Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (662359)
- Arts and Humanities (578080)
- Law (545743)
- Education (386650)
- Medicine and Health Sciences (328533)
-
- Physical Sciences and Mathematics (294639)
- Life Sciences (255970)
- Engineering (198222)
- History (183868)
- Business (150658)
- Higher Education (145512)
- Anthropology (116065)
- Religion (110351)
- Archaeological Anthropology (96478)
- Communication (89507)
- Sociology (87296)
- Library and Information Science (80662)
- Medical Specialties (78833)
- United States History (78675)
- Psychology (74087)
- Computer Sciences (63881)
- Public Affairs, Public Policy and Public Administration (63288)
- Earth Sciences (59554)
- Creative Writing (58120)
- Public Health (54803)
- Environmental Sciences (52770)
- English Language and Literature (47860)
- Economics (47578)
- Educational Administration and Supervision (46649)
- Music (46100)
- Institution
-
- University of South Florida (163400)
- University of New Mexico (139724)
- University of Nebraska - Lincoln (114054)
- Kenyon College (112902)
- University of Montana (98561)
-
- University of Mississippi (95095)
- University of New Hampshire (79835)
- Brigham Young University (72322)
- Georgia Southern University (61716)
- Eastern Illinois University (58586)
- Utah State University (57328)
- Mississippi State University (54721)
- Western Michigan University (53079)
- University of Kentucky (52546)
- Murray State University (50654)
- Purdue University (50131)
- University of Colorado Law School (47507)
- Louisiana State University (45265)
- Brigham Young University Law School (44030)
- Western Kentucky University (43096)
- Villanova University Charles Widger School of Law (42892)
- California Polytechnic State University, San Luis Obispo (42577)
- University of Central Florida (42550)
- University of Dayton (41462)
- University of Alabama at Birmingham (38141)
- Chulalongkorn University (37842)
- San Jose State University (37195)
- University of Northern Iowa (36029)
- Yale University (33913)
- Missouri University of Science and Technology (33681)
- Keyword
-
- Newspaper (47941)
- Latin America (31541)
- Press release; media release; press statement; news media information (30839)
- Spanish (30834)
- History (30062)
-
- Humans (30046)
- University of New Mexico (29737)
- UNM (29639)
- LADB (29608)
- LAII (29608)
- Latin American and Iberian Institute (29608)
- Education (29072)
- United States (21530)
- Student newspaper (20280)
- Newsletter (19720)
- EIU (19634)
- Georgia Southern University (18971)
- Newspapers (18270)
- Deaf culture (17102)
- Hearing impaired (17092)
- Pastoral care of people with disabilities (17060)
- Church work with the deaf -- Catholic Church (17052)
- Deaf -- Periodicals (17043)
- Athletics (16878)
- Marriage (16189)
- Poetry (15550)
- Students (15193)
- Higher education (14681)
- Female (14594)
- COVID-19 (14479)
- Publication Year
-
- 2026 (117418)
- 2025 (158905)
- 2024 (194723)
- 2023 (164160)
- 2022 (169251)
-
- 2021 (196933)
- 2020 (170125)
- 2019 (166243)
- 2018 (170935)
- 2017 (161807)
- 2016 (160213)
- 2015 (146927)
- 2014 (136908)
- 2013 (131238)
- 2012 (125422)
- 2011 (108885)
- 2010 (104283)
- 2009 (96217)
- 2008 (93176)
- 2007 (79589)
- 2006 (75020)
- 2005 (70576)
- 2004 (71799)
- 2003 (59153)
- 2002 (64850)
- 2001 (55424)
- 2000 (58962)
- 1996 (62750)
- 1992 (53281)
- 1990 (53857)
- Publication
-
- Four Valleys Archive (90475)
- Theses and Dissertations (74539)
- Faculty Publications (45981)
- Electronic Theses and Dissertations (35666)
- University of Montana News Releases, 1928, 1956-present (30912)
-
- Faculty Scholarship (25552)
- Dissertations (23818)
- The Auk (22791)
- Documents (21936)
- Theses (21766)
- Browse All News (21496)
- Articles (19819)
- Walden Dissertations and Doctoral Studies (19635)
- Masters Theses (18671)
- Master's Theses (18447)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (15281)
- Session Laws 1951-2000 (15051)
- NotiSur (13785)
- Faculty, Staff and Student Publications (13701)
- Hillsborough County Marriage Records (13681)
- University of Mississippi News (13497)
- Obituaries (13320)
- The Murray Ledger & Times (13003)
- Sheet Music Collection (12976)
- Michigan Law Review (12811)
- Defensive Publications Series (12721)
- University of Montana Course Syllabi (12469)
- Honors Theses (12168)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (11969)
- Condor (11821)
- Publication Type
Articles 169321 - 169350 of 5206117
Full-Text Articles in Entire DC Network
Role Of Financial Inclusion In Poverty Alleviation In Jigawa State Nigeria; The Moderating Effect Of Financial Literacy, Abdulnasir Yola Turawa, Aminu Jakada, Nadira Madaki Iliyasu, Abdullahi Dayyabu Marmara
Role Of Financial Inclusion In Poverty Alleviation In Jigawa State Nigeria; The Moderating Effect Of Financial Literacy, Abdulnasir Yola Turawa, Aminu Jakada, Nadira Madaki Iliyasu, Abdullahi Dayyabu Marmara
Journal of Economics and Administrative Sciences
A need for research that examines how financial inclusion alleviates poverty in Jigawa state with a specific focus on the moderating effect of financial literacy. The study utilizes Partial Least Squares Structural Equation Modeling (PLS-SEM). Financial inclusion was found to contribute to poverty alleviation by granting access to essential financial amenities like loans, savings, and insurance. Additionally, financial literacy significantly curbs this relationship by enhancing the efficiency of financial inclusion in poverty alleviation. Individuals who utilize financial services more effectively were found to have higher financial literacy, resulting in improved financial stability, increased savings, and investments in income-generating activities. Recommendation …
Activation And Suppression Mechanisms Of The Nrg1 Helper Nlrs, Yu-Ru Wang, Ruize Zhang, Daowen Wang, Yong Wang, Zheng Qing Fu
Activation And Suppression Mechanisms Of The Nrg1 Helper Nlrs, Yu-Ru Wang, Ruize Zhang, Daowen Wang, Yong Wang, Zheng Qing Fu
Faculty Publications
No abstract provided.
2025-2026 Lindenwood University Graduate Course Catalog, Lindenwood University
2025-2026 Lindenwood University Graduate Course Catalog, Lindenwood University
Course Catalogs
Lindenwood University Graduate Course Catalog
2025-2026 Lindenwood University Undergraduate Course Catalog, Lindenwood University
2025-2026 Lindenwood University Undergraduate Course Catalog, Lindenwood University
Course Catalogs
Lindenwood University Undergraduate Course Catalog
A Pilot Structured Mentorship Program To Increase Pediatric Advanced Practice Provider Engagement At An Academic Institution, Erica Annotti, Dnp, Aprn, Pnp
A Pilot Structured Mentorship Program To Increase Pediatric Advanced Practice Provider Engagement At An Academic Institution, Erica Annotti, Dnp, Aprn, Pnp
Doctor of Nursing Practice Final Project Abstract
Introduction/Purpose: Advanced Practice Providers (APPs) transitioning into academic healthcare often face challenges related to role clarity, professional identity, and emotional support, which can hinder their engagement and retention. This quality improvement project aimed to design, implement, and evaluate a structured mentorship pilot program for pediatric APPs to increase work engagement by 10%.
Methods: Grounded in the Strong Model for Advanced Practice and Wagner’s Caring Mentorship Framework, the project employed a mixed-methods QI design. Four pediatric APPs (n=4) participated in an 8-week structured mentorship program. Interventions included the intentional pairing of mentors and mentees, biweekly one-on-one sessions, and targeted professional development …
Curved Confinement Directs Anchoring-Mediated Structural Transitions In Highly Chiral Liquid Crystal Shells, Sepideh Norouzi, Jeremy Money, Stiven Villada-Gil, José Martínez-Gonález, Monirosadat Sadati
Curved Confinement Directs Anchoring-Mediated Structural Transitions In Highly Chiral Liquid Crystal Shells, Sepideh Norouzi, Jeremy Money, Stiven Villada-Gil, José Martínez-Gonález, Monirosadat Sadati
Faculty Publications
Cholesteric liquid crystals (CLCs) confined in curved geometries exhibit a rich spectrum of defectmediated morphologies governed by the interplay between chirality, curvature, surface anchoring, and confinement. This study systematically investigates structural transitions in highly chiral CLC shells under asymmetric anchoring conditions, focusing on the effects of shell thickness and curvature on pitch axis reorientation and defect formation. Utilizing microfluidic techniques, we generate core–shell droplets with independently tunable anchoring at inner and outer aqueous interfaces. Transitioning from planar–planar to planar-homeotropic boundary conditions via surfactant-mediated modulation induces profound reorganizations in the director field, giving rise to focal conic domains (FCDs), stripe patterns, …
Reconsidering “Luxury” Bones: Comprehending The Capacity For Care Coordination In Maine’S Oral Health Policy Environment, Molly S. Williams
Reconsidering “Luxury” Bones: Comprehending The Capacity For Care Coordination In Maine’S Oral Health Policy Environment, Molly S. Williams
All Student Scholarship
Case management takes a comprehensive and coordinated approach to providing healthcare for patients who often have complex or chronic needs. It began as a practice in medical care in the early 1900s, and it has roots in both social welfare and public health. The evolution and formalization in the U.S. medical care system can be traced over time: the earliest practitioners were nurses and social workers engaging with charitable organizations; expansion of some services followed the introduction of general welfare benefits in the Social Security Act and workers’ compensation insurance (1930s); insurance companies began covering services to assist World War …
On The Garoufalidis-Kashaev State-Integral Invariant, Amelia Palmer Dusenbury
On The Garoufalidis-Kashaev State-Integral Invariant, Amelia Palmer Dusenbury
Boise State University Theses and Dissertations
This thesis explores a construction of the family of topological invariants for certain oriented 3-manifolds based on the state-integral approach developed by Andersen, Garoufalidis, and Kashaev in the Archimedean setting. Starting from an ideal triangulation of a 3-manifold equipped with angle data, variables are assigned to the faces and tetrahedra, taking values in a so-called 'Gaussian group'. The invariant is defined by integrating a distribution defined from the combinatorics of the triangulation and a special function over a product of the Gaussian group. The special function is a quantum dilogarithm, whose valuable feature, the pentagon relation, ensures the resulting integral …
Implementation Of A Zen Room To Decrease Perceived Stress: A Quality Improvement Project, Michelle Tat
Implementation Of A Zen Room To Decrease Perceived Stress: A Quality Improvement Project, Michelle Tat
Doctor of Nursing Practice Final Project Abstract
Introduction: This quality improvement project addresses a lack of quiet space for staff to de-stress. The goal was to create a Zen room at a substance abuse treatment facility to decrease self-perceived stress in staff by 15% within three months.
Methodology: The PDSA cycle was applied to the creation of a Zen room. Stress was measured with questions from the Perceived Stress Scale at baseline, entry, and exit. 23 participants recorded Zen room entry. Limitations included small sample size and exit survey attrition. Implementation challenges included budget issues and low response rates. Stress levels were compared at baseline, room entry, …
Evaluation Of The Psychometric Properties Of The Social Communication Questionnaire In Rural Kenya, Patricia Kipkemoi, Jeanne Savage, Joseph Gona, Kenneth Rimba, Martha Kombe, Paul Mwangi, Collins Kipkoech, Danielle Posthuma, Charles Newton, Amina Abubakar
Evaluation Of The Psychometric Properties Of The Social Communication Questionnaire In Rural Kenya, Patricia Kipkemoi, Jeanne Savage, Joseph Gona, Kenneth Rimba, Martha Kombe, Paul Mwangi, Collins Kipkoech, Danielle Posthuma, Charles Newton, Amina Abubakar
Institute for Human Development, East Africa
Children can be reliably diagnosed with autism as early as 3 years of age, and early interventions are initiated. There is often a significant gap between the age of onset of symptoms (2–3 years) and diagnosis (8–10 years) in Africa. We conducted a study to validate the Social Communication Questionnaire (SCQ) as a screening instrument in a rural setting in Kenya. The study was conducted along the Kenyan Coast. Study participants included 172 children with a neurodevelopmental disorder (NDD) diagnosis (84 of which were autism) and 112 controls. Internal consistency was evaluated through the use of Cronbach’s alpha, confirmatory factor …
Light & Faith: August 2025, Taylor University
Promoting Understanding Of Soft Power Theory : A Case Study Of Confucius Institutes Along The Belt And Road, Dan Yang
Lingnan Theses (Doctoral degree)
This dissertation explores the function of Confucius Institutes (CI) as key tools within China’s soft power approach, particularly in the framework of the Belt and Road Initiative (BRI). It provides a detailed and empirically based analysis of how these institutes operate within various national contexts. Drawing upon Joseph Nye’s soft power theory and supported by literature on public diplomacy, this study assesses the ways in which CIs translate cultural, linguistic, and educational assets into international influence. Despite the rapid expansion of CIs globally, their actual effectiveness in achieving cultural diplomacy and tangible soft power outcomes remains uncertain. Advocates emphasize the …
香港电动车的消费者行为与政策评估, Shu Ching Paul Lau
香港电动车的消费者行为与政策评估, Shu Ching Paul Lau
Lingnan Theses (Doctoral degree)
研究旨在找出电动车发展中影响消费者行为的各种因素,涵盖补贴政策、充电设施、消费行为和环保意识进行深入调查;分析电动车发展和政策带来的挑战与机遇;探讨电动车消费者行为与补贴政策的因果关系;评估香港电动车政策及发展带来的影响和解决方案。
本研究运用SPSS软件对问卷调查进行分析,并结合深度访谈;通过定量与定性相结合的研究方法,交叉检测和验证,增强文章的内容和深度;以“三元交互决定论” 和“决策理论”为基础,构建认知、政策、行为、反馈模型,凸显本研究的独特价值。
研究成果提出策略性、替代性和创意性的解决方案; 优化政策的前期阶段积极补贴消费者购车;第二阶段,引入并推广安装智能充电桩设施,实现快速充电以满足需求,改善充电设施供需平衡;最后阶段,加强执行力度,推动绿色出行,鼓励频繁使用电动车的消费者;避免浪费公帑,实现可持续发展。
本研究还提出了补贴政策调整方案,建议不仅在理论上具有先进性,而且在实践中也体现出高效性和清晰性,为政策制定者提供了科学、坚实的理论支撑;调整方案不仅简明扼要,而且能够增强实施效果,有利于为政策制定者提供科学依据的建议;成为本文的重要发现,为学术研究提供了科学、有价值的参考。
This research aims to find out the various factors that influence consumer behavior in the development of electric vehicles, and conduct in-depth investigations into subsidy policies, charging facilities, consumer behavior and environmental awareness; analyze the challenges and opportunities brought by the development and policies of electric vehicles; explore the causal relationship between electric vehicle consumer behavior and subsidy policies; evaluate the impact and solutions brought by Hong Kong's electric vehicle policies and development.
This study used SPSS software to analyze the questionnaire survey and combined it with in-depth interviews; through a combination of quantitative …
Serum Syndecan-1 Is Associated With Kidney And Cardiovascular Outcomes In Idiopathic Nephrotic Syndrome., Colin Bauer, Arshia Anand, Christine Sethna, Jonathan Troost, Tarak Srivastava, Imtiazul Islam, Audrey Fetsko, Julie A. Dougherty, William E. Smoyer, Richard J. Johnson, Gabriel Cara-Fuentes
Serum Syndecan-1 Is Associated With Kidney And Cardiovascular Outcomes In Idiopathic Nephrotic Syndrome., Colin Bauer, Arshia Anand, Christine Sethna, Jonathan Troost, Tarak Srivastava, Imtiazul Islam, Audrey Fetsko, Julie A. Dougherty, William E. Smoyer, Richard J. Johnson, Gabriel Cara-Fuentes
Manuscripts, Articles, Book Chapters and Other Papers
INTRODUCTION: Idiopathic nephrotic syndrome (INS) is associated with important kidney and cardiovascular morbidities. We tested the hypothesis that serum syndecan-1, a marker of endothelial glycocalyx injury, can help identify patients at risk for unfavorable kidney and cardiovascular outcomes.
METHODS: We included 348 children and adults with INS (n = 35 unbiopsied, n = 141 minimal change disease [MCD] and n = 172 focal segmental glomerulosclerosis [FSGS]) from the Nephrotic Syndrome Study Network (NEPTUNE) cohort and 34 healthy participants (n = 22 adults, n = 12 children). We measured baseline serum syndecan-1 levels using an enzyme-linked immunosorbent assay and …
Language Brokering Conditions The Indirect Association Between Mexican‐Origin Adolescents’ Academic Discrimination And Educational Expectations, Su Yeong Kim, Yayu Du, Chantal Alvarado, Wei Xiang Sim, Wen Wen, Tianlu Zhang, Jingyi Shen
Language Brokering Conditions The Indirect Association Between Mexican‐Origin Adolescents’ Academic Discrimination And Educational Expectations, Su Yeong Kim, Yayu Du, Chantal Alvarado, Wei Xiang Sim, Wen Wen, Tianlu Zhang, Jingyi Shen
Research Collection School of Social Sciences
Mexican‐origin adolescents, a significant portion of the US Latino population, often experience a decline in educational expectations from early to late adolescence. Contextual factors such as academic discrimination and language brokering for parents may contribute to this decline. This study investigates the indirect effect of academic discrimination experienced in middle school on educational expectations in young adulthood through high school grades and engagement, and the moderating role of language brokering experiences in these relations. Data were collected from 604 Mexican‐origin adolescents across four waves from 2012 to 2023. Academic discrimination experiences in middle school were negatively associated with school grades …
August 2025 News Releases, University Of Montana--Missoula. Office Of University Relations
August 2025 News Releases, University Of Montana--Missoula. Office Of University Relations
University of Montana News Releases, 1928, 1956-present
No abstract provided.
Genotype Distribution Of Human Papillomavirus Among Women With Cervical Cancer Stratified By Hiv Status In Tanzania, Alita Mrema, Mamsau Ngoma, Emmanuel L. Lugina, Atukuzwe Kahakwa, Chacha Josiah Mwita, Salama Iddy, Eulade Rugengamizi, Kandali Samwel, John Ngowi, Salum J. Lidenge, Charles Wood, Julius Mwaiselage
Genotype Distribution Of Human Papillomavirus Among Women With Cervical Cancer Stratified By Hiv Status In Tanzania, Alita Mrema, Mamsau Ngoma, Emmanuel L. Lugina, Atukuzwe Kahakwa, Chacha Josiah Mwita, Salama Iddy, Eulade Rugengamizi, Kandali Samwel, John Ngowi, Salum J. Lidenge, Charles Wood, Julius Mwaiselage
School of Medicine Faculty Publications
Background Cervical cancer (CC) is the leading cancer among women in Tanzania, especially among those between the ages of 15 and 44. The prevalence of high-risk Human papillomavirus (HR-HPV)-16/18 women in the general population at any given time is 3.3%. HR-HPVs 16 or 18 are the primary cause of CC. The distribution of HPV genotypes among women with CC according to HIV status is unknown in Tanzania. This study aimed to determine the HPV genotype distribution according to HIV status among women with CC in Tanzania. Methods This cross-sectional study was done at Ocean Road Cancer Institute (ORCI) in Tanzania …
Hiv-1 Tat Induces Transient Tlr4/6 Downregulation In Human Microglia Cells: Implications For Neuroinflammation, Shrimayi Gillella, Olivia Antony, Biju Bhargavan, George C. Njoku, Narendran Annadurai, Georgette D. Kanmogne
Hiv-1 Tat Induces Transient Tlr4/6 Downregulation In Human Microglia Cells: Implications For Neuroinflammation, Shrimayi Gillella, Olivia Antony, Biju Bhargavan, George C. Njoku, Narendran Annadurai, Georgette D. Kanmogne
Posters: 2025 Summer Undergraduate Research Program
Microglia, the resident immune cells of the central nervous system (CNS), plays a pivotal role in neuroinflammation associated with HIV infection. Toll-like receptors (TLRs) are critical innate immune sensors expressed in microglia, and their dysregulation is implicated in HIV-associated neurocognitive disorders (HAND). In this preliminary study, we examined the basal expression of TLRs and the impact of HIV-Tat on their expression using the human microglial HMC3 cell line.
First, the microglial identity of HMC3 cells was confirmed by the expression of Iba1, a microglia-specific marker. RT-PCR analysis revealed basal expression of TLR2, TLR4, andTLR6, with TLR4 showing the highest expression …
Internet Of Things And Modern Digital Evidence Collection, Muhammad T. Haider
Internet Of Things And Modern Digital Evidence Collection, Muhammad T. Haider
Student Theses
The ever-evolving landscape of technology and its innovations are populating our houses, streets and all kinds of industries. The use of smart devices is booming from most developed nations to underdeveloped countries. The complications which come with the use of the Internet of Things has been an active discussion for the past many years. If we look around in a room of 30 people, we will most likely find double the amount of IoT devices than the people in that room. All of those devices are connected to the Internet, and are communicating with data servers across the world. The …
Cg18562578 Methylquant Assay For The Discrimination Of Monozygotic Twins, Amber P. Chauca
Cg18562578 Methylquant Assay For The Discrimination Of Monozygotic Twins, Amber P. Chauca
Student Theses
Monozygotic (MZ) twins have identical DNA, making traditional profiling methods insufficient in their discrimination. However, MZ twins can be differentiated by their levels of DNA methylation. Our research group previously developed a methodology to detect cg18562578 DNA methylation levels in MZ twins based on a two- step PCR approach and a cg18562578 MethylQuant Assay. That study generated data for only 64% of the samples it investigated, and showed a discrimination power of 77% to discriminate between MZ twins. Here, we used the same methodology but a different approach to determine DNA methylation in 73 previously unsuccessful twin pairs. We diluted …
Further Investigation Of Environmental Factors On Rapid Shear In Fibers Of A Polyester-Cotton Blend, Daniel K. Oh
Further Investigation Of Environmental Factors On Rapid Shear In Fibers Of A Polyester-Cotton Blend, Daniel K. Oh
Student Theses
Rapid shear is a process that occurs in thermoplastic materials when they interact with a high-velocity impact. In forensics, these interactions would typically be from a bullet interacting with clothing that consisted of synthetic fibers. When the interaction occurs, bulb-like shapes appear on damaged fiber ends, distinguishing them from other kinds of damage. The reason why these shapes occur is varied, but one prevailing factor seems to be the heat generated by the impact.
In prior experiments, the factor of temperature being important to the formation of the phenomenon, different environmental simulations that affected the sample’s temperature were done on …
Bystanders Intervening During Acts Of Cyberbullying: Examining The Moderating Influence Of “Likes” And Pleas For Help, Joseph Kallman
Bystanders Intervening During Acts Of Cyberbullying: Examining The Moderating Influence Of “Likes” And Pleas For Help, Joseph Kallman
Student Theses
Abstract
Cyberbullying research has only recently begun exploring “cyberstanders,” also known as bystanders, and their role in cyberbullying, as well as testing the bystander effect (Barlinska et al., 2013; Machackova et al., 2013; Obermaier et al., 2016; Shultz et al., 2014). In the current study, we aim to deepen our understanding of the bystander effect by manipulating the number of likes, which will indicate the number of bystanders present and the plea for help on social media via Twitter among college students, by examining how participants respond to fictitious cyberbullying incidents. The results of this study did not support our …
Population Dynamics Of Feral Hemp (Cannabis Sativa L.) Across Illinois, Bryan Scott Foster
Population Dynamics Of Feral Hemp (Cannabis Sativa L.) Across Illinois, Bryan Scott Foster
Dissertations
Hemp (Cannabis sativa L.) is an historically cultivated species re-emerging in modern agriculture due to its utility as a fiber, grain, and cannabinoid crop. While industrial hemp refers to cultivated varieties bred for specific agronomic traits and legally defined by low tetrahydrocannabinol (THC) content, feral hemp, often called "ditch weed", represents escaped or naturalized populations descended from historical cultivation. These unmanaged populations persist and spread in disturbed habitats across North America, particularly in the Midwestern U.S., raising ecological and agronomic concerns due to their potential for genetic contamination, invasive behavior, and interactions with native species and agricultural systems. The overall …
08-19-25 Hsc Committee Meeting Agenda, Patricia Serna
08-19-25 Hsc Committee Meeting Agenda, Patricia Serna
HSC Committee (A subcommittee of the UNM Board of Regents)
08-19-25 HSC Committee Meeting Agenda
Computational Frameworks To Unravel The Immune Landscape, Shan He
Computational Frameworks To Unravel The Immune Landscape, Shan He
Dissertations and Theses (Open Access)
Recent advances in immunotherapy, including immune checkpoint blockade (ICB) and adoptive cell therapy, face challenges such as resistance and immune-related adverse events, partly due to our limited understanding of the immune signaling pathways. While high- throughput genomic data provide unprecedented resolution into these immune pathways, their full potential is limited by the lack of well-annotated, context-specific immune gene sets. To address this need, I developed a workflow to construct immune gene sets by integrating RNA- seq datasets and performing decomposition. Using this approach, I constructed 28 immune- specific gene sets from 83 bulk RNA-seq datasets and 12 Natural Killer (NK) …
Insights Into The Radiation Chemistry Of Flash Radiation Therapy, Alan E. Lopez Hernandez
Insights Into The Radiation Chemistry Of Flash Radiation Therapy, Alan E. Lopez Hernandez
Dissertations and Theses (Open Access)
Purpose: FLASH radiation therapy (FLASH-RT) is an emerging modality that delivers radiation at ultra-high dose rates (UHDR) and has shown consistent normal tissue sparing while preserving tumor control compared to conventional RT—a phenomenon termed the FLASH effect. Despite promising results, the mechanisms behind the FLASH effect remain unclear. Many hypotheses point to radiolytic interactions, but experimental validation is limited. This work aims to develop a robust experimental platform to evaluate the relationship between radiolytic species production and physical beam parameters relevant to FLASH-RT, alongside dosimetry tools for reliable UHDR beam characterization.
Methods: A beam collector (BC) Faraday cup detector was …
Resolving Intra-Tumoral Heterogeneity Of Breast Cancer Using Single-Cell Multi-Omics, Yun Yan
Resolving Intra-Tumoral Heterogeneity Of Breast Cancer Using Single-Cell Multi-Omics, Yun Yan
Dissertations and Theses (Open Access)
Breast cancer is a highly heterogeneous disease characterized by diverse genetic, transcriptional, and epigenetic landscapes. Understanding how intra-tumoral heterogeneity (ITH) influences therapeutic response and drives tumor evolution remains a central challenge in cancer biology. Here, we leverage single-cell multi-omics technologies to dissect the cell states and gene expression programs underlying breast cancer heterogeneity, with a focus on triple-negative breast cancer (TNBC) and estrogen receptor-positive (ER+) breast cancer.
In the first part, we applied single-cell RNA sequencing and spatial transcriptomics to profile over 400,000 cells from 101 treatment-naïve TNBC patients. We identified 4 archetypes at the patient level and 13 metaprograms …
Use Of The Protein Misfolding Cyclic Amplification For Food Safety And Drug Discovery, Maria R. Benavente Garcia-Huidobro
Use Of The Protein Misfolding Cyclic Amplification For Food Safety And Drug Discovery, Maria R. Benavente Garcia-Huidobro
Dissertations and Theses (Open Access)
Prion diseases are fatal neurodegenerative disorders caused by the misfolding of the normal prion protein (PrPC) into its infectious form (PrPSc). While the zoonotic potential of chronic wasting disease (CWD) remains uncertain, the presence of prions in food products raises public health concerns. Additionally, therapeutic strategies for prion diseases remain limited. This thesis presents a methodological exploration of the Protein Misfolding Cyclic Amplification (PMCA) technique to address these challenges in two key areas: (1) detecting CWD prions in processed meats subjected to common cooking procedures, and (2) identifying potential anti-prion compounds through a high-throughput PMCA adaptation. …
Facilitating The Clinical Translation Of Flash Radiotherapy Through Dosimetry Development And Beam Parameter Optimization, Kevin Liu
Dissertations and Theses (Open Access)
Advisory Professor: Emil Schüler, PhD
Radiation therapy (RT) is a crucial component of curative cancer therapy, with a majority of cancer patients in the United States receiving RT as part of treatment. The goal of RT is to maximize the therapeutic index in curing disease while minimizing any associated normal-tissue complications1. Recently, ultra-high dose-rate (UHDR) RT (mean dose rates ≥40 Gy/s for a total duration of ≤200 ms) has been reported to selectively spare normal tissues and organs while maintaining an isoeffective tumoricidal effect compared to conventional (CONV) dose rate RT in a variety of in vivo preclinical …
Predicting Genetic Interactions Using Functional Interaction Networks, Iulia Veronica Gheorghe
Predicting Genetic Interactions Using Functional Interaction Networks, Iulia Veronica Gheorghe
Dissertations and Theses (Open Access)
Mapping genetic interactions is central to understanding cellular systems and identifying therapeutic vulnerabilities, particularly in the context of cancer. Among these interactions, synthetic lethality, where simultaneous loss of two genes is lethal but loss of either alone is tolerated, offers a powerful framework for selectively targeting tumor-specific dependencies. In model organisms like S. cerevisiae, comprehensive double-knockout screens have revealed detailed genetic interaction maps, enabling systems-level insights into pathway structure, gene function, and cellular organization. Replicating this achievement in human cells, however, is complicated by the scale and complexity of the human genome. Recent advances in genome-wide CRISPR knockout screening have …