Digital Commons Network^™

How Human Personality Will Change With The Use Of Artificial Intelligence, John Mayer

UNH Personality Lab

INTRODUCTION: Human personality changes in response to new habits, situations, and maturation, among other causes. As people interact with artificial intelligence (AI), their personalities are likely to change, from their emotional responses to their self-concept.

METHODOLOGY: This theoretical account draws together empirical studies of how personality changed in response to past technological innovations, changes in personal interactions observed in people’s AI usage, changes that arise from the use and disuse of cognitive skills, and works on the self-concept. Research reports in the review were selected according to their relevance and quality.

THEORETICAL STATEMENT: While AI becomes increasingly human-like, humans increasingly …

Physician Peer Review: Just Culture And Practical Implementation In An Emergency Department, Christian Fromm, Monica Colicino, Merle A. Carter, Elizabeth M. Datner

Einstein Health Papers

BACKGROUND: Although regulatory agencies require hospitals to engage in peer review to maintain accreditation, quality assurance review processes are not standardized, and well-structured peer review of clinical cases involving medical errors and adverse events governed by Just Culture principles is not widespread. We implemented such an emergency department (ED) physician peer review process and performed an analysis of cases that underwent review.

METHODS: We formed an ED physician peer review committee at our institution guided by Just Culture principles, including promotion of a culture of safety to encourage open reporting of errors and near misses, and top-down leadership commitment to …

Menopause And Motherhood: Shaping Women’S Lived Experiences, Michelle M. Ness

Biennial Convention (CONV)

Motherhood is a multifaceted role influenced by various transitions during midlife, including changing relationship dynamics with children and significant others and the onset of menopause. Mothers often shift from hands-on caregiving to an advisory role with their adult children during this time. This shift coincides with hormonal changes associated with menopause, exacerbating physical and psychological symptoms, including hot flashes, mood swings, and sleep disturbances. The hormonal changes associated with menopause profoundly impact women's emotional well-being and interpersonal relationships, potentially increasing susceptibility to mood disorders such as depression and anxiety. Additionally, the increased demand for balance between family responsibilities and professional …

Recipe For Success: Mixing A Savory Partnership With Hr In Cooking Up A Nurse Leader Succession Plan, Lourdes Moore, Jacqueline Brock, Maureen Padilla

Biennial Convention (CONV)

Succession planning is vital to transformational leadership which advocates for ongoing leadership development.¹ In 2016, Nursing strategically cooked up a savory nurse succession plan program with a secret sauce-Human Resources (HR). The plan’s purpose was to establish a cohort of leaders with skills and knowledge continuity, manage risk of retirements, and offer overall leader development.² Strengthened in 2022, the Nursing-HR partnership added key ingredients: a defined plan with leadership competencies, alignment to organizational culture and priorities, and multi-layered development.^3,4 The plan consists of five courses (phases).

1. Assess: Target critical roles with high-level oversight: chief nursing officer …

From Insight To Impact: Cns Consults In The Cvicu, Sarah Beldin, Kristina Boudreau

Biennial Convention (CONV)

Clinical Nurse Specialists (CNSs) are frequently consulted for their expertise, but formalizing this process via the electronic medical record (EMR) provides new opportunities for direct correlation of utilization of the CNS as a patient intervention to outcomes improvement. This project established a structured CNS consult process in the Cardiovascular Intensive Care Unit (CVICU), enabling multidisciplinary team members to order CNS consults tied to various concerns and access detailed post-consult notes in real time.

This project aimed to formalize CNS consults in the CVICU using EMR integration to enhance interdisciplinary collaboration and improve patient outcomes. By enabling team members to request …

Innovative Teaching Strategies: Linking Social Determinants Of Health To Diabetes Management, Christine A. Sump, Donna L. Rose, Nicole Frazier

Biennial Convention (CONV)

With an estimated 38.4 million Americans having diabetes (Center for Disease Control [CDC], 2024) and well-documented diabetes disparities, it is imperative that social determinants of health (SDOH) and its impact on diabetes outcomes be an integral part of undergraduate nursing education. Literature supports a direct relationship in SDOH to diabetes prevalence, complications, and patient outcomes (American Diabetes Association [ADA], 2024; Hill-Briggs & Fitzpatrick, 2023). There is much literature describing learning strategies in diabetes education. However, there is minimal literature regarding SDOH research in nursing curricula (Lee & Wilson, 2020; Liu et al., 2023). There was no literature support found that …

Women’S Experiences With Traditional Medicine For Treatment Of Cervical Cancer: A Qualitative Study, David Asakitogum, Lydia Aziato, Lillian Akorfa Ohene

Biennial Convention (CONV)

Background: Over 60% of patients with cancer in sub-Saharan Africa used traditional medicine for cancer treatment (Alegbeleye et al., 2020, Mwaka et al., 2020). The common predictors of traditional medicine use include being a female (Kristoffersen et al., 2022, Aboufaras et al., 2023). However, there is limited empirical information about the experiences of women with traditional medicine usage for the treatment of cervical cancer. The current study explored the experiences of women who used traditional medicine for the treatment of cervical cancer in Accra, Ghana.

Methods: An exploratory qualitative research design was used in this study. A semi-structured interview …

Integrating The 'My Pt Care Strategy' Into Behavioral Health Nursing Curriculum: Reflective Insights, Nadia Ali Muhammad Ali Charania, Lorraine Wadlington, Mona Shattell

Biennial Convention (CONV)

Professional development for nursing educators in person-centered care (PCC) is essential for advancing its integration within academic and clinical settings, particularly in preparing nursing professionals to address the complexities of modern healthcare. The World Health Organization (2022) emphasizes the necessity of inclusive stakeholder engagement in mental health care, while organizations such as the American Association of Colleges of Nursing (2021) and Quality and Safety Education for Nurses (2020) advocate for holistic, evidence-based and individualized care. Despite these guidelines, there are gaps in effectively incorporating PCC within mental health services, underscoring the urgent need for innovative educational approaches.

The newly developed …

Red Midge Larvae Are An Invertebrate Alternative Diet To Beef Liver For Planarian Husbandry, Jonah Pacis , '25, Danielle Ireland, Evangeline Coffinas, Jerome Sheehan, Kate Sun , '27, Eva-Maria S. Collins

Biology Faculty Works

Freshwater planarians are an emerging model for toxicology and neuroscience because of their amenability to rapid behavioral screening and remarkable ability to regenerate a cephalized nervous system. As invertebrates, planarians can help reduce the use of vertebrates in research; however, laboratories typically maintain planarians on diets of homogenized organic beef or chicken liver, raising ethical concerns with feeding a vertebrate diet. Organic liver is difficult to obtain, and preparation methods vary, introducing intra- and interlaboratory variability. Here, we show that Dugesia japonica planarians can be maintained for over a year on commercially available red midge larvae (RML), a natural prey …

Success Rate Of Ultrasound-Guided Intravenous Intervention In Difficult Intravenous Access Patients, Evelyn Almera Factora Mulvaney

Biennial Convention (CONV)

Background: Traditional visualization, palpation, and landmarking peripheral veins for IV access are not helpful in patients with difficult veins. However, multiple studies and publications on difficult intravenous access (DIVA) of hospitalized patients have shown that using ultrasound to guide the cannulation of a peripheral vein improves the success rate in the first attempt to establish IV access in DIVA patients.

Purpose: This evidence-based practice (EBP) change project aims to train critical care nurses on the use of ultrasound in patients with difficult IV access and to increase first attempts on DIVA patients with the use of ultrasound.

Methods: The translational …

The Mechanism Of Action Of Remote Electrical Neuromodulation (Ren) In Treating Migraine And Potentially Other Idiopathic Pain Conditions, Marius Birlea, Christopher L. Robinson, Eden Mama, Alit Stark-Inbar, Alon Ironi, Daniel Atashsokhan, Thomas Berk

College of Nursing Faculty Papers & Presentations

Purpose of Review

This review provides evidence for the mechanism of action (MOA) of Remote Electrical Neuromodulation (REN), a non-pharmacological therapeutic technology for treating migraine and other symptoms manifested by certain idiopathic pain diseases. It discusses the main physiological and anatomical aspects associated with conditioned pain modulation (CPM), and how REN is applied for the treatment of migraine pain and other symptoms.

Recent Findings

The REN wearable device (Nerivio®) is FDA cleared for acute and preventive treatment of migraine in patients aged 8 years and above, and CE marked in patients aged 12 and above. In brief, the REN MOA …

Adolescent Sexting: An Exploration Of Teacher’S Perspectives Of The Relationship And Sex Education (Rse) Based Curriculum, Grace Byrne, Leigh-Ann Sweeney, Sinead Tobin

Irish Journal of Applied Social Studies

Sexting has emerged as a normative aspect of adolescent sexual exploration in Ireland and internationally. While much attention has been given to the risks and negative aspects of sexting, contemporary literature highlights the potential positives associated with adolescent sexting. Within this precarious context, little is known about the attention sexting commands within formal education of adolescents in Ireland. To better understand teachers’ perspectives of the positionality of sexting within Relationship and Sex Education (RSE) curriculum in Ireland, the researchers employed a qualitative interpretivist approach in interviewing eight RSE teachers actively delivering sex education in Irish secondary schools. Teacher’s narratives were …

Apocalypticism And Prognostication In Early ShiʿI Literature, Mohammad Amin Mansouri

All Faculty Scholarship for the College of Arts and Humanities

This article studies the origins of Jafr, an apocalyptic, eschatological and occult book attributed to the first Shiʿi imam, ʿAlī ibn Abī Ṭālib (d. 661). While it remains unclear whether Jafr was ever physically composed, it became associated with lettrism (ʿilm al-ḥurūf) in medieval Sunni and Shiʿi literature. Jafr gradually evolved into a crucial component of Islamic occult traditions and influenced various cosmological theories as well as the letter-magic practices of prominent Sunni and Shiʿi occultists. Despite its historical significance, confusion regarding Jafr’s roots, authorship and content in Shiʿi sources from the third to fifth centuries AH …

Crispr Disruption Of Scarna1 Reduces Pseudouridylation In Spliceosomal Rna U2 At U89 And Perturbs The Transcriptome In Hek293t Cells, Amanda Gardner-Kay, Lynndy Le, Michael Filla, Nataliya Kibiryeva, James E. O'Brien Jr., Douglas C. Bittel

Student Publications

Small Cajal body-associated RNAs (scaRNAs) are essential for biochemical modification of spliceosomal RNAs and spliceosome function. Changes in scaRNA expression level have been associated with developmental issues, including cancer and congenital heart defects (CHDs), although the mechanism remains unclear. Small Cajal body-associated RNA 1 (scaRNA1) guides pseudouridylation at uridine 89 (Ψ89) of the spliceosomal RNA U2, a highly conserved modification that may be critical for spliceosome function. To investigate the role of scaRNA1 in splicing regulation, CRISPR-Cas9 genome editing was used to introduce targeted deletions in the scaRNA1 locus in HEK293T cells. Edited clones were identified by T7 endonuclease I …

Developing Ehealth Interventions To Improve Diabetes Management In Emerging Adulthood: Qualitative Formative Study, Susan Eggly, Steven J Ondersma, Deborah A Ellis

Faculty, Staff and Student Publications

Background: Emerging adulthood is a high-risk period during which many with type 1 diabetes demonstrate suboptimal diabetes management and glycemic control. There is a need for effective, scalable interventions designed specifically for this population. Technology-based approaches are readily accessible to this age group. Furthermore, interventions consistent with self-determination theory-which posits that the fulfillment of psychological needs for autonomy, self-efficacy, and relatedness promotes intrinsic motivation for change-may resonate well with emerging adults' developmental needs for establishing independence and autonomy, and growing their social network.

Objective: This study aimed to enhance the potential relevance, sustainability, and efficacy of 3 self-determination theory-informed mobile …

Human Plasma Proteomic Profile Of Clonal Hematopoiesis, Linke Li, Shamsudheen K Vellarikkal, Md Mesbah Uddin, Abhishek Niroula, Gabriel Griffin, Michael C Honigberg, Amy E Lin, Christopher J Gibson, Daniel H Katz, Usman A Tahir, Shi Fang, Jacqueline S Dron, Michael Pan, Sara Haidermota, Shriienidhie Ganesh, Tajmara Antoine, Joshua Weinstock, Thomas R Austin, Gina M Peloso, Whitney Hornsby, Peter Ganz, Joann E Manson, Bernhard Haring, Charles Kooperberg, Alexander P Reiner, Joshua C Bis, Bruce M Psaty, Yuan-I Min, Adolfo Correa, Leslie A Lange, Wendy S Post, Jerome I Rotter, Stephen S Rich, James G Wilson, Benjamin L Ebert, Bing Yu, Christie M Ballantyne, Josef Coresh, Vijay G Sankaran, Alexander G Bick, Siddhartha Jaiswal, Robert E Gerszten, Nhlbi Trans-Omics For Precision Medicine, Peter Libby, Rajat M Gupta, Pradeep Natarajan

Faculty, Staff and Student Publications

Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 participants (3881 with CHIP) from TOPMed and UK Biobank (UKB) with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2917 proteins by Olink in UKB), we identify 32 and 345 proteins from TOPMed and UKB, respectively, associated with CHIP and most prevalent driver genes (DNMT3A, TET2, and ASXL1). These …

Ottawa Needs Legal Tools To Hit Back In Trade Wars, Barry Appleton

Other Publications

No abstract provided.

Feasibility And Acceptability Of An Implementation Strategy To Enhance Use Of Classroom-Based Physical Activity Approaches In Elementary Schools: A Mixed Methods Study, Kempson Onadeko, Maria E Fernández

Faculty, Staff and Student Publications

Background: Classroom-based approaches are an evidence-based way to improve children's physical activity; however, they are inconsistently implemented in schools. We developed MAGIC (Movement for Academic Growth In Classrooms), a multifaceted implementation strategy that consists of leadership training, teacher training, and a monthly newsletter to improve use of classroom-based physical activity approaches. The purpose of this study is to examine the feasibility and acceptability of MAGIC among elementary school teachers and leaders.

Methods: We used an embedded, convergent mixed methods design. We provided the MAGIC implementation strategy to a partner elementary school. We then administered surveys to teachers to quantitatively examine …

Met Overexpression Is Associated With Superior Immunotherapy Benefit In Advanced Non-Small Cell Lung Cancer, Luisa M Solis Soto, Waree Rinsurongkawong, Bingnan Zhang, Haniel A Araujo, Yasir Y Elamin, Mehmet Altan, Claudio A Arrechedera, Jianling Zhou, Khaja B Khan, Wei Lu, Elliana Young, Carl M Gay, Tina Cascone, Lauren A Byers, Ferdinandos Skoulidis, George Blumenschein, Frank V Fossella, Anne Tsao, Marcelo V Negrao, Natalie Vokes, Jia Wu, Hai T Tran, Ignacio I Wistuba, J Jack Lee, Don L Gibbons, Ara A Vaporciyan, John V Heymach, Xiuning Le, Jianjun Zhang

Faculty, Staff and Student Publications

Background/objectives: MET overexpression is common in non-small cell lung cancer (NSCLC). The correlation between MET overexpression and immune checkpoint inhibitor (ICI) efficacy in NSCLC is underexplored.

Methods: In this retrospective observational cohort study, we curated a dataset of 279 stage IV NSCLC patients who received ICI treatment and had MET expression assessed by CLIA-certified immunohistochemistry (IHC) assay. MET expression was graded on a scale from 0 to 3+, with overexpression defined as 2+ or 3+. Clinicopathological features associated with MET expression were assessed using logistic regression. Overall survival (OS) and progression-free survival (PFS) were evaluated via Kaplan-Meier analysis and the …

Improving Diagnostic Accuracy In Preoperative Glioma Classification: Performance Of Knowledge-Enhanced Large Language Models Compared With Radiologists, Wei Hu, Bing Wu, Xiaobo Zhou, Guotai Wang, Kang Li, Qiang Yue

Faculty, Staff and Student Publications

Accurate preoperative MRI classification of gliomas is essential but challenging due to complex radiological features and inter-observer variability. This study evaluated three large language models (LLMs) for VASARI-based glioma classification compared to radiologist interpretations. We retrospectively analyzed 150 histopathologically confirmed gliomas (43 circumscribed astrocytic, 53 high-grade diffuse, 54 low-grade diffuse gliomas) using standardized MRI protocols. Three radiologists extracted VASARI features, while three LLMs (GPT-4, Claude3.5-Sonnet, Claude3.0-Opus) analyzed these features using standard input-output or knowledge-enhanced prompting incorporating diagnostic guidelines. Knowledge-enhanced prompting consistently outperformed standard prompting, improving diagnostic consistency (intra-model agreement: Sonnet κ = 0.91, Opus κ = 0.92, GPT-4 κ = …

Transdisciplinary Perspectives On Ai: The Fourth Annual Conference Of The European Culture And Technology Laboratory, Connell Vaughan, Ioana Madalina Moldovan, Silivan Moldovan, Noel Fitzpatrick

Books/Book Chapters

The fourth annual conference of the ECT Lab+ was hosted by Technical University of Cluj-Napoca over two days in October 2024 at the Cluj Innovation Park. The conference brought together experts from the Arts, Humanities, Social Sciences, Technology, and other fields to discuss and reflect on the advent of Artificial Intelligence and how the associated technologies are transforming how we live, work and study. Under the title Transdisciplinary perspectives on AI: Alternative Histories, Current Practices and Possible Futures the conference moved beyond simplistic technophila and technophobia to consider whether we can co-evolve with these new technologies which combine machine learning …

Non-Invasive Ultrasonic Neuromodulation Of The Human Nucleus Accumbens Impacts Reward Sensitivity, Siti N Yaakub, John Eraifej, Nadège Bault, Mathilde Lojkiewiez, Elouan Bellec, Jamie Roberts, Noah S Philip, Amir Puyan Divanbeighi Zand, Alexander L Green, Matthew F S Rushworth, Elsa F Fouragnan

School of Psychology

Precisely neuromodulating deep brain regions could bring transformative advancements in both neuroscience and treatment. We demonstrate that non-invasive transcranial ultrasound stimulation (TUS) can selectively modulate deep brain activity and affect learning and decision making, comparable to deep brain stimulation (DBS). We tested whether TUS could causally influence neural and behavioural responses by targeting the nucleus accumbens (NAcc) using a reinforcement learning task. Twenty-six healthy adults completed a within-subject TUS-fMRI experiment with three conditions: TUS to the NAcc, dorsal anterior cingulate cortex (dACC), or Sham. After TUS, participants performed a probabilistic learning task during fMRI. TUS-NAcc altered BOLD responses to reward …

Circadian Rhythm Disruption Is Related To Self-Diagnosis Of Mental Illness, Ruth E. Propper, John Kang, Michael Sawyer

Department of Psychology Faculty Scholarship and Creative Works

Purpose

The goal of this research was to examine the relationship between self-reported circadian disruption during the week and on weekends, and self-diagnosis of mental illness. It was hypothesized that circadian disruption would be associated with mental illness self-diagnosis.

Methods

Using previously collected data wherein undergraduate students completed a series of questionnaires we examined Weekday bedtime/waketime variability, measured via question two from the Sleep Disorders Symptom Check List -- 25, and calculated social jetlag score, examining these as a function of Mental Illness Diagnosis Category and Sex.

Results

Increased circadian disruption was significantly associated with more self-diagnosed mental illnesses ( …

The 23rd International Medical, Pharmaceutical, Cosmeceutical And Health Science Symposium (Impachs), Sultan Qaboos University

Sultan Qaboos University Medical Journal

No abstract provided.

Synthesis Of Sustainable Self-Foaming Glass Ceramics Using Waste Glass And Aluminium Dross, Abba Musa Hassan

Student Works (2020-2029)

The growing global demand for sustainable materials has driven extensive research into lightweight insulating materials, such as self-foaming glass ceramics (SFGCs), which align closely with the principles of a circular economy. While the alkali activation of aluminosilicates offers an environmentally friendly alternative to conventional, energy-intensive industrial methods for producing glass-based foams, current approaches often depend on synthetic foaming agents, high-speed agitation, and elevated sintering temperatures. These factors adversely affect slurry rheology, resulting in suboptimal microstructures, reduced mechanical strength, increased production costs, and negative environmental impacts. This study contributes to the advancement of the field by developing eco-friendly SFGCs using soda-lime …

How Experiencing Eudaimonic Emotions Through Music Shapes Prosocial And Altruistic Behavior: Introducing A Unified Model Of Music-Listening-Induced Eudaimonia (Ummie), Rebecca Tukachinsky Forster, Daniel H. Spitz, Tal-Chen Rabinowitch, Roni Granot

Communication Faculty Articles and Research

This paper introduces the Unified Model of Music-Listening Induced Eudaimonia (UMMIE), which offers an integrated novel theoretical framework to explain how music listening promotes prosocial and altruistic outcomes. Drawing on communication and psychology research, UMMIE maintains that elicitation of eudaimonic emotions can be appraised inwards, towards oneself, and thus contribute to the individual's personal growth, wellbeing, and development, or outwards, by connecting to something bigger than oneself, to humanity in general, which could possibly then lead to enhanced prosocial and altruistic attitudes and behaviors. The model specifies musical, situational, and individual variables that serve as moderators and increase the likelihood …

The Clinical Pharmacist As Principal Investigator—2026, Dave L. Dixon, Leo F. Buckley, Raniah Aljadeed, William L. Baker, Samuel C. Greer, Amy Y. Kang, S. Casey Laizure, Abbie D. Leino, Robert Maclaren, Milap C. Nahata, Tien M. H. Ng, Elaine Nguyen

Pharmacy Faculty Articles and Research

The American College of Clinical Pharmacy (ACCP) first described the role and history of the pharmacist as principal investigator (PI) in 2000. An update was published in 2010, citing evidence from NIH and the ClinicalTrials.gov registry that showed an increase in the number of individuals with a Pharm.D. degree engaging in pharmacist-directed research. The 2025 ACCP Publications Committee was charged with providing an update to the 2010 paper. Key findings include a substantial increase in the total amount of federal funding awarded to schools of pharmacy (SoP) between 2011 and 2023, a modest increase in the number of pharmacists receiving …

A Phase 1/2 Study Of Ds-1594 Menin Inhibitor In Relapsed/Refractory Acute Leukemias, Jayastu Senapati, Marina Konopleva, Ghayas C Issa, Elias Jabbour, Tapan Kadia, Gautam Borthakur, Nicholas J Short, Musa Yilmaz, Indraneel Deshmukh, Joie Alvarez, Sanam Loghavi, Guilin Tang, Hussein A Abbas, Michael Andreeff, Kapil Bhalla, Narasimha M Midde, Nabil Said, Amy Noyalis, Derek E Mires, Jing Ning, Lianchun Xiao, Farhad Ravandi, Guillermo Garcia-Manero, Hagop M Kantarjian, Naval G Daver

Faculty, Staff and Student Publications

Several menin inhibitors are in development targeting menin dependent leukemias, however available preclinical results show variable level of activity. We report the phase 1 portion (to establish a recommended phase 2 dose [RP2D]) and pharmacokinetic analysis of a phase 1/2 first-in-human clinical trial of DS-1594b menin inhibitor. Eligible patients included adults (≥ 18 years of age) with relapsed/refractory (R/R) acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) including but not restricted to those with KMT2A-rearrangement (r) or NPM1 mutation. Seventeen patients at a median of age 56 years (range, 19-82 years) were treated, 15 (88%) had R/R AML, and …

Soluble Immune Factor Profiles In Blood And Csf Associated With Lrrk2 Mutations And Parkinson's Disease, Roshni Jaffery, Yuhang Zhao, Sarfraz Ahmed, Jackson G Schumacher, Jae Ahn, Yujia Wang, Jiayin Zhang, Ken Chen, Hussein Tawbi, Jian Wang, Michael A Schwarzschild, Weiyi Peng, Xiqun Chen

Faculty, Staff and Student Publications

Mutations in LRRK2, a leading genetic cause of Parkinson's disease (PD), are linked to immune dysregulation, but the immune profiles in the periphery and central nervous system (CNS) remain incompletely defined. This study utilized a large cohort of serum samples (n = 651) and matched CSF samples (n = 129) from LRRK2 mutation carriers and non-carriers, with and without PD, to assess immune regulators using Luminex immunoassay. After correction for multiple comparisons, LRRK2 mutations were associated with significantly elevated serum levels of SDF-1 alpha and TNF-RII, while CSF markers such as BAFF, CD40L, and IL-27 were nominally reduced. Regardless of …

Brain Power Comparison Between Microgravity And Head-Down Tilt Bed Rest: An Electroencephalography Approach, María Sevilla-García, Adrián Quivira-Lopesino, Pablo Cuesta, Sandra Pusil, Ricardo Bruña, Patrique Fiedler, Fernando Maestu, Ana Maria Cebolla, Guy Cheron, Katharina Brauns, Alexander C Stahn, Michael E Funke

Faculty, Staff and Student Publications

This study examines neurophysiological changes in microgravity by comparing EEG data from two ground analog 60-day head-down tilt bed rest (HDBR) experiments (ESA/DLR “Cocktail” and “RSL”) and the NEUROSPAT experiment in space. The primary objective was to determine whether HDBR could effectively model spaceflight’s impact on the human brain’s EEG signal. In the HDBR dataset, increases in relative delta (2–4 Hz) (p <  0.01) and theta (4–8 Hz) (p <  0.001) power bands were observed during a two-month HDBR experiment, predominantly in the left temporal and parieto-occipital regions. Conversely, the NEUROSPAT dataset showed a significant increase in beta (12–30 Hz) (p <  0.05) power in the left somatosensory cortex during in-flight conditions, suggesting a potential adaptation to disrupted proprioceptive input and motor control in microgravity. The contrasting findings between the two datasets indicate that while HDBR can simulate some aspects of microgravity, it may not serve as a model for all central nervous system changes, especially those related to proprioception and motor functions. This highlights the need for further research, including larger sample sizes, consistent EEG recording conditions, and integration of additional physiological and cognitive markers to fully understand the effects of prolonged microgravity.