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An Aphasic Child With Behavioral Abnormality Landau–Kleffner Syndrome, Shatanik Sarkar, Chaitali Patra, Malay Kumar Dasgupta

Indian Journal of Health Sciences and Biomedical Research KLEU

Acquired epileptic aphasia, otherwise known as Landau–Kleffner syndrome, is a childhood epilepsy syndrome, characterized by acquired aphasia, seizures, behavioral abnormalities, and abnormal electroencephalography (EEG), in various combinations. Sometimes, some intracranial pathologies, such as brain tumor, head injury, demyelination, and neurocysticercosis, have been found in association. Here, we report a case of a 5-year-old male child presenting with gradual loss of speech, behavioral abnormalities, such as hyperactivity, inattentiveness, and abnormal EEG findings, but without the classical seizures seen with this syndrome.

Neuro-Behcet's Disease A Report Of Three Clinically Distinct Cases From North-West India, Chandramohan Sharma, Banshilal Kumawat, Kaushik R. Rana, Tarachand Saini

Indian Journal of Health Sciences and Biomedical Research KLEU

Behcet's disease (BD) is a multisystem inflammatory disorder with various neurological manifestations common in the Middle-East countries but scarcely reported in the Indian literature. We report three patients of neuro-BD with different neurological manifestations. Two cases presented as cerebral venous sinus thrombosis and the third case as pachymeningitis. It should be included in the differential diagnosis of any neurological disorder with a diagnostic dilemma as it is potentially treatable condition.

A Study To Evaluate Cardiovascular Responses By Using Treadmill And Ergometer Bicycle Exercise In Young Adults, Alok Kumar Yadav, Jayasheela G. Bagi

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND AND OBJECTIVE:

Exercise is inevitable to keep good health status, advised for health promotion, diagnosis of diseases, and rehabilitation. Different types of exercise are performed as exercise tolerance, but tolerance is not same for every individual. Thus, the objective of this study is to evaluate the cardiovascular responses for three different intensities of exercise using treadmill and bicycle ergometer at fixed heart rate (HR) value in young healthy adults.

METHODS:

After obtaining the ethical clearance from the Institutional Ethical Committee, a total of 130 participants were screened and 48 randomly selected male and female individuals with age group of …

Prevalence Of Menopausal Symptoms Among Postmenopausal Women Of Urban Belagavi, Karnataka, Nidhi Pathak, M. S. Shivaswamy

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

According to the World Health Organization (1981), natural menopause is defined as no menses for 12 consecutive months with no obvious intervening cause. During the menopause, women may experience vasomotor, psychosocial, physical, as well as sexual dysfunction. Studies on menopausal issues and health demand priority in Indian scenario due to the growing population of menopausal women as a result of their increased life expectancy.

OBJECTIVE:

To know the prevalence of menopausal symptoms in the postmenopausal women aged 40–60 years.

METHODOLOGY:

A community-based cross-sectional study was conducted between January 1, 2016, and December 31, 2016, using a predesigned, pretested, structured …

Knowledge And Practice Of Needlestick Injury Preventive Measures Among Nurses Of Sana'a City Hospitals In Yemen, Gawad M. A. Alwabr

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

A needlestick injury is an accidental skin-penetrating stab wound from a hollow-bore needle containing another person's blood or body fluid, leading to infection of diseases transmitted by blood such as hepatitis B virus, hepatitis C virus, and human immunodeficiency virus. The purpose of this study is to assess the level of knowledge and practice of needlesticks injury prevention measures and to estimate the incidence of exposure to needlestick injury among nurses working in the governmental hospitals in Sana'a city, Yemen.

MATERIALS AND METHODS:

A cross-sectional study among a random sample of nurses (

n

= 259) were conducted. A …

To Compare Efficacy Of Bupivacaine And Bupivacaine With Dexamethasone For Supraclavicular Brachial Plexus Block In Patients Undergoing Upper-Limb Surgeries A One -Year Randomized Controlled Trial, Shwetank Rai, K. S. Kedareshvara

Indian Journal of Health Sciences and Biomedical Research KLEU

OBJECTIVE:

Brachial plexus block is a viable alternative to general anaesthesia as it provides adequate muscle relaxation, excellent intraoperative and post operative analgesia. Dexamethasone, a synthetic glucocorticoid was combined with local anaesthetics to study the effects . This study was conducted to compare the onset and duration of sensory and motor block following administration of either bupivacaine and bupivacaine- Dexamethasone in patients undergoing upper limb surgeries under USG guided supraclavicular block.

MATERIALS AND METHODS:

60 ASA I / II patients between of 18 and 60 years who underwent elective upper limb surgeries randomly allocated into two groups of 30 each …

Effectiveness Of Planned Teaching Program On Home Management And Its Side Effects In Terms Of Knowledge Among Caregivers Of Patients Receiving Chemotherapy At Selected Tertiary Care Hospital, Belagavi, Jonathan Borges, Preeti Bhupali, Deepak Bagi

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Cancer is most fatal disease, and the caregivers taking care of the cancer patients have a vital role to play in their health-care wellness. As chemotherapy is one of the treatments for cancer, the side effects of chemotherapy are very important to be manage at home by the caregivers. The most effective way of giving information to the caregivers was by giving a planned teaching programme (PTP) and enhancing their knowledge regarding home management and its side effects of chemotherapy.

OBJECTIVES:

The objective of this study was to assess the knowledge of caregivers of patients receiving chemotherapy; to administer …

A Randomized Controlled Trial To Evaluate The Efficacy Of Karpura Ghrita As A Topical Analgesic With Lignocaine Jelly 2% In Posthemorrhoidectomy Pain, Vivek Rajeshwar Shukla, Amruta Ashok Wali, Tajahmed Noorahmed Dongargaon

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Effective postoperative pain control is an essential component of the care of the surgical patient. Uncontrolled pain may cause restlessness and thereby delay in wound healing. Haemorrhoids are certainly one of the commonest ailments that afflict mankind. NSAID's have been traditionally been used to relieve pain after minor or major surgery. There are many modes of treating the local pain like by lignocaine Jelly2%, glycerine packing, diclofenac suppository which reduces the pain but they may bring delayed wound healing. The use of

Karpura-Ghrita

is mentioned in classics after

shastrakriya

for Pain (Vedana) management. Hence, this study is planned to …

Awareness Of Gestational Diabetes Mellitus Among Pregnant Women Attending A Tertiary Health Center, Vineeta Dhyani, Niranjana S. Mahantashetti, M. S. Ganachari, Sanjay Kambar, Vikrant Ghatnatti

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND AND OBJECTIVES:

Awareness of gestational diabetes mellitus (GDM) among pregnant women is poor. However, increasing awareness may help in diagnosis and prevention of maternal and fetal complications. Hence, this study was aimed at evaluating the knowledge in diagnosed GDM pregnant women.

METHODOLOGY:

This cross-sectional study was conducted from October 2014 to March 2017. A total of 500 registered pregnant women diagnosed to have GDM residing within 5 km of the study area aged more than 18 years who were willing to participate in the study were enrolled in the study. The participants were provided with the questionnaire which was …

A Clinical Study On Triphaladi Compound And Shunthyadi Eye Drop In The Management Of Computer Vision Syndrome, Shashi Prakash Gupta, D. B. Vaghela

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Computer vision syndrome (CVS) is a group of symptoms which crop up from the extended viewing of the visual display terminals, when the demands of the task exceed the abilities of the viewer. The symptoms of CVS include eyestrain, dry eyes, burning sensation, headache, focusing difficulties, and neck and shoulder pain.

AIM:

This study aims to evaluate the efficacy of

Triphaladi

compound and

Shunthyadi

eye drops in the management of CVS.

MATERIALS AND METHODS:

In this trial, forty patients were registered, of which 37 completed the treatment. In Group A, 18 patients had been prescribed

Triphaladi

compound internally and …

Two-Dimensional-Quantitative Structure-Activity Relationship Studies Of A Novel Series Of Diaryl Furanone Derivatives An Approach To Design Selective And Effective Cyclooxygenase-2 Inhibitors, Manjula K. Chikkamath, Pratibha M. Huded, Swetha S. Kokatnur, Akshata S. Menasinakai, Mahesh B. Palkar

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Over a decade, a large number of selective cyclooxygenase-2 (COX-2) inhibitors with diverse chemical characteristics have been designed but only a few have emerged as drugs.

MATERIALS AND METHODS:

In the present study, two-dimensional-quantitative structure-activity relationship (2D-QSAR) studies were performed on a set of 43 novel derivatives of diaryl furanone using V-Life Molecular Design Suite (MDS 3.5) QSAR plus module using multiple linear regression (MLR) and Partial Least Square (PLS) regression methods against a COX-2 enzyme.

RESULTS AND DISCUSSION:

PLS method has displayed a very significant prediction results. QSAR model was generated by a training set of 33 molecules …

Evaluation Of The Effects Of Laser Irradiation On The Rate Of Tooth Movement A Split-Mouth Study, Urvi Harish Mal, Manjunath Malagan

Indian Journal of Health Sciences and Biomedical Research KLEU

AIM AND OBJECTIVE:

The aim of this study is to evaluate the rate of tooth movement caused by laser during individual canine retraction in the maxillary arch.

MATERIALS AND METHODS:

The study was done on 10 patients requiring upper first premolar extraction on both the sides and individual canine retraction using closed NiTi coil spring with high anchorage. A split-mouth technique was carried out where the right quadrant was the experimental side and left quadrant was the control side. On experimental side, canine was irradiated with Ga-As semiconductor laser (wavelength – 940 nm, output – 0.2 mW for 25 s, …

Comparison Of Vitamin “C” Levels In Naturally Ripened And Artificially Ripened Mangoes, Jayashree Neelakantha Majagi, Vanishree Basavraj Jabannavar

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Fruits are very good sources of micronutrients. In the present era, eating fruits is questionable due to hazardous effects of artificial ripener usage on fruits. Ascorbic acid (C

6

H

8

O

6

), a major antioxidant water-soluble vitamin, acts as a reducing agent for many metabolic reactions as a coenzyme. Since it is heat-labile, fruits remain as a prime source as they are eaten uncooked. Mangoes, Banana, and Papaya are the most commonly subjected fruits for artificial ripening. However, artificial ripeners such as ethephon and calcium carbide have antinutritional and hazardous effects on health. This study analyzed the …

Vitamin B12 Insufficiency In Excess Folic Acid Downregulates Methylenetetrahydrofolate Reductase Gene And Increases Homocysteine, Tumor Necrosis Factor-Alpha, And Oxidative Stress In Hepatocytes, Tejas Shah, Kalpana Joshi, Sanjay Mishra

Indian Journal of Health Sciences and Biomedical Research KLEU

OBJECTIVE:

Folate and Vitamin B12 (B12) are crucial for normal growth, development, and cellular functions. The aim of this study was to determine the effect of required and excess folic acid (FA) concentration and imbalance of FA and B12 caused due to folate fortification on hepatocytes health and function

in vitro

.

MATERIALS AND METHODS:

Human hepatocellular carcinoma (HepG2) cells were cultured in FA and B12 deficient media for 15 days and further were supplemented with required FA: (6 μM) and excess FA: (60 μM) individually and in combination with B12: (500 nM). We assessed HepG2 proliferation, viability, tumor necrosis …

Expression Of Estrogen Receptor, Progesterone Receptor, And Human Epidermal Growth Factor Receptor Type 2/Neu In Surface Epithelial Ovarian Tumors And Its Clinicohistopathological Correlation, Neeta Verma, Madhu Kumar, Mala Sagar, Suresh Babu, Atin Singhai, Nisha Singh, Sujata Dev, Vijay Kumar

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Ovarian cancers represent the 4

th

most frequent type of cancers among females and are the most common cause of death from gynecological cancers in the world.

AIMS AND OBJECTIVES:

The aim is to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2/neu) immunohistochemical markers in surface epithelial ovarian tumors and its clinicopathological correlation with CA-125 level, histological type, grading of tumors, and prognosis of ovarian tumors.

MATERIALS AND METHODS:

This study included 48 cases of surface epithelial ovarian tumors including serous, mucinous, and adenocarcinoma Not Otherwise Specified (NOS). After grossing …

Review Of Selected Herbal Phytoconstituents For Potential Melanoma Treatment, Bhaskar Kallappa Kurangi, Sunil Satyappa Jalalpure

Indian Journal of Health Sciences and Biomedical Research KLEU

Malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. The current chemotherapies have a relatively low success rate due to the development of multidrug resistance and side effects. Hence, there is need of discovering new compounds that are safe and more effective against melanoma to improve the efficiency and to lower the treatment cost for cancer care. Melanoma chemoprevention with natural herbal phytoconstituents is an emerging strategy to prevent, cure, or treat melanoma. This review summarizes the latest research in melanoma chemoprevention and treatment using the herbal phytoconstituents. Relevant mechanisms involved in the pharmacological …

The Role Of Microbiome In Cancer, R. B. Nerli, Shridhar C. Ghagane

Indian Journal of Health Sciences and Biomedical Research KLEU

No abstract provided.

Survival In A Case Of Aluminum Phosphide Poisoning With Severe Myocardial Toxicity, Priya Bansal, Subhash Giri, Rohit Bansal, Laxmikant Ramkumarsingh Tomar

Indian Journal of Health Sciences and Biomedical Research KLEU

Aluminum phosphide (AlP) is a commonly used pesticide (insecticide) in developing countries like India. It is also one of the most common and deadly causes of suicidal poisoning in rural areas, with a lethal dose of 150–500 mg (unexposed tablet) in adults. Death is due to the rapid release of phosphine gas which causes cellular and mitochondrial toxicity leading to cardiovascular collapse and multiorgan failure. Here, we describe a case of AlP poisoning in a young male who developed severe myocarditis and metabolic acidosis after consumption of 3 g of AlP. In spite of a poor predicted outcome, the patient …

Deep Cerebral Venous Thrombosis As A Presenting Feature Of Systemic Lupus Erythematosus, Chandra Mohan Sharma, Banshi Lal Kumawat, Kaushik Ramanlal Rana, Ankur Garg

Indian Journal of Health Sciences and Biomedical Research KLEU

Systemic lupus erythematosus (SLE) is an autoimmune disease with various systemic manifestations. Neurological manifestations include cognitive decline, headache, seizure, stroke, and aseptic meningitis. Cerebral venous sinus thrombosis (CVST) is a very rare manifestation of SLE and occasionally can be the presenting feature of SLE. However, thrombosis of a deep venous system as a presenting feature of SLE is scarcely reported. We report a case of a 42-year-old female who presented with a deep cerebral vein thrombosis and was subsequently diagnosed SLE. The clinician should be aware regarding this uncommon presentation of SLE as CVST. A high index of suspicion is …

Concurrent Infarction In Bilateral Middle Cerebellar Peduncles Rare Presentation Of Stroke, Chandra Mohan Sharma, Banshi Lal Kumawat, Ankur Garg, Vikas Sharma

Indian Journal of Health Sciences and Biomedical Research KLEU

Although some pathologies like demyelination have predilection for middle cerebellar peduncles (MCPs), infarction of bilateral MCP simultaneously is an exceedingly rare presentation of stroke. Patient was a 70-year-old smoker and hypertensive male presented with acute onset vertigo, imbalance while walking and slurred speech for 2 days and examination revealed horizontal nystagmus bilaterally, scanning speech with cerebellar signs and Modified Rankin Score (MRS) of 3. Magnetic resonance imaging brain showed symmetrical areas of diffusion restriction in both MCP, and there was occlusion of bilateral vertebral arteries (partial occlusion of right and complete occlusion of left) and basilar artery in computed tomography …

Clinical Evaluation Of Nasya Karma In Cervical Spondylosis Case Series, Sangeeta R. Tanwar, Anup B. Thakar, Rajkala Ramteke

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Cervical spondylosis is one of the most common degenerative, neurological conditions of the cervical spine by which a major part of population is affected. In today's mobile era, for higher achievements and ambitions, man is moving faster to Mars life and is more prone to degenerative disorders. Apart from age, other risk factors for cervical spondylosis include occupations that may cause more stress on neck, certain neck injuries, incorrect posture while sitting or walking, smoking, sedentary lifestyle and genetic factors. Modern therapies such as analgesics, muscle relaxants, steroids, physiotherapies, and even operative procedures are not fulfilling the patients' goal …

A Morphometric Study Of Femoral Length, Anterior Neck Length, And Neck-Shaft Angle In Dry Femora A Cross-Sectional Study, Prabha Nand Chaudhary, V. S. Shirol, Rajendra D. Virupaxi

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

As the environment plays an important role in the development, the regional variation of the femur bone is influenced by geographical area, sex, stature, and heredity. In the present study, measurements on the adult human dry femora have been carried out. The knowledge of variations in the parameters of dry femora will help the orthopedicians and also assist prosthetists to design a suitable prosthesis for restoration of normal neck-shaft angle (NSA) and will also help forensic anthropologists to determine the sex.

Objectives:

The objectives of this present study is to determine the various parameters including femoral length, anterior neck …

Design, Formulation, And Evaluation Of, Fatima Sanjeri Dasankoppa, Pooja Solankiy, Hasanpasha N. Sholapur, Vilas G. Jamakandi, Vinuta M. Sajjanar, Pooja M. Walveka

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

The significant problem in the ocular drug delivery is the attainment of optimal drug concentration at the site of action. Development of therapeutic agents that require repeated long-term administration is a driver for the sustained release drug delivery systems, to result in less frequent dosing, and less invasive techniques. Therefore, to overcome the anatomical barriers and ocular bioavailability constrains, a novel drug delivery system

in situ

gels have been developed.

Materials and Methods:

The

in situ

gelling system comprises gellan gum, an anionic polymer responsible for the ionic gelation. Methylcellulose a nonionic polymer contributes for the viscosity and gels …

Influence Of Strength And Proprioception Training On Functional Ankle Stability Among Young Skaters, Priyanka Mudaliar, Snehal Dharmayat

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Stability of the ankle joint during functional activities depends on the presence of intact neural input from proprioceptors in the joint capsules, ligaments, muscles, tendons, and skin. Roller skaters are prone for more ankle injuries due to the nature of the sport. Repetitive falls and sprains lead to deficits that account for decreased performance and increased risk of falls.

Purpose:

The purpose of this study is to determine the effect of strength and proprioceptive training on functional ankle stability among young skaters.

Design:

This was a single arm pre- and post-experimental study.

Settings:

The study was conducted at two …

Treatment Patterns In Type 2 Diabetes Mellitus A Cross-Sectional Study, Dhongadi Prashant, Sanjay Kambar

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Diabetes is one of the most common noncommunicable diseases in the world. There is an epidemic of diabetes in developing and nondeveloping countries. Treatment patterns play a very important role in the control of blood glucose levels of the patient.

Methodology:

A total of 520 type 2 diabetes mellitus patients in the area of Urban Health Centre, Ashok Nagar, were interviewed with the help of a predesigned and pretested questionnaire. Data were collected by house-to-house visit.

Results:

Out of the 520 participants, 264 were male and 256 were female. Oral hypoglycemic agents were the most common modality of treatment …

A Cadaveric Study “Measurements Of Tricuspid Valve Using Cardiac Sizer In The North Karnataka Region”, Supriya Premkumar, Suresh P. Desai, R. D. Virupaxi

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

The right atrioventricular orifice is guarded by a complex called as tricuspid valve complex. The complex consists of atrioventricular orifice, annulus, leaflets, chordae tendineae, and papillary muscles. The right atrioventricular orifice passes the blood to the right ventricle in one-way direction, and this orifice is guarded by valve called as tricuspid valve. Tricuspid valve prevents the back flow of blood into the right atrium.

Materials and Methods:

This study was done on thirty human cadavers, which included 15 male and 15 female cadavers belonging to age group ranging from 50 to 70 years. Diameter of tricuspid valve was recorded …

Formulation And Characterization Of Oxiconazole-Loaded Emulgel For Topical Application, A. P. Gadad, Amol Prakash Magdum, P. M. Dandagi, U. B. Bolmal, Shriraj Kamat

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Oxiconazole nitrate is a new topical broad spectrum antifungal agent used to treat superficial fungal infections. It has a low aqueous solubility due to which different techniques are employed to enhance its bioavailability. Emulgel has emerged as one of the most interesting topical drug delivery system for hydrophobic drugs like Oxiconazole as it has dual release control systems i.e. emulsion and gel.

Objective:

In the present work an attempt was made to prepare Emulgel of Oxiconazole nitrate for enhancing its topical delivery.

Materials and Methods:

Emulgel formulations were characterized by various parameters like pH, viscosity, spreadability, extrudability,

in vitro …

Female Factors Infertility Laparoscopic Evaluation At A Public Health Facility In Ilorin, Nigeria, Lukman Omotayo Omokanye, Sabi Ibrahim, Abdulwaheed Olajide Olatinwo, Kabir Abayomi Durowade, Sikiru Abayomi Biliaminu, Ganiyu Adekunle Salaudeen

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Infertility is a problem of global proportions, the majority being the residents of developing countries. The contribution of female factor is assuming a tremendous proportion. Laparoscopy remains an indispensable tool in the evaluation of the fertility potential of these female partners.

Aims:

This study was aimed at determining the various causes of female factor infertility among female partners of infertile couple in a tertiary health facility.

Methods:

A cross-sectional observational study of ninety seven (97) eligible infertile women who underwent diagnostic laparoscopy between 1st January 2012 and 31st December 2015 were enrolled for the study. The data were analyzed …

Influence Of Occupation On Median Nerve Cross-Sectional Area In Apparently Healthy Volunteers, Anthony Chukwuka Ugwu, Benjamin Efiong Udoh, Alhaji Modu Ali, Mohammed Abba, Emmanuel Buba, Mohammed Yusuf Mohammed

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Sonographic measurement of the median nerve has been proposed as a useful alternative to the electrodiagnostic test in the diagnosis of the carpal tunnel syndrome because of its ability to reveal morphological changes.

Objective:

The objective of this study was to investigate the influence of occupation, gender, and hand dominance on the median nerve cross-sectional area (MNCSA).

Methodology:

One hundred and eighty apparently healthy volunteers were recruited for the study. Hand dominance was ascertained in all volunteers. The device used was Voluson P8 ultrasound system with a 12-MHz transducer, using custom preset for musculoskeletal ultrasound. The Anteroposterior (D

1 …

Assessment Of Knowledge Regarding Hazards Of Tobacco Use Among Police Personnel In Belagavi City A Cross-Sectional Study, Sudheer Shivalingappa Mang, Appasaheb S. Wantamutte, Ashwini Narasannavar, Mubashir Angolkar

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Tobacco is a serious threat to health and ranks second as a cause of death globally, and it also ranks fourth in its input to years of life lost. The worldwide tobacco related mortality rate reached up to 4 million per year in 1998 and is expected to become 10 million per year in 2030. This is more than the total deaths from tuberculosis, malaria, maternal, and major childhood conditions combined.

Objective:

The aim is to assess the level of knowledge regarding hazards of tobacco use among police personnel in Belagavi city.

Methodology:

This study design was a cross-sectional …