Digital Commons Network^™

The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons Of The Transcriptomic Landscapes Across Mouse Models, Ling Cai, Fangjiang Wu, Qinbo Zhou, Ying Gao, Bo Yao, Ralph J Deberardinis, George K Acquaah-Mensah, Vassilis Aidinis, Jennifer E Beane, Shyam Biswal, Ting Chen, Carla P Concepcion-Crisol, Barbara M Grüner, Deshui Jia, Robert A Jones, Jonathan M Kurie, Min Gyu Lee, Per Lindahl, Yonathan Lissanu, Corina Lorz, David Macpherson, Rosanna Martinelli, Pawel K Mazur, Sarah A Mazzilli, Shinji Mii, Herwig P Moll, Roger A Moorehead, Edward E Morrisey, Sheng Rong Ng, Matthew G Oser, Arun R Pandiri, Charles A Powell, Giorgio Ramadori, Mirentxu Santos, Eric L Snyder, Rocio Sotillo, Kang-Yi Su, Tetsuro Taki, Kekoa Taparra, Phuoc T Tran, Yifeng Xia, J Edward Van Veen, Monte M Winslow, Guanghua Xiao, Charles M Rudin, Trudy G Oliver, Yang Xie, John D Minna

Faculty, Staff and Student Publications

Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to compare in a centralized fashion. In this study, we established the Lung Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model. Meticulous curation and collaboration with data depositors produced a robust and comprehensive database, …

G-Quadruplex Stabilizer Cx-5461 Effectively Combines With Radiotherapy To Target Α-Thalassemia/Mental Retardation X-Linked-Deficient Malignant Glioma, Sharvari Dharmaiah, Prit Benny Malgulwar, William E Johnson, Brandon A Chen, Vladislav Sharin, Benjamin T Whitfield, Christian Alvarez, Vasudev Tadimeti, Ahsan S Farooqi, Jason T Huse

Faculty, Staff and Student Publications

Background: Inactivation of α-thalassemia/mental retardation X-linked (ATRX) represents a defining molecular feature in large subsets of malignant glioma. ATRX deficiency gives rise to abnormal G-quadruplex (G4) DNA secondary structures, enhancing replication stress and genomic instability. Building on earlier work, we evaluated the extent to which pharmacological G4 stabilization selectively enhances DNA damage and cell death in ATRX-deficient preclinical glioma models.

Methods: Using the G4 stabilizer CX-5461, we treated patient-derived glioma stem cells (GSCs) in vitro and GSC flank and intracranial murine xenografts in vivo to evaluate efficacy as both a single agent and in combination with ionizing radiation (IR), the …

Enhancing Motor Function In Individuals With Lower Limb Amputation Through Peerbased Learning Of Balance And Fall Recovery Skills, Zoe Castle, Jer Ja Chuang, Jewel Granados, Danna Shaw

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: Lower limb amputation (LLA) is a devastating condition that is becoming more prevalent in the United States. We examined the effects of peer-based action observation learning on the brain activation and the eyetracking pattern in individuals with LLA.

Methods: Fourteen individuals with LLA (51.9±12.6 years, 4 females, 9 with transfemoral amputations) were asked to learn a balance task through observing the movements demonstrated by individuals with LLA or persons with intact limbs. Electroencephalogram (EEG) signals, visual attention time, and peak saccade velocity were recorded when participants watched the demonstration videos. Power spectral density (PSD) was used to analyze the …

Gotta Be Fresh: Comedy Central’S Workaholics, Masculinity, And Paratextual Decay, Adamandrew Lenox

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis examines social media marketing materials for Workaholics, a sitcom aired on Comedy Central from 2011 to 2017, to study paratextual temporality/ephemerality, the “brand as friend” social media strategy, and how masculinity is articulated through paratexts. The project incorporates theories from the fields of social media and internet marketing studies, television content and industry studies, and promotional paratext studies. Research centered on 100 Workaholics X (formerly Twitter) posts, published from January 2012 to March 2017. Posts were collected using Google Chrome extension TwExportly. Qualitative textual and content analysis of these paratexts results in three categories of findings. First, I …

Quick And Easy Method For The Determination Of Cocaine And Six Metabolites In Postmortem Hair, Samantha C. Mulkeen

Student Theses

Hair testing is increasing in popularity in toxicology because of its long window of detection and ease of collection and sample storage. However, it has its limitations largely due to external contamination of drugs. In particular, cocaine (COC) is a common offender of this as it has several routes of consumption. Analyzing metabolites of COC may be the key to distinguishing between consumption and external contamination. The aim of the present study was to develop a quick, easy, and sensitive method for the detection and quantification of COC, benzoylecgonine (BE), norcocaine (NCOC), cocaethylene (CE), anhydroecgonine methyl ester (AEME), meta-hydroxy-cocaine (m-OH-COC), …

Exploring Arabic, Russian, And Spanish Native Language Teachers’ Perceptions Of The Flipped Classroom Model Through The Lens Of The Technology Acceptance Model (Tam2), David I. Daoud

Doctoral Dissertations

The flipped classroom has become increasingly popular across various educational settings over the last two decades. In the flipped classroom model (FCM), the teacher spends less time on traditional in-classroom activities like lecturing and giving tests, which are instead assigned as homework, and more time on hands-on learning. Although research has shown the FCM is effective in a variety of learning settings, little is known about native language teachers' perceptions of the FCM. This study explored the perceptions of 41 native Arabic, Russian, and Spanish foreign language instructors regarding the FCM at a college-level language institution. The study aimed to …

Long-Term Efficacy Of Pembrolizumab And The Clinical Utility Of Ctdna In Locally Advanced Dmmr/Msi-H Solid Tumors, Michael Lapelusa, Wei Qiao, Bryan Iorgulescu, Francis San Lucas, Keyur Patel, Deepak Bhamidipati, Jane Varkey Thomas, Nancy You, Wai Chin Foo, Dipen Maru, Selvi Thirumurthi, Van Morris, Scott Kopetz, Michael Overman, Kaysia Ludford

Faculty, Staff and Student Publications

Neoadjuvant immunotherapy can induce pathologic complete response (pCR) in patients with localized deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) tumors. The long-term outcomes of these patients are unknown, as is the clinical utility of measuring circulating tumor DNA (ctDNA). Follow-up was evaluated in patients enrolled in a phase II trial (NCT04082572) that evaluated the efficacy and safety of pembrolizumab in patients with localized dMMR/MSI-H tumors. The primary outcomes of this trial have previously been reported. 3-year EFS and OS rates were 80% (95% CI: 66% - 93%) and 94% (95% CI: 86% - 100%). Patients without detectable ctDNA after pembrolizumab had …

Secondary Educators’ Knowledge And Perceptions Of Their Own Self-Efficacy As It Relates To 504 Plan Accommodations For Students Diagnosed With Adhd, Anne Richardson

Seton Hall University Dissertations and Theses (ETDs)

This study investigated the role of Section 504 accommodations in meeting the needs of secondary students with attention-deficit/hyperactivity disorder (ADHD) in the United States. While legislation requires equitable education for students with disabilities, gaps remain in understanding how educators perceive their own abilities in implementing Section 504 plans for students with ADHD. The study used a qualitative research design to explore the academic and organizational challenges faced by secondary school students with ADHD, specifically examining the knowledge, perceptions, and self-efficacy of secondary educators regarding ADHD strategies and 504 plan accommodations. Semi-structured interviews were conducted via Zoom with 11 educators from …

Women And Stem − A 2025 Update, Robyn C. Blackburn, Susan R. Madsen

Marketing and Strategy Faculty Publications

Although the term STEM (science, technology, engineering and math) was coined in 2001 by Judith A. Ramaley of the National Science Foundation and had been used informally in the previous decade,¹ the push for STEM in the US began in the 1950s with Russia launching Sputnik and the US subsequently pouring billions of dollars into educating students to ensure the nation became a technological global power. However, the gender gap in STEM fields today reduces the innovation that could be achieved with more unique perspectives contributing to the field. Closing the gender gap in STEM is vital because scientific …

Constructing The Soliton Wave Structure And Stability Analysis To Generalized Calogero–Bogoyavlenskii–Schiff Equation Using Improved Simple Equation Method, Mina Fahim, Hamdy Mohamed Ahmed, Islam Samir Soliman, Mohamed Elsaid, Kamal Hassan Eldib

Basic Science Engineering

In this work, we investigated the (3+1)-dimensional generalized Calogero–Bogoyavlenskii–Schiff equation, which models long wave propagation in shallow water and plays a significant role in fluid mechanics and plasma physics. Using the improved simple equations method, we obtained various solutions, including dark, bright, and singular solitons, and combinations of singular periodic solutions and exponential rational solutions. Additionally, we performed a linear stability analysis to examine the stability properties of these wave solutions. To further illustrate their characteristics during propagation, we provided 3D and contour plots for some opted wave solutions.

Effect Of Β-Alanine Supplementation On Inflammation Response And Subsequent Muscle Function Following An Acute Bout Of Resistance Training., David F. Smith

Masters Theses, 2020-current

Purpose: This study aimed to examine the effects of β-alanine supplementation on the inflammation response, as measured by Interleukin-6 (IL-6) levels, and subsequent muscle function in resistance-trained individuals following a single bout of resistance exercise.

Methods: Fourteen resistance-trained subjects were recruited for a double-blind, between-group experiment. Following a two-week washout period (if needed), subjects were randomly assigned to receive either 6.8g of β-alanine daily or a placebo. After the supplementation period, subjects performed a standardized exhaustive squat protocol (10 sets of 10 repetitions at 60% of their estimated 1RM). Venous blood samples were collected pre-exercise, 24-hours post, and 72-hours post …

Examining Validity And Reliability Evidence For The Multicultural Neuropsychological Scale (Muns) Party Subtest Scores, Madyson Hernandez

Masters Theses, 2020-current

Neuropsychological tests were developed primarily for Westernized, Educated, Industrialized, Rich, and Democratic (WEIRD) populations (Henrich, 2020; Fernández & Abe, 2018). According to the American Academy of Clinical Neuropsychology (AACN) Relevance 2050 Initiative project, approximately sixty percent of Americans will be deemed unsuitable for neuropsychological testing because test norms are primarily based on European Americans who speak English (AACN, 2015). To aid in effective cross-cultural neuropsychological assessment, The Multicultural Neuropsychological Scale (MUNS; Fernández et al., 2018) was developed to be easily translatable to various languages. The MUNS is a 40-minute neuropsychological test battery that examines cognitive abilities such as reading fluency, …

Characteristics Of Parent-Adolescent Relationships As Predictors Of Adolescents’ Future Emotion Regulation Abilities, Jaclyn H. Snyder

Masters Theses, 2020-current

Adolescence is a critical period for the development of emotion regulation skills and parents play a pivotal role in the shaping of such skills. Indeed, several characteristics of the parent-child relationship have been implicated in adolescents’ emotional development. Namely, parental acceptance of adolescents’ emotions, the quality of parent-child attachment, and the tactics parents utilize to resolve conflict with their child appear to be significant sources of influence. The current study aimed to examine each of these three factors as possible predictors of adolescents’ emotion regulation abilities later in life. Additionally, this study sought to understand the relative strength of these …

Role Of The Pediatric Rdn In Conducting The Pediatric Nutrition Focused Physical Exam: Training, Clinical Practice And Barriers, Sarah M. Kowalewski

Masters Theses, 2020-current

Abstract:

Background: The pediatric nutrition focused physical exam (PNFPE) is important for completing comprehensive assessment in pediatric patients, particularly those at risk for malnutrition. The PNFPE helps to identify the depletion of fat and muscle stores, as well as micronutrient deficiencies.

Methods: Pediatric RDNs, self-identified through CDR and practice group membership, were surveyed-to investigate their training, clinical practice, documentation, and barriers to use of the PNFPE. The survey instrument, validated by content experts and analyzed for reliability, was approved by our university’s IRB.

Results: A total of 65.8% of respondents held a graduate degree and 81.6% held a specialty certification. …

Unheard Voices: A Poetic Inquiry Into The Menace Of Child Abuse In Nigeria, Folajimi Kalejaye

Masters Theses, 2020-current

My project explores poetic inquiry as an arts-based methodology for evocatively representing stories and voices of survivors of child violence in Nigeria from 2013 – 2024. More specifically, I explore poetic inquiry for personal reflection and re/mediation of news stories, editorials, and documentaries that present child violence. Remediation is a practice of representing existing media content through affective forms so as to evoke a deeper meaning and encourage critical reflection of lived experiences. As such, rather than narrating these children's experience from conventional storied standpoints of pain, abuse, trauma, and violence, I poetically interpret their stories to amplify children's voices …

Collisions: The Enlivened Entanglements Of The Object-Self, Grace P. Smith

Masters Theses, 2020-current

This piece is a performance collage centered around objects and our entanglements with them. Through unpacking five objects in my life and their histories and interrogating three interwoven levels of narrative (the historical, the personal, and the aesthetic), I playfully displace the subject/object hierarchy to contribute to broader theoretical discussions regarding the agency of objects, resulting in novel insights through the collisions produced from the performance collage.

Sundown In Indiana: A Midwest Story Of Racism, Exclusion, And Memory, Kelsey A. Snyder

Masters Theses, 2020-current

Sundown towns were a prominent aspect of the northern life from the early 1900s till in some places till the 1970s but they have been lost to history. These towns have been silenced and erased not just from the history books but from public memory. Indiana is my home state and the three towns that will be discussed have all had an impact on my personal development especially in understanding race. Decatur and Huntington places I have called home, both have been classified as sundown towns. The third, Marion was the location of the one the last known lynchings in …

The Voices Of Black Motherscholars: Navigating Academia, Motherhood, And Beyond, Danae Peterson

Masters Theses, 2020-current

The experiences of Black women in academia are shaped by the intersection of multiple, often conflicting identities. As mothers and scholars, Black women navigate the complex terrain of competing responsibilities, societal expectations, and institutional barriers, all while striving to achieve personal and professional aspirations. This daily balancing act is complicated by the compounded effects of racism and sexism in academia, coined as misogynoir (Bailey, 2018). Misogynoir, a specific form of anti-Black racist misogyny, manifests through stereotyping, marginalization, and invisibility affecting Black women’s ability to thrive in academic spaces that were not designed with them in mind (Patton & Njoku, 2019). …

Power Impacts Target Goals And Responses To Racism, Urmi Chatterjee

Masters Theses, 2020-current

Racial microaggressions are harmful to people of color (POC) and inhibit their social functioning in the long term. Explicit forms of racism have been focused on in previous studies on interpersonal racial interactions. While studies have found the effect of confrontation on POC who experience subtle racism, other forms of responses to racism lack research. Are responses influenced by how powerful targets are? What happens when a powerful target experiences subtle racism? This study shows how power shapes the strategies people of color use to respond to subtle racism. We used a negotiation framework between three types of goals and …

Varied Versus Non-Varied Behavior-Specific Praise On Student On-Task Behavior, Jessica Boss

Masters Theses, 2020-current

The current study examined the effects of praise statements on students’ behavior by assessing how varied and non-varied behavior-specific praise statements effect student on-task behavior. An alternating treatment design was used to compare the treatment conditions of varied and non-varied BSP. During baseline, participants were not given feedback on their praise statements or their interactions. After baseline, participants were taught to a mastery criterion on varied and non-varied BSP conditions. In the experimental phase, the participants alternated between a condition providing non-varied BSP and a condition providing varied BSP. The results of this study showed that both varied and non-varied …

Item Response Predictors Of Disengagement On The Pisa, Juste M. Mehou

Masters Theses, 2020-current

International assessments, such as the Programme for International Student Assessment (PISA), are instrumental in understanding educational progress, assessing teaching effectiveness, and ensuring institutional accountability (OECD, 2023). Central to the validity of these assessments is the assumption that students will exert sufficient effort and perform to the best of their abilities (AERA, APA, & NCME, 2014). This assumption is essential to ensure that scores accurately reflect students' true abilities (Wise & Kong, 2005). However, there is a documented concern that students often exhibit low effort in low-stakes tests, such as the PISA, where individual results have no direct consequences (Wise & …

Empowering Paraprofessionals Through Behavioral Skills Training: Abc Data Recording, Addison Raso

Masters Theses, 2020-current

This study investigates the efficacy of the behavior skills training (BST) framework in enhancing data collection procedures for paraprofessionals. An add-in component analysis was used to evaluate the effectiveness of individual BST components. Three participants (i.e., Nathan, Molly, Bailey) were assessed across baseline, instruction, modeling, rehearsal, and feedback phases. Nathan showed little improvement, with low and variable performance across phases. Molly demonstrated gradual improvement, achieving high accuracy in the final phase with feedback. Bailey exhibited an initial decline, followed by a steady increase, reaching near-perfect accuracy in the final phase. Data analysis revealed an additive effect with feedback having the …

Evaluating The Use Of Positive Self-Talk As An Antecedent Intervention For On-Task Behavior In Adolescents With Adhd, Sydney Setchel West

Masters Theses, 2020-current

The purpose of this study was to examine the effects of using positive self-talk statements to increase the on-task work behavior of students with ADHD who have low baseline levels of on-task work behavior. A multiple baseline design across two participants was used to assess the impacts of the intervention. During the baseline phase, on-task work behavior was measured for participants as they completed independent work. Following baseline, participants were removed from the classroom and recited 5-10 positive self-statements regarding their ability to focus on their work. Data were taken on the participants on-task work behavior after returning to their …

Adapting A Contingency Contract Across Environments For Interfering Behaviors And Coping Skills, Samantha N. Eckstein

Masters Theses, 2020-current

The purpose of this study was to examine the effects of taking an already successful contingency contract for an individual and adapting it to two separate environments to determine the effects on interfering behaviors and the utilization of coping skills. An AB design was utilized to allow for comparison of effects between conditions (i.e., control and treatment). The independent variable was the contingency contract(s) used across all settings and there were three dependent variable measures. These were the effects on interfering behaviors, skills demonstrated, and the utilization of coping skills. There is not enough evidence shown in the data to …

Experimentally Testing A Mechanism Of Urban Adaptation: Are Wild Catbirds Able To Immediately Adjust Their Song In Response To Urban Noise?, Eriberto Osorio

Masters Theses, 2020-current

Anthropogenic noise is loud and low-frequency (low-pitch) sound with frequencies spanning from 1-2.5 kHz in frequency. In noisy urban areas, many birds sing songs with higher minimum frequencies, which can avoid the masking effects of anthropogenic noise. However, the mechanism for an individual to alter spectral aspects of bird song in real time to avoid the masking effect of urban noise is unknown. Immediate flexibility is the ability a bird may use to shifts their song frequency or amplitude in response to noise fluctuations in the environment. Some species that sing higher frequency songs in noisy habitats are not able …

The Effects Of Goal Setting With Performance Feedback On A Teacher’S Use Of Praise And Reprimand Statements, Elisabeth Morris

Masters Theses, 2020-current

The purpose of this study was to further extend the literature on teacher praise-to-reprimand (PTR) ratios by systematically replicating a study by Criss et al. (2023). This study evaluated the effects of goal setting with performance feedback on a special education teacher’s use of BSP and reprimands. A changing criterion design was used to gradually increase the participant’s use of BSP in 15 min whole group reading sessions with up to four students in grades 4^th through 6^th. The results of the study demonstrate a functional relation with the intervention and participant’s use of BSP. Implications for …

Making Their Voices Heard: Virginia Women's Organizations As Agents Of Community Change From 1945 To 1955, Preston C. Morgan

Masters Theses, 2020-current

After World War II, Virginian women’s organizations experienced increases in membership and in community influence. For the next decade, Virginian women in various non-partisan organizations would take intentional efforts to position women as activists of change, creating and training women for public and civic contributions. Organizational women began to see themselves as having growing responsibility for their community’s wellbeing. This study will analyze this growing grassroots organization movement by examining records from organizations like the Winchester Women’s Civic League, the women’s missionary societies of the First Baptist Church and Salem Lutheran Church, and Madison College. This study will analyze this …

Grief As Slip: (How Little I Show) An Exploration In Clay, When Words Are Not Enough, Michelle A. Smith

Masters Theses, 2020-current

Grief as Slip (how little I show) implies that even as we acknowledge our mortality and the fleeting nature of life, we still only reveal a fraction of our true selves or our deeper realities. The ceramic artwork in this exhibition carries and conveys a journey through the present and remembered emotions of the artists’ personal narrative. By juxtaposing the tactile nature of clay with the ethereal quality of human experience, Smith contemplates the profound interplay between material transformation and emotional resilience. The exhibition’s intent is to translate the essence of complex emotional states into abstracted forms so they can …

Ritual And Revolution: Rethinking Roman Women’S Influence On Religion, Katlin Smith

Masters Theses, 2020-current

This thesis challenges the long-standing portrayal of Roman women as passive figures. Focusing on the mid-to-late Roman Republic and early Empire (264 B.C.E.–180 C.E.), it argues that women were active participants in Roman society, particularly through their engagement in religious life. Drawing on the theory of “lived religion,” this study highlights how religion offered Roman women opportunity to interact with both domestic and public spheres in socially acceptable means. Religion allowed women to exercise influence, power, and autonomy otherwise denied to them in political or legal contexts. Through a combination of textual analysis and material evidence, such as inscriptions and …

Sacral Glitch, Kareena Naresh Solanki

Masters Theses, 2020-current

Growing up in a multifaith environment in Mumbai, I witnessed many religious sites and people with diverse beliefs. My parents always remained open-minded to other faiths, and my house remained replete with idols of deities of different religions. I studied Nichiren Buddhism, particularly the Lotus Sutra, as my mother began practising it along with her faith in Hinduism. Philosophical studies became a part of my life at the age of nine. Catholic prayers turned into rituals in my convent school days, and Islamic prayers resonated from afar. I often reflect on the influence of multiple religions in shaping my approach …