The Effects Of Continuous Insulin Pump Therapy On Glycemic Control In Pregnant Type 1 Diabetics, 2017 Dominican University of California
The Effects Of Continuous Insulin Pump Therapy On Glycemic Control In Pregnant Type 1 Diabetics, Kimberly Kelsey
Senior Theses and Capstone Projects
Type 1 Diabetics have various ways of managing their diabetes that have been studied for their effectiveness. Pregnancy in the Type 1 Diabetic has been understudied. It is known that Diabetics in general have poorer pregnancy outcomes because of poor glycemic control. This coupled with the fact that the body needs 3-4 times more insulin as pregnancy comes to an end makes managing blood glucose levels challenging for diabetics (Lowdermilk, 2016, p. 689). For the Type 1 Diabetic, there are two main ways to control diabetes: multiple daily injections using at least two type of insulin and continuous subcutaneous insulin ...
Removal Of Endocrine Disrupting Compounds Using Membrane Bioreactor, 2017 University of Arkansas, Fayetteville
Removal Of Endocrine Disrupting Compounds Using Membrane Bioreactor, Mohanad Ali Abdulsahib Kamaz
Theses and Dissertations
The presence of endocrine disrupting compounds (EDCs) and pharmaceutically active compounds (PhAC) such as pesticides, personal care products, antibiotics and pharmaceutical compounds, in sewage, industrial, and domestic waters has extensively become the major concern for health and environmental organizations. These compounds have the ability to interact with mammalian endocrine system and disrupting their functions. The traditional activated sludge processes are designed to degrade solids, organic carbon and nitrogen loading. Although several treatment steps in a wastewater treatment plant can contribute to partial removal of EDCs, effective removal has been a challenge due to their resistant chemical and biological degradation and ...
Endocrine And Metabolic Effects Of Consuming Sugar-Sweetened Beverages: Preclinical And Clinical Studies", 2017 University of California, Davis
Endocrine And Metabolic Effects Of Consuming Sugar-Sweetened Beverages: Preclinical And Clinical Studies", Peter Havel
Science Seminar Series
Peter J. Havel of the School of Veterinary Medicine at UC Davis will speak on his research on Endocrine and Metabolic Effects of Consuming Sugar-Sweetened Beverages: Preclinical and clinical studies at this Science Seminar Series lecture.
The Psychophysiological Correlates Of Personality, Trauma, Posttraumatic Stress Disorder And Social Support, 2017 University of Nevada, Las Vegas
The Psychophysiological Correlates Of Personality, Trauma, Posttraumatic Stress Disorder And Social Support, Meghan E. Pierce
UNLV Theses, Dissertations, Professional Papers, and Capstones
Theories considering the etiology of psychopathy suggest that trauma exposure, specifically childhood maltreatment and sexual abuse, is related to the development of callous-unemotional traits in children and adolescents, which are precursors to psychopathic traits in adulthood. Furthermore, posttraumatic stress disorder has an opposite relationship with many of the emotional and behavioral components of the two-factor model of psychopathy. Specifically, PTSD is positively associated to IA and traits associated with it and negatively associated with FD. Thus, this study sought to expand upon the current theories of a trauma-based etiology of psychopathy by investigating the relationship between trauma, PTSD, and psychopathic ...
The Dangers Of Fat Metabolism And Pufa: Why You Don’T Want To Be A Fat Burner, 2017 Rutgers University - New Brunswick/Piscataway
The Dangers Of Fat Metabolism And Pufa: Why You Don’T Want To Be A Fat Burner, Kyle J. Mamounis
Journal of Evolution and Health
No abstract provided.
The Impact Of Various Predator Perceptions On Stress Response And Spatial Memory In Birds, 2017 The University of Western Ontario
The Impact Of Various Predator Perceptions On Stress Response And Spatial Memory In Birds, Chlöe S. N. Carter
Western Research Forum
The Impact of Various Predator Perceptions on Stress Response and Spatial Memory in Birds
This project will explore the impact of environmental stressors on the cognitive abilities of birds. Predator perception has been demonstrated to elicit a stress response by elevating stress hormones which can alter the behaviour of birds. The aim of this study is to observe if chronic stress from differently perceived threats of predation in an individual’s environment will lead to differences in the spatial memory abilities in two species of birds. I predict that chronic stress resulting from predator stimuli will impair the bird ...
Amh/Mis As A Contraceptive That Protects The Ovarian Reserve During Chemotherapy, 2017 Massachusetts General Hospital
Amh/Mis As A Contraceptive That Protects The Ovarian Reserve During Chemotherapy, Motohiro Kano, Amanda E. Sosulski, Lihua Zhang, Hatice D. Saatcioglu, Dan Wang, Nicholas Nagykery, Mary E. Sabatini, Guangping Gao, Patricia K. Donahoe, David Pepin
Open Access Articles
The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which is gradually depleted during a woman's reproductive lifespan, resulting in menopause. Mullerian inhibiting substance (MIS) (or anti-Mullerian hormone/AMH), which is produced by granulosa cells of growing follicles, has been proposed as a negative regulator of primordial follicle activation. Here we show that long-term parenteral administration of superphysiological doses of MIS, using either an adeno-associated virus serotype 9 (AAV9) gene therapy vector or recombinant protein, resulted in a complete arrest of folliculogenesis in mice. The ovaries of MIS-treated mice were smaller than those in controls ...
Botswana’S Elephant-Back Safari Industry – Stress-Response In Working African Elephants And Analysis Of Their Post-Release Movements, 2017 University of Massachusetts Amherst
Botswana’S Elephant-Back Safari Industry – Stress-Response In Working African Elephants And Analysis Of Their Post-Release Movements, Tanya Lama
Understanding how African elephants (Loxodonta africana) respond to human interactions in ecotourism operations is critical to safeguarding animal and human welfare and sustaining wildlife ecotourism activities. We investigated the stress response of elephants to a variety of tourist activities over a 15-month period at Abu Camp in northern Botswana. We compared fecal glucocorticoid metabolite (FGM) concentrations across three elephant groups, including: eight elephants in an elephant-tourism operation (Abu herd), three elephants previously reintroduced back into the wild from the Abu herd, and wild elephants. There were no differences in FGM concentrations between the three groups of elephants. The highest observed ...
Glucocorticoid-Dependent Circadian Modulation Of Prefrontal Cortex Molecular Clocks And Functioning, 2017 University of Colorado at Boulder
Glucocorticoid-Dependent Circadian Modulation Of Prefrontal Cortex Molecular Clocks And Functioning, Elizabeth R. Woodruff
Psychology and Neuroscience Graduate Theses & Dissertations
Circadian rhythms are 24-hour fluctuations in physiology and behavior that are driven by the oscillatory expression of positive arm (Clock, Bmal1) and negative arm (Period, Per; Cryptochrome, Cry) core clock genes. Glucocorticoid hormone (CORT) circulation exhibits robust circadian rhythmicity, which stabilizes physiological and behavioral clocks during times of unanticipated environmental change. In Chapter 2 of this dissertation, I extend CORT’s stabilizing nature to the effect of constant light-induced disruption of circadian locomotor activity. In Chapter 3, I show that the presence and appropriate circadian phasing of CORT circulation is necessary for normal prefrontal cortex (PFC) Per1, Per2, and Bmal1 ...
Neonatal Hair Cortisol In Relation To Maternal Environment, Sociodemographic Factors, And Infant Birth And Growth Outcomes In Rural Gambia, 2017 University of Colorado at Boulder
Neonatal Hair Cortisol In Relation To Maternal Environment, Sociodemographic Factors, And Infant Birth And Growth Outcomes In Rural Gambia, Sara Fardi
Anthropology Graduate Theses & Dissertations
Maternal stress during pregnancy, whether physical, immunological, or psychosocial, influences maternal physiology and can leave the fetus vulnerable to adverse effects of maternal and environmental stress. The Developmental Origins of Health and Disease hypothesis suggests that the gestational period, through environmental and maternal signals, has significant impact on the health outcomes for the fetus, infant, and later adult. Environmental and maternal signals can be translated to the developing fetus through epigenetic mechanisms, changes in cell cycle regulation and tissue differentiation, and endocrine pathways.
The Gambia is characterized by strong seasonality that, in rural areas, influences maternal workload, food availability, and ...
Glucocorticoids And Parental Effort In Tree Swallows (Tachycineta Bicolor), 2017 University of Montana
Glucocorticoids And Parental Effort In Tree Swallows (Tachycineta Bicolor), Mackenzie Prichard
Undergraduate Theses and Professional Papers
All vertebrates respond to stressful situations through the release of hormones called glucocorticoids (CORT). These hormones alter processes within the body to prioritize long term survival over immediate reproduction. It is hypothesized that this is helps individuals survive until conditions become more favorable for successful reproduction. Historically, stress was hypothesized to primarily to pull organisms out of reproductive life history stages when unfavorable conditions made offspring survival slim (otherwise known as the “CORT-tradeoff hypothesis”). However, recent evidence suggests that birds actively feeding nestlings show elevated CORT levels, possibly due to the increased metabolic demands of parenthood. This relationship has been ...
The Effects Of Adaptogens On The Physical And Psychological Symptoms Of Chronic Stress, 2017 Georgia State University
The Effects Of Adaptogens On The Physical And Psychological Symptoms Of Chronic Stress, Tosin O. Ajala
DISCOVERY: Georgia State Honors College Undergraduate Research Journal
Stress is a state of disharmony or threatened homeostasis. The maintenance of homeostasis in stages of internal or external challenges, called stressors, requires constant adjustments of hormonal, behavioral, and autonomic functions. The nuances of life may bring about unwanted stress to the human body. Some of the top causes of stress in America include work, finances, relationships, and health. There are numerous physical and psychological symptoms associated with long-term “chronic” stress, which include chronic fatigue, frustration, irritability, insomnia, frequent headaches, chest and back pain, weakness, and weight gain or weight loss. These symptoms of chronic stress are associated with depression ...
The Effects Of Perinatal Oxycodone Exposure On The Stress Axis And Neurobehavior, 2017 University of Kentucky
The Effects Of Perinatal Oxycodone Exposure On The Stress Axis And Neurobehavior, Thitinart Sithisarn
Theses and Dissertations--Physiology
Opiate addiction is now a major public health problem. Pregnant women continue to use opiates during gestation; up to 5.4% of pregnant women report using illicit drugs during pregnancy. Previous studies have shown that perinatal insults and exposure to opiates such as morphine in utero can affect the development of the hypothalamic-pituitary-adrenal (HPA)-axis of the offspring and are associated with higher risk of developing neurobehavioral problems. Oxycodone, a semisynthetic putative kappa opioid receptor and partial mu opioid receptor agonist is now one of the most frequently abused pain killers during pregnancy, however limited data are available regarding whether ...
Assessing For Awareness And Knowledge Regarding Diabetes In Pre-Diabetes Obese Patients, 2017 Walden University
Assessing For Awareness And Knowledge Regarding Diabetes In Pre-Diabetes Obese Patients, Remona Lysa Brown
Walden Dissertations and Doctoral Studies
Over the past few decades, there has been an increase in prevalence of diabetes in the United States. Prevention of diabetes and improving patients' knowledge and awareness of diabetes are crucial for healthcare providers. Using the Health Belief Model (HBM) as a theoretical foundation, the student used the National Diabetes Prevention Program (NDPP) from the Centers for Disease Control and Prevention (CDC), to improve awareness and knowledge of diabetes among obese individuals with prediabetes. The key research question of this project was to determine whether the patients' diabetes knowledge and awareness improved after the NDPP program. A convenience sample of ...
Inflammatory Gene Expression In Women Diagnosed With Polycystic Ovarian Syndrome, 2016 Pittsburg State University
Inflammatory Gene Expression In Women Diagnosed With Polycystic Ovarian Syndrome, Myles K. Taylor
Electronic Thesis Collection
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The pathophysiology of PCOS has conventionally thought to originate from androgen excess. However, recent evidence suggests that androgen excess is a downstream consequence to inflammatory dysregulation and subsequent metabolic abnormalities. Inflammatory mRNA gene expression of TNFa and IL-1ß in mononuclear cells isolated from women diagnosed with PCOS was explored using qPCR. Additionally, the correlations between body mass index (BMI) and fasting glucose on mRNA expression of TNFa and IL-1ß were explored. mRNA expression of both TNFa and IL-1ß were found to be significantly higher in PCOS ...
Glutathione S-Transferase P In Glucose Homeostasis In Mice., 2016 University of Louisville
Glutathione S-Transferase P In Glucose Homeostasis In Mice., Shubha Ghosh Dastidar
Electronic Theses and Dissertations
High calorie diets have fostered the current pandemic of obesity and comorbid conditions of non-alcoholic fatty liver disease (NAFLD), systemic insulin resistance (IR) and type 2 diabetes (T2D). Hepatic glutathione S-transferases (GSTs) are dysregulated in obesity, NAFLD and diabetes. The multifunctional GST pi isoform (GSTP) catalyzes acrolein metabolism and inhibits JNK (c-Jun NH2-terminal kinase). The purpose of this study was to test specifically whether GSTP deficiency disturbs glucose homeostasis in mice. Hepatic GST proteins were downregulated by short-term high fat diet (HFD) in wild type (WT) mice concomitant with glucose intolerance, increased hepatic JNK activation and protein-acrolein ...
Using A Mouse Model To Investigate Male Bias In Autism Spectrum Disorder Incidence., 2016 University of Louisville
Using A Mouse Model To Investigate Male Bias In Autism Spectrum Disorder Incidence., Elizabeth Ann Gordon
Electronic Theses and Dissertations
The review (Chapter 1) overviews our current understanding of the sex bias in autism spectrum disorders (ASD), whereby males are 4 times more likely to develop the condition. The longstanding uncertainty surrounding the etiology of autism can be informed by inclusion of both sexes in future research to better understand the mechanism responsible for this sex bias. Both clinical studies and animal models are useful tools to elucidate the underlying cause(s) of sexual dimorphic morphological, physiological, and behavioral differences in the ASD phenotype. Sex differences in social behaviors are common across species, underscoring the importance of assessing baseline sex ...
Chrebp Regulates Fructose-Induced Glucose Production Independently Of Insulin Signaling, 2016 Beth Israel Deaconess Medical Cente
Chrebp Regulates Fructose-Induced Glucose Production Independently Of Insulin Signaling, Mi-Sung Kim, Sarah A. Krawczyk, Ludivine Doridot, Alan J. Fowler, Jennifer X. Wang, Sunia A. Trauger, Hye Lim Noh, Hee Joon Kang, John K. Meissen, Matthew Blatnik, Jason K. Kim, Michelle Lai, Mark A. Herman
University of Massachusetts Medical School Faculty Publications
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant. Specifically, insulin fails to suppress glucose production, yet successfully stimulates de novo lipogenesis. The mechanisms underlying this dysregulation remain controversial. Here, we hypothesized that carbohydrate-responsive element-binding protein (ChREBP), a transcriptional activator of glycolytic and lipogenic genes, plays a central role in this paradox. Administration of fructose increased hepatic hexose-phosphate levels, activated ChREBP, and caused glucose intolerance, hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis in mice. Activation of ChREBP was required for the increased expression of glycolytic and lipogenic genes as well as ...
Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, 2016 Marshall University, Joan C. Edwards School of Medicine
Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd
Franklin D. Shuler
Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation of ...
Macrophages Are Regulators Of Whole Body Metabolism: A Dissertation, 2016 University of Massachusetts Medical School
Macrophages Are Regulators Of Whole Body Metabolism: A Dissertation, Joseph C. Yawe
GSBS Dissertations and Theses
Obesity is the top risk factor for the development of type 2 diabetes mellitus in humans. Obese adipose tissue, particularly visceral depots, exhibits an increase in macrophage accumulation and is described as being in a state of chronic low-grade inflammation. It is characterized by the increased expression and secretion of inflammatory cytokines produced by both macrophages and adipocytes, and is associated with the development of insulin resistance. Based on these observations, we investigated the potential role of macrophage infiltration on whole body metabolism, using genetic and diet-induced mouse models of obesity.
Using flow cytometry and immunofluorescence imaging we found that ...