Yttrium-89 Nmr Spectroscopy, A New Probe For Calcium-Binding Proteins,
2015
Marquette University
Yttrium-89 Nmr Spectroscopy, A New Probe For Calcium-Binding Proteins, Richard Holz, William Horrocks
Richard C. Holz
No abstract provided.
Molecular Discrimination Of Type-I Over Type-Ii Methionyl Aminopeptidases,
2015
Utah State University
Molecular Discrimination Of Type-I Over Type-Ii Methionyl Aminopeptidases, Krzysztof Swierczek, Alicja Copik, Sabina Swierczek, Richard Holz
Richard C. Holz
Two residues that are conserved in type-I methionyl aminopeptidases (MetAPs) but are absent in all type-II MetAPs are the cysteine residues (Escherichia coli MetAP-I: C59 and C70) that reside at the back of the substrate recognition pocket. These Cys residues are 4.4 Å apart and do not form a disulfide bond. Since bacteria and fungi contain only type-I MetAPs while all human cells contain both type-I and type-II MetAPs, type-I MetAPs represent a novel antibiotic/antifungal target if type-I MetAPs can be specifically targeted over type-II. Based on reaction of the thiol-specific binding reagent 5,5‘-dithio-bis(2-nitrobenzoic acid) (DTNB) with the type-I MetAP …
Zinc Aminopeptidases, Aminopeptidase From Vibrio Proteolyticus (Aeromonas Proteolytica) As Prototypical Enzyme,
2015
Marquette University
Zinc Aminopeptidases, Aminopeptidase From Vibrio Proteolyticus (Aeromonas Proteolytica) As Prototypical Enzyme, Richard Holz, Anna Starus, Danuta Gillner
Richard C. Holz
No abstract provided.
Dual-Sensor Fluorescent Probes Of Surfactant-Induced Unfolding Of Human Serum Albumin,
2015
William & Mary
Dual-Sensor Fluorescent Probes Of Surfactant-Induced Unfolding Of Human Serum Albumin, Christopher J. Abelt
Arts & Sciences Articles
Two extrinsic fluorescent probes, 3-(dimethylamino)-8,9,10,11-tetrahydro-7H-cyclohepta[a]naphthalen-7-one (1) and 7-(dimethylamino)-2,3-dihydrophenanthren-4(1H)-one (2), are used to probe the unfolding of human serum albumin by sodium dodecyl sulfate (SDS). These probes respond separately to the polarity and H-bond-donating ability of their surroundings. Competitive binding experiments show that fluorophore 1 binds to site I (domain IIA) and 2 binds to site II (domain IIIA). The local acidity of 1 in site I is out of the sensing range of 1, whereas the local acidity of 2 in site II is calculated to be nearly zero on Catalans solvent acidity index. Both probes show that the first …
Synthesis And Formation Mechanism Of Cuins2 Nanocrystals With A Tunable Phase,
2015
University of South Carolina - Columbia
Synthesis And Formation Mechanism Of Cuins2 Nanocrystals With A Tunable Phase, Chao Yu, Linlin Zhang, Long Tian, Dan Liu, Fanglin Chen, Cheng Wang
Fanglin Chen
Chalcopyrite CuInS2 (CIS) hierarchical structures composed of nanoflakes with a thickness of about 5 nm were synthesized by a facial solvothermal method. The thermodynamically metastable wurtzite phase CIS would be obtained by using InCl3 instead of In(NO3)3 as In precursor. The effects of the In precursor and the volume of concentrated HCl aqueous solution on the phases and morphologies of CIS nanocrystals have been systematically investigated. Experimental results indicated that the obtained phases of CIS nanocrystals were predominantly determined by precursor-induced intermediate products. The photocatalytic properties of chalcopyrite and wurtzite CIS in visible-light-driven degradation of …
Angular Momentum,
2015
Washington University in St. Louis
Autophagy-Mediated Mechanisms Of Chemoresistance In Cancer,
2015
Brigham Young University
Autophagy-Mediated Mechanisms Of Chemoresistance In Cancer, David Broadbent, Dr. Joshua Andersen
Journal of Undergraduate Research
The resistance of tumor cells to chemotherapy is a critical problem in the clinic and is a common cause of mortality in cancer. Emerging data suggests that resistance to chemotherapy is caused by a tumor-expressed protein called 14-3-3ζ, yet the mechanism to explain 14-3-3ζ-mediated chemoresistance is not completely understood (1). Rapid growing tumors often outgrow their blood supply resulting in regions of hypoxia (low glucose and oxygen). These cells must adapt or die and those that do adapt often become metastatic and chemoresistant. A recently proposed mechanism by which cancer cells are able to adapt to hypoxia is via autophagy, …
Importance And Reliability Of Small Basis Set Ccsd(T) Corrections To Mp2 Binding And Relative Energies Of Water Clusters,
2015
Bucknell University
Importance And Reliability Of Small Basis Set Ccsd(T) Corrections To Mp2 Binding And Relative Energies Of Water Clusters, Berhane Temelso, Carla Renner, George Shields
Berhane Temelso
MP2 describes hydrogen-bonded systems well, yet a higher-order electron correlation correction in the form of a CCSD(T) calculation is usually necessary to achieve benchmark quality energies. We evaluated the importance and reliability of small basis set CCSD(T) corrections to MP2(δCCSD(T)) both on the binding (ΔE) and relative (ΔΔE) MP2 energies for a large number of systems including four water dimer stationary points and 57 other clusters up to undecamers, (H2O)11. By comparing the MP2 energies with CCSD(T) and the explicitly correlated MP2-F12 energies with variants of CCSD(T)-F12 using different basis sets, we were able to establish that the correction to …
P-24 Synthesis Of Arginine-Based Heterocyclic Amines,
2015
Andrews University
P-24 Synthesis Of Arginine-Based Heterocyclic Amines, Andrew Stewart
Honors Scholars & Undergraduate Research Poster Symposium Programs
Heterocyclic Amines (HCAs) are a group of mutagenic and carcinogenic chemicals found in muscle meat after grilling, frying, or broiling. Research studies show that very low amounts of HCAs are created from creatinine reacting with another amino acid at temperatures greater than 200 °C. Other studies show that plant-based arginine can substitute for creatine forming a new class of mutagenic HCAs, but also in low yields. We sought to develop a direct, higher yielding method of producing these arginine-HCAs based on a procedure previously used to synthesize creatine-HCAs. Greater amounts of arginine-HCA speeds analysis, chemical characterization, and toxicity assessment.
P-22 Hydroxyl Functional Group Number Determination Of Pamam Dendrimers With Nir-Spectroscopy,
2015
Andrews University
P-22 Hydroxyl Functional Group Number Determination Of Pamam Dendrimers With Nir-Spectroscopy, Seth Stacey
Honors Scholars & Undergraduate Research Poster Symposium Programs
The goal of this project is to investigate the use of NIR-spectroscopy to quantify the number of OH functional groups attached to poly (amido amine) or PAMAM dendrimers in a manner that is quick, cost effective and easily reproducible. Obtaining the approximate number of hydroxyl functional groups (OH#) in a dendrimer is crucial in determining what role it can play in bonding and reactivity to other molecules. NIR-spectroscopy has the potential to allow for the recovery of the sample or at least to minimize the amount needed for analysis while providing an accurate determination of the OH# of a dendrimer.
Tb162: Red Maple And White Pine Litter Quality: Initial Changes With Decomposition,
2015
Selected Works
Tb162: Red Maple And White Pine Litter Quality: Initial Changes With Decomposition, Mairin T. Delaney, Ivan J. Fernandez, Jeffrey A. Simmons, Russel D. Briggs
Ivan J. Fernandez
The specific objectives of this study were (a) to define the organic and inorganic composition of foliar litter from red maple (Acer rubrum L.) and white pine (Pinus strobus L.), and (b) to determine the shifts in the organic and inorganic composition of these two litter types during the initial stages of decomposition. These two species were chosen because of their prominence in the northeastern U.S. and the contrast they afforded in litter quality characteristics which have a strong influence on litter decomposition.
Tb195: Element Concentrations In Maine Forest Vegetation And Soils,
2015
Selected Works
Tb195: Element Concentrations In Maine Forest Vegetation And Soils, Chandra J. Mcgee, Ivan J. Fernandez, Stephen A. Norton, Constance S. Stubbs
Ivan J. Fernandez
Bioaccumulation of trace metals in plant tissues can present a health risk to wildlife, and potentially to humans. The Passamaquoddy Tribe in Maine was concerned about health risks of cadmium (Cd) because of a health advisory for moose liver and kidney consumption due to high Cd levels. In addition to Cd, this study evaluated concentrations of aluminum (Al), calcium (Ca), copper (Cu), iron (Fe), potassium (K), magnesium (Mg), manganese (Mn), nickel (Ni), phosphorus (P), lead (Pb), and zinc (Zn) in four common terrestrial moose-browse species, associated forest soils, and two species of aquatic vegetation on Passamaquoddy tribal land in eastern …
Tb164: Precipitation Chemistry At The Greenville, Maine, Nadp/Ntn Station,
2015
Selected Works
Tb164: Precipitation Chemistry At The Greenville, Maine, Nadp/Ntn Station, Ivan Fernandez, Llew Wortman
Ivan J. Fernandez
This report details results from the Greenville, Maine, NADP/NTN site supported by the Maine Agricultural and Forest Experiment Station. The site is located in Piscataquis County at 69°39'52" longitude and 45°29'23" latitude at approximately 322 m elevation. The site consists of a single Aerochem Metrics® Automatic Sensing Wet/Dry Precipitation Collector that provides samples for chemical analysis and a Belfort® Recording Rain Gage and Event Recorder for accurate determinations of precipitation volume. Samples are collected every Tuesday morning 52 weeks a year.
Green Synthesis, Photocatalytic And Photoelectrochemical Performance Of Au-Graphene Nanocomposite,
2015
Universiti Brunei Darussalaam
Green Synthesis, Photocatalytic And Photoelectrochemical Performance Of Au-Graphene Nanocomposite, Mohammad Mansoob Khan Dr, Mohammad Ehtisham Khan, M. H. Cho
Dr. Mohammad Mansoob Khan
A simplistic and environment friendly approach using electrochemically active biofilms (EABs) was developed for the synthesis of Au-Graphene (Au-G) nanocomposite without the use of surfactants or capping agents. The as-prepared Au-G nanocomposite was characterized by X-ray diffraction, diffuse reflectance spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, photoluminescence spectroscopy, and transmission electron microscopy. In this study, the anchoring of gold nanoparticles (AuNPs) on graphene sheets was achieved using an EAB. The EAB assists in the bio-reduction of Au3+ to Au0, and the AuNPs prevent the aggregation of graphene sheets and keep them apart because of the decrease in attractive forces between the …
Purine-Based Triazoles,
2015
Missouri University of Science and Technology
Purine-Based Triazoles, Prakash Reddy, Nanditha G. Nair, Mark A. Smith, Wataru Kudo
Chemistry Faculty Research & Creative Works
A pharmaceutical composition for inhibiting at least protein kinase in a cell of a subject includes a purine based triazole.
The Creation And Evaluation Of Novel Canine Training Aids For Cocaine Using Molecularly Encapsulated Sol-Gel Polymers And An Investigation Of Canine Field Accuracy,
2015
Florida International University
The Creation And Evaluation Of Novel Canine Training Aids For Cocaine Using Molecularly Encapsulated Sol-Gel Polymers And An Investigation Of Canine Field Accuracy, Michelle Cerreta
FIU Electronic Theses and Dissertations
Biological detectors, such as canines, are valuable tools used for the rapid identification of illicit materials. However, recent increased scrutiny over the reliability, field accuracy, and the capabilities of each detection canine is currently being evaluated in the legal system. For example, the Supreme Court case, State of Florida v. Harris, discussed the need for continuous monitoring of canine abilities, thresholds, and search capabilities. As a result, the fallibility of canines for detection was brought to light, as well as a need for further research and understanding of canine detection. This study is two-fold, as it looks to not only …
Synthesis Of 2-Acylphenol And Flavene Derivatives From The Ruthenium-Catalyzed Oxidative C-H Acylation Of Phenols With Aldehydes,
2015
Marquette University
Synthesis Of 2-Acylphenol And Flavene Derivatives From The Ruthenium-Catalyzed Oxidative C-H Acylation Of Phenols With Aldehydes, Hanbin Lee, Chae S. Yi
Chemistry Faculty Research and Publications
The cationic ruthenium hydride complex [(C6H6)(PCy3)(CO)RuH]+BF4− has been found to be an effective catalyst for the oxidative C–H coupling reaction of phenols with aldehydes to give 2-acylphenol compounds. The coupling of phenols with α,β-unsaturated aldehydes selectively gives the flavene derivatives. The catalytic method mediates direct oxidative C–H coupling of phenol and aldehyde substrates without using any metal oxidants or forming wasteful byproducts.
Ogden College Of Science & Engineering Newsletter (Spring 2015),
2015
Western Kentucky University
Ogden College Of Science & Engineering Newsletter (Spring 2015), Cheryl Stevens, Dean
Ogden College of Science & Engineering Publications
No abstract provided.
Unambiguous Evaluation Of The Relative Photolysis Rates Of Nitro Indolinyl Protecting Groups Critical For Brain Network Studies,
2015
Florida Institute of Technology
Unambiguous Evaluation Of The Relative Photolysis Rates Of Nitro Indolinyl Protecting Groups Critical For Brain Network Studies, Richard L. Comitz, Yannick P. Ouedraogo, Nasri Nesnas
Chemistry and Chemical Engineering Faculty Publications
Nitrated indolinyl photoprotecting groups are crucial tools extensively used in the study of neuronal signal transduction. Mononitrated photolabile protecting groups have been used effectively, however, recent advances in the introduction of a second nitro group have shown improvement in the photo efficiency of neurotransmitter (agonist) release, albeit, to varying extents, depending on the assessment methods employed. An unambiguous method is discussed based on Nuclear Magnetic Resonance (NMR), which is shown to be an effective technique in the relative overall rate comparison amongst varying nitrated protecting groups. Mononitrated and dinitrated photolabile protecting groups such as CDNIGlu and MNI-Glu are used as …
Temperature Dependent C-Axis Hole Mobilities In Rubrene Single Crystals Determined By Time-Of-Flight,
2015
St. Cloud State University
Temperature Dependent C-Axis Hole Mobilities In Rubrene Single Crystals Determined By Time-Of-Flight, Russell L. Lidberg, Tom J. Pundsack, Neale O. Haugen, Lucas R. Johnstone, C. Daniel Frisbie
Physics and Astronomy Faculty Publications
Hole mobilities (μ) in rubrene single crystals (space group Cmca) along the crystallographic c-axis have been investigated as a function of temperature and applied electric field by the time-of-fight method. Measurements demonstrate an inverse power law dependence on temperature, namely,μ=μ0T−n with n = 1.8, from room temperature down to 180 K. At 296 K, the average value of μ was found to be 0.29 cm2/Vs increasing to an average value of 0.70 cm2/Vs at 180 K. Below 180 K a decrease in mobility is observed with further cooling. Overall, these results confirm the …
