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Left Bundle Area Pacing Outcomes Among Patients With Very Wide Qrs – Insights From An African Registry, Willy Mucyo, Mzee Ngunga, Miriam Msunza, Jeilan Mohamed, Marcus Ngantcha, Brian Vezi Sep 2025

Left Bundle Area Pacing Outcomes Among Patients With Very Wide Qrs – Insights From An African Registry, Willy Mucyo, Mzee Ngunga, Miriam Msunza, Jeilan Mohamed, Marcus Ngantcha, Brian Vezi

Internal Medicine, East Africa

Background: Left Bundle Area Pacing (LBAP) is a promising alternative to conventional cardiac resynchronization therapy. There is a high prevalence of dilated cardiomyopathy in Africa, which is often associated with very wide QRS. However, data on LBAP outcomes in Africa are limited. Objective To evaluate the procedural and clinical outcomes of LBAP among African patients with very wide QRS durations.

Methods: The Multicenter African Cardiac Outcomes in Pacing (MACOP) registry enrolled 311 patients in Kenya and South Africa who underwent LBAP between 2021 and 2024. We evaluated procedural and clinical outcomes. Patients were stratified by baseline QRSd (normal …


Women's Unique Health Needs And The Sustainable Development Goals: A Meeting Report From The 79th United Nations General Assembly Science Summit, Irene Aninye, Sarah Chew, Nicole Althaus, Michele Barry, Ru-Fong Cheng, Carolyn Harris, Eleanor Nwadinobi, Beth Battaglino, Aisha Brooks, Marleen Temmerman Sep 2025

Women's Unique Health Needs And The Sustainable Development Goals: A Meeting Report From The 79th United Nations General Assembly Science Summit, Irene Aninye, Sarah Chew, Nicole Althaus, Michele Barry, Ru-Fong Cheng, Carolyn Harris, Eleanor Nwadinobi, Beth Battaglino, Aisha Brooks, Marleen Temmerman

Centre of Excellence in Women and Child Health

Biological sex, hormones, and gender uniquely affect health and disease, often resulting in disparities for women across the lifespan and from different racial and ethnic groups, geographical locations, and socio economic backgrounds. Without intentional investment and infrastructure to support good health and wellbeing for women,half of the world’s population remains vulnerable to preventable morbidity and mortality. The Society for Women’s Health Research and ECHAlliance–The Global Health Connector convened a women’s health programas part of the 10th Annual Science Summit during the United Nations 79th General Assembly. This hybrid event was held in New York, NY, (USA) and virtually in September …


Policy Evaluation With Nonlinear Trended Outcomes: Covid-19 Vaccination Rates In The United States, Lynn Bergeland Morgan, Peter C. B. Phillips, Donggyu Sul Sep 2025

Policy Evaluation With Nonlinear Trended Outcomes: Covid-19 Vaccination Rates In The United States, Lynn Bergeland Morgan, Peter C. B. Phillips, Donggyu Sul

Research Collection School Of Economics

This paper discusses pitfalls in two way fixed effects (TWFE) regressions when the outcome variables contain nonlinear and possibly stochastic trend components. If a policy change shifts trend paths of outcome variables, TWFE estimation can distort results and invalidate inference, especially in a context of evolving policy decisions. A robust solution is proposed by allowing for dynamic club membership empirically using a relative convergence test procedure. The determinants of respective club memberships are assessed by panel ordered logit regressions. The approach allows for policy evolution and shifts in outcomes according to a convergence cluster framework with transitions over time and …


Examining The Influence Of Encoding And Retrieval Contexts On 2- To 4-Year-Olds' Acquisition Of Nouns And Verbs, Piper Swearengin, Patrick Mihalicz, Leah Marsh, Zoe Baker, Faith Perry, Susan A. Graham, Jane B. Childers Sep 2025

Examining The Influence Of Encoding And Retrieval Contexts On 2- To 4-Year-Olds' Acquisition Of Nouns And Verbs, Piper Swearengin, Patrick Mihalicz, Leah Marsh, Zoe Baker, Faith Perry, Susan A. Graham, Jane B. Childers

Psychology Faculty Research

This study investigates whether the context in which a word is learnt affects noun and verb learning. There is mixed evidence in studies of noun learning, and no studies of background perceptual context in verb learning. Two-, three-, and four-year-olds (n = 162) saw a novel object moved in a novel way while hearing four novel words, either nouns or verbs. They were asked to generalize the word to a similar action or object shown in the same or different context. Results demonstrate that 2- and 3-year-olds were more accurate at test when learning nouns than verbs, demonstrating that verb …


Opioid Withdrawal Treatment: Buprenorphine/Naloxone (Suboxone), Children's Mercy Kansas City Sep 2025

Opioid Withdrawal Treatment: Buprenorphine/Naloxone (Suboxone), Children's Mercy Kansas City

Clinical Pathways

No abstract provided.


Stand For Support, Shatter The Silence: Administrative Approaches To Eradicate Bullying In Higher Education, Elaine M. Mora, Shawn P. Saladin Sep 2025

Stand For Support, Shatter The Silence: Administrative Approaches To Eradicate Bullying In Higher Education, Elaine M. Mora, Shawn P. Saladin

School of Rehabilitation Services & Counseling Faculty Publications

Bullying in higher education has become a widespread and complex issue that affects staff, faculty, and students worldwide, causing a detrimental impact on both psychological health and academic achievement. This paper provides a comprehensive examination of the phenomenon, encompassing all its manifestations, underlying causes, and significant consequences. The study, which draws on academic literature, outlines the various forms of bullying, including cyberbullying, mobbing, microaggressions, and social exclusion, and highlights the adverse effects these behaviors have on both individuals and academic communities. The research emphasizes how critical it is to comprehend the power relationships that exist in higher education settings and …


September 9, 2025 Executive Board Meeting Minutes Sep 2025

September 9, 2025 Executive Board Meeting Minutes

NASIG Newsletter

No abstract provided.


Advancing Social Sustainability In Operations And Supply Chain Management: A Multi-Theoretical Exploration Of Technology, Task Familiarity, And Sustainability Interactions, Satabdi Hazarika Sep 2025

Advancing Social Sustainability In Operations And Supply Chain Management: A Multi-Theoretical Exploration Of Technology, Task Familiarity, And Sustainability Interactions, Satabdi Hazarika

Graduate Theses and Dissertations

Social sustainability in operations and supply chain management (OSCM) centers on generating economic value through practices that safeguard people, communities, and broader societal systems impacted by the supply chain. While the importance of such practices is increasingly recognized, firms face persistent challenges in embedding social sustainability into formal management systems. This dissertation tackles three such challenges, with a particular focus on safety in trucking—a vital yet underexamined aspect from the lens of social sustainability. Safety performance in this context is influenced by the complexities of using advanced safety technologies, the demanding and solitary nature of truck driving, and the temporal …


Beech Bark Disease Agent Responses To Exogenous Application Of Tree Defense Inducing Phytohormones, Erin Reilly Sep 2025

Beech Bark Disease Agent Responses To Exogenous Application Of Tree Defense Inducing Phytohormones, Erin Reilly

Master's Theses and Capstones

Pathogens and insects face several barriers to successful infection and colonization of a host plant, including a range of physical and chemical defenses, some of which are inducible (modified or initiated by attack or infection). These interactions can be complex and are influenced by environmental conditions, tree physiological status, host age, and timing of attack. Non-native pathogens and insects can have an advantage against a plant’s evolved chemical defenses, but they are also subject to abiotic stressors and conditions. In North America, beech bark disease (BBD) is a disease complex where the beech (Fagus grandifolia) host is subject to concurrent …


The Development Of A Meteorological Buoy For Measuring Turbulent Fluxes Along The Air-Sea Boundary Layer, Jane Maria Schwadron Sep 2025

The Development Of A Meteorological Buoy For Measuring Turbulent Fluxes Along The Air-Sea Boundary Layer, Jane Maria Schwadron

Master's Theses and Capstones

The Air-Sea Flux Buoy (ASFB) is part of a larger effort implemented by the U.S. Department of Energy (DoE) to characterize the dynamics of the marine atmospheric boundary layer (MABL). The ASFB samples the 3D wind velocities, air temperature, and water vapor to derive the air-sea eddy-covariance fluxes of momentum, heat, and humidity. The solar radiation, water temperature, rain intensity, barometric pressure, and water salinity are sampled to estimate the bulk-parameterized stability conditions. A GNSS inertial navigation system enables centimeter-scale motion correction and an onboard cellular modem provides real-time telemetry. Computational fluid dynamics (CFD) simulations, hydrostatic analysis, mooring simulations, and …


Analysis Of Nutrient Accumulation Within A Bioretention System, Amina Halim Nefic Sep 2025

Analysis Of Nutrient Accumulation Within A Bioretention System, Amina Halim Nefic

Master's Theses and Capstones

Bioretention systems are widely used in stormwater management to mitigate nutrient pollution, particularly nitrogen and phosphorus. Over time, these systems undergo changes in nutrient retention efficiency due to organic matter accumulation and biogeochemical transformations. This study examines the distribution and long-term retention of total nitrogen (TN), total Kjeldahl nitrogen (TKN), nitrate (NO3-), total phosphorus (TP), and orthophosphate (PO43-) within a 16-year-old bioretention system. A combination of k-means clustering and non-parametric statistical tests (Kruskal-Wallis and Wilcoxon rank-sum tests) were employed to analyze nutrient concentrations across different soil depths and media types. Results indicate that TN and TKN are concentrated in the …


Stand-In Standing, Matthew I. Hall Sep 2025

Stand-In Standing, Matthew I. Hall

Scholarly Works

When the interests of a state, or of the federal government, are at issue in a lawsuit, those interests are typically represented by the Executive branch. But not always: The Supreme Court has repeatedly held that states, and the federal government, may delegate their claims to non-governmental litigants in some circumstances. But the Court has never defined the exact boundaries of when stand-in standing is permitted. And states have recently begun to exploit this doctrinal uncertainty, by enacting laws that are arguably, and in some cases flagrantly, unconstitutional, but outsourcing the enforcement of those laws to private individuals. The avowed …


A Dynamic Hierarchical Attention Framework For Multimodal Malware Detection, Tamanna Nazmin Sep 2025

A Dynamic Hierarchical Attention Framework For Multimodal Malware Detection, Tamanna Nazmin

Graduate Theses and Dissertations

The increasing use of Android in the worldwide mobile ecosystem has come along with a significant increase in advanced malware, highlighting the critical necessity for efficient, scalable, and adaptable detection systems. Despite recent advancements in machine learning improving malware detection, the majority of current solutions are limited to one, two, or three data modalities, hence neglecting the comprehensive behavioral spectrum of contemporary multi-vector threats. This thesis presents the first comprehensive multimodal framework for Android malware detection, which combines textual, time-series (temporal), graph-based (structural), and visual information using an innovative hierarchical attention mechanism and Dynamic Fusion Controller(DFC). Our methodology consistently classifies …


Evaluation Of Tracheal And Cecal Microbial Composition In Heat Stressed Broilers Supplemented With Phytogenic Additives, Andressa Silveira Stein Sep 2025

Evaluation Of Tracheal And Cecal Microbial Composition In Heat Stressed Broilers Supplemented With Phytogenic Additives, Andressa Silveira Stein

Graduate Theses and Dissertations

The rise in global temperatures has become a concern due to its significant impact on the agricultural sector, including poultry production. Heat stress caused by high temperatures directly affects animal welfare, health and productivity, leading to major losses in the poultry sector. In broilers, heat stress affects feed consumption, weight gain, mortality and may also lead to changes in the microbiome, which can increase the predisposition to disease and impact the overall performance of these animals. The aim of this thesis was to reproduce field conditions, simulating an increase in temperature, and to evaluate possible changes in the respiratory and …


Understanding Glufosinate Resistance In Palmer Amaranth And Examination Of Additives For Improved Weed Control, Pamela Carvalho-Moore Sep 2025

Understanding Glufosinate Resistance In Palmer Amaranth And Examination Of Additives For Improved Weed Control, Pamela Carvalho-Moore

Graduate Theses and Dissertations

The aim of this dissertation was to: 1) provide an in-depth review about the potential use of natural and synthetic glutathione S-transferase (GST) inhibitors to enhance herbicidal activity or induce crop safety; 2) determine if the addition of metabolic inhibitors to glufosinate is an effective approach to enhance weed control; 3) investigate the mechanism conferring resistance to glufosinate in a highly-resistant Palmer amaranth accession; 4) characterize the genomic rearrangement involved in glutamine synthetase 2 amplification in a Palmer amaranth accession resistant to both glufosinate and glyphosate; 5) quantify the distribution of glufosinate resistance among Palmer amaranth accessions within a 15-km …


Fpga-Based Overlay Accelerators With Massive Parallel Processing Units To Accelerate Deep Neural Networks, Ehsan Kabir Sep 2025

Fpga-Based Overlay Accelerators With Massive Parallel Processing Units To Accelerate Deep Neural Networks, Ehsan Kabir

Graduate Theses and Dissertations

Deep neural networks (DNNs) are widely used in applications such as classification, prediction, and regression. Various DNN architectures, such as convolutional neural networks (CNN), multilayer perceptrons (MLP), long short-term memory (LSTM), recurrent neural networks (RNN), and transformers, have become leading machine learning techniques in these applications. They require significant computational resources and have substantial memory demands due to intensive matrix-matrix multiplications and complex data flows. Hence, efficient utilization of on-chip computational and memory resources is essential to maximize parallelism and minimize latency. Designing an optimal tiling scheme that aligns effectively with the architecture is also necessary. Modern FPGAs are equipped …


Constraining The Properties And Formation Pathways Of Low Mass X-Ray Binaries In Early-Type Galaxies, Andrew Paul Ferrell Sep 2025

Constraining The Properties And Formation Pathways Of Low Mass X-Ray Binaries In Early-Type Galaxies, Andrew Paul Ferrell

Graduate Theses and Dissertations

In this dissertation, we explore how low-mass X-ray binaries (LMXBs) form and evolve in nearby early-type galaxies. We investigate X-ray binary (XRB) luminosity function (XLF) scaling relations for Chandra-detected populations of LMXBs within the footprints of 24 early-type galaxies. Our sample includes Chandra and Hubble Space Telescope observed galaxies at D ≲ 25Mpc that have estimates of the globular cluster (GC) specific frequency (SN) reported in the literature. As such, we are able to directly classify X-ray-detected sources as being coincident with unrelated background/foreground objects, GCs, or sources that are within the fields of the galaxy targets. We model the …


Digital Inclusion Baseline Survey, Katharine Willis Sep 2025

Digital Inclusion Baseline Survey, Katharine Willis

Faculty of Arts, Humanities and Business Datasets

We undertook a survey of Cornwall residents to understand their level of digital skills against a national baseline. The survey questions were designed to mirror the methodology of the Lloyds Bank Consumer Digital Index in order to gain Cornwall data against a national baseline . Consultation was undertaken with the Good Things Foundation and Digital Poverty alliance in the development of the survey questions. The Good Things Foundation provided three additional questions: “questions for digital inclusion” which we agreed to pilot as part of the survey.


Leviathans And Liberation: Did Whaling Contribute To The Decline Of Slavery?, Topher L. Mcdougal, Austin Choi‐Fitzpatrick Sep 2025

Leviathans And Liberation: Did Whaling Contribute To The Decline Of Slavery?, Topher L. Mcdougal, Austin Choi‐Fitzpatrick

School of Peace Studies: Faculty Scholarship

No abstract provided.


Identification Of Metabolic Pathways And Hub Genes Associated With Ultrasound Subcutaneous Fat And Muscle Depth Of The Longissimus Muscle In Cull Beef Cows Using Gene Co-Expression Analysis, Harshraj Shinde, Kyle R. Mcleod, Jeffrey W. Lehmkuhler Sep 2025

Identification Of Metabolic Pathways And Hub Genes Associated With Ultrasound Subcutaneous Fat And Muscle Depth Of The Longissimus Muscle In Cull Beef Cows Using Gene Co-Expression Analysis, Harshraj Shinde, Kyle R. Mcleod, Jeffrey W. Lehmkuhler

Animal and Food Sciences Faculty Publications

Beef production is an important component of the world’s food supply, with production being near 59 million tons in 2023 (USDA, 2023). Enhancing our understanding of the factors influencing metabolism will lead to improvements in production efficiency. Using RNA-seq and WGCNA of longissimus muscle samples, gene expression and metabolic pathway analyses were performed to examine relationships with ultrasound and body mass variables. In this study, body weight (BW), ultrasound back fat (BF), ultrasound muscle depth (MD), and body condition score (BCS) were traits recorded for 18 cull beef cows. As expected, all production-related traits monitored (WT, BF, MD, and BCS) …


Law Library Blog (September 2025): Legal Beagle's Blog Archive, Roger Williams University School Of Law Sep 2025

Law Library Blog (September 2025): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.


2025 Montana Tourism Outlook: Balancing Innovation And Tradition - Montana Economic Seminar Presentation, Melissa Weddell Sep 2025

2025 Montana Tourism Outlook: Balancing Innovation And Tradition - Montana Economic Seminar Presentation, Melissa Weddell

Institute for Tourism and Recreation Research Publications

No abstract provided.


Synthesis And Characterization Of Tio2 Nanoparticles Via Hydrothermal And Sol-Gel Technique For Water Treatment, Aya Sami, Selma Al-Jawad, Natheer Jamal Imran Sep 2025

Synthesis And Characterization Of Tio2 Nanoparticles Via Hydrothermal And Sol-Gel Technique For Water Treatment, Aya Sami, Selma Al-Jawad, Natheer Jamal Imran

Journal of Applied Sciences and Nanotechnology

Titanium dioxide (TiO2) has attracted significant interest for water treatment applications due to its non-toxic nature and high photocatalytic activity. In this study, TiO2 nanoparticles were synthesized using two different methods to evaluate their photocatalytic performance in degrading organic contaminants from wastewater. Sample S1 was prepared via the sol–gel method, while sample S2 was synthesized using a hydrothermal approach. X-ray diffraction (XRD) analysis confirmed that both samples crystallized in the tetragonal anatase phase, with average crystallite sizes of 12 nm for S1 and 29 nm for S2. Field-emission scanning electron microscopy (FE-SEM) revealed spherical particles with uniform morphology for both …


Durability, Mechanical, And Corrosion Characteristics Of Recycled Aggregate Concrete Utilizing Locally Sourced Waste And Ultrafine Cerium Oxide, Ansam Hashim, Rana Anaee, Mohammed Nasr Sep 2025

Durability, Mechanical, And Corrosion Characteristics Of Recycled Aggregate Concrete Utilizing Locally Sourced Waste And Ultrafine Cerium Oxide, Ansam Hashim, Rana Anaee, Mohammed Nasr

Journal of Applied Sciences and Nanotechnology

This study seeks to identify an environmentally sustainable method for utilizing the synergetic effects of window glass (WG), ceramic powder (CP), and ultrafine cerium oxide (UFC) in developing concrete containing 25% coarse ceramic aggregate. Four different mixtures were formulated. The first represents control, consisting of 100% ordinary Portland cement (OPC), two other mixtures were composed of 10% WG, 10% CP and 80% OPC, and the fourth mixture consisted of four compositions of 79.5% OPC, 10% WG, 10% CP, and 0.5% UFC. The effect of these additives on recycled ceramic concrete (RA) properties, including workability and setting time, compressive strength, total …


Structural Characteristics Of Alumina Nanoparticles Synthesised By Dc Reactive Sputtering Technique, Noor Naji, Ali Aljubouri, Raid Ismail Sep 2025

Structural Characteristics Of Alumina Nanoparticles Synthesised By Dc Reactive Sputtering Technique, Noor Naji, Ali Aljubouri, Raid Ismail

Journal of Applied Sciences and Nanotechnology

In this work, Al2O3 nanoparticles were synthesized using the DC reactive sputtering technique. A highly pure aluminum target was sputtered within a gas mixture containing oxygen. The structural characteristics of the synthesized nanoparticles were introduced by X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), and atomic force microscopy (AFM). An inter-electrode distance of 4 cm can describe the operation parameters, Ar: O2 gas mixing ratio of 50:50, applied voltage of 1500 V and discharge current of 25 mA. The prepared samples showed a polycrystalline structure with an amorphous nature due to the formation of nanoparticles, which …


Optimal And Harmful Social Media Use By Teens With Disabilities: Leveraging Benefits While Minimizing Adverse Effects, Rommel Johnson, Elaine Mora Sep 2025

Optimal And Harmful Social Media Use By Teens With Disabilities: Leveraging Benefits While Minimizing Adverse Effects, Rommel Johnson, Elaine Mora

School of Rehabilitation Services & Counseling Faculty Publications

This article investigates the dual role of social media as both a beneficial and a harmful tool for teens with disabilities (TWDs), emphasizing its impact on identity formation, self-expression, and community engagement. Social media platforms provide TWDs with opportunities for autonomy and empowerment, offering an avenue to connect with peers, share personal stories, and engage in self-advocacy. However, the same platforms pose significant risks, including cyberbullying, loss of privacy, and problematic social media use. The article highlights rehabilitation professionals' need to understand these underlying forces, ensuring that TWDs can leverage social media's benefits while minimizing its adverse effects. By reviewing …


Adaptability Treatment, Amy M. Glaspey Sep 2025

Adaptability Treatment, Amy M. Glaspey

University Grant Program Reports

The funding was used to purchase wearable recording devices (and receivers) to record the speech productions of preschool children engaged in group speech therapy where the adaptability approach was implemented. Data were recorded for speech sound productions and intervention practice to monitor progress and dosage.


Knowledge, Attitude And Practice Of Artificial Intelligence Among Healthcare Professionals: An Online Cross-Sectional Survey, Nikhil R, Divya K L, Mahabaleshwar Mamadapur, Harshwardhan S Patil, Shashirekha B, Hema Sameera Pinnam, Purna Bansal Sep 2025

Knowledge, Attitude And Practice Of Artificial Intelligence Among Healthcare Professionals: An Online Cross-Sectional Survey, Nikhil R, Divya K L, Mahabaleshwar Mamadapur, Harshwardhan S Patil, Shashirekha B, Hema Sameera Pinnam, Purna Bansal

Digital Journal of Clinical Medicine

Background: Deep learning-powered Artificial Intelligence-driven assistance offers enormous potential to improve healthcare by facilitating administrative work, diagnosis, and the treatment of chronic diseases. The gap between clinical values and the day-to-day realities of primary care practice might widen if AI is not successfully incorporated.

Methods: A cross-sectional design was used to evaluate healthcare professionals' perceptions and understanding of AI within a clinical setting. The study was conducted among 456 Health care Workers from May to November 2024.

Results: Among 456 participants, 55.7% were MBBS students/interns, and 37.9% were postgraduates/professionals. More than 50% supported AI integration, and 62.3% of MBBS …


Cardiogenic Shock With Acute Myocardial Infarction Among Older Adults In The United States, Taha Mansoor, Ali Bin Jabbar, Mahmoud Ismayl, Dylan Yu, Kartik Gupta, Sachin Parikh, Austin Brubaker, Abdul Minhas, Dmitry Abramov, Salim S. Virani Sep 2025

Cardiogenic Shock With Acute Myocardial Infarction Among Older Adults In The United States, Taha Mansoor, Ali Bin Jabbar, Mahmoud Ismayl, Dylan Yu, Kartik Gupta, Sachin Parikh, Austin Brubaker, Abdul Minhas, Dmitry Abramov, Salim S. Virani

Population Health, East Africa

Background: Characteristics and outcomes associated with cardiogenic shock (CS) with acute myocardial infarction (AMI) in older patients have not been well characterized.

Objectives: The purpose of this study was to investigate characteristics and outcomes of older patients admitted with CS with AMI.

Methods: We used the National Inpatient Sample database to evaluate clinical characteristics of hospitalizations, clinical outcomes, and health care utilization of hospitalizations of older patients ≥80 years with CS and AMI from 2003 to 2021. We also compared data from older patients with a reference relatively younger patient population (18-79 years).

Results: During the study period, …


Induction Of An Early Ifn-Γ Cellular Response And High Plasma Levels Of Sdf-1Α Are Inversely Associated With Covid-19 Severity And Residence In Rural Areas In Kenyan Patients, Perpetual Wanjiku, Benedict Orindi, John Kimotho, Shahin Sayed, Reena Shah, Mansoor Saleh, Viviane Olouch, Ann Karanu, Jasmit Shah, Zaitun Nneka Sep 2025

Induction Of An Early Ifn-Γ Cellular Response And High Plasma Levels Of Sdf-1Α Are Inversely Associated With Covid-19 Severity And Residence In Rural Areas In Kenyan Patients, Perpetual Wanjiku, Benedict Orindi, John Kimotho, Shahin Sayed, Reena Shah, Mansoor Saleh, Viviane Olouch, Ann Karanu, Jasmit Shah, Zaitun Nneka

Pathology, East Africa

Introduction COVID-19 was less severe in Sub-Saharan Africa (SSA) compared with Europe and North America. It is unclear whether these differences could be explained immunologically. Here we determined levels of ex vivo SARS-CoV-2 peptide-specific IFN-γ producing cells, and plasma cytokines and chemokines over the first month of COVID-19 diagnosis among Kenyan COVID-19 patients from urban and rural areas.

Methods Between June 2020 and August 2022, we recruited and longitudinally monitored 188 COVID-19 patients from two regions in Kenya, Nairobi (urban, n=152) and Kilifi (rural, n=36), with varying disease severity – severe, mild/moderate, and asymptomatic. IFN-γ secreting cells were enumerated at …