveolar edema. In contrast to direct ischemic lung injury, lung neutrophil recruitment during remote …

Maintenance Of Graft Tissue-Resident Foxp3+ Cells Is Necessary For Lung Transplant Tolerance In Mice, Wenjun Li, Yuriko Terada, Yun Zhu Bai, Yuhei Yokoyama, Hailey M. Shepherd, Junedh M. Amrute, Amit I. Bery, Zhiyi Liu, Jason M. Gauthier, Marina Terekhova, Jon H. Ritter, Varun Puri, Ramsey R. Hachem, Maxim N. Artyomov, Kory J. Lavine, Ruben G. Nava, Andrew E. Gelman, Daniel Kreisel, Et Al.

2020-Current year OA Pubs

Mechanisms that mediate allograft tolerance differ between organs. We have previously shown that Foxp3+ T cell-enriched bronchus-associated lymphoid tissue (BALT) is induced in tolerant murine lung allografts and that these Foxp3+ cells suppress alloimmune responses locally and systemically. Here, we demonstrated that Foxp3+ cells that reside in tolerant lung allografts differed phenotypically and transcriptionally from those in the periphery and were clonally expanded. Using a mouse lung retransplant model, we showed that recipient Foxp3+ cells were continuously recruited to the BALT within tolerant allografts. We identified distinguishing features of graft-resident and newly recruited Foxp3+ cells and showed that graft-infiltrating Foxp3+ …

Modulation Of Her2 Internalization Enhances Single-Dose Antibody-Drug Potency In Her2+ Gastric Cancer, Abbey Zidel, Alex Benton, Emma Brown, Shayla Shmuel, Alex Vanover, Sandeep Surendra Panikar, Ron Bose, Haeseong Park, Andrew A Davis, Patrícia M R Pereira

2020-Current year OA Pubs

HER2 is a membrane receptor tyrosine kinase overexpressed in 18-20% of gastric tumors. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that targets HER2-positive (HER2

Towards A Sustainable Construction Industry: A Fuzzy Synthetic Evaluation Of Critical Barriers To Entry And The Retention Of Women In The South African Construction Industry, Olugbenga Oladinrin, Abimbola Windapo, Joao Alencastro, Muhammad Rana

School of Art, Design and Architecture

Over the past few decades, numerous efforts have been made to increase the proportion of women in the construction industry, coupled with various calls for legislation and rules to prohibit gender discrimination. Despite these efforts, minimal progress has been noticed in the construction industry. While recruitment remains crucial, the current culture in construction reveals a knowledge gap in recruitment and retention in employment—a concept known as a ‘leaky pipeline’. Lack of awareness of career options and the challenges of working in a male-dominated, occasionally discriminatory workplace are some of the significant barriers to attracting and keeping women in the construction …

Improving Independent Living And Quality Of Life For Dementia Patients With Open-Interface Sensor-Based Home Monitoring, Harish Kambampati, Damon Berry, Julie Doyle, Orla Moran, Jonathan Turner, Michael Wilson, Suzanne Smith, Dympna O'Sullivan

Research Outputs: 2025-Present

Living with dementia is a challenging journey for both those with dementia and their families. Besides memory loss and cognitive decline, persons with dementia often face challenges of independent living and loss of quality of life. To enhance and extend the period of independent living, an open-source software and commercial sensor-based home monitoring system is being developed. These sensors are relatively compatible with home environments, can be personalized for different users, and provide constant support including reminders, also allowing for early identification of physical or behavioural changes. They assist not only in managing everyday activities of people with dementia but …

Improving The Readability Of Dementia Information Documents Using Chatgpt, Jonathan Turner, Damon Berry, Julie Doyle, Harish Kambampati, Orla Moran, Suzanne Smith, Michael Wilson, Dympna O'Sullivan

Research Outputs: 2025-Present

There is much information available on dementia, but information may not be written at an appropriate level for a lay reader. One aim of the CoDESIGN project is to simplify information available for those who have lower levels of literacy. We investigate the potential to simplify documents to reflect the literacy abilities of the reader. We report on the ability of ChatGPT to modify documents to such target reading levels while retaining the accuracy and completeness of the documents, while avoiding the introduction of errors. Results suggest that human supervision is required before documents can be made available to readers.

Identifying Key Factors Associated With Assistive Technology Availability For Dementia Care Using Machine Learning, Wai Hang Kwok, Syed Afaq Ali Shah, Guanjin Wang

Research outputs 2022 to 2026

This study explores the factors influencing the availability of assistive technology for people with dementia through the application of machine learning. The analysis identified key factors, including carer support, protective legislation, and access to reimbursable products from the WHO Global Health Observatory. A random forest model with high accuracy emphasises the importance of targeted resources and policies in improving dementia care infrastructure.

Divergent Dna Methylation Dynamics In Marsupial And Eutherian Embryos, Bryony J. Leeke, Wazeer Varsally, Sugako Ogushi, Jasmin Zohren, Sergio Menchero, Aurélien Courtois, Daniel M. Snell, Aurélie Teissandier, Obah Ojarikre, John L. Vandeberg

School of Medicine Publications

Based on seminal work in placental species (eutherians)1,2,3,4,5,6,7,8,9,10, a paradigm of mammalian development has emerged wherein the genome-wide erasure of parental DNA methylation is required for embryogenesis. Whether such DNA methylation reprogramming is, in fact, conserved in other mammals is unknown. Here, to resolve this point, we generated base-resolution DNA methylation maps in gametes, embryos and adult tissues of a marsupial, the opossum Monodelphis domestica, revealing variations from the eutherian-derived model. The difference in DNA methylation level between oocytes …

Facial Dermatoses In E-Cigarette Users And The Role Of Nicotine-Induced Oxidative Stress, Kaitlyn Miner, Paige Daly, Alexander Torres, Corinne Rutkowski, Olivia Penela, Louis Falk, Madeleine Dumke, Kelly Frasier

Student Publications

Facial dermatoses in e-cigarette users arise from nicotine-induced oxidative stress, inflammatory signaling, and barrier dysfunction, contributing to an increased prevalence of acneiform eruptions, perioral dermatitis, and rosacea exacerbations. E-cigarette aerosols contain nicotine, volatile organic compounds, and reactive oxygen species (ROS) that disrupt cutaneous homeostasis by impairing antioxidant defense mechanisms and promoting lipid peroxidation in the epidermis. Nicotine exposure induces mitochondrial dysfunction in keratinocytes and sebocytes, leading to dysregulated sebum production, enhanced Cutibacterium acnes colonization, and increased susceptibility to inflammatory acne. Additionally, nicotine-mediated vasoconstriction and endothelial dysfunction reduce dermal microcirculation, compromising oxygen delivery and delaying wound healing, while heightened expression of …

Systems And Methods For Binaural Audio Reproduction, Kellie Shaw

Defensive Publications Series

A computer-implemented method for binaural audio reproduction may include (i) retrieving binaural audio data captured by a device that comprises at least one microphone and at least one camera, (ii) isolating a subset of the binaural audio data that represents audio captured from objects within a field of view of the at least one camera, and (iii) balancing audio levels for the binaural audio data such that the subset of the binaural audio data is more clearly audible than data that is not within the subset and spatial cues for the binaural audio data are preserved. Various other methods, systems, …

Equal Pay, Unequal Opinions: Navigating The Ongoing Circuit Split On Prior Pay As An Affirmative Defense Under The Equal Pay Act, Emily G. Young

University of Cincinnati Law Review

No abstract provided.

Too Hot, Too Cold: The Search For Just-Right Platform Liability For Recommendation Algorithms, Hannah May

University of Cincinnati Law Review

No abstract provided.

Utilizing Equitable Remedies Via The Defend Trade Secrets Act's Extraterritorial Reach To Enforce Judgments Against Foreign Defendants, Marty Ishmael

University of Cincinnati Law Review

No abstract provided.

Shield, Sword, Or Relic Of Yore? The Apex Doctrine's Quest In The Modern Legal Arena (And What Future Battles May Bring), Katerina Fernandez

University of Cincinnati Law Review

No abstract provided.

.Com Or .Gov: Should The First Amendment Care? A Proposed Alternative To Moody V. Netchoice, Llc's Editorial Discretion Rule, Jt Degrinney

University of Cincinnati Law Review

No abstract provided.

Paper Houses: Identifying The Housing Remedies Gap And How To Close It, Shannon Price

University of Cincinnati Law Review

No abstract provided.

Confronting The Duty To Capitalize In Veil-Piercing, Douglas C. Michael

University of Cincinnati Law Review

In corporate law, the doctrine of “piercing the corporate veil” allows courts to hold shareholders personally liable for corporate obligations. The doctrine—which now also applies to entities other than corporations—has been widely criticized as imprecise and unworkable. I respond to that criticism in the area of veil-piercing law which remains most intractable—the case of the tort victim who remains unsatisfied after exhausting corporate assets. Although most commentators have eschewed talk of any duty owed by the business owner to vest the business with sufficient assets, I argue that courts and legislatures should recognize—confront—such a duty. I look to negligence law …

Ncaa Women Athletes And Nil Pay Disparities: Are They Students Under Title Ix, Employees Under Title Vii, Or Both?, Michael H. Leroy

University of Cincinnati Law Review

Title IX requires schools to eliminate gender disparities in financial benefits and publicity for athletes. This Article shows that men’s basketball players in major National Collegiate Athletic Association (NCAA) conferences were paid an average of $171,272 in 2024, compared to $16,222 for women. Analysis of a prominent basketball program shows that it coordinates with its Name, Image, and Likeness (NIL) collective to monetize NIL donor access in favor of men.

This Article provides legal arguments to show that NIL pay disparities create Title IX liability for NCAA schools: (1) Congress intended Title IX to end sex discrimination against students, (2) …

A View From Inside: The Federal Government's Pivotal Role In Securing And Advancing Access To Justice, Kalpana Kotagal

University of Cincinnati Law Review

No abstract provided.

Transgender Equality: An Inflection Point For Equal Protection?, Katie Eyer

University of Cincinnati Law Review

No abstract provided.

Welcome To The Journal Of Integrative Physiology, Maurie J. Luetkemeier

The Journal of Integrative Physiology

The Journal of Integrative Physiology is dedicated to the development of you, the student researcher as you learn to publish your scholarly works via the peer review process. We welcome your physiology related research studies that you conduct in conjuction with your faculty mentor.

Comparing Apples To Oranges From Photoreceptors To Inferotemporal Cortex, Qasim Zaidi, Xu Yi, Akihito Maruya, Bevil Conway

MODVIS Workshop

No abstract provided.

Perceptograms And Cortical Models For Amblyopic Form Distortions, Akihito Maruya, Farzaneh Olianezhad, Jingyun Wang, Jose-Manuel Alonso, Qasim Zaidi

MODVIS Workshop

No abstract provided.

The Joy Of Quitting [Book Review], Jj Pionke

Disability in LIS (DisLIS)

The Joy of Quitting is a day in the life kind of comic of Keiler Roberts where she focuses on child-rearing, relationships, her art, multiple sclerosis, depression, and many other topics.

Bayesian Model Predicts Confidence In Perceptual Decision, Xinyi Yuan, Ralf M. Haefner

MODVIS Workshop

No abstract provided.

A Model Of V1 Complex Cells Based On Factorizing Amplitude And Phase, Galen Chuang, Bruno Olshausen

MODVIS Workshop

How does visual cortex form increasingly complex and invariant representations? We address this question starting from our understanding of natural images and V1. Although it is well-known that the relative phases of frequency components in images contain important structure, the standard model of V1 complex cells discards phase information within the receptive field. We propose a model for disentangling invariances and their accompanying transformations based on a complex-valued sparse coding model adapted from Cadieu & Olshausen 2012. This model makes phase information explicit by factorizing images into both phase and amplitude components, with structure represented by amplitude and phase patterns, …

Influence Of Task On The Geometry Of A Perceptual Space, Jonathan D. Victor, Mary M. Conte

MODVIS Workshop

Perceptual spaces are representations of a sensory or cognitive domain in which the domain’s elements correspond to points, and distances between these points are perceptual differences. Proximity relationships within a perceptual space can support a variety of functions, including discrimination, grouping, learning, and generalization. These diverse functions may use the features of the domain in different ways, resulting in task-dependent influences on the geometry of the space.

To identify and characterize these influences, we focused on a domain of visual textures. These textures varied across many dimensions, including mean luminance and low- and high-order spatial correlations, which formed the axes …

Navigating The Moral Landscape: Courage, Cowardice, And The Educator's Call To Action, Scott H. Sorvaag

Essays in Education

Contemporary educators face an increasingly complex and challenging landscape. This essay explores the vital role of courage and the influence of cowardice in shaping educators' moral leadership and professional practice. By integrating insights from human development reports, leadership theory, and educational philosophy, this essay argues that understanding the internal continuum between courage and cowardice is crucial for educators seeking to create transformative learning environments. The essay provides actionable strategies for fostering courage in daily practice and nurturing partnerships between schools, parents, and communities.

The Haunting Of Alejandra [Book Review], Amanda Boyer

Disability in LIS (DisLIS)

This review explores V. Castro’s The Haunting of Alejandra as a powerful portrayal of postpartum depression and generational trauma through the lens of horror and magical realism. Drawing on personal experience, the review highlights how the novel offers an unflinching look at the emotional weight of motherhood and the lasting impact of inherited pain.