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Articles 1 - 30 of 6634

Full-Text Articles in Physiology

Ischemic Preconditioning Does Not Improve Time Trial Performance In Recreational Runners, Alexander Hk Montoye, Clara J. Mitchinson, Olivia R. Townsend, Conner H. Nemmers, Caroline N. Serkaian, Brian C. Rider Sep 2020

Ischemic Preconditioning Does Not Improve Time Trial Performance In Recreational Runners, Alexander Hk Montoye, Clara J. Mitchinson, Olivia R. Townsend, Conner H. Nemmers, Caroline N. Serkaian, Brian C. Rider

International Journal of Exercise Science

International Journal of Exercise Science 13(6): 1402-1417, 2020. Some evidence indicates that ischemic preconditioning (IPC) may positively affect endurance exercise performance, but IPC’s effect on running performance is unclear. This study’s purpose was to examine the effect of IPC on running performance in recreational runners. Participants (n=12) completed IPC, a sham (SH) condition, and a leg elevation without blood restriction (LE) control condition on separate days (order randomized). For IPC, blood was restricted using blood pressure cuffs inflated to 220 mmHg at the thigh. For SH, the cuffs were inflated to only 20 mmHg. For LE ...


Validity And Reliability Of The Vo2 Master Pro For Oxygen Consumption And Ventilation Assessment, Alexander Hk Montoye, Joseph D. Vondrasek, James B. Hancock Ii Sep 2020

Validity And Reliability Of The Vo2 Master Pro For Oxygen Consumption And Ventilation Assessment, Alexander Hk Montoye, Joseph D. Vondrasek, James B. Hancock Ii

International Journal of Exercise Science

International Journal of Exercise Science 13(4): 1382-1401, 2020. This study assessed validity and reliability of the VO2 Master Pro portable metabolic analyzer for assessment of oxygen consumption (VO2) and minute ventilation (VE). In Protocol 1, eight male participants (height: 182.6 ± 5.8 cm, weight: 79.6 ± 8.3 kg, age: 41.0 ± 12.3 years) with previous competitive cycling experience completed an hour-long stationary cycling protocol twice, progressing from 100-300 Watts every 10 minutes while wearing the VO2 Master and a criterion measure (Parvomedics) for five minutes each, at each stage. In Protocol 2, 16 ...


Evaluation Of Muscle Damage, Body Temperature, Peak Torque And Fatigue Index In Three Different Methods Of Strength Gain, Nathalie De Almeida Barros, Felipe J. Aidar, Dihogo De Matos Professor, Raphael Fabrício De Souza, Eduardo Borba Neves, Breno Guilherme De Araujo Tinoco Cabral, Enilton Aparecido Camargo, Victor Machado Reis Sep 2020

Evaluation Of Muscle Damage, Body Temperature, Peak Torque And Fatigue Index In Three Different Methods Of Strength Gain, Nathalie De Almeida Barros, Felipe J. Aidar, Dihogo De Matos Professor, Raphael Fabrício De Souza, Eduardo Borba Neves, Breno Guilherme De Araujo Tinoco Cabral, Enilton Aparecido Camargo, Victor Machado Reis

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 1352-1365, 2020. The aim of this study was to evaluate and compare three different strength training protocols for the lower limbs by using biochemical indicators of muscle damage, thermographic analysis, and neuromuscular performance. In total, 10 men (age: 22.50 ± 2.84 years; weight, 75.45 ± 6.86 kg) completed the study. All the athletes were subjected to three methods of resistance training (RT): traditional, tension, and occlusion training. Serum concentrations of creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase were used as indicators of muscle damage. To measure muscle strength, the ...


Cross-Validation Of Ratings Of Perceived Exertion Derived From Heart Rate Target Ranges Recommended For Pregnant Women, Danilo F. Da Silva, Shuhiba Mohammad, Kelly Ann Hutchinson, Kristi B. Adamo Sep 2020

Cross-Validation Of Ratings Of Perceived Exertion Derived From Heart Rate Target Ranges Recommended For Pregnant Women, Danilo F. Da Silva, Shuhiba Mohammad, Kelly Ann Hutchinson, Kristi B. Adamo

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 1340-1351, 2020. Currently, there are no established evidence-based rating of perceived exertion (RPE) targets for physical activity (PA) in pregnant women. Yet, a set of target heart rate (HR) ranges have been recommended. Using the Borg Scale, we aimed to determine and validate the RPE target ranges for different PA intensities derived from the recommended HR ranges in the 2019 Canadian Guideline for PA throughout pregnancy. We assessed 13 pregnant women (age: 31.2 ± 3.5 years; gestational age: 20.5 ± 5.0 weeks) using the following three phases: 1) the incremental submaximal ...


High-Protein Diet Associated With Resistance Training Improves Performance And Decreases Adipose Index In Rats, Paula Caroline De Almeida, Thiago Da Rosa Lima, Eudes Thiago Pereira Avila, Geovane José Tolazzi, Letícia Pereira Cavalcante, James W. Navalta, Ramires Tibana, Roberto Lopes De Souza, Neuber José Segri, Édila Cristina De Souza, Roberto Carlos Vieira Jr., Fabrício Azevedo Voltarelli Sep 2020

High-Protein Diet Associated With Resistance Training Improves Performance And Decreases Adipose Index In Rats, Paula Caroline De Almeida, Thiago Da Rosa Lima, Eudes Thiago Pereira Avila, Geovane José Tolazzi, Letícia Pereira Cavalcante, James W. Navalta, Ramires Tibana, Roberto Lopes De Souza, Neuber José Segri, Édila Cristina De Souza, Roberto Carlos Vieira Jr., Fabrício Azevedo Voltarelli

International Journal of Exercise Science

International Journal of Exercise Science 13(2): 1366-1381, 2020. The study tested the hypothesis that a high protein diet based on isolated whey protein (IWP) associated with strength training improves performance and reduces body fat without promoting health damage. Male Wistar rats, 45 days old, were divided into four groups (n = 8 / group): normoprotein sedentary (IWP 14%; NS); hyperprotein sedentary (IWP 35%; HS); normoprotein trained (IWP 14%; NT) and hyperprotein trained (IWP 35%; HT). All groups performed the maximum load test at the beginning and after the vertical ladder training protocol for 6 weeks (3x/week). The performance improved in ...


Efficient Cocaine Degradation By Cocaine Esterase-Loaded Red Blood Cells, Luigia Rossi, Francesca Pierigè, Marco Agostini, Noemi Bigini, Veronica Termopoli, Yingting Cai, Fang Zheng, Chang-Guo Zhan, Donald W. Landry, Mauro Magnani Sep 2020

Efficient Cocaine Degradation By Cocaine Esterase-Loaded Red Blood Cells, Luigia Rossi, Francesca Pierigè, Marco Agostini, Noemi Bigini, Veronica Termopoli, Yingting Cai, Fang Zheng, Chang-Guo Zhan, Donald W. Landry, Mauro Magnani

Molecular Modeling and Biopharmaceutical Center Faculty Publications

Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Unfortunately, the native enzyme was highly unstable and the corresponding mutagenized derivatives, RBP-8000 and E196-301, although improving in vitro thermo-stability and in vivo half-life, were a partial solution to the problem. For cocaine use disorder treatment, an efficient cocaine-metabolizing enzyme with a longer residence time in circulation would be needed. We investigated in vitro the possibility of developing red blood cells (RBCs) loaded with RBP-8000 and E196-301 as a biocompatible system to metabolize cocaine for a longer period of time. RBP 8000 stability within human ...


Expression And Localization Of The 14-3-3 (Ywha) Protein Family Within Mammals, Neha Kumrah, Santanu De Sep 2020

Expression And Localization Of The 14-3-3 (Ywha) Protein Family Within Mammals, Neha Kumrah, Santanu De

Mako: NSU Undergraduate Student Journal

The 14-3-3 (YWHA) are a family of homologous, acidic, and highly conserved proteins expressed abundantly and ubiquitously in a wide array of organisms ranging from plants to animals, including humans, which regulate important cellular events. Within mammals, seven isoforms of 14-3-3 exist: β, γ, ε, ζ, η, τ, and σ (stratifin), each of which is encoded by a unique gene. Studies have shown similar expression patterns among mammalian species. The 14-3-3 proteins are commonly expressed and have proven to play critical roles in proper cellular localization, function, and homeostatic regulation. Numerous researchers have investigated the expression and localization patterns of ...


The Acute Effects Of The Covid-19 Pandemic On Physical Activity And Sedentary Behavior In University Students And Employees, Jacob E. Barkley, Andrew Lepp, Ellen Glickman, Gregory S. Farnell, Jake Beiting, Ryan Wiet, Bryan Dowdell Aug 2020

The Acute Effects Of The Covid-19 Pandemic On Physical Activity And Sedentary Behavior In University Students And Employees, Jacob E. Barkley, Andrew Lepp, Ellen Glickman, Gregory S. Farnell, Jake Beiting, Ryan Wiet, Bryan Dowdell

International Journal of Exercise Science

International Journal of Exercise Science 13(5): 1326-1339, 2020. The COVID-19 pandemic has closed non-essential businesses which may alter individuals’ leisure behaviors. Consequently, physical activity and sedentary behavior may be negatively impacted as many fitness and recreational centers have been closed. This study aimed to examine the impact of the pandemic on physical activity and sedentary behavior in a sample of university students and employees before and after the university cancelled face-to-face classes and closed campus. Participants (N = 398) completed the validated Godin physical activity questionnaire and the International Physical Activity Questionnaire which assessed physical activity and sedentary behavior pre- ...


Differences Between Males And Females In Determining Exercise Intensity, Jozelyn Rascon, Elizabeth Trujillo, Francisco J. Morales-Acuna, Alvaro N. Gurovich Aug 2020

Differences Between Males And Females In Determining Exercise Intensity, Jozelyn Rascon, Elizabeth Trujillo, Francisco J. Morales-Acuna, Alvaro N. Gurovich

International Journal of Exercise Science

International Journal of Exercise Science 13(4): 1305-1316, 2020. Even though there are physiological differences between males and females, heart rate (HR), ratings of perceived exertion (RPE), power output (PO), oxygen consumption (VO2), and blood lactate (BL) levels have been used as measures of exercise intensity independently of sex. The purpose of this study was to determine differences between sexes in different exercise intensity models. Thirty (15 females) young, healthy individuals were scheduled for two testing visits 48-72 hours apart. During the first testing visit, a graded exercise test (GXT), with BL obtained at the end of each exercise ...


The Acute Effects Of Antagonist Stretching On Agonist Movement Economy, Justin Shahtout, Shawn Henry, Dylan Ito, Kyle Savellano Aug 2020

The Acute Effects Of Antagonist Stretching On Agonist Movement Economy, Justin Shahtout, Shawn Henry, Dylan Ito, Kyle Savellano

International Journal of Exercise Science

International Journal of Exercise Science 13(4): 1295-1304, 2020. Current research on the effects of stretching on movement performance varies. However, these studies focused on stretching agonist and antagonist muscle responsible for movement production. Few studies investigated the influence of antagonist stretching on exercise performance. The purpose of this study is to examine the acute effects of antagonist stretching on agonist movement economy. 14 participants (5 male, 9 females; 168.32 ± 7.63 cm stature; 65.00 ± 7.28 kg mass) completed baseline active ROM (AROM) and passive ROM (PROM) measurements. The experimental design required participants to complete two 5 ...


Integrative Dance For Adults With Down Syndrome: Effects On Postural Stability, Sarah E. Dipasquale, Benjamin Canter, Mary Roberts Aug 2020

Integrative Dance For Adults With Down Syndrome: Effects On Postural Stability, Sarah E. Dipasquale, Benjamin Canter, Mary Roberts

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 1317-1325, 2020. Postural stability, one’s ability to maintain an upright stable position, is a crucial aspect of functional mobility and independent living. The purpose of this study was to examine if integrative dance classes have the potential to improve the postural stability in individuals with Down syndrome (DS). Utilizing a one group design, seven participants with DS were evaluated before and after a 12-week integrative dance class (ClinicalTrials.gov#NCT03660423). Postural stability was evaluated in uni- and bilateral quiet standing using a Wii Balance Board. Stability levels were measured based on changes ...


A Comparative Analysis Of Army Body Composition Standards For Women, Adam G. Tedford, Veronika Pribyslavska, Lance G. Bryant, Eric M. Scudamore Aug 2020

A Comparative Analysis Of Army Body Composition Standards For Women, Adam G. Tedford, Veronika Pribyslavska, Lance G. Bryant, Eric M. Scudamore

International Journal of Exercise Science

International Journal of Exercise Science 13(7): 1275-1282, 2020. The aim of this study was to compare body fat percentage (BF%) of women measured using the U.S. Army standard body composition assessment (ABC) and two common laboratory measures of body composition to evaluate the efficacy of ABC within this population. The BF% of 27 women (21.5 ± 1.8 years) was assessed using the 7-site skinfold, air plethysmography, and ABC measurements. The initial physical fitness test (IPFT) was used to determine if participants met the criteria required for admittance into basic combat training. A repeated measures ANOVA identified differences ...


Long-Term Tennis Participation And Health Outcomes: An Investigation Of “Lifetime” Activities, Katherine E. Spring, Megan E. Holmes, Johneric W. Smith Aug 2020

Long-Term Tennis Participation And Health Outcomes: An Investigation Of “Lifetime” Activities, Katherine E. Spring, Megan E. Holmes, Johneric W. Smith

International Journal of Exercise Science

International Journal of Exercise Science 13(7): 1251-1261, 2020. Lifetime sports, such as tennis, provide opportunities for participation throughout the lifespan and has been linked with lower risk of cardiovascular disease, obesity, and depression. The objective of this study was to consider the influence of chronic tennis participation on various parameters of health. Members of the International Tennis Federation (ITF) completed a survey consisting of questions from International Physical Activity Questionnaire (IPAQ), Behavior Risk Factor Surveillance System (BRFSS), Satisfaction With Life Survey (SWLS), and specific tennis participation questions. Descriptive characteristics were calculated for all variables and a chi-squared analysis was ...


Accuracy Of 5 Common Age-Predicted Maximal Heart Rate Equations, Daniel Shookster, Bryndan Lindsey, Nelson Cortes, Joel Martin Aug 2020

Accuracy Of 5 Common Age-Predicted Maximal Heart Rate Equations, Daniel Shookster, Bryndan Lindsey, Nelson Cortes, Joel Martin

International Journal of Exercise Science

International Journal of Exercise Science 13(7): 1242-1250, 2020. Age-predicted maximal heart rate (APMHR) is an essential measure for healthcare professionals in determining cardiovascular response to exercise testing, exertion, and prescription. Although multiple APMHR prediction equations have been validated for specific populations, the accuracy of each within a general population requires testing. We aimed to determine which APMHR equation (Fox, Gellish, Gulati, Tanaka, Arena, Astrand, Nes, Fairbarn) most accurately predicts max heart rate (HRmax) in a general population. HRmax from 99 graded treadmill exercise tests (GXT) were measured. GXTs ended upon volitional fatigue and were only included for ...


Effects Of Three Modest Levels Of Proximal Loading On Marathon Pace Running Economy, Jackson W. Gaddie, Emily P. Kennedy, Matt Green, Lauren G. Killen, Braxton A. Linder, Angela A. Heinkel, Eric K. O'Neal Aug 2020

Effects Of Three Modest Levels Of Proximal Loading On Marathon Pace Running Economy, Jackson W. Gaddie, Emily P. Kennedy, Matt Green, Lauren G. Killen, Braxton A. Linder, Angela A. Heinkel, Eric K. O'Neal

International Journal of Exercise Science

International Journal of Exercise Science 13(7): 1120-1131, 2020. This study examined the effect of modest increases in proximal body mass on running economy expressed as metabolic cost (MC). External loads of 1.6 (L), 2.4 (M), and 3.2 kg (H) were added to the anterior and posterior torso region of male (n = 18) and female (n = 18) runners using a double-layered compression garment with gel inserts. MC was evaluated using stoichiometry equations of data collected via indirect calorimetry. Data was collected during four, 5-min running bouts at marathon pace for the 3 load levels and an unloaded ...


Job-Specific Physical Fitness Changes Measured By The Work Sample Test Battery Within Deputy Sheriffs Between Training Academy And Their First Patrol Assignment, Robert G. Lockie, Rodney Pope, Olivia Saaroni, Joseph Dulla, J. Jay Dawes, Robin Marc Orr Aug 2020

Job-Specific Physical Fitness Changes Measured By The Work Sample Test Battery Within Deputy Sheriffs Between Training Academy And Their First Patrol Assignment, Robert G. Lockie, Rodney Pope, Olivia Saaroni, Joseph Dulla, J. Jay Dawes, Robin Marc Orr

International Journal of Exercise Science

International Journal of Exercise Science 13(4): 1262-1274, 2020. Deputy Sheriffs need to exhibit job-specific fitness throughout their occupational lifespan. This study evaluated job-specific fitness changes measured by the Work Sample Test Battery (WSTB) in deputy sheriffs from training academy to patrol school (refresher program completed before first patrol assignment). WSTB data for 34 deputy sheriffs (28 males, 6 females) was retrospectively analyzed. The WSTB included five tests: a 99-yard obstacle course (99OC); a 165-pound body drag (BD); 6-foot chain link fence (CLF) and solid wall (SW) climbs; and a 500-yard run (500R). WSTB task times measured at the end ...


Effect Of Chronotype On Sleep Quality In A Laboratory Setting, Brianna D. Harfmann, Natashia Swalve, John Mitrzyk, Alex Montoye Aug 2020

Effect Of Chronotype On Sleep Quality In A Laboratory Setting, Brianna D. Harfmann, Natashia Swalve, John Mitrzyk, Alex Montoye

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 1283-1294, 2020. Sleep is undoubtedly important for human health as insufficient sleep has been associated with a plethora of diseases. Adequate sleep assessment is critical in clinical and research settings, however current sleep assessment protocols fail to account for circadian rhythms, despite the fact that sleep is a well-recognized circadian process. Purpose: The purpose of this study was to determine if circadian parameters, such as chronotype, influence sleep quality in a sleep laboratory setting. Methods: In order to investigate this, twenty participants (10 men and 10 women) aged 18-31 years old had their ...


Esport: Fortnite Acutely Increases Heart Rate Of Young Men, Silvio Valladao, Jake Middleton, Thomas Andre Aug 2020

Esport: Fortnite Acutely Increases Heart Rate Of Young Men, Silvio Valladao, Jake Middleton, Thomas Andre

International Journal of Exercise Science

International Journal of Exercise Science 13(6): 1217-1227, 2020. Esports has rapidly increased in online play and viewing. A myriad of literature focuses on heart rate (HR) during traditional athletic competition, little research has addressed the HR responses of individuals playing esports and none in the esport: Fortnite. The purpose of this study was to compare the HR response during a 3-hour seated session of the esport: Fortnite to resting HR. Male college students (n = 23; age = 21 ± 1.8 years; BMI = 25.7 ± 3.9; Esport mean hours per week = 13 ± 8.7) were recruited to participate in the ...


Patient And Provider Communication Regarding Exercise During Pregnancy In A Rural Setting, Maire M. Blankenship, Kim Link, Samantha Henry, Rachel A. Tinius Aug 2020

Patient And Provider Communication Regarding Exercise During Pregnancy In A Rural Setting, Maire M. Blankenship, Kim Link, Samantha Henry, Rachel A. Tinius

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 1228-1241, 2020. Women in rural settings are at increased risk for adverse pregnancy outcomes. One potential way to improve pregnancy outcomes in rural settings is through physical activity promotion. However, given the disparities in prenatal care, women in rural areas may not receive information from their health care provider regarding physical activity during pregnancy. Therefore, the purpose of this study was to examine patient and provider communication in a rural setting (both patients’ and providers’ perspectives) regarding physical activity during pregnancy. A mixed methods study was performed among patients and providers in an ...


Nano-Vesicle (Mis)Communication In Senescence-Related Pathologies, Sherin Saheera, Ajay Godwin Potnuri, Prasanna Krishnamurthy Aug 2020

Nano-Vesicle (Mis)Communication In Senescence-Related Pathologies, Sherin Saheera, Ajay Godwin Potnuri, Prasanna Krishnamurthy

COVID-19 Publications by UMMS Authors

Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm and are present in various biological fluids such as saliva, plasma, urine etc. These cargo-laden extracellular vesicles arise from endosome-derived multivesicular bodies and are known to carry proteins and nucleic acids. Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role ...


The Impact Of External Loads Carried By Police Officers On Vertical Jump Performance, Amy Wiley, Aaron Joseph, Robin Marc Orr, Ben Schram, Charles Kornhauser, Ryan J. Holmes, J. Jay Dawes Aug 2020

The Impact Of External Loads Carried By Police Officers On Vertical Jump Performance, Amy Wiley, Aaron Joseph, Robin Marc Orr, Ben Schram, Charles Kornhauser, Ryan J. Holmes, J. Jay Dawes

International Journal of Exercise Science

International Journal of Exercise Science 13(6): 1179-1189, 2020. The purpose of this study was to examine the impact that external loads have on vertical jump height and peak anaerobic power output (PAPw) of police officers during a vertical jump (VJ) test. Retrospective data of 47 (mean age 38.79 ± 7.97 years) police officers from a US Law Enforcement Agency (LEA) were used for analysis. VJ heights and body mass were used in the Sayers Peak Power Equation to calculate PAPw. Power-to-weight (P:W) ratios were then calculated by dividing PAPw by the officer’s body mass. VJ height ...


Not All Hift Classes Are Created Equal: Evaluating Energy Expenditure And Relative Intensity Of A High-Intensity Functional Training Regimen, Jonathan D. Browne, Robert Carter, Anthony Robinson, Brigette Waldrup, Geoffrey Zhang, Erik Carrillo, Minhsang Dinh, Michael T. Arnold, Jonathan Hu, Eric V. Neufeld, Brett A. Dolezal Aug 2020

Not All Hift Classes Are Created Equal: Evaluating Energy Expenditure And Relative Intensity Of A High-Intensity Functional Training Regimen, Jonathan D. Browne, Robert Carter, Anthony Robinson, Brigette Waldrup, Geoffrey Zhang, Erik Carrillo, Minhsang Dinh, Michael T. Arnold, Jonathan Hu, Eric V. Neufeld, Brett A. Dolezal

International Journal of Exercise Science

International Journal of Exercise Science 13(4): 1206-1216, 2020. The demand for efficient and effective exercises has grown in concert with increased attention to fitness as a determinant of overall health. While past studies have examined the benefits traditional conditioning exercises, there have been few investigations of high intensity functional training (HIFT). The aim of this study was to measure the energy expenditure and relative intensity from participation in a signature, 35-minute group-based HIFT regimen. During the HIFT session, 13 volunteers (aged 23-59 years, 6 females) donned a portable breath-by-breath gas analyzer and a heart rate monitor. Mean caloric expenditure ...


Physiological Responses To Repeated Running Sprint Ability Tests: A Systematic Review, Jérémie Charron, Juan Emmanuel Veliz-Garcia, Philippe Roy, Pierre-Marc Ferland, Alain Steve Comtois Aug 2020

Physiological Responses To Repeated Running Sprint Ability Tests: A Systematic Review, Jérémie Charron, Juan Emmanuel Veliz-Garcia, Philippe Roy, Pierre-Marc Ferland, Alain Steve Comtois

International Journal of Exercise Science

International Journal of Exercise Science 13(4): 1190-1205, 2020. The purpose of this study was to review acute physiological responses induced by repeated running sprint ability (RRSA) tests that could serve as references for practitioners utilising repeated sprints as a performance measure with athletes. This research was conducted following the PRISMA methodology. The systematic search was conducted in November 2019 and yielded 26 different scientific articles. Only peer-reviewed full-text article were included as abstracts are too short to allow proper explanation of the RRSAT methodology that was employed. According to the present literature, practitioners should use the following assessments: the ...


Characterization Of Viral Insulins Reveals White Adipose Tissue Specific Effects In Mice, Martina Chrudinová, Francois Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Czech Academy Of Sciences, Harvard Medical School, Boston College Aug 2020

Characterization Of Viral Insulins Reveals White Adipose Tissue Specific Effects In Mice, Martina Chrudinová, Francois Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Czech Academy Of Sciences, Harvard Medical School, Boston College

University of Massachusetts Medical School Faculty Publications

Members of the insulin/IGF superfamily are well conserved across the evolutionary tree. We recently showed that four viruses in the Iridoviridae family possess genes that encode proteins highly homologous to human insulin/IGF-1. Using chemically synthesized single chain (sc), i.e. IGF-1-like, forms of the viral insulin/IGF-1 like peptides (VILPs), we previously showed that they can stimulate human receptors. Because these peptides possess potential cleavage sites to form double chain (dc), i.e. more insulin-like, VILPs, in this study, we have characterized dc forms of VILPs for Grouper iridovirus (GIV), Singapore grouper iridovirus (SGIV) and Lymphocystis disease virus-1 ...


Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Toward Goblet Cell Lineage In The Mouse Intestine, Joyce H. Li, Subir Ray, Alper Kucukural, Gerard Gradwohl, Andrew B. Leiter Aug 2020

Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Toward Goblet Cell Lineage In The Mouse Intestine, Joyce H. Li, Subir Ray, Alper Kucukural, Gerard Gradwohl, Andrew B. Leiter

University of Massachusetts Medical School Faculty Publications

BACKGROUND and AIMS: Transient expression of Neurog3 commits intestinal secretory progenitors to become enteroendocrine-biased progenitors and hence drive enteroendocrine differentiation. Loss of Neurog3 in mouse resulted in the depletion of intestinal enteroendocrine cells (EECs) and an increase in goblet cells. Earlier studies in developing mouse pancreas showed Neurog3 gene dosage in endocrine and exocrine cell fate allocation. We aimed to determine whether Neurog3 gene dosage controls fate choice of enteroendocrine progenitors.

METHODS: We acquired mutant Neurog3 reporter mice carrying 2, 1, or null Neurog3 alleles to study Neurog3 gene dosage effect by lineage tracing. Cell types arising from Neurog3+ progenitors ...


Changes In Selected Physiological Parameters Following A Training Block Of Specific Circuit Training Among National Top-Level Basketball Players, Brigitte Affidéhomé Tonon, Polycarpe Nounagnon Gouthon, Issiako Bio Nigan, Romario Vankan Akpatchi, Basile Nouatin Aug 2020

Changes In Selected Physiological Parameters Following A Training Block Of Specific Circuit Training Among National Top-Level Basketball Players, Brigitte Affidéhomé Tonon, Polycarpe Nounagnon Gouthon, Issiako Bio Nigan, Romario Vankan Akpatchi, Basile Nouatin

International Journal of Exercise Science

International Journal of Exercise Science 13(6): 1156-1166, 2020. The study aims at measuring the effects of six weeks of specific circuit training (SCT) according to the 15-15 modality, on selected physiological parameters in national top-level basketball players. It was an intervention study, undertaken with 44 senior players randomly assigned to two groups depending on the program: intervention (IG: n = 22; SCT) and control (CG: n = 22; usual content of the defending champion team's), submitted to a six-week training block. The heart rate recovery at 1 (HRR1) and then 2 (HRR2) minutes, the double product (DP) and O2 ...


The Determinants Of Marathon Performance: An Observational Analysis Of Anthropometric, Pre-Race And In-Race Variables, Alison Keogh, Olwyn O'Connor Sheridan, Oisin Mccaffrey, Siofra Dunne, Alanna Lally, Cailbhe Doherty Aug 2020

The Determinants Of Marathon Performance: An Observational Analysis Of Anthropometric, Pre-Race And In-Race Variables, Alison Keogh, Olwyn O'Connor Sheridan, Oisin Mccaffrey, Siofra Dunne, Alanna Lally, Cailbhe Doherty

International Journal of Exercise Science

International Journal of Exercise Science 13(6): 1132-1142, 2020. Researchers investigating the determinants of marathon performance have previously focused on pre-race (e.g. training) or in-race (e.g. pacing) variables, but not both. This cross-sectional study, therefore, sought to elucidate the relationship between training behaviours, in-race pacing and anthropometric variables with eventual marathon finish time. A self-report questionnaire collecting athletes’ anthropometrics, training behaviours and recent race times was administered to 260 participants in the 2018 Dublin Marathon. Participants’ race numbers were cross referenced with in-race split times and finish times to determine their race performance. The accuracy or pragmatism of ...


Motivational Coaching Improves Intrinsic Motivation In Adult Fitness Program Participants, Victoria J. Gaesser, William M. Maakestad, Erik S. Hayes, Stephen J. Snyder Aug 2020

Motivational Coaching Improves Intrinsic Motivation In Adult Fitness Program Participants, Victoria J. Gaesser, William M. Maakestad, Erik S. Hayes, Stephen J. Snyder

International Journal of Exercise Science

International Journal of Exercise Science 13(5): 1167-1178, 2020. The purpose of this study was to measure intrinsic motivation following the implementation of motivational coaching strategies in a semester long personalized adult fitness program. Sixty individuals (40 female/ 20 male, age= 48 ± 15 yrs) participated as clients in an undergraduate exercise training program led by student trainers at Taylor University. The program took place during two consecutive semesters, therefore subject participation ranged from one to two semesters. In addition to personalized exercise prescription, student trainers implemented motivational strategies using a motivational coaching guide aimed at increasing individuals’ overall intrinsic motivation ...


The Sport Concussion Assessment Tool-5 (Scat5): Baseline Assessments In Ncaa Division I Collegiate Student-Athletes, Kyle M. Petit, Jennifer L. Savage, Abigail C. Bretzin, Morgan Anderson, Tracey Covassin Aug 2020

The Sport Concussion Assessment Tool-5 (Scat5): Baseline Assessments In Ncaa Division I Collegiate Student-Athletes, Kyle M. Petit, Jennifer L. Savage, Abigail C. Bretzin, Morgan Anderson, Tracey Covassin

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 1143-1155, 2020. The purpose of this study was to report baseline values for the SCAT5 in NCAA Division I collegiate student-athletes, while also evaluating if sex, health diagnoses, or sport type influenced baseline performance. A sample of 462 collegiate student-athletes (212 females, 250 males, (19.21±1.32 years)) completed the SCAT5 prior to the 2017-18, 2018-19 or 2019-20 athletic seasons. Descriptive statistics were reported for symptom total (22 possible), symptom severity (132 possible), orientation (5 possible), immediate memory (30 possible), concentration (5 possible), delayed recall (10 possible), total SAC score (50 possible ...


Body Composition, Metabolism And Inflammation In Breast Cancer Survivors And Healthy Age-Matched Controls: A Cross-Sectional Analysis, Takudzwa A. Madzima, Caroline D. Deaterly Aug 2020

Body Composition, Metabolism And Inflammation In Breast Cancer Survivors And Healthy Age-Matched Controls: A Cross-Sectional Analysis, Takudzwa A. Madzima, Caroline D. Deaterly

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 1108-1119, 2020. Breast cancer survivors (BCS) experience treatment induced alterations in body composition including the loss of bone mineral density (BMD) and lean soft tissue (LST). These changes can affect the metabolism and the systemic inflammatory environment of BCS. Objective: To evaluate the differences in body composition, resting energy expenditure (REE), and inflammation in BCS and age-matched women without a prior cancer diagnosis (control). Methods: Seventeen post-menopausal BCS (stages 0-III; age: 59 ± 9 years) and 18 (59 ± 6 years) controls had their total body and regional (lumbar spine, femur, and forearm) BMD, LST ...