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Relationships Between Psychosocial Aspects Of Stuttering And Self-Disclosure Of Stuttering In A Japanese Sample, Daichi Iimura, Saburo Takahashi, Mizuki Aoki, Kentaro Yoshizawa, Kota Yanai, Shoko Miyamoto, Michael P. Boyle Sep 2026

Relationships Between Psychosocial Aspects Of Stuttering And Self-Disclosure Of Stuttering In A Japanese Sample, Daichi Iimura, Saburo Takahashi, Mizuki Aoki, Kentaro Yoshizawa, Kota Yanai, Shoko Miyamoto, Michael P. Boyle

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Purpose We aimed to psychometrically evaluate a Japanese version of the Disclosure of Stuttering Scale, from Boyle et al. (2018), and identify the psychosocial factors associated with level of stuttering self-disclosure among adults who stutter.

Methods: Adults who stutter were recruited via stuttering self-help groups in Japan and the authors’ contacts. Participants completed their demographics, the Disclosure of Stuttering Scale and other psychological scales assessing affective, cognitive, and social aspects of stuttering via an online survey. We analyzed 180 participants after those with unreliable or duplicate responses were excluded. The scale’s reliability and validity were confirmed, and multiple linear regression …


Relationships Between Psychosocial Aspects Of Stuttering And Self-Disclosure Of Stuttering In A Japanese Sample, D Iimura, S Takahashi, M Aoki, K Yoshizawa, K Yanai, S Miyamoto, Michael P Boyle Sep 2026

Relationships Between Psychosocial Aspects Of Stuttering And Self-Disclosure Of Stuttering In A Japanese Sample, D Iimura, S Takahashi, M Aoki, K Yoshizawa, K Yanai, S Miyamoto, Michael P Boyle

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Purpose: We aimed to psychometrically evaluate a Japanese version of the Disclosure of Stuttering Scale, from Boyle et al. (2018), and identify the psychosocial factors associated with level of stuttering self-disclosure among adults who stutter. Methods: Adults who stutter were recruited via stuttering self-help groups in Japan and the authors' contacts. Participants completed their demographics, the Disclosure of Stuttering Scale and other psychological scales assessing affective, cognitive, and social aspects of stuttering via an online survey. We analyzed 180 participants after those with unreliable or duplicate responses were excluded. The scale's reliability and validity were confirmed, and multiple linear regression …


Ask Dr. Wang: A Community Conversation On Ai At Cary Library, Stephen Yang, Zhengjia Yang, Julie Yin, Eric Gu, Jiawei Liu Sep 2026

Ask Dr. Wang: A Community Conversation On Ai At Cary Library, Stephen Yang, Zhengjia Yang, Julie Yin, Eric Gu, Jiawei Liu

Paul English Applied Artificial Intelligence (AI) Institute Publications

This report describes a community engagement project by the Youth STEAM Initiative (YSI) in conjunction with a public talk by Dr. Haixun Wang, “How AI Remembers, Imagines, and Creates,” held at the Cary Memorial Library in Lexington, Massachusetts. Prior to the talk, YSI collected questions and perspectives from community members through an online survey, gathering thirteen responses spanning students, parents, and professionals. This report summarizes the talk, themes that emerged from those responses, the community’s views on AI creativity, and reflections from the YSI team.


Constrained Multiview Contrastive Learning For Jointly Supervised Representation Learning, Siyuan Dai, Kai Ye, Kun Zhao, Yang Du, Haoteng Tang, Liang Zhan Sep 2026

Constrained Multiview Contrastive Learning For Jointly Supervised Representation Learning, Siyuan Dai, Kai Ye, Kun Zhao, Yang Du, Haoteng Tang, Liang Zhan

Computer Science Faculty Publications

Purpose

To develop a mutual information (MI)–based mechanism for quantifying representation distance, and to introduce a constrained multiview learning paradigm that dynamically re-ranks and selects sample views, thereby improving contrastive representation learning for lung lesion segmentation on CT images—addressing the difficulty of measuring distances in high-dimensional feature spaces and the impracticality of constructing large positive–negative sample banks in the medical domain.

Materials and Methods

The proposed framework, termed MIMIC (Mutual Information-based constrained Multi-view Contrastive learning), generates multiple frequency-domain views of CT images and performs a dynamic MI-based representation re-ranking and selection process to improve the quality of positive and negative …


Dancing In Circles: Bon Dance As Performance Of The Past, Travis Robb Kim Sep 2026

Dancing In Circles: Bon Dance As Performance Of The Past, Travis Robb Kim

Dissertations, Theses, and Capstone Projects

This capstone project traces the contours of the Japanese folk dance tradition of Bon Dance in Hawaiʻi through the nuances of public scholarship, diaspora, and racial capitalism by producing an original play which aims to perform the knowledge and praxis which the performance ritual puts forward. Treating Bon Dance as muse, the original play examines the necessity of turning to the past in order to disrupt a future made inevitable by oppressive systems; a fiction that comments on and critiques the predictive and generative technologies that have embedded themselves into society at large. Through intertwining conversations that explore prophecy and …


Sedentary Behaviors And Functional Disability Among Chinese Older Adults (2008–2018): Evidence Including Mahjong, Yen-Han Lee, Yen-Chang Chang, Minzhi Ye, Cai Xu Sep 2026

Sedentary Behaviors And Functional Disability Among Chinese Older Adults (2008–2018): Evidence Including Mahjong, Yen-Han Lee, Yen-Chang Chang, Minzhi Ye, Cai Xu

School of Social Work Faculty Publications

Purpose: This study examined how different types of sedentary behavior relate to changes in functional disability, measured by activities of daily living (ADL) and instrumental activities of daily living (IADL), among Chinese older adults.

Major findings: Using data from 17,939 participants in four waves (2008–2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), sedentary behavior was categorized into four types: none, playing mahjong only, combining these with other sedentary activities, and other activities alone (e.g., reading and watching TV). Cox two-state regression models estimated the hazard of transitioning in ADL and IADL disability. Engaging in sedentary behaviors was generally …


Impact Of Exercise On Mental Health In Inpatient Settings, Samuel Blake Rn, Nathaniel Clark Rn Sep 2026

Impact Of Exercise On Mental Health In Inpatient Settings, Samuel Blake Rn, Nathaniel Clark Rn

Nurse Residency

In adult psychiatric inpatients with mental illness, how does participation in a structured exercise program compared with standard inpatient care affect depression, anxiety, and overall mental health outcomes during hospitalization?


Night Shift-Specific Training & Engagement, Keith Procell Rn, Kyleigh Keitel Rn Sep 2026

Night Shift-Specific Training & Engagement, Keith Procell Rn, Kyleigh Keitel Rn

Nurse Residency

In night shift hospital workers (P) does mandatory daytime attendance for required education (I), compared to shift-aligned, asynchronous, or flexible scheduling of education (C), increase health risks associated with circadian disruption (O), as supported by current research?


Ask The Professor: How Will The Recent U.S. Supreme Court Decision In Sripetch Impact Future Sec And Cftc Disgorgement Cases?, Ronald Filler Sep 2026

Ask The Professor: How Will The Recent U.S. Supreme Court Decision In Sripetch Impact Future Sec And Cftc Disgorgement Cases?, Ronald Filler

Articles & Chapters

No abstract provided.


Algorithm Aversion In Academic Libraries: User Resistance To Ai-Enabled Discovery And Search Services, Fenfang Cao, Lvting Bu, Yi Huang, Yu Chi, Hengyi Fu Sep 2026

Algorithm Aversion In Academic Libraries: User Resistance To Ai-Enabled Discovery And Search Services, Fenfang Cao, Lvting Bu, Yi Huang, Yu Chi, Hengyi Fu

Faculty Research, Scholarly, and Creative Activity

Academic libraries increasingly deploy AI-enabled services such as intelligent search, recommendation systems, and chat-based assistance to support scholarly resource discovery. However, some users remain reluctant to rely on these tools. This phenomenon, often described as algorithm aversion, has been widely examined in healthcare and finance but remains underexplored in library contexts. This study investigates the factors associated with algorithm aversion in academic digital libraries and examines how these factors relate to one another. A two-phase mixed-method design was adopted. First, 41 semi-structured interviews with users from Chinese university libraries were analyzed using grounded theory. This stage produced 58 initial concepts, …


The Impact Of Stigma On The Mmpi-3 Scores Of An Indo-Caribbean Community Sample, Julia Persaud-Naipaul Sep 2026

The Impact Of Stigma On The Mmpi-3 Scores Of An Indo-Caribbean Community Sample, Julia Persaud-Naipaul

Theses and Dissertations

Evaluation of personality and psychological disorders is accomplished through the use of psychometric measures. However, tests require interpretation of test responses using a normative criterion based on a particular population that may not fully consider the effect of cultural influences on an individual’s level of willingness to report psychological difficulties. For example, individuals in collectivistic cultures may not be as willing to self-report problems because mental illness is often perceived as a source of embarrassment and shame. One culturally unique population that has been overlooked in psychological assessment is the Indo-Caribbean population. Their specific cultural values, beliefs, attitudes, and practices …


Combining Acute Alcohol Administration With Accelerated Prefrontal Theta Burst Stimulation, Michael J. Wesley, William J. Mcgarrigle, Mark T. Fillmore Sep 2026

Combining Acute Alcohol Administration With Accelerated Prefrontal Theta Burst Stimulation, Michael J. Wesley, William J. Mcgarrigle, Mark T. Fillmore

Psychology Faculty Publications

Introduction: Acute alcohol intoxication impairs inhibitory control. Intermittent theta-burst stimulation (iTBS) of the dorsolateral prefrontal cortex may alter executive control, but little is known about whether accelerated iTBS can be combined with controlled alcohol administration. Methods: This double-blind, sham-controlled pilot study evaluated feasibility and preliminary behavioral effects of accelerated left prefrontal iTBS during acute alcohol intoxication in healthy young adults (N = 10). Participants completed a Cued Go/No-Go task at baseline and near peak breath alcohol concentration after active or sham iTBS delivered in two bouts separated by 30 min. Results: All participants in the analytic sample completed both stimulation …


Nicotine Self-Administration Suppresses Both Pro- And Anti-Inflammatory Accumbens Cytokines But Does Not Induce Apoptosis In Female Rats, Ashley M. White, Daryl L. Richie, Percell T. Kendrick, Kathleen R. Mcnealy, Robert M. Flight, Hunter N.B. Moseley, Christa L. Corley, Cassandra D. Gipson Sep 2026

Nicotine Self-Administration Suppresses Both Pro- And Anti-Inflammatory Accumbens Cytokines But Does Not Induce Apoptosis In Female Rats, Ashley M. White, Daryl L. Richie, Percell T. Kendrick, Kathleen R. Mcnealy, Robert M. Flight, Hunter N.B. Moseley, Christa L. Corley, Cassandra D. Gipson

Psychology Faculty Publications

Nicotine can alter neuroimmune signaling within the brain reward pathway, and specifically, within the nucleus accumbens (NAc). Despite clinically meaningful sex differences in nicotine use as well as known sex differences in immune system function, no studies have evaluated NAc neuroimmune consequences following nicotine use in females. Thus, the present study evaluated cytokine expression and neuronal apoptosis in the ventral striatum (which encompasses the NAc) in ovary-intact female Long-Evans rats following nicotine or saline self-administration. Circulating cytokine levels were also evaluated in serum. Overall, pro-inflammatory cytokine levels were suppressed within the ventral striatum, with tumor necrosis factor-alpha (TNFα) being the …


Tailoring The Unified Protocol For The Treatment Of Burnout, Athena Gândilă, Andrei Rusu, Zselyke Pap, Bogdan T. Tulbure, Delia Vîrgă, Shannon Sauer-Zavala Sep 2026

Tailoring The Unified Protocol For The Treatment Of Burnout, Athena Gândilă, Andrei Rusu, Zselyke Pap, Bogdan T. Tulbure, Delia Vîrgă, Shannon Sauer-Zavala

Psychology Faculty Publications

Burnout persists as an unresolved issue, as the effectiveness of interventions remains a subject of ongoing debate. To address the need for more suitable intervention approaches, this study describes a methodology for adapting the Unified Protocol (UP), an evidence-based cognitive-behavioral intervention, for group-based use to treat burnout. To ensure that the intervention reflected lived experiences, we employed a co-design methodology based on the Experience-Based Co-Design Framework. The sample comprised participants currently experiencing burnout or who had experienced it within the past year (n = 4) and a panel of experts (n = 4) actively working with individuals experiencing burnout. The …


Tennessee Archivist 45, No. 4, Society Of Tennessee Archivists Sep 2026

Tennessee Archivist 45, No. 4, Society Of Tennessee Archivists

Tennessee Archivist newsletters

Fall 2026 issue of the Tennessee Archivist, a newsletter produced by the Society of Tennessee Archivists.


Identifying Influential Drivers To The Utilization Of Prefabrication On Student Housing At Cal Poly: A Case Study On The Delivery Method, Dominique Giang Sep 2026

Identifying Influential Drivers To The Utilization Of Prefabrication On Student Housing At Cal Poly: A Case Study On The Delivery Method, Dominique Giang

Construction Management

As universities experience increasing enrollment and housing shortages, student housing projects require efficient delivery methods capable of meeting strict occupancy deadlines while minimizing disruption to active campus environments. This research investigates the influential drivers behind the utilization of prefabrication on an ongoing student housing project at California Polytechnic State University, San Luis Obispo. The seven-story project consists of 417 student beds and incorporates repetitive layouts and prefabricated building components. Through qualitative interviews with key project stakeholders involved in early decision-making and field execution, the study examines how project objectives, construction constraints, and delivery considerations influenced the decision to implement prefabrication. …


Whose Job Is It To Care For The Poor? Public Support, Private Charity, And Crowding Out In Canada Since 1960, Sandra J. Peart Sep 2026

Whose Job Is It To Care For The Poor? Public Support, Private Charity, And Crowding Out In Canada Since 1960, Sandra J. Peart

Jepson School of Leadership Studies articles, book chapters and other publications

Executive Summary 

  • This study explores whether increased public spending has “crowded out” private donations to charitable organizations. 
  • Private charities emerged during industrialization to provide mutually beneficial services to individuals in need. 
  • In Canada, government social spending increased both on a per capita basis and as a percentage of GDP after 1961. The percentage of GDP allotted to social spending rose and fell from then until the late 1990s, but rose thereafter, with a spike during the COVID years. It has fallen and risen gradually since 2022. 
  • All in all, social benefit spending as a percentage of GDP has roughly doubled, …


Cattle Industry Funding Scheme 2024-25 Annual Report, Department Of Primary Industries And Regional Development, Western Australia Sep 2026

Cattle Industry Funding Scheme 2024-25 Annual Report, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

The Cattle IFS addresses pest and disease threats relevant to the biosecurity of the WA Cattle industry and currently operates across the whole of WA. The IFS contribution is paid on the sale of cattle (0.20 cents per head/carcass) produced within WA.


Opposition To Renewable Energy Facilities In The United States: September 2026 Edition, Romany M. Webb, Ivonne Norman Sep 2026

Opposition To Renewable Energy Facilities In The United States: September 2026 Edition, Romany M. Webb, Ivonne Norman

Sabin Center for Climate Change Law

For the first time in nearly 2 decades, the United States is seeing rapid growth in electricity demand, driven by the data center boom as well as expanding electrification. Total electricity use in the United States reached a record high of 4,430 terawatt hours (TWh) in 2025 — almost 3 percent above 2024 levels — and is expected to continue growing at a similar rate through 2050. Meeting this increased demand, while continuing to advance action on climate change, will require a massive ramp up in renewable energy development. Notable progress was made in 2025, with utility-scale solar generation in …


Graduate School Blog - September 2026, Cynthia Haynes Sep 2026

Graduate School Blog - September 2026, Cynthia Haynes

UofM Grad School Blog

This issue spotlights Dr. Deborah Tollefsen’s latest Removing Barriers to Graduate Student Success installment on graduate students who are also parents and the importance of institutional support. We also highlight a UofM graduate alumna, upcoming graduate student events, the Fall 2026 Mastering Graduate School Webinar Series, and opportunities to connect through the Graduate Student Association.


Deterring Political Deceit: A Constitutional Argument To Defend The People's Democracy (2026), David Chang Sep 2026

Deterring Political Deceit: A Constitutional Argument To Defend The People's Democracy (2026), David Chang

Books

More than ever, influencers and politicians communicate political messages that they do not believe to be true. This political deceit is constitutionally valueless, harms public discourse, and impedes effective public decision-making. Yet, under current doctrine, the Supreme Court would invalidate any regulation of deceitful political advocacy as an abridgment of political speech.

In Deterring Political Deceit, David Chang explores why traditional efforts to target falsity in political speech have been rooted in constitutional error. While the Court has determined that the defamation of public officials is unprotected, it wrongly declared that false statements of fact lack constitutional value, and …


September 2026, Office Of Sustainability Sep 2026

September 2026, Office Of Sustainability

Office of Sustainability Newsletter

No abstract provided.


Biocorrosion And Biocompatibility Of Absorbable Mg-Li-Y Wires For Temporary Cardiovascular Scaffolds, Mitchell L. Connon, Weilue He, Ryan Jacoby, Kenneth Macleod, Carolyn W. Czerniak, Keith W. Macrenaris, Calum Macleod, David Bow, Alex Lamere, Zoe Haase, Jeremy Goldman, Mark Steckel, Roger J. Guillory Sep 2026

Biocorrosion And Biocompatibility Of Absorbable Mg-Li-Y Wires For Temporary Cardiovascular Scaffolds, Mitchell L. Connon, Weilue He, Ryan Jacoby, Kenneth Macleod, Carolyn W. Czerniak, Keith W. Macrenaris, Calum Macleod, David Bow, Alex Lamere, Zoe Haase, Jeremy Goldman, Mark Steckel, Roger J. Guillory

Michigan Tech Publications

The use of bioabsorbable metals in cardiovascular applications has shown potential to offer clinical advantages over conventional permanent materials such as stainless steel or cobalt-chromium. Among these, magnesium (Mg) is at the forefront of research for bioabsorbable stent design due to its favorable biocompatibility, suitable mechanical properties, controlled absorption kinetics, and a growing body of supportive clinical data. In this study, we determined that the novel magnesium-lithium-yttrium alloy system featured excellent properties as a bioabsorbable material candidate. The corrosion behavior and histological response were assessed at two levels of yttrium content, 0.5% and 2.0% (by weight). This study found that …


Pengembangan Media Komik Untuk Meningkatkan Pengetahuan Tentang Menggambar Komik Pada Peserta Didik Kelas Viii Smpn 15 Kota Malang, Khairani Indah Damayanti, Abdul Rahman Prasetyo Sep 2026

Pengembangan Media Komik Untuk Meningkatkan Pengetahuan Tentang Menggambar Komik Pada Peserta Didik Kelas Viii Smpn 15 Kota Malang, Khairani Indah Damayanti, Abdul Rahman Prasetyo

Journal of Innovation and Teacher Professionalism

This study was motivated by students’ limited understanding of comic drawing concepts and the need for learning media to support art education. It aimed to analyze learning needs, develop comic-based learning media, and examine its feasibility, practicality, and effectiveness. The study employed a Research and Development (R&D) approach using the ADDIE model, comprising analysis, design, development, implementation, and evaluation. The implementation involved 29 eighth-grade students at SMPN 15 Malang, Indonesia. Media feasibility was assessed by subject-matter and media experts, practicality was evaluated based on student and teacher responses, and effectiveness was analyzed using pre-test, post-test, and N-gain scores. The validation …


Ecu-Malnett V2, Matthew G. Gaber, Mohiuddin Ahmed, Michael N. Johnstone Sep 2026

Ecu-Malnett V2, Matthew G. Gaber, Mohiuddin Ahmed, Michael N. Johnstone

Research Datasets

ECU-MALNETT (ECU MALware NETwork Traffic) is a real world, reproducible dataset of labeled benign and malicious network flows built from the Peekaboo execution corpus. Peekaboo runs evasive malware with dynamic binary instrumentation and records raw host-level PCAPs while granting full Internet access, yielding noisy, real-world captures with background OS activity and concurrent processes. To derive trustworthy labels from these traces, we apply Construct, a baseline aware, zero-trust labeling framework. Construct first ingests a baseline capture to establish reference sets (DNS qnames, HTTP hosts, TLS SNIs, and socket endpoints) and grows a conservative benign IP pool only via whitelisted DNS resolutions. …


From Green Presence To Perceived Greenery: Everyday Mobility And Perceptual Availability In Singapore, Ziheng Zeng, Sonny Rosenthal, Orlando Woods Sep 2026

From Green Presence To Perceived Greenery: Everyday Mobility And Perceptual Availability In Singapore, Ziheng Zeng, Sonny Rosenthal, Orlando Woods

Research Collection College of Integrative Studies

Urban greenery may be abundant in transit-oriented cities, yet green presence does not necessarily become perceptually available to people moving through it. This paper distinguishes green supply, perceived greenery, and green experience, and examines the step at which greenery enters awareness during travel. The study combined 21 days of ecological momentary assessment from 68 participants in Singapore, yielding 6,794 in-trip moments, and 25 route-reconstruction interviews. A satellite normalized difference vegetation index (NDVI) provided a top-down baseline of green supply, and a street-level green view index (GVI) from Google Street View (GSV), matched to 5,824 moments, provided a co-located eye-level baseline. …


The Stickiness Of Meritocratic Beliefs From Adolescence To Adulthood In Singapore, Yen Kiat Chong, Shin Bin Tan, Vincent Chua, Han Ei Chew Sep 2026

The Stickiness Of Meritocratic Beliefs From Adolescence To Adulthood In Singapore, Yen Kiat Chong, Shin Bin Tan, Vincent Chua, Han Ei Chew

Research Collection Office of Impact

The belief in meritocracy has been rising over the past few decades in developed countries. While many studies have focused on the belief in meritocracy, its distribution across groups and its effects, much less is known about how beliefs may change as individuals age and undergo major life transitions. Using linear growth models on three waves of panel data from a national youth survey in Singapore, we found that the major life transitions to adulthood – progressing through the education system (e.g., completing tertiary education), transiting from full-time studies to full-time work, getting married and becoming a parent – predicted …


Biodesulfurization Of Crude Oil Using Locally Isolated Pseudomonas Aeruginosa From Oil-Contaminated Soil In Iraqi Kurdistan, Yousif Mohammed Sharif, Sherwan Mohammed Simo, Lokman Aziz Abdulkareem, Muthanna H. Al-Dahhan Sep 2026

Biodesulfurization Of Crude Oil Using Locally Isolated Pseudomonas Aeruginosa From Oil-Contaminated Soil In Iraqi Kurdistan, Yousif Mohammed Sharif, Sherwan Mohammed Simo, Lokman Aziz Abdulkareem, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Locally sourced crude oil from Iraqi Kurdistan contains recalcitrant organosulfur compounds that impair air quality, corrode refinery equipment, and hinder compliance with fuel sulfur regulations. This study isolated a Pseudomonas sp. closely related to the Pseudomonas aeruginosa from oil-contaminated soil near Kashy Refinery (Duhok Province, Kurdistan Region, Iraq) and evaluated its biodesulfurization potential as an environmentally friendly alternative to hydrodesulfurization. Batch experiments were conducted at 34 °C and atmospheric pressure using mineral salts medium supplemented with 1%, 3%, and 5% (v/v) Tawki crude oil. The highest sulfur removal efficiency of 83.33% was obtained at 1% (v/v) crude oil after 10 …


Intracommunity Social Capital Systems Of Class And Caste In South Asian Intimate-Partner Violence Survivor Outcomes, Vriddhi Vinay Sep 2026

Intracommunity Social Capital Systems Of Class And Caste In South Asian Intimate-Partner Violence Survivor Outcomes, Vriddhi Vinay

Dissertations, Theses, and Capstone Projects

This study theorizes how caste and class function as transnational forms of social capital that structure intimate partner violence (IPV) outcomes among South Asian diasporic women in the New York City metropolitan area. While existing IPV scholarship foregrounds migration status, gender, and legal precarity, it often treats South Asian communities as internally homogeneous and overlooks how intracommunity hierarchies mediate access to support. Drawing on social capital theory and postcolonial feminist frameworks, this research positions caste and class stratification as underexamined axes of stratification within United States-based IPV analysis. Using survey data from 24 South Asian woman-identifying IPV survivors in New …


Role Of The Corticostriatal Pathway In Learning With Interoceptive Nicotine Stimulus, Tyler Allen Sep 2026

Role Of The Corticostriatal Pathway In Learning With Interoceptive Nicotine Stimulus, Tyler Allen

Doctoral Dissertations

Tobacco use, primarily smoking, is the leading preventable cause of death, causing eight million deaths annually. Nicotine, the main addictive constituent of tobacco, acts as a reinforcer and as an interoceptive conditioned stimulus. While its pharmacology is well studied, the neural mechanisms of learning with nicotine remain underexplored. We examined the role of prelimbic cortex (PL) projections to the anterior dorsomedial caudate putamen (a-dmCPu) in nicotine-evoked goal-tracking. To achieve pathway-specific inhibition, we expressed Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in male and female rats. Subsequently, rats underwent self-administration conditioning in which active responses delivered intravenous (IV) nicotine followed …