Configurationally Stable, Enantioenriched Organometallic Nucleophiles In Stereospecific Pd-Catalyzed Cross-Coupling Reactions: An Alternative Approach To Asymmetric Synthesis,
2015
The Graduate Center, City University of New York
Configurationally Stable, Enantioenriched Organometallic Nucleophiles In Stereospecific Pd-Catalyzed Cross-Coupling Reactions: An Alternative Approach To Asymmetric Synthesis, Chao-Yuan Wang, Joseph Derosa, Mark R. Biscoe
Publications and Research
Several research groups have recently developed methods to employ configurationally stable, enantioenriched organometallic nucleophiles in stereospecific Pd-catalyzed cross-coupling reactions. By establishing the absolute configuration of a chiral alkyltin or alkylboron nucleophile prior to its use in cross-coupling reactions, new stereogenic centers may be rapidly and reliably generated with preservation of the known initial stereochemistry. While this area of research is still in its infancy, such stereospecific cross-coupling reactions may emerge as simple, general methods to access diverse, optically active products from common enantioenriched organometallic building blocks. This minireview highlights recent progress towards the development of general, stereospecific Pd-catalyzed crosscoupling reactions …
Heterometallic Titanium–Gold Complexes Inhibit Renal Cancer Cells In Vitro And In Vivo,
2015
CUNY Brooklyn College
Heterometallic Titanium–Gold Complexes Inhibit Renal Cancer Cells In Vitro And In Vivo, Jacob Fernandez-Gallardo, Benelita T. Elie, Tanmoy Sadhukha, Swayam Prabha, Mercedes Sanau, Susan A. Rotenberg, Joe W. Ramos, Maria Contel
Publications and Research
Following recent work on heterometallic titanocene–gold complexes as potential chemotherapeutics for renal cancer, we report here on the synthesis, characterization and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba ¼ S–C6H4–COO) bound to gold(I)-phosphane fragments through a thiolate group [(h-C5H5)2TiMe(m-mba)Au(PR3)]. The compounds are more stable in physiological media than those previously reported and are highly cytotoxic against human cancer renal cell lines. We describe here preliminary mechanistic data involving studies on the interaction of selected compounds with plasmid (pBR322) DNA used as a model nucleic acid, and with selected protein kinases from a …
Physicochemical And Structural Analysis Of Polymers As Putative Drugs,
2015
VCU
Physicochemical And Structural Analysis Of Polymers As Putative Drugs, Meghan L. Thompson
Theses and Dissertations
Sulfated low molecular weight lignins (LMWLs) have shown good activity as anticoagulants by allosterically inhibiting thrombin, as well as promising agents for treating emphysema through inhibition of elastolysis, oxidation, and inflammation. Sulfated LMWLs are chemo-enzymatically synthesized from starting monomers caffeic, ferulic, and sinapic acid into sulfated dehydropolymers known as CDS, FDS, and SDS. To further the LMWLs’ development as drugs, their structural composition and physicochemical characteristics were defined in this work. The molecular weight distribution profile of the sulfated LMWLs from size exclusion chromatography performed on a high pressure liquid chromatography system (SEC-HPLC) changed from bimodal when no surfactant is …
Heteroatom-Doped Nanoporous Carbons: Synthesis, Characterization And Application To Gas Storage And Separation,
2015
Virginia Commonwealth University
Heteroatom-Doped Nanoporous Carbons: Synthesis, Characterization And Application To Gas Storage And Separation, Babak Ashourirad
Theses and Dissertations
Activated carbons as emerging classes of porous materials have gained tremendous attention because of their versatile applications such as gas storage/separations sorbents, oxygen reduction reaction (ORR) catalysts and supercapacitor electrodes. This diversity originates from fascinating features such as low-cost, lightweight, thermal, chemical and physical stability as well as adjustable textural properties. More interestingly, sole heteroatom or combinations of various elements can be doped into their framework to modify the surface chemistry. Among all dopants, nitrogen as the most frequently used element, induces basicity and charge delocalization into the carbon network and enhances selective adsorption of CO2. Transformation of …
Dispersant Effects On Zinc Dialkyldithiophosphate (Zddp) Tribofilm Structure And Composition,
2015
Virginia Commonwealth University
Dispersant Effects On Zinc Dialkyldithiophosphate (Zddp) Tribofilm Structure And Composition, Makaye Tabibi
Theses and Dissertations
For decades, global regulations and government mandates have driven technological developments to improve vehicle fuel economy. Tribological components found in all automotive engines contain metal-on-metal contact zones that may result in increased friction and wear, reducing overall engine efficiency. Lubricant additives such as antiwear and friction modifying components are added to motor oils to prevent some of the damages that may occur at contact zones and improve friction. The effects of other additive components, such as dispersants, that are prevalent in a lubricant additive package on the anti-wear layer remain relatively unknown. Polyisobutenyl Succinimide (PIBSI) dispersants were evaluated for their …
The Contribution Of Methionine To The Stability Of The Escherichia Coli Metniq Abc Transporter-Substrate Binding Protein Complex,
2015
University of San Francisco
The Contribution Of Methionine To The Stability Of The Escherichia Coli Metniq Abc Transporter-Substrate Binding Protein Complex, P. Nguyen, N. Kadaba, J. Y. Lai, Janet G. Yang, D. C. Rees
Chemistry Faculty Publications
Despite the ubiquitous role of ATP-binding cassette (ABC) importers in nutrient uptake, only the Escherichia coli maltose and vitamin B12 ABC transporters have been structurally characterized in multiple conformations relevant to the alternating access transport mechanism. To complement our previous structure determination of the E. coli MetNI methionine importer in the inward facing conformation (Kadaba et al. (2008) Science 321, 250–253), we have explored conditions stabilizing the outward facing conformation. Using two variants, the Walker B E166Q mutation with ATP+EDTA to stabilize MetNI in the ATP-bound conformation and the N229A variant of the binding protein MetQ, shown in …
The Allosteric Regulatory Mechanism Of The Escherichia Coli Metni Methionine Atp Binding Cassette (Abc) Transporter,
2015
University of San Francisco
The Allosteric Regulatory Mechanism Of The Escherichia Coli Metni Methionine Atp Binding Cassette (Abc) Transporter, Janet G. Yang, D. C. Rees
Chemistry Faculty Publications
The MetNI methionine importer of Escherichia coli, an ATP binding cassette (ABC) transporter, uses the energy of ATP binding and hydrolysis to catalyze the high affinity uptake of d- and l-methionine. Early in vivo studies showed that the uptake of external methionine is repressed by the level of the internal methionine pool, a phenomenon termed transinhibition. Our understanding of the MetNI mechanism has thus far been limited to a series of crystal structures in an inward-facing conformation. To understand the molecular mechanism of transinhibition, we studied the kinetics of ATP hydrolysis using detergent-solubilized MetNI. We find that transinhibition is …
Chemistry 101-001 General Chemistry I Fall 2015,
2015
Parkland College
Chemistry 101-001 General Chemistry I Fall 2015, Steven L. Mullen
Chemistry Courses
No abstract provided.
Chemistry 102-001 General Chemistry Ii Spring 2015,
2015
Parkland College
Chemistry 102-001 General Chemistry Ii Spring 2015, Kim Bode
Chemistry Courses
No abstract provided.
Chemistry 100-051w Online Introduction To Chemistry Fall 2015,
2015
Parkland College
Chemistry 100-051w Online Introduction To Chemistry Fall 2015, Christina Beatty
Chemistry Courses
No abstract provided.
Chemistry 101-005 General Chemistry Fall 2015,
2015
Parkland College
Chemistry 101-005 General Chemistry Fall 2015, Christina Beatty
Chemistry Courses
No abstract provided.
Chemistry 100-002 Introduction To Chemistry Fall 2015,
2015
Parkland College
Chemistry 100-002 Introduction To Chemistry Fall 2015, Andrew Holm
Chemistry Courses
No abstract provided.
Chemistry 102-002 General Chemistry Ii Fall 2015,
2015
Parkland College
Chemistry 102-002 General Chemistry Ii Fall 2015, Manuel I. Rodriguez
Chemistry Courses
No abstract provided.
Chemistry 100-001 Introduction To Chemistry Fall 2015,
2015
Parkland College
Chemistry 100-001 Introduction To Chemistry Fall 2015, Kim Bode
Chemistry Courses
No abstract provided.
Chemistry 102-001 General Chemistry Ii Fall 2015,
2015
Parkland College
Chemistry 102-001 General Chemistry Ii Fall 2015, C. Britt Carlson
Chemistry Courses
No abstract provided.
Chemistry 101-009 General Chemistry I Fall 2015,
2015
Parkland College
Chemistry 101-009 General Chemistry I Fall 2015, Philip Rabe
Chemistry Courses
No abstract provided.
Chemistry 106 Chemistry For Health Professions Fall 2015,
2015
Parkland College
Chemistry 106 Chemistry For Health Professions Fall 2015, Kim Bode
Chemistry Courses
No abstract provided.
Chemistry 100-201 Introduction To Chemistry Fall 2015,
2015
Parkland College
Chemistry 100-201 Introduction To Chemistry Fall 2015, Steven Mullen
Chemistry Courses
No abstract provided.
Chemistry 102-005 General Chemistry Ii Fall 2015,
2015
Parkland College
Chemistry 102-005 General Chemistry Ii Fall 2015, Kevin Tucker
Chemistry Courses
No abstract provided.
Chemistry 101-006 General Chemistry I Fall 2015,
2015
Parkland College
Chemistry 101-006 General Chemistry I Fall 2015, Manuel I. Rodriguez
Chemistry Courses
No abstract provided.
