Random Trilobe Packing Using Rigid Body Approach And Local Gas-Liquid Hydrodynamics Simulation Through Cfd With Experimental Validation,
2022
Missouri University of Science and Technology
Random Trilobe Packing Using Rigid Body Approach And Local Gas-Liquid Hydrodynamics Simulation Through Cfd With Experimental Validation, Binbin Qi, Sebastián Uribe, Omar Farid, Muthanna H. Al-Dahhan
Chemical and Biochemical Engineering Faculty Research & Creative Works
It is quite difficult to measure the local information of the gas/liquid flow inside random packed extrudate catalyst beds in a large scale. Obtaining the local information through computational fluid dynamic (CFD) simulations in such system is also difficult due to the complexity of random particle packing and two-phase flow simulation. An efficient packing scheme was implemented to randomly pack 2917 trilobe particles (10 cm in height) in a 2-inch column to represent the trickle bed reactor (TBR) based on the rigid body approach. The generated geometry was used to define the computational domain for the two-phase hydrodynamics simulation based …
Review Of Biomechanical Studies And Finite Element Modeling Of Sternal Closure Using Bio-Active Adhesives,
2022
Missouri University of Science and Technology
Review Of Biomechanical Studies And Finite Element Modeling Of Sternal Closure Using Bio-Active Adhesives, Amatulraheem Al-Abassi, Marcello Papini, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
The most common complication of median sternotomy surgery is sternum re-separation after sternal fixation, which leads to high rates of morbidity and mortality. The adhered sternal fixation technique comprises the wiring fixation technique and the use of bio-adhesives. Adhered sternal fixation techniques have not been extensively studied using finite element analysis, so mechanical testing studies and finite element analysis of sternal fixation will be presented in this review to find the optimum techniques for simulating sternal fixation with adhesives. The optimal wiring technique should enhance bone stability and limit sternal displacement. Bio-adhesives have been proposed to support sternal fixation, as …
Establishing Pteridine Metabolism In A Progressive Isogenic Breast Cancer Cell Model – Part Ii,
2022
Missouri University of Science and Technology
Establishing Pteridine Metabolism In A Progressive Isogenic Breast Cancer Cell Model – Part Ii, Lindsey Rasmussen, Zachary Foulks, Jiandong Wu, Casey Burton, Honglan Shi
Chemistry Faculty Research & Creative Works
Introduction: Determining the biological significance of pteridines in cancer development and progression remains an important step in understanding the altered levels of urinary pteridines seen in certain cancers. Our companion study revealed that several folate-derived pteridines and lumazines correlated with tumorigenicity in an isogenic, progressive breast cancer cell model, providing direct evidence for the tumorigenic origin of pteridines. Objectives: This study sought to elucidate the pteridine biosynthetic pathway in a progressive breast cancer model via direct pteridine dosing to determine how pteridine metabolism changes with tumorigenicity. Methods: First, MCF10AT breast cancer cells were dosed individually with 15 pteridines to determine …
Drug-Facilitated Sexual Assault At The University Of Arkansas,
2022
University of Arkansas, Fayetteville
Drug-Facilitated Sexual Assault At The University Of Arkansas, Barrett Weidman
Chemical Engineering Undergraduate Honors Theses
This work was written to fulfill two main purposes. First, to help survivors of Drug-Facilitated Sexual Assault (DFSA) process their experience by compiling the toxicological, pharmacological, and distribution of the three most used date-rape drugs. Second, to gauge the knowledge and interest of University of Arkansas students regarding drug impairments, sexual assault education, and bystander intervention training. A survey was conducted for the latter and revealed that 91.6% of students believe the University’s existing sexual assault prevention education and bystander intervention training have room for improvement. Also, 37.1% of students who have received this education report that the programming does …
Isolation And Production Of Tandem Collagen Binding Domain From Clostridial Collagenase Colg And Developments In C1q Reagent Production For Future Molecule Characterization Work,
2022
University of Arkansas, Fayetteville
Isolation And Production Of Tandem Collagen Binding Domain From Clostridial Collagenase Colg And Developments In C1q Reagent Production For Future Molecule Characterization Work, Stephanie Beitle
Chemical Engineering Undergraduate Honors Theses
This thesis covers a two part project: the production methods to create a double collagen binding domain molecule with a growth factor for wound healing applications and the development of a new in-house production method for isolating C1q from bovine blood. The wound healing molecule was created using transformation, sonication, and purification before being tested via electrophoresis SDS page and Western blots to confirm the molecule’s presence. The C1q in-house production method utilizes an ultrafiltration flow cell rather than dialysis at a critical point in the process, allowing for researchers to not only be able to use a single small …
Erythrocyte Deformability In Response To Glucose Using Liquid Crystals,
2022
University of Arkansas, Fayetteville
Erythrocyte Deformability In Response To Glucose Using Liquid Crystals, Jayden Goff
Biomedical Engineering Undergraduate Honors Theses
The worldwide prevalence of diabetes mellitus is rapidly increasing with about 9.3% of the adult population living with the disease. People with diabetes have trouble regulating their blood glucose levels which typically leads to hyperglycemia. Under normal physiological conditions, erythrocytes can undergo deformations in response to shear stress when passing through capillaries with a smaller diameter. Poorly managed hyperglycemia can lead to the glycosylation of erythrocyte membrane proteins and hemoglobin. This glycosylation leads to increased rigidity of the cells along with decreased deformability in response to mechanical stress; therefore, these cells have a higher susceptibility of getting stuck in the …
Recovery Of Degraded Ni-Rich Nmc811 Particles For Lithium-Ion Batteries,
2022
Missouri University of Science and Technology
Recovery Of Degraded Ni-Rich Nmc811 Particles For Lithium-Ion Batteries, Han Yu, Yan Gao, James Kirtley, Gabriel Borgmeyer, Xiaoqing He, Xinhua Liang
Chemical and Biochemical Engineering Faculty Research & Creative Works
Nickel-rich cathode materials attract a lot of attention due to their high energy density. However, their sensitivity to air and moisture hinders their practical applications. Exposing Ni-rich NMC in the air will produce by-products that are not conducive to lithium-ion transmission. Water washing can be used to remove by-products on the surface, but it can also introduce new problems, such as the generation of NiO on the particle surface, which will reduce the electrochemical performance of the material. In this study, Al2O3atomic layer deposition (ALD) was applied on degraded NMC811 particles to recover the electrochemical performance …
Effects Of Continuous In Situ Low-Dose Ionizing Radiation On Microorganisms,
2022
Clemson University
Effects Of Continuous In Situ Low-Dose Ionizing Radiation On Microorganisms, Molly E. Wintenberg
All Dissertations
Precise detection and monitoring of nuclear fuel cycle, enrichment, and weapon development activities are critical for supporting warfighter preparation in chemical, biological, radiological, nuclear, and explosives (CBRNE) operations, clandestine activities, and nuclear compliance. A biological sensing system could serve as an alternative to traditional detection methods by using organic material naturally present in the environment to discreetly detect residual trace nuclear material. Microorganisms provide an optimal platform for an alternative sensing system; however, their response to low levels of ionizing radiation is poorly characterized. Combining the power of next-generation sequencing and transcriptomic analysis, this dissertation takes an approach to obtain …
Feasibility Study Of Implementing Gamma-Ray Computed Tomography On Measuring Aggregate Distribution And Radiation Shielding Properties Of Concrete Samples,
2022
Missouri University of Science and Technology
Feasibility Study Of Implementing Gamma-Ray Computed Tomography On Measuring Aggregate Distribution And Radiation Shielding Properties Of Concrete Samples, Omar Farid, Nima Farzadnia, Kamal Khayat, Muthanna H. Al-Dahhan
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
Aggregate segregation is one of the key defects that impair the performance of concrete at fresh and hardened stages. This study aims to assess the feasibility of using an advanced technique to identify/scan/determine the aggregate segregation of concrete elements and determine radiation shielding properties of the concrete. The gamma-ray computed tomography (γ-CT) technique was employed to study aggregate distribution/dispersion in self-consolidating concrete (SCC). Accordingly, two SCC mixtures with moderate segregation (MS) and high segregation (HS) levels were cast and compared with highly stable SCC with no segregation (NS). The γ-CT scans were located on three different levels of concrete specimens …
Reactive Oxygen Species (Ros)-Responsive Size-Reducible Nanoassemblies For Deeper Atherosclerotic Plaque Penetration And Enhanced Macrophage-Targeted Drug Delivery,
2022
Missouri University of Science and Technology
Reactive Oxygen Species (Ros)-Responsive Size-Reducible Nanoassemblies For Deeper Atherosclerotic Plaque Penetration And Enhanced Macrophage-Targeted Drug Delivery, Jianhua He, Wenli Zhang, Xiaoju Zhou, Fengfei Xu, Jiahui Zou, Qiqi Zhang, Yi Zhao, Hongliang He, Hu Yang, Jianping Liu
Chemical and Biochemical Engineering Faculty Research & Creative Works
Nanoparticle-based therapeutics represent potential strategies for treating atherosclerosis; however, the complex plaque microenvironment poses a barrier for nanoparticles to target the dysfunctional cells. Here, we report reactive oxygen species (ROS)-responsive and size-reducible nanoassemblies, formed by multivalent host-guest interactions between β-cyclodextrins (β-CD)-anchored discoidal recombinant high-density lipoprotein (NP3ST) and hyaluronic acid-ferrocene (HA-Fc) conjugates. The HA-Fc/NP3ST nanoassemblies have extended blood circulation time, specifically accumulate in atherosclerotic plaque mediated by the HA receptors CD44 highly expressed in injured endothelium, rapidly disassemble in response to excess ROS in the intimal and release smaller NP3ST, allowing for further …
Model-Guided Design Of Rna-Based Synthetic Circuits For The Dynamic Regulation Of Gene Expression,
2022
Louisiana State University and Agricultural and Mechanical College
Model-Guided Design Of Rna-Based Synthetic Circuits For The Dynamic Regulation Of Gene Expression, Jordan R. Ryan
LSU Master's Theses
A longstanding goal in synthetic biology has been to build synthetic gene circuits with the ability to harness nature’s capability of precise gene expression regulation. Advancements in RNA technology have established RNA-based regulators with distinct advantages over traditional protein-based regulators such as faster signal propagation, versatile programmability, and low cellular burden, which has created an interest in the field to construct innovative synthetic gene circuits using de novo RNA- based regulators. However, our understanding of the behavior and kinetics of RNA-RNA interactions for the construction of gene circuits is incomplete. This thesis proposes a model-guided design framework that integrates mechanistic …
Photo-Induced Drug Release From Polymeric Micelles And Liposomes: Phototriggering Mechanisms In Drug Delivery Systems,
2022
American University of Sharjah
Photo-Induced Drug Release From Polymeric Micelles And Liposomes: Phototriggering Mechanisms In Drug Delivery Systems, Najla M. Salkho, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Faculty Publications
Chemotherapeutic drugs are highly effective in treating cancer. However, the side effects associated with this treatment lower the quality of life of cancer patients. Smart nanocarriers are able to encapsulate these drugs to deliver them to tumors while reducing their contact with the healthy cells and the subsequent side effects. Upon reaching their target, the release of the encapsulated drugs should be carefully controlled to achieve therapeutic levels at the required time. Light is one of the promising triggering mechanisms used as external stimuli to trigger drug release from the light-responsive nanocarriers. Photo-induced drug release can be achieved at a …
Tuning Electrochemical Interactions And Polymer Electrolyte Interfaces For Enhanced Organic Acid Separations Using Electrodeionization,
2022
Louisiana State University and Agricultural and Mechanical College
Tuning Electrochemical Interactions And Polymer Electrolyte Interfaces For Enhanced Organic Acid Separations Using Electrodeionization, Matthew Leo Jordan
LSU Doctoral Dissertations
Chemical separations are critical processes for chemical and industrial plants to purify and isolate products however current separation technologies, such as distillation, rely on energy intensive processes. Electrochemical separation processes, such as electrodialysis and electrodeionization, are an energy efficient alternative that are emerging as an alternative for thermal-based separations. Organic acids are weakly ionizable species and susceptible for purification from process streams using electrochemical processes. Recently the fermentation route has garnered greater attention as a means for producing value-added chemicals, such as organic acids, from a renewable feedstock and aiding the circular economy. Some of the challenges electrodialysis faces for …
Protocol To Engineer Nanofilms Embedded
Lipid Nanoparticles For Controlled And Targeted
Drug Delivery (Nectar),
2022
University of Nebraska-Lincoln
Protocol To Engineer Nanofilms Embedded Lipid Nanoparticles For Controlled And Targeted Drug Delivery (Nectar), Rashi Porwal, Stephen L. Hayward, Srivatsan Kidambi
Department of Chemical and Biomolecular Engineering: Faculty Publications
We present a protocol to engineer a substrate-mediated delivery platform comprising hyaluronic acid-coated lipid nanoparticles (HALNPs) embedded into polyelectrolyte multilayer (PEM) films. This platform allows controlled spatiotemporal release of lipid nanoparticles (LNP) by embedding them within the polyelectrolyte multilayer films matrix. HALNP conjugate with antibodies also adds the ability for targeted delivery. The use of LNP enables this platform to encapsulate both hydrophobic and hydrophilic drugs. This platform can easily be reproduced and utilized for various biomedical drug delivery applications. For complete details on the use and execution of this protocol, please refer to Hayward et al. (2015, 2016a, 2016b), …
Influence Of Saccharide Modifications On Heparin Lyase Iii Substrate Specificities,
2022
Missorui University of Science and Technology
Influence Of Saccharide Modifications On Heparin Lyase Iii Substrate Specificities, Jiandong Wu, Pradeep Chopra, Geert Jan Boons, Joseph Zaia
Chemical and Biochemical Engineering Faculty Research & Creative Works
A Library of 23 Synthetic Heparan Sulfate (HS) Oligosaccharides, Varying in Chain Length, Types, and Positions of Modifications, Was Used to Analyze the Substrate Specificities of Heparin Lyase III Enzymes from Both Flavobacterium Heparinum and Bacteroides Eggerthii. the Influence of Specific Modifications, Including N-Substitution, 2-O Sulfation, 6-O Sulfation, and 3-O Sulfation on Lyase III Digestion Was Examined Systematically. It Was Demonstrated that Lyase III from Both Sources Can Completely Digest Oligosaccharides Lacking O-Sulfates. 2-O Sulfation Completely Blocked Cleavage at the Corresponding Site; 6-O and 3-O Sulfation on Glucosamine Residues Inhibited Enzyme Activity. We Also Observed that There Are Differences in …
Torrefaction Of Oil Palm Empty Fruit Bunch Biomass,
2022
Universiti Malaya
Torrefaction Of Oil Palm Empty Fruit Bunch Biomass, Mohamad Azri Sukiran
Student Works (2020-2029)
Empty fruit bunches (EFB) have great potential to be used as a renewable fuel. Its current low rate of utilization due largely to high moisture content and low calorific value (CV) can be overcome via a thermal pretreatment namely torrefaction. This study investigated the effects of torrefaction temperature, residence time, particle size and moisture content on EFB’s final products distribution and their characteristics in a fixed bed reactor. The solid products (torrefied EFB) obtained were analyzed by various methods such as proximate and ultimate analyses, CV, scanning electron microscopy (SEM), Fourier transform infrared (FTIR), x-ray diffraction (XRD) and thermogravimetric analysis …
Examining The Effect Of A Chitosan Biopolymer On Alkali-Activated Inorganic Material For Aqueous Pb(Ii) And Zn(Ii) Sorption,
2022
Missouri University of Science and Technology
Examining The Effect Of A Chitosan Biopolymer On Alkali-Activated Inorganic Material For Aqueous Pb(Ii) And Zn(Ii) Sorption, Sukanta K. Mondal, Chenglin Wu, Felix C. Nwadire, Ali A. Rownaghi, Aditya Kumar, Yusuf Adewuyi, Monday Uchenna Okoronkwo
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
Biopolymers and alkali-activated materials have attracted a great deal of attention as adsorbents for the removal of heavy metal contaminants from aqueous solutions. Both materials are sustainable and feature unique properties, but biopolymers are relatively more expensive or difficult to prepare and exhibit low mechanical and surface properties, a narrow pH range, and thermal stability. In this study, hybrid adsorbents were prepared from both types of material, by alkali activation of low-cost fly ash precursors accompanied by incorporation of 0-2%mass chitosan biopolymer. Two types of alkaline activating solutions, NaOH and Na2SiO3, were employed to generate two sets of hybrid adsorbents …
Recent Advancements In Electrochemical Conversion Of Carbon Dioxide,
2022
BIT Sindri, India
Recent Advancements In Electrochemical Conversion Of Carbon Dioxide, Nandan Nag, Amit Kumar, Sumit Sharma, Sandeep Kumar, Amit K. Thakur
Civil & Environmental Engineering Faculty Publications
Electrochemical reduction of carbon dioxide into eco-friendly and clean products is a promising approach to eradicate pollution. Although carbon dioxide emission is inhibited by the advent of renewable sources of energy, it is present in the atmosphere and needs to be cleaned. The reduction of carbon dioxide from atmospheric gases can be accomplished by its adsorption and subsequent transportation to electrolytic chambers, where it is reduced to hydrocarbons, organic acids or carbonates. This review focuses on developing a three compartment electrochemical cell to reduce carbon dioxide used as a catholyte. Various factors affecting the electrochemical reduction of carbon dioxide and …
Effect Of Açai Berry Extract Application On The Bond Strength To The Bleached Enamel Using An Experimental Etch-And-Rinse Adhesive,
2022
Missouri University of Science and Technology
Effect Of Açai Berry Extract Application On The Bond Strength To The Bleached Enamel Using An Experimental Etch-And-Rinse Adhesive, Lamiaa M. Moharam, Haidy N. Salem, Shahinaz N. Hassan
Chemical and Biochemical Engineering Faculty Research & Creative Works
Background: To evaluate the bleached enamel shear bond strength (SBS) after antioxidants application using an experimental adhesive. Material and Methods: Sixty sound human molars had their roots removed then cut into buccal and lingual halves and mounted in acrylic blocks. Enamel bleaching was done using an in-office chemical bleaching agent. Specimens were arbitrarily allocated into 12 groups (n=10) regarding the three experimental levels of the study: two antioxidant agents [10% açai berry extract, 10% sodium ascorbate prepared gels (applied for 15-min) and the control group (no antioxidant application)], two adhesive materials [commercial etch-and-rinse (ER) adhesive and an experimental ER adhesive] …
Austenitic, Duplex, And Lean Duplex Stainless Steel Critical Pitting Temperature In Simulated Concrete Environment,
2022
The University of Akron
Austenitic, Duplex, And Lean Duplex Stainless Steel Critical Pitting Temperature In Simulated Concrete Environment, Bobby Giebel
Williams Honors College, Honors Research Projects
In this work, the critical pitting temperature (CPT) will be observed for a selection of austenitic (316LN and 24100) and duplex (2205), and lean duplex (2304, 2001) stainless steels in simulated concrete pore solution. To study the influence of temperature on the pitting stability of the stainless steels, three temperatures were tested: 25oC, 45oC, and 65oC for cyclic potentiodynamic polarization (CPP) and electrochemical impedance spectroscopy (EIS). Electrochemical properties of the interfaces we studied via EIS analysis. Kinetics were studied via CPP testing. To reveal the critical pitting temperature of the stainless steels, cyclic thermammetry was used. Characterization of the pits …
