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Advancing Novel Contrast Agents For Applications In Fluorescence-Guided Neurosurgery Using Fluorescence Cryotomography, Augustino Vittorio Scorzo

Dartmouth College Ph.D Dissertations

Fluorescence guided surgery (FGS) is an emerging surgical technique that aims to help surgeons identify tissue types to assist in surgical decision making - ideally providing “cut-by-color” guidance. A primary application for this approach is the identification of tumor tissue to achieve more accurate and complete tumor removal while simultaneously minimizing damage to surrounding normal tissue. The cornerstone of tumor visualization for FGS is the administration of fluorescent contrast agents, or in some cases metabolic precursors, designed to accumulate specifically in tumor tissue, and a wide range of agents that use different targeting mechanisms are currently under investigation. Although these …

Mechanistic Insights Into The Flash Effect: The Role Of Oxygen And Radiation Chemistry In Ultra-High Dose Rate Radiation Therapy, Jacob Pierce Sunnerberg

Dartmouth College Ph.D Dissertations

The development of new cancer therapies focuses on widening the therapeutic ratio between tumor control and normal tissue toxicity. Over the last decade, ultra-high dose rate (UHDR) radiation therapy, commonly known as FLASH radiotherapy (FLASH-RT), has shown promising potential to reduce normal tissue toxicity while maintaining tumor control. However, the underlying mechanisms of the FLASH effect remain poorly understood. This thesis explores the radiation-chemical basis of FLASH-RT, focusing on the role of oxygen and reactive oxygen species in modulating biological outcomes.

A comprehensive set of in vitro studies demonstrated that UHDR delivery significantly alters radiation chemistry compared to conventional dose …

The Impact Of Polymycovirus 1 On Aspergillus Fumigatus Pathogenesis During Lung Infection, Alexander W. Rapp

Dartmouth College Ph.D Dissertations

The genus Aspergillus comprises over 250 species of fungi. Within this genus, only a handful of species cause disease in humans. One species is Aspergillus fumigatus (A.f.), an environmentally ubiquitous, saprophytic fungal pathogen. Lung infections due to A.f. range from invasive infection to allergic forms of the disease. Allergic bronchopulmonary aspergillosis (ABPA) is one of the most severe forms and presents as a hypersensitivity that often results in off-target damage to the surrounding airways. Patients with ABPA are sensitized to fungal antigens and this is commonly seen in cystic fibrosis and genetic predispositions. Recent data from our lab shown how …

Working Paper No. 97, Business Sabotage In Theory And Practice, Nathan Lewis-Lusso

Working Papers in Economics

This inquiry seeks to establish that theoretical advances offered earlier on by one Karl Marx and some decades later by one Thorstein Veblen offer insights into forms of business sabotage. Drawing upon their writings, this inquiry considers how in the writings of Marx, already in the mid-nineteenth century surplus value extraction and pecuniary sabotage serve as structural features found in a market-based economy. Marx’s consideration of surplus labor and artificial scarcity reveals how private investment seeks to constrain production in order to preserve and enhance profitability. Veblen’s theory of institutional sabotage complements Marx’s view by showing how firms could delay …

The Fangs Of Philosophy: Religious Experience As A Persuasive Device, Lukas A. Dunford

Comparative Literature Undergraduate Senior Theses

The philosophical systems of Plato and Lucretius use the religious experience to compel readers into their distinct philosophical versions of reality. This compulsion is necessary for philosophy. This study’s three philosophical systems reappropriate this experience from the existing structures of religion to violently produce conviction in readers. The religious experience is not window dressing over the arguments of the philosophical systems, but a necessary component that reorients the audience into a new discursive reality. Ultimately, the philosophers we examine will show how the knowledge structure of philosophy becomes able to grip the audience, consuming them into its reality – how …

Magicicada And Mathematics: What The Parochiality Of Our Explanations Means For The Indispensability Argument, Jadyn Malone

Philosophy Senior Theses

This thesis examines whether the indispensability argument justifies belief in the existence of mathematical entities. I adopt ontological naturalism, arguing that we should believe in entities that feature in our best scientific theories, which are determined through inference to the best explanation. The indispensability argument contends that because mathematical entities are explanatorily indispensable to our best scientific theories – as demonstrated by examples like the prime number explanation of cicada life cycles – we should believe they exist just as we believe in electrons and stars.

However, I identify a challenge: our scientific explanations are inherently parochial, shaped by human …

Puppycide By Gavel: How The Judiciary Uses The Police Killing Of Dogs To Reinforce Justifications For Police Violence, Jeremy J. Smith

Qualitative Criminology (QC)

"Police discharge their firearms more often at dogs than humans, and as a profession, kill thousands of dogs every year. The number of dogs killed by police during these encounters has government officials declaring that an “epidemic” is occurring within policing itself, with some commentators referring to this trend as “puppycide” or “canicide.” The purpose of this article is to examine how the judiciary rationalizes canicide, or the police killing of dogs, and the role canicide plays in the justification of police violence. To do this, the article provides a sociolegal and ethnographic content analysis of federal court cases and …

الأقليات الدينية في لبنان: دراسة في الثقافة الأساسية للمعتقدات الدينية والموروثات الاجتماعية وتأثيرهما على السلوك الجمعي - الموحّدون الدروز أنموذجًا, حسام نصّار

Horizons et Conjonctures

تندرج هذه الأطروحة من ضمن المباحث التي تتمحور حول دراسة الثقافة الأساسية للموروث الاجتماعي ومفاهيم الدين والتديّن، وتأثيرها على السلوك الجمعي عند الموحّدين الدروز، بوصفهم أقلّية عددية في لبنان. ولمّا كان الارتباط وثيقًا بين تأثير الموروثات الاجتماعية على المفاهيم الدينية من جهة، وتأثير المعتقدات الدينية على السلوكيات الاجتماعية من جهة أخرى، بات البحث العلمي في بنية المنظومة الدينية والاجتماعية، وحتّى السياسية، شرطًا لتظهير بعض مكوّناتها وعناصرها ومجمل مناهجها وأسسها، وذلك من أجل معرفة أسباب ربط الأفكار والسلوكيات الدينية بالهوية الطائفية والمذهبية
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Humanizing The Icu: Implementation Of Personalized Communication Boards In The Sicu Drives Enhanced Patient And Family Experience, Stephen D. Hoefler

Master's Theses

Objective: Research has established the importance of personalized communication in critical care settings, where standardized tools like whiteboards can improve patient and family engagement.

Aim: This project aims to develop a personalized communication board in the surgical intensive care unit (SICU) at a Bay Area academic quaternary care facility that, once implemented, will achieve at least 75% utilization in patient rooms by May 2025, enhancing communication and patient experiences.

Methods: Surveys were conducted with patients, families, and staff to gather stakeholder input and guide the design of a new standardized whiteboard model with personalized elements. Results: Based on stakeholder feedback, …

Study Of The Performance Of A Laser Structure Based On A Fiber Ring And A Dual-Bottle Whispering Gallery Mode Microresonator, Anuradha Rout, V.R Anand, Zhe Wang, Zhouchen Wang, Rayhan Habib Jibon, Yuliya Semenova

Research Outputs: 2025-Present

This study examines the impact of a dual-bottle whispering gallery mode (WGM) microresonator on the performance of a laser structure based on a fiber ring, focusing on the modes switching and generating single- and multi-mode emissions. Through experimental analyses, we demonstrate how the unique geometry of dual-bottle resonators affects lasing behavior, providing insights that could advance applications of the proposed laser structure in telecommunications and photonic sensing systems.

The Structure Of The Drp1 Lattice On Membrane, Kristy Rochon, Anelise N. Hutson, Jason A. Mears

Faculty Scholarship

Mitochondrial health relies on the membrane fission mediated by dynamin-related protein 1 (Drp1). Previous structural studies of Drp1 on remodeled membranes were hampered by heterogeneity, leaving a critical gap in the understanding of the mitochondrial fission mechanisms. Here we present a cryo-electron microscopy structure of full-length human Drp1 decorated on membrane tubules. Using the reconstruction of average subtracted tubular regions (RASTR) technique, we report that Drp1 forms a locally ordered lattice along the tubule without global helical symmetry. The filaments in the lattice are similar to dynamin rungs with conserved stalk interactions. Adjacent filaments are connected by GTPase domain interactions …

First Opinions, Second Reactions: A Collection Of Innovative Online Reviews Of Literature For Children And Young Adults, Janet Alsup, Christy Wessel-Powell

Purdue University Press Books

First Opinions, Second Reactions: A Collection of Innovative Online Reviews of Literature for Children and Young Adults features selected pieces from the journal First Opinions, Second Reactions, which reviews children’s and young adult books. The journal, and this book, consist of reviews of books written by scholars of children’s and YA literature, followed up with responses from those who share the books with their intended audiences—children and teens. The editors have selected twelve issues classified under four thematic categories (social and political issues; diversity and inclusion; identification and empathy; and genre study) to represent the depth and breadth of …

October 7 And International Police Cooperation:The Silence Of Interpol, Mathieu Deflem

Faculty Publications

Aim: The aim of this study is to explore the background and interpretation of Interpol’s silence following the terrorist attacks committed by Hamas against Israel on October 7, 2023. The author examines the international policing implications of the events, with special attention to why the world’s largest police organization failed to issue any substantive response.

Methodology: The research is based on a sociological analysis combining a historical and institutional overview of Interpol’s counterterrorism activities with the examination of the organization’s communications and institutional decisions. It relies on qualitative sources and an interpretive, case study-based approach using public documents, records, and …

Probabilities With Values In Scaled Hyperbolic Numbers, Daniel Alpay, Ilwoo Choo

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this paper, we introduce a notion of a probabilistic measure which takes values in t-scaled hyperbolic numbers for t ∈ R, with a system of axioms generalizing directly Kolmogorov’s axioms. i.e., we establish a suitable measure theory in the set Dt of all t-scaled hyperbolic numbers for arbitrarily fixed t ∈ R.

Macrophage Heterogeneity And Function In The Lung, Xin Li

Dartmouth College Ph.D Dissertations

Macrophages are critical custodians of the lung, orchestrating immune surveillance, maintaining tissue homeostasis, and coordinating both innate and adaptive responses. This dissertation examines their heterogeneity and specialized functions, focusing on IMs, which reside in the lung interstitium, and AMs, which occupy the airspace. Through comprehensive single-cell transcriptomic profiling of murine and human samples, we identify multiple IM and AM subsets defined by distinct chemokine, cytokine, receptor, and innate immune gene signatures. These subsets display clear divisions of labor, contributing to immune cell recruitment, tertiary lymphoid structure formation, and alveolar homeostasis.

In IMs, coordinated chemokine programs not only recruit inflammatory cells …

Asymmetric Cingulum Bundle Connectivity Is Modulated By Paracingulate Sulcus Morphology, Isabel A Danstrom, Joshua A Adkinson, Meghan E Robinson, Lu Lin, Atul Maheshwari, Ben Shofty, Garrett Banks, Mohammed Hasen, Sameer A Sheth, Alica M Goldman, Eleonora Bartoli, Sarah R Heilbronner, Kelly R Bijanki

Faculty, Staff and Students Publications

The cingulum bundle (CB) is a group of axons supporting connectivity among several functional brain networks relevant in healthy and diseased states. The paracingulate sulcus (PCS) is present in at least one cerebral hemisphere across 70% of the population. PCS presence versus absence is linked to differences in structure and function of the anterior cingulate cortex, though the influence of PCS on the white matter of the CB remains unknown. The objective of this work was to define the CB electrographic connectivity profile and determine the impact of PCS morphology on CB engagement. Single-pulse electrical stimulation in combination with stereo-electroencephalography …

A Compression-Based Dependence Measure For Causal Discovery By Additive Noise Models, H. J. Ong, B. G. Lim, B. R. Tiu, Renzo Roel P. Tan

Quantitative Methods and Information Technology Faculty Publications

In this work, we introduce a novel compression-based dependence measure (CDM) for causal discovery. Our proposed measure leverages data compression to quantify dependence, offering a new approach that is effective even with small data sizes. Through extensive simulations with general additive noise models, causal additive models, and linear non-Gaussian acyclic models, we demonstrate the relative superiority of CDM over existing methods. Additionally, we validate our approach using the cause-effect pairs benchmark dataset, where CDM shows comparable accuracy across various sample sizes. To close, we discuss the sensitivity of CDM to data scales, an issue shared by other causal discovery methods. …

Eng 5000-600 Introduction To Methods And Issues In English Studies, Marjorie Worthington

Summer 2025

No abstract provided.

Integrated Density Functional Theory And Experimental Study Of Optical And Electronic Properties For Mos2/ (Metal=Au, Pt, Ni, Cu) And Mos2/Graphene/Metal Heterointerfaces, Shishir Timilsena, Sanju Gupta, Muhammad I. Bhatti, Nicholas Dimakis

School of Integrative Biological & Chemical Sciences Faculty Publications

We present computational simulations and experimental analyses of various heterointerfaces constructed from two-dimensional molybdenum disulfide (MoS2) and graphene on gold (Au), platinum (Pt), nickel (Ni), and copper (Cu) substrates. We combined density functional theory electronic structure, optical properties, and work function to elucidate heterostructure changes due to metal selection, corroborated with experimentally determined surface electronic properties. Here, we correlate shifts in the metal d-band center relative to the Fermi energy with the MoS2 bandgaps and bandgaps in the Dirac point region of the MoS2/graphene/Metal heterointerfaces. For the Ni heterointerfaces, the upshift of the metal d-band relative to the Fermi energy …

Molecular Mechanisms Of L-Type Calcium Channel Dysregulation In Heart Failure, Arbab Khalid, Abu-Bakr Ahmed, Randeep Gill, Taha Shaikh, Joshua Khorsandi, Ali Kia

Department of Internal Medicine Faculty Research

The L-type calcium channels (LTCCs) function as the main entry points that convert myocyte membrane depolarization into calcium transients, which drive every heartbeat. There is increasing evidence to show that maladaptive remodeling of these channels is the cause of heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). Recent experimental, translational, and clinical studies have improved our understanding of the roles LTCC expression, micro-domain trafficking, and post-translational control have in disrupting excitation–contraction coupling, provoking arrhythmias, and shaping phenotype specific hemodynamic compromise. We performed a systematic search of the PubMed and Google Scholar databases (2015–2025, …

Management And Optimization Of Chronic Renal Insufficiency In The Setting Of Kidney Cancer A Systematic Review, Jessica K. Cobb, Hiroko Miyagi, Jad Chahoud, Claude Bassil, Philippe E. Spiess

Division of Internal Medicine Faculty Papers & Presentations

PURPOSE: There is a bidirectional relationship between chronic kidney disease and the incidence of renal cell carcinoma. Despite the frequency of patients with both chronic kidney disease and renal cell carcinoma, there are limited systematic reviews detailing the nuanced treatment. This review provides comprehensive insights for clinicians for managing chronic kidney disease, and renal cell carcinoma. Methods and Methods: We reviewed published literature that examined either chronic kidney disease and renal cell carcinoma or an indirect contributor of both.

RESULTS: We compare and contrast renal cell carcinoma treatment with partial and radical nephrectomies, ablative techniques, and radiation and their impact …

Pvc Biodegradation Potential Of Native Fungal Strains From Mt. Hood National And Tillamook State Forests, Bristol Ozturgut

University Honors Theses

Polyvinyl chloride (PVC) is a toxic, degradation-resistant environmental waste product. Recent research has revealed fungal enzymatic activity capable of biodegrading plastics. As PVC infiltrates local environments, it becomes imperative to determine the adaptability of local fungi to PVC substrates. In this experiment, 100 local native fungal strains sampled from the Tillamook State and Mt. Hood National forests and one commercial strain of common oyster mushroom were investigated for their ability to colonize and digest PVC by direct isolation on 0.1% and 0.2% PVC-enriched limited growth media. Substrates for positive cultures were imaged using Fourier transform infrared spectroscopy to analyze potential …

At Home In Horror: Women And Body Horror, Brooklynn Kreps

University Honors Theses

While most discussion around the subgenre of body horror focuses on its birthplace of film, the richest iterations come from women writing body horror fiction to explain the experience of womanhood. As body horror focuses on fear of painful or absurd mishap with the body. Women experience pain or absurdity in their own bodies every day with processes like menstruation, pregnancy, puberty, and heightened chances of becoming a victim of sexual assault. Furthermore, women experience society's forceful shaming and fear about natural processes of the body and experiences such as anger and sexual desire. Using this idea as a framework, …

The Potential For Improv As A Therapeutic Tool In The Context Of Dialectical Behavior Therapy: Suggestions For Dbt Clinicians, Jocelyn Borden

University Honors Theses

This thesis explores the theoretical and practical intersections between improvisational theater and Dialectical Behavior Therapy (DBT), proposing that the core tenets of improv closely align with the philosophical foundation and therapeutic goals of DBT. Aimed at mental health professionals, this work provides a conceptual framework and praxis for incorporating improv-based activities into DBT skills training to enhance client engagement, experiential learning, and emotional resilience. Through an examination of improv theory, parallels with DBT principles, and practical suggestions for integration, the thesis outlines how applied improvisation can be used as a supplemental tool in traditional DBT treatment. The final section includes …

So Who Gets To Be Modern? Jadidism And Reform In Late Nineteenth And Early Twentieth Century Russia, Grant Douglas Linville

University Honors Theses

Jadidism was a sociocultural reformist project from the 1880s to 1920s developed by Muslim intellectuals in the Russian Empire and the Soviet Union. The Jadidist movement derives its name from the "new-method" (usul-al Jadid) schools that spread Jadid pedagogy, which revolved around the inclusion of secular topics and Western knowledge as well as instruction in local, Tatar, and Russian languages, in addition to the already present religious studies accompanied by Arabic and Persian taught in the Islamic educational institutions the maktab and madrasa (primary and higher education respectively). Over time Jadidism grew to encompass a host of societal …

Where's The Dim Sum? Art, Oral History, And The Chinese American Diaspora In Portland, Or, Rayli Dornan

University Honors Theses

This thesis examines the history, transformation, and contemporary significance of Portland's Chinatown through an oral history framework, emphasizing the voices of Chinese American artists. Beginning with a comprehensive historical overview from the mid-nineteenth-century Gold Rush migrations and railroad labor to twentieth-century exclusion, dispossession under urban renewal, and the late-twentieth-century dispersal into suburbs, the thesis traces how structural racism and policy shaped both the physical landscape and communal life of Oregon's Chinese diaspora. Through in-depth interviews with local artists, this research aims to illuminate how individual experiences of identity, belonging, and creative expression navigate the tensions between heritage and adaptation.

Drawing …

Self-Representation In Manga: The Importance Of Gay & Lesbian Visibility In Japanese Society, Rylan Newsom

University Honors Theses

This thesis examines the evolving landscape of gay and lesbian self-representation in Japanese manga through a hermeneutic analysis of three key texts: My Lesbian Experience with Loneliness by Kabi Nagata, and My Brother's Husband and Our Colors by Gengoroh Tagame. It investigates how manga functions not only as a storytelling medium but as a sociocultural mirror, uniquely positioned to illuminate the often-invisible negotiations of identity, shame, and social position that queer individuals experience in Japan. Through the lens of Takie Lebra's concept of bun (role or place in society), this project explores the ways in which queer characters seek legitimacy, …

Characterization Of The Quaternary Active Twin Lakes Fault, Mount Hood, Oregon, Johnathan Peterson

University Honors Theses

The High Cascades chain of volcanoes results from Cascade Arc volcanism and is responsible for the generation of the highest topography in the state of Oregon. Surrounding Mt. Hood at the crest of the Cascade chain in northern Oregon is the Mt. Hood Fault Zone, an extensional fault zone of generally north-south trending normal faults that down-drop this high volcanic topography. The Twin Lakes Fault is located just south of Mt. Hood and is one of the southernmost faults in the Mt. Hood Fault Zone, previously mapped as approximately 12-13 km in length. This study provides the first in-depth characterization …

Is Anoxia Tolerance A Common Trait In Fish Cell Lines?, Lori Tran

University Honors Theses

Most vertebrates need a constant supply of oxygen to sustain life, with disruption to O₂ supply or delivery quickly leading to cell and tissue damage and death. Many aquatic species are able to withstand long periods without O₂ due to evolving to survive the regular periods of hypoxia and anoxia in their natural habitat. The Austrofundulus limnaeus, or the annual killifish, in particular have shown the highest anoxia tolerance in all vertebrates and is a promising model for developing effective treatments for anoxia-related damage, such as heart attacks and strokes. The A. limnaeus are not the only …

Beyond Capitalist Realism: Indigenous Worldviews As Critique And Alternative, Celine Jessup

University Honors Theses

This paper engages Mark Fisher's Capitalist Realism: Is There No Alternative? as a foundational critique of late capitalism's ideological dominance, and proposes Indigenous worldviews as both a critical lens and a generative alternative. Fisher defines capitalist realism as a pervasive structure that colonizes imagination, depoliticizes systemic crises, and renders other ways of living unthinkable. He illustrates how capitalism commodifies resistance, pathologizes dissent, and obscures accountability, particularly through institutions like the call center and discourses on mental health and climate change. In contrast, the paper turns to Indigenous political theories—drawing on thinkers such as Kim TallBear, Daniel Heath Justice, Ocean Ripeka …