Digital Commons Network^™

Photosensitizer-Loaded Glycogen For Photodynamic Therapy Of Tumor, Keke Ma, Jiurui Fang, Huijie Zhang, Jinghua Chen

Journal of Food Science and Biotechnology

[Objective ] The aim of this study is to synthesize aminated glycogen (NG) for loading of the photosensitizer TTVBA and construct a nano drug delivery system (NGT NPs ) for photodynamic therapy (PDT ) of tumors.[Method ] Positively charged NG was synthesized through modification of glycogen with diethylenetriamine (DETA ).Then,TTVBA was encapsulated by NG via electrostatic interaction to prepare NGT NPs.The prepared NGT NPs were characterized by infrared spectroscopy,dynamic light scattering (DLS ),and transmission electron microscopy (TEM ).The hemolysis assay was performed to evaluate the biocompatibility of NGT NPs.The reactive oxygen species (ROS ) generation capability of cells treated with …

Prokaryotic Expression , Purification , And Polyclonal Antibody Preparation Of Chlamydomonas Reinhardtii Channelrhodopsin 1, Jiurong Wang, Bin Xue, Zhenchuan Fan

Journal of Food Science and Biotechnology

[Objective ] This study aims to prepare a highly specific antibody against channelrhodopsin- 1 (ChR 1) from Chlamydomonas reinhardtii (C.reinhardtii ) and investigate its regulatory mechanisms in cellular phototaxis and negative phototaxis.[Method ] The recombinant expression vector pET- 28a(+)-chr1 was constructed and transformed into Escherichia coli (E.coli ) BL21 (DE3) competent cells.The expression of the fusion protein 6×His∷ChR 1 was induced with IPTG,and the obtained protein was purified by nickel-affinity chromatography.The purified protein was used to immunize New Zealand white rabbits for the production of ChR 1 antiserum.ChR 1-specific IgG antibodies were enriched from the antiserum through protein A purification.The …

Engineering Escherichia Coli Tolerance To Improve Succinic Acid Production, Jingyu Pan, Yongsheng Tang, Jia Liu, Cong Gao, Xiaomin Li, Wei Song, Wanqing Wei, Guipeng Hu, Jing Wu, Liming Liu, Xiulai Chen

Journal of Food Science and Biotechnology

[Objective ] This study aims to enhance the high osmotic pressure tolerance of Escherichia coli (E.coli ) for the efficient production of succinic acid.[Method ] Adaptive evolution,transcriptomic analysis,reverse metabolic engineering,and fermentation optimization were employed for improving E.coli tolerance to high osmotic pressure.[Result ] By analyzing the key factors influencing succinic acid production by fermentation,osmotic pressure was identified as the critical factor reducing succinic acid production efficiency.A mutant strain,E.coli FN-6,with tolerance to high osmotic pressure was obtained through adaptive evolution.The key gene cusC responsible for osmotic pressure tolerance was identified by transcriptomic analysis.After optimization of the expression level of cusC,the engineered …

Study On The Antioxidant Effects Of Natural Antioxidants And Their Derivatives On Anchovy (Engraulis Japonicus ) Oil, Xuyang Ding, Fujun Liu, Fawen Yin, Dayong Zhou

Journal of Food Science and Biotechnology

[Objective ] The aim of this study is to evaluate and improve the antioxidant effects of natural antioxidants and their derivatives on anchovy (Engraulis japonicus ) oil.[Method ] The 60 ℃ accelerated oxidation model was used to evaluate the antioxidant effects of phytic acid,tea polyphenols (TP),rosemary extract,ascorbyl palmitate,vitamin E,tea polyphenol palmitate (TPP),and bamboo leaf extract on anchovy oil based on the peroxide value (POV ),thiobarbituric acid reactive substances (TBARS ) value,relative intensity of free radicals,and fatty acid composition.[Result ] TPP (single antioxidant ) and TPP+TP (composite antioxidant ) demonstrated the strongest antioxidant effects on anchovy oil.[Conclusion ] Although the antioxidant …

Establishment Of Surface-Enhanced Raman Spectroscopy For Detection Of Escherichia Coli O157:H7, Panxue Wang, Cen Li, Xiang Li, Ying Liu, Guoliang Li

Journal of Food Science and Biotechnology

[Objective ] This study aims to improve the detection specificity and sensitivity for Escherichia coli (E.coli ) O157:H7.[Method ] A high ly specific and sensitive method for the detection of E.coli O157:H7 was established based on magnetic separation and signal amplification strategies combined with surface-enhanced Raman spectroscopy (SERS ).Aptamers were used as recognition elements and combined with magnetic beads and polystyrene (PS) microspheres to construct a separation probe (MB@Apt ) and a signal amplification Raman tag (4-MBN@PS@Apt ),respectively.[Result ] In the presence of E.coli O157:H7,MB@Apt and 4-MBN@PS@Apt formed a “sandwich ” structured composite (MB@Apt/ E.coli O157:H7/4-MBN@PS@Apt ),which could be rapidly …

Rapid Determination Of Vitamin B 1 In Infant Formula Milk Powder By Fluorescent Microsphere Immunochromatographic Assay, Qianqian Lu, Ting Yang, Yongwei Feng, Jialin Hu, Hua Kuang, Chuanlai Xu, Lingling Guo

Journal of Food Science and Biotechnology

[Objective ] A fluorescent immunochromatographic assay was established based on vitamin B 1 monoclonal antibody to measure the vitamin B 1 in infant formula milk powder.[Method ] The performance of vitamin B 1 monoclonal antibody was evaluated.On this basis,a highly sensitive fluorescent immunochromatographic test strip was developed.[Result ] The vitamin B 1 monoclonal antibody showed high sensitivity,affinity,and specificity.The fluorescent immunochromatographic test strip showed a visual limit of detection (vLOD ) of 10 μg/kg,a cut-off value of 200 μg/kg,and a calculated limit of detection (cLOD ) of 2.056 μg/kg.In addition,the recovery rate of this method was 97.3%~115.4%.The test results of the …

Colloidal Carbon-Labelled Immunochromatographic Assay For Rapid Detection Of Marbofloxacin Residues In Animal-Derived Foods, Xiujin Chen, Biao An, Jian Tao, Xinhao Yin, Yao Wang, Huawei Niu, Zhaozhou Li, Min Zhang

Journal of Food Science and Biotechnology

[Objective ] A colloidal carbon-labelled immunochromatographic assay with competitive inhibition was developed for the detection of marbofloxacin (MBF ) residues in milk powder and chicken.[Method ] The anti-MBF polyclonal antibody prepared in the author 's laboratory was employed to produce the colloidal carbon-labelled immunoprobe.The effects of pH of reaction system,resuspension solution,treatment solution of sample pad,standard dilution buffer,mass concentration of colloidal carbon,mass concentration of primary antibody,mass concentration of coating antigen,and mass concentration of secondary antibody on the MBF colloidal carbon-labelled immunochromatographic assay were investigated.The sensitivity,specificity,stability,and accuracy of the method were determined.[Result ] Under optimal conditions,the cut-off value of the method was …

Construction Of Staphylococcus Aureus Detection Method Based On, Silver Nanoclusters Dna, Xiaotong Lu, Jinzhao Li, Xinjun Du

Journal of Food Science and Biotechnology

[Objective ] A simple and sensitive detection method for Staphylococcus aureus is established for the efficient detection of this pathogen in food.[Method ] Targeting Staphylococcus aureus,a simple and sensitive fluorescent detection method for Staphylococcus aureus,EXPAR-P-AgNCs,was developed based on exponential amplification reaction (EXPAR ) combined with DNA silver nanoclusters (P-AgNCs ).A recognition probe was designed to initiate EXPAR in the presence of Staphylococcus aureus,generating a large amount of target DNA(T).The binding of T to hairpin P displaced the G-rich strand from P-AgNCs,resulting in a decrease in the relative fluorescence intensity of P-AgNCs and enabling the detection of Staphylococc us aureus.[Result ] …

Physicochemical Indicators , Microbial Diversity , And Volatile Substances In The Qupi And Quxin Of High-Temperature Daqu, Dan Xie, Cheng Wu, Wenyu Zhao, Jianfeng Hu, Pingyan Cheng, Yuanlin Bi, Junlin Yang, Xiaolong You, Diqiang Wang

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the physicochemical indicators,microbial diversity,and volatile substances in the Qupi (surface ) and Quxin (core) of high-temperature Daqu.[Method ] High-throughput sequencing and headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS ) were employed to compare the microbial diversity,volatile substances,and physicochemical indicators between Qupi and Quxin of three types of Daqu.[Result ] The moisture mass fraction in Qupi of the three types of Daqu was lower than that in Quxin (P<0.05),and the moisture mass fraction was the lowest in the Qupi of white Daqu (WP) and the highest in the Quxin of yellow Daqu (YX).The acidity of Qupi and Quxin were in the order of Quxin of black Daqu (BX) > YX > Qupi of black Daqu (BP) > Quxin of white Daqu (WX) > Qupi of yellow Daqu (YP) > WP.High-throughput sequencing results showed that Firmicutes and …

Revitalization Of Endangered Languages With Ai, Ivory Yang

Dartmouth College Master’s Theses

The preservation and revitalization of endangered languages, particularly those with minimal digital presence, presents significant challenges for computational linguistics. This thesis addresses these challenges by proposing novel methods for language identification and data generation, focusing on underrepresented Indigenous languages, specifically Nüshu, Native American and Native Alaskan languages.

In the first study, a COLING 2025 paper, we present NüshuRescue, an AI-driven framework designed to facilitate the preservation of Nüshu, an endangered script used exclusively by Yao women in China. Using minimal seed data, we demonstrate how GPT-4-Turbo can generate new translations, expanding a publicly available Nüshu-Chinese corpus, achieving 48.69% accuracy in …

Exploring The Effects Of Anthropogenic Habitat Change On Euplerid Carnivore Occupancy In A Humid Evergreen Forest, South-East Madagascar, C. Cardinal, Timothy M. Eppley, M. Andriamorasata, G. Donati

Anthropology Faculty Publications and Presentations

Mammalian carnivores are vulnerable to anthropogenic pressures, including habitat modifications, disturbance, and the introduction of non‐native species. Forests throughout Madagascar are under persistent pressure from extraction of timber and non‐timber products, and conversion of forest habitat to agriculture. Yet research into the impact of anthropogenic pressures on endemic carnivores is only recent, and relatively little is known about their populations in the extreme south of the island. We sought to explore how disturbance affects the occurrence of small carnivores in lowland humid forests and their varying degrees of adaptability to human‐modified landscapes. To answer this, we conducted exploratory camera trap …

Lawrence University One Hundred Seventy-Sixth Commencement, Sunday, June 15, 2025, Lawrence University

Commencement Programs

No abstract provided.

Finite-Temperature Kinetic Ferromagnetism In The Square-Lattice Hubbard Model, Robin C. Newby, Ehsan Khatami

Faculty Research, Scholarly, and Creative Activity

While the exact phase diagram of the Fermi-Hubbard model remains poorly understood despite decades of progress, nearly 60 years ago Nagaoka proved that a single dopant in an otherwise half-filled Hubbard system can bring about ferromagnetism through kinetic means. The phenomenon was recently observed with ultracold atoms in triangular optical lattices. Here, we explore the kinetic ferromagnetism within the square lattice Hubbard model and its strong-coupling counterpart, the t-J model, at finite temperatures in the thermodynamic limit via numerical linked-cluster expansions. We find evidence of ferromagnetic Nagaoka polarons at dopings up to ∼30% away from half filling for a variety …

Working Paper No. 102, Knowledge And Power: Towards Anintellectual Biography Of Michel Foucault, Amanda Bergeson

Working Papers in Economics

This inquiry seeks to establish that in his efforts as an intellectual, scholar, and author of books that would include Discipline and Punish [1975], Michel Foucault emphasizes the importance of power and power relations, especially of an authority (such as a sovereign) over the common people. Drawing from Discipline and Punish [1975], this inquiry considers how Foucault’s understanding of genealogy got rooted and shaped by Friedrich Nietzsche’s critique of history; a view which altogether challenged the idea of historical progress, while also revealing the contingent nature of truth. The second section considers how sovereign power evolves into disciplinary mechanisms embedded …

Working Paper No. 95, Jeremy Bentham And English Common Law, Anastasia Klingler

Working Papers in Economics

This inquiry seeks to establish that in his book, The Theory of Legislation [1802], author Jeremy Bentham (1748-1832) critiqued English Common Law while also posing solutions and alternatives. The first part of this inquiry considers Bentham’s critique of the degrees of vagueness and confusion that could be associated with what is noted as “Common Law” with its emphasis upon the “principle of expectation.” In addition, this inquiry introduces and considers Bentham’s warnings against uses associated with the English legal system and its emphasis upon the importance of “precedent,” as this emphasis is argued to open risks for abuse by courts …

Working Paper No. 98, Selma Mushkin And The Emergence Of The Field Of Health Economics, Sadie Kautz

Working Papers in Economics

This inquiry seeks to establish that through her effective efforts, Selma Mushkin promoted and shaped the field of Health Economics. Perhaps most importantly, she redefined health as a form of human capital that needed to be considered as both essential and integral to economic growth. In her 1958 paper: “Toward a Definition of Health Economics,” she defined the scope of this emerging field through emphasizing how improved resource allocation could lead to efficiency gains. Appearing as her 1962 article in the Journal of Political Economy, with “Health as an Investment” Mushkin advanced the idea that--much like education--public spending on health …

Working Paper No. 103, Russia And The Myriad Of Challenges Associatedwith ‘Relative Backwardness’, Jacob Wood

Working Papers in Economics

This inquiry seeks to establish that over recent of centuries Russia exhibits signs of what is termed as ‘relative backwardness.’ Drawing from Alexander Gershenkron’s (1962, 62-70) understanding of ‘backwardness in historical perspective,’ as well as Karl Marx’s ([1845] 1977, 39-43) concept of ‘historical materialism,’ this inquiry examines how successive Russian regimes sought to close the developmental gap with western countries through state-led modernization efforts. What stands out is that when confronted with attempting deep structural challenges, each leader turned to centralized authority and coercive reforms—not by choice, but out of necessity. Our inquiry considers Nicolas II’s failure to modernize Russia’s …

How’S It Growing? Tools For Observing Snow And Sea Ice In A Changing Arctic Ocean, Ian Alexander Raphael

Dartmouth College Ph.D Dissertations

September Arctic sea ice extent has diminished by roughly 50% in the 45 years since satellite observations began. The Arctic Ocean may experience ice-free summers within the next decade, with implications for habitat, resource extraction, geopolitics, and local and global climate change. To predict how Arctic sea ice will change in the future, we need to understand its behavior in the present. In situ sea ice mass balance measurements (snow accumulation, ice growth, snow and ice surface melt, and bottom melt) are essential for studying the processes driving rapid changes in the ice pack, and for validating remote sensing measurements …

Advancing Novel Contrast Agents For Applications In Fluorescence-Guided Neurosurgery Using Fluorescence Cryotomography, Augustino Vittorio Scorzo

Dartmouth College Ph.D Dissertations

Fluorescence guided surgery (FGS) is an emerging surgical technique that aims to help surgeons identify tissue types to assist in surgical decision making - ideally providing “cut-by-color” guidance. A primary application for this approach is the identification of tumor tissue to achieve more accurate and complete tumor removal while simultaneously minimizing damage to surrounding normal tissue. The cornerstone of tumor visualization for FGS is the administration of fluorescent contrast agents, or in some cases metabolic precursors, designed to accumulate specifically in tumor tissue, and a wide range of agents that use different targeting mechanisms are currently under investigation. Although these …

Mechanistic Insights Into The Flash Effect: The Role Of Oxygen And Radiation Chemistry In Ultra-High Dose Rate Radiation Therapy, Jacob Pierce Sunnerberg

Dartmouth College Ph.D Dissertations

The development of new cancer therapies focuses on widening the therapeutic ratio between tumor control and normal tissue toxicity. Over the last decade, ultra-high dose rate (UHDR) radiation therapy, commonly known as FLASH radiotherapy (FLASH-RT), has shown promising potential to reduce normal tissue toxicity while maintaining tumor control. However, the underlying mechanisms of the FLASH effect remain poorly understood. This thesis explores the radiation-chemical basis of FLASH-RT, focusing on the role of oxygen and reactive oxygen species in modulating biological outcomes.

A comprehensive set of in vitro studies demonstrated that UHDR delivery significantly alters radiation chemistry compared to conventional dose …

The Impact Of Polymycovirus 1 On Aspergillus Fumigatus Pathogenesis During Lung Infection, Alexander W. Rapp

Dartmouth College Ph.D Dissertations

The genus Aspergillus comprises over 250 species of fungi. Within this genus, only a handful of species cause disease in humans. One species is Aspergillus fumigatus (A.f.), an environmentally ubiquitous, saprophytic fungal pathogen. Lung infections due to A.f. range from invasive infection to allergic forms of the disease. Allergic bronchopulmonary aspergillosis (ABPA) is one of the most severe forms and presents as a hypersensitivity that often results in off-target damage to the surrounding airways. Patients with ABPA are sensitized to fungal antigens and this is commonly seen in cystic fibrosis and genetic predispositions. Recent data from our lab shown how …

Working Paper No. 97, Business Sabotage In Theory And Practice, Nathan Lewis-Lusso

Working Papers in Economics

This inquiry seeks to establish that theoretical advances offered earlier on by one Karl Marx and some decades later by one Thorstein Veblen offer insights into forms of business sabotage. Drawing upon their writings, this inquiry considers how in the writings of Marx, already in the mid-nineteenth century surplus value extraction and pecuniary sabotage serve as structural features found in a market-based economy. Marx’s consideration of surplus labor and artificial scarcity reveals how private investment seeks to constrain production in order to preserve and enhance profitability. Veblen’s theory of institutional sabotage complements Marx’s view by showing how firms could delay …

The Fangs Of Philosophy: Religious Experience As A Persuasive Device, Lukas A. Dunford

Comparative Literature Undergraduate Senior Theses

The philosophical systems of Plato and Lucretius use the religious experience to compel readers into their distinct philosophical versions of reality. This compulsion is necessary for philosophy. This study’s three philosophical systems reappropriate this experience from the existing structures of religion to violently produce conviction in readers. The religious experience is not window dressing over the arguments of the philosophical systems, but a necessary component that reorients the audience into a new discursive reality. Ultimately, the philosophers we examine will show how the knowledge structure of philosophy becomes able to grip the audience, consuming them into its reality – how …

Magicicada And Mathematics: What The Parochiality Of Our Explanations Means For The Indispensability Argument, Jadyn Malone

Philosophy Senior Theses

This thesis examines whether the indispensability argument justifies belief in the existence of mathematical entities. I adopt ontological naturalism, arguing that we should believe in entities that feature in our best scientific theories, which are determined through inference to the best explanation. The indispensability argument contends that because mathematical entities are explanatorily indispensable to our best scientific theories – as demonstrated by examples like the prime number explanation of cicada life cycles – we should believe they exist just as we believe in electrons and stars.

However, I identify a challenge: our scientific explanations are inherently parochial, shaped by human …

Puppycide By Gavel: How The Judiciary Uses The Police Killing Of Dogs To Reinforce Justifications For Police Violence, Jeremy J. Smith

Qualitative Criminology (QC)

"Police discharge their firearms more often at dogs than humans, and as a profession, kill thousands of dogs every year. The number of dogs killed by police during these encounters has government officials declaring that an “epidemic” is occurring within policing itself, with some commentators referring to this trend as “puppycide” or “canicide.” The purpose of this article is to examine how the judiciary rationalizes canicide, or the police killing of dogs, and the role canicide plays in the justification of police violence. To do this, the article provides a sociolegal and ethnographic content analysis of federal court cases and …

الأقليات الدينية في لبنان: دراسة في الثقافة الأساسية للمعتقدات الدينية والموروثات الاجتماعية وتأثيرهما على السلوك الجمعي - الموحّدون الدروز أنموذجًا, حسام نصّار

Horizons et Conjonctures

تندرج هذه الأطروحة من ضمن المباحث التي تتمحور حول دراسة الثقافة الأساسية للموروث الاجتماعي ومفاهيم الدين والتديّن، وتأثيرها على السلوك الجمعي عند الموحّدين الدروز، بوصفهم أقلّية عددية في لبنان. ولمّا كان الارتباط وثيقًا بين تأثير الموروثات الاجتماعية على المفاهيم الدينية من جهة، وتأثير المعتقدات الدينية على السلوكيات الاجتماعية من جهة أخرى، بات البحث العلمي في بنية المنظومة الدينية والاجتماعية، وحتّى السياسية، شرطًا لتظهير بعض مكوّناتها وعناصرها ومجمل مناهجها وأسسها، وذلك من أجل معرفة أسباب ربط الأفكار والسلوكيات الدينية بالهوية الطائفية والمذهبية
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Humanizing The Icu: Implementation Of Personalized Communication Boards In The Sicu Drives Enhanced Patient And Family Experience, Stephen D. Hoefler

Master's Theses

Objective: Research has established the importance of personalized communication in critical care settings, where standardized tools like whiteboards can improve patient and family engagement.

Aim: This project aims to develop a personalized communication board in the surgical intensive care unit (SICU) at a Bay Area academic quaternary care facility that, once implemented, will achieve at least 75% utilization in patient rooms by May 2025, enhancing communication and patient experiences.

Methods: Surveys were conducted with patients, families, and staff to gather stakeholder input and guide the design of a new standardized whiteboard model with personalized elements. Results: Based on stakeholder feedback, …

Study Of The Performance Of A Laser Structure Based On A Fiber Ring And A Dual-Bottle Whispering Gallery Mode Microresonator, Anuradha Rout, V.R Anand, Zhe Wang, Zhouchen Wang, Rayhan Habib Jibon, Yuliya Semenova

Research Outputs: 2025-Present

This study examines the impact of a dual-bottle whispering gallery mode (WGM) microresonator on the performance of a laser structure based on a fiber ring, focusing on the modes switching and generating single- and multi-mode emissions. Through experimental analyses, we demonstrate how the unique geometry of dual-bottle resonators affects lasing behavior, providing insights that could advance applications of the proposed laser structure in telecommunications and photonic sensing systems.

The Structure Of The Drp1 Lattice On Membrane, Kristy Rochon, Anelise N. Hutson, Jason A. Mears

Faculty Scholarship

Mitochondrial health relies on the membrane fission mediated by dynamin-related protein 1 (Drp1). Previous structural studies of Drp1 on remodeled membranes were hampered by heterogeneity, leaving a critical gap in the understanding of the mitochondrial fission mechanisms. Here we present a cryo-electron microscopy structure of full-length human Drp1 decorated on membrane tubules. Using the reconstruction of average subtracted tubular regions (RASTR) technique, we report that Drp1 forms a locally ordered lattice along the tubule without global helical symmetry. The filaments in the lattice are similar to dynamin rungs with conserved stalk interactions. Adjacent filaments are connected by GTPase domain interactions …

First Opinions, Second Reactions: A Collection Of Innovative Online Reviews Of Literature For Children And Young Adults, Janet Alsup, Christy Wessel-Powell

Purdue University Press Books

First Opinions, Second Reactions: A Collection of Innovative Online Reviews of Literature for Children and Young Adults features selected pieces from the journal First Opinions, Second Reactions, which reviews children’s and young adult books. The journal, and this book, consist of reviews of books written by scholars of children’s and YA literature, followed up with responses from those who share the books with their intended audiences—children and teens. The editors have selected twelve issues classified under four thematic categories (social and political issues; diversity and inclusion; identification and empathy; and genre study) to represent the depth and breadth of …