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Dgat1 Is A Lipid Metabolism Oncoprotein That Enables Cancer Cells To Accumulate Fatty Acid While Avoiding Lipotoxicity, Daniel J. Wilcock, Melissa Kasheta, Craig J. Ceol 2020 University of Manchester

Dgat1 Is A Lipid Metabolism Oncoprotein That Enables Cancer Cells To Accumulate Fatty Acid While Avoiding Lipotoxicity, Daniel J. Wilcock, Melissa Kasheta, Craig J. Ceol

University of Massachusetts Medical School Faculty Publications

Dysregulated cellular metabolism is a hallmark of cancer. As yet, few druggable oncoproteins directly responsible for this hallmark have been identified. Increased fatty acid acquisition allows cancer cells to meet their membrane biogenesis, ATP, and signaling needs. Excess fatty acids suppress growth factor signaling and cause oxidative stress in non-transformed cells, but surprisingly not in cancer cells. Molecules underlying this cancer adaptation may provide new drug targets. Here, we identify Diacylglycerol O-acyltransferase 1 (DGAT1), an enzyme integral to triacylglyceride synthesis and lipid droplet formation, as a frequently up-regulated oncoprotein allowing cancer cells to tolerate excess fatty acids. DGAT1 over-expression alone ...


Circadian Disruption With Constant Light Exposure Exacerbates Atherosclerosis In Male Apolipoproteine-Deficient Mice, Jeffrey M. Chalfant, Deborah A. Howatt, Lisa R. Tannock, Alan Daugherty, Julie S. Pendergast 2020 University of Kentucky

Circadian Disruption With Constant Light Exposure Exacerbates Atherosclerosis In Male Apolipoproteine-Deficient Mice, Jeffrey M. Chalfant, Deborah A. Howatt, Lisa R. Tannock, Alan Daugherty, Julie S. Pendergast

Biology Faculty Publications

Disruption of the circadian system caused by disordered exposure to light is pervasive in modern society and increases the risk of cardiovascular disease. The mechanisms by which this happens are largely unknown. ApolipoproteinE-deficient (ApoE−/−) mice are studied commonly to elucidate mechanisms of atherosclerosis. In this study, we determined the effects of light-induced circadian disruption on atherosclerosis in ApoE−/− mice. We first characterized circadian rhythms of behavior, light responsiveness, and molecular timekeeping in tissues from ApoE−/− mice that were indistinguishable from rhythms in ApoE+/+ mice. These data showed that ApoE−/− mice had no inherent circadian disruption and therefore were an appropriate ...


Examining Grit Like Qualities In Nfl Qbs, John Beck, Mark DeBeliso 2020 3DQB

Examining Grit Like Qualities In Nfl Qbs, John Beck, Mark Debeliso

International Journal of Exercise Science

International Journal of Exercise Science 13(5): 912-923, 2020. In order to excel in the National Football League (NFL) it would seem reasonable to assume an athlete has grit which consists of the constructs of consistency of interest and perseverance of effort. Grit-like qualities such as endurance, urgency and intensity, self-confidence, need for encouragement, and self-criticality may be of particular value for the athlete playing the Quarterback (QB) position. The purpose of the study was to assess the 5 grit-like constructs of endurance, urgency and intensity, self-confidence, need for encouragement, and self-criticality among NFL QBs. The Flippen ProfileTM assessment ...


Case Report Of A Remote Ischemic Preconditioning Intervention During Aerobic Exercise In A 44-Year-Old Amateur Triathlete Male With A History Of Acute Myocardial Infarction, Maxime Caru, François Lalonde, Hugo Gravel, Chantal Daigle, Daniel Curnier 2020 University of Montreal

Case Report Of A Remote Ischemic Preconditioning Intervention During Aerobic Exercise In A 44-Year-Old Amateur Triathlete Male With A History Of Acute Myocardial Infarction, Maxime Caru, François Lalonde, Hugo Gravel, Chantal Daigle, Daniel Curnier

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 924-937, 2020. Over the years, exercise has become increasingly important in patients with acute myocardial infarction (AMI). However, AMI patients need to be closely monitored since they maintain cardiovascular disease risks, such as ventricular repolarization abnormalities in electrocardiograms during exercise and rest. A recent study showed the need to focus on the different potential mechanisms and the applicability of remote ischemic preconditioning (RIPC) for cardiac patients engaged in exercise rehabilitation. This is the first case report that explores the effectiveness of an RIPC intervention in a 44-year-old amateur triathlete male with a history ...


The Effects Of Walking With A Load In The Heat On Physiological Responses Among Military Reserve Female Cadets, Nurul Atikah Shuhada, Marilyn L.Y. Ong, Chee Keong Chen 2020 Universiti Sains Malaysia

The Effects Of Walking With A Load In The Heat On Physiological Responses Among Military Reserve Female Cadets, Nurul Atikah Shuhada, Marilyn L.Y. Ong, Chee Keong Chen

International Journal of Exercise Science

International Journal of Exercise Science 13(2): 900-911, 2020. This study aimed to investigate the effects of walking in a hot and humid environment while wearing a combat suit with a load on physiological responses among the Malaysian Military Reserve Officer Training Unit (ROTU) female cadets. Eight healthy female ROTU cadets (age: 21.3 ± 1.0 years old; height: 156.3 ± 4.9 cm; weight: 55.6 ± 7.5 kg) participated in this randomised, crossover trial. They walked for 1 h on a treadmill at 3 km.h-1 while carrying either 8.2 kg load (WL) or without load ...


Donning A Novel Lower-Limb Restrictive Compression Garment During Training Augments Muscle Power And Strength, Jaxon T. Baum, Robert P. Carter, Eric V. Neufeld, Brett A. Dolezal 2020 David Geffen School of Medicine at University of California, Los Angeles

Donning A Novel Lower-Limb Restrictive Compression Garment During Training Augments Muscle Power And Strength, Jaxon T. Baum, Robert P. Carter, Eric V. Neufeld, Brett A. Dolezal

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 890-899, 2020. The popularity of graduated compression garments (GCG) in sport and exercise is largely driven by the abundance of anecdotal claims suggesting their efficacy. A new line of compression apparel, restrictive compression garments (RCG), integrate novel resistance technology into lower-limb compression garments designed to provide variable resistance to movement. This study aimed to investigate the effect of donning an RCG during a 4-week training program on selected performance variables. Twelve college-aged males were recruited for four weeks of lower-body strength-power resistance training. Participants were randomized 1:1 and blinded to (i) an ...


Effects Of Horizontal And Incline Bench Press On Neuromuscular Adaptations In Untrained Young Men, Suene F. N. Chaves, Valdinar A. Rocha-Júnior, Irismar G. A. Encarnação, Hugo C. Martins-Costa, Eduardo D. S. Freitas, Daniel B. Coelho, Frederico S. C. Franco, Jeremy P. Loenneke, Martim Bottaro, João B. Ferreira-Júnior 2020 Federal Institute of Sudeste of Minas Gerais, Campus Rio Pomba, MG, Brazil

Effects Of Horizontal And Incline Bench Press On Neuromuscular Adaptations In Untrained Young Men, Suene F. N. Chaves, Valdinar A. Rocha-Júnior, Irismar G. A. Encarnação, Hugo C. Martins-Costa, Eduardo D. S. Freitas, Daniel B. Coelho, Frederico S. C. Franco, Jeremy P. Loenneke, Martim Bottaro, João B. Ferreira-Júnior

International Journal of Exercise Science

International Journal of Exercise Science 13(6): 859-872, 2020. The aim of the current study was to investigate the effects of horizontal and incline bench press as well as the combination of both exercises on neuromuscular adaptation in untrained young men. Forty-seven untrained men were randomly assigned to one of the three groups: 1) a horizontal bench press group (n= 15), 2) an incline bench press group (n= 15), and 3) a combination (horizontal + incline) group (n= 17). Training was conducted once a week for eight weeks, with equalized number of sets among groups. Muscle thickness, isometric strength and electromyography ...


The Influence Of Sport-Related Concussion On Lower Extremity Injury Risk: A Review Of Current Return-To-Play Practices And Clinical Implications, Jason M. Avedesian, Tracey Covassin, Janet S. Dufek 2020 University of Nevada, Las Vegas

The Influence Of Sport-Related Concussion On Lower Extremity Injury Risk: A Review Of Current Return-To-Play Practices And Clinical Implications, Jason M. Avedesian, Tracey Covassin, Janet S. Dufek

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 873-889, 2020. Sport-related concussions (SRCs) are now classified as a major health concern affecting athletes across all sporting levels, with recent evidence suggesting upwards of 3.8 million SRCs occur each year. Multiple injury surveillance datasets have recently determined that athletes post-SRC, compared to non-concussed counterparts, are at greater risk for lower extremity (LE) injury beyond the resolution of traditional SRC assessment batteries. However, it is presently uncertain if common clinical practices (symptom reporting, neuropsychological (NP) examination, and static postural control analysis) can determine athletes at risk for LE injury following an SRC ...


The Effect Of Timing And Type Of Exercise On The Quality Of Sleep In Trained Individuals, Victoria Burgess, Jose Antonio, Helen Bland, Ronald Wagner, Jaime Tartar, Bridget Melton 2020 Concordia University, River Forest Illinois

The Effect Of Timing And Type Of Exercise On The Quality Of Sleep In Trained Individuals, Victoria Burgess, Jose Antonio, Helen Bland, Ronald Wagner, Jaime Tartar, Bridget Melton

International Journal of Exercise Science

International Journal of Exercise Science 13(7): 837-858, 2020. Sleep is an extremely important component for overall health and for a well-balanced training program. Recent studies have highlighted the interaction between sleep, recovery, and performance in elite and recreational athletes alike. Exercise has been known to affect the quality of sleep, nevertheless the impact is not well understood in the current research, particularly the effects of exercise timing and intensity on sleep quality. The purpose of this study was to understand if exercise timing and intensity significantly impact sleep quality among recreational exercisers. The participants involved were recreational exercisers who ...


Impact Of Hydration Status On Jump Performance In Recreationally Trained Males, Paul T. Donahue, Samuel Wilson, Charles Williams, Christopher M. Hill, Melinda Valiant, John Garner 2020 University of Southern Mississippi

Impact Of Hydration Status On Jump Performance In Recreationally Trained Males, Paul T. Donahue, Samuel Wilson, Charles Williams, Christopher M. Hill, Melinda Valiant, John Garner

International Journal of Exercise Science

International Journal of Exercise Science 13(4): 826-836, 2020. The vertical jump is commonly used as a means of evaluating athlete readiness. Athletes have been shown to arrive to training and competition in a hypohydrated state. Thus, this investigation sought to examine the impact of hydration status on both countermovement (CMJ) and squat jump (SJ) performance. Twenty-five recreationally trained males completed three CMJ and SJ in a euhydrated, hypohydrated and control condition. Conditions were separated by a minimum of 24 hours. Hydration status was assessed using urine specific gravity. Jump performance was evaluated using both kinematic and kinetic data obtained ...


Evaluation Of Repetitive Jumping Intensity On The Digi-Jump Machine, T. Scott Lyons, James W. Navalta, Whitley J. Stone, Scott W. Arnett, Mark A. Schafer, Laura Igaune 2020 Western Kentucky University

Evaluation Of Repetitive Jumping Intensity On The Digi-Jump Machine, T. Scott Lyons, James W. Navalta, Whitley J. Stone, Scott W. Arnett, Mark A. Schafer, Laura Igaune

International Journal of Exercise Science

Cardiorespiratory endurance is an important element of aerobic fitness, particularly in weight management and reducing risk for cardiovascular disease. While there are numerous options for aerobic exercise, rope jumping is often overlooked. In addition to regular exercise and a healthy diet, the American Heart Association strongly recommends rope jumping. The first purpose of this study was to determine the steady state metabolic cost of repetitive jumping on the Digi-Jump machine to evaluate whether exercise on this device is more or less strenuous than similar exercise with a jump rope, as demonstrated in previous literature. A second purpose was to determine ...


Cardiovascular And Stride Frequency Differences During Land And Aquatic Treadmill Walking, Jessica Burton, Sarah Duffey, Amber Hammonds, Anna LeDuc, Rachel Shumate, John Coons, Ryan T. Conners 2020 The University of Alabama in Huntsville

Cardiovascular And Stride Frequency Differences During Land And Aquatic Treadmill Walking, Jessica Burton, Sarah Duffey, Amber Hammonds, Anna Leduc, Rachel Shumate, John Coons, Ryan T. Conners

International Journal of Aquatic Research and Education

This study examined heart rate (HR) and stride frequency (SF) values of 30 college-aged males and females during dry-land (DL) and aquatic walking (AW). Aquatic walking trials were completed in an underwater treadmill with the water depth at waist level; the water temperature (31℃ ± 0.1℃) and room temperature (26.6℃ ± 0.1℃) were maintained at thermoneutral levels throughout the study. During each walking condition, HR and SF were recorded at treadmill speeds of 1 mph, 2 mph, and 3 mph. Participants were instructed to walk with their hands at their sides swinging as they would when walking on dry-land ...


Features Of Acceleration And Angular Velocity Using Thigh Imus During Walking In Water, Koichi Kaneda, Yuji Ohgi, Mark McKean, Brendan Burkett 2020 Chiba Institute of Technology

Features Of Acceleration And Angular Velocity Using Thigh Imus During Walking In Water, Koichi Kaneda, Yuji Ohgi, Mark Mckean, Brendan Burkett

International Journal of Aquatic Research and Education

Ten participants were assessed while walking in water and on land with wearable inertial measurement units (IMUs) attached to the right thigh. Longitudinal acceleration, anterior-posterior acceleration, and frontal axis angular velocity were measured at 100 Hz, matched with video analysis sampled at 25 Hz during the walking trials. The longitudinal acceleration showed almost 1 g from initial heel contact to 70% of one cycle, and the anterior-posterior acceleration showed a sinusoidal pattern, synchronizing the approximate posture of the thigh in water. The frontal axis angular velocity fluctuated less while walking in water compared with on land, because thigh motion speed ...


The Effect Of Intensified Illuminance And Artificial Light At Night On Fitness And Susceptibility To Abiotic And Biotic Stressors, Grascen Shidemantle 2020 Binghamton University

The Effect Of Intensified Illuminance And Artificial Light At Night On Fitness And Susceptibility To Abiotic And Biotic Stressors, Grascen Shidemantle

Biological Sciences Student Scholarship

Changing light conditions due to human activities represents an important emerging environmental concern. Although changes to natural light conditions can be independently detrimental, in nature, organisms commonly face multiple stressors. To understand the consequences of altered light conditions, we exposed a model amphibian (wood frog; Lithobates sylvaticus) to a control and two anthropogenic light conditions: intensified daytime illuminance and artificial light at night - ALAN (intensified daytime illuminance + extended photoperiod). We measured (1) metrics of fitness (hatching success as well as survival to, size at, and time to metamorphosis) (2) susceptibility (time to death) to a commonly cooccurring anthropogenic stressor, road ...


Kids Don’T Float…And Their Parents Don’T Either: Using A Family-Centered Approach In Alaska’S Kids Don’T Float Program, Michelle E. E. Bauer, Audrey R. Giles, Justina Marianayagam, Kelli M. Toth 2020 University of Ottawa

Kids Don’T Float…And Their Parents Don’T Either: Using A Family-Centered Approach In Alaska’S Kids Don’T Float Program, Michelle E. E. Bauer, Audrey R. Giles, Justina Marianayagam, Kelli M. Toth

International Journal of Aquatic Research and Education

The goal of this experiential report is to outline the adoption of a family-centered Kids Don’t Float approach. We conducted a critical synthesis of information to reflect the expansion of the Kids Don’t Float program into a more family-centered approach. The critical synthesis provided insights into why we should adopt this approach, how it was implemented, and how it influenced drowning incidents compared to the previously used child-centered approach. The adoption of a family-centered approach may contribute to reducing drowning incidents by targeting parents, providing safety information to families, and promoting parental modelling of life jackets. Program evaluators ...


Motor Behavior Literature Fails To Translate: A Preliminary Investigation Into Coaching And Focus Of Attention In Recreational Distance Runners., Masahiro Yamada, Jed Diekfuss, Louisa Raisbeck 2020 University of North Carolina at Greensboro

Motor Behavior Literature Fails To Translate: A Preliminary Investigation Into Coaching And Focus Of Attention In Recreational Distance Runners., Masahiro Yamada, Jed Diekfuss, Louisa Raisbeck

International Journal of Exercise Science

International Journal of Exercise Science 13(5): 789-801, 2020. The benefits of using an external focus relative to an internal focus for endurance activities are well documented. However, literature has revealed that internally focused instructions are predominantly adopted in the field, and existing data are limited to highly-skilled level populations. Moreover, athletes’ focus of attention during fatigue invoking activities is unknown. The purpose of the current study was to examine what type of feedback and instructions experienced recreational individuals receive and their self-adopted focus of attention when fatigued. Distance runners answered a questionnaire related to instruction and feedback from coaches ...


Internal Training Load Measures During A Competitive Season In Collegiate Women Lacrosse Athletes, Jennifer Fields, Michael Esco, Justin Merrigan, Jason White, Margaret T. Jones 2020 George Mason University

Internal Training Load Measures During A Competitive Season In Collegiate Women Lacrosse Athletes, Jennifer Fields, Michael Esco, Justin Merrigan, Jason White, Margaret T. Jones

International Journal of Exercise Science

International Journal of Exercise Science 13(4): 778-788, 2020. Monitoring internal load provides useful and non-invasive markers of training stress and adaptation. However, the relationship between internal load measures across a competitive window remains inconclusive and limited. The purpose of this study was to report various internal load measures, as well as their relationship, across a season in Division I women lacrosse athletes (n = 20). Ultra-short natural logarithm of the root mean square of successive differences (lnRMSSD), salivary testosterone, cortisol, the testosterone:cortisol ratio, and self-reported measures of fatigue and recovery were collected weekly for 13 weeks. Means ± SD were ...


Acute Physiologic Effects Of Performing Yoga In The Heat On Energy Expenditure, Range Of Motion, And Inflammatory Biomarkers, Bradley Lambert, Katherine Miller, Domenica Delgado, Kalyan Chaliki, Joshua Lee, Guillermo Bauza, Francesca Taraballi, David Dong, Ennio Tasciotti, Joshua Harris, Patrick McCulloch 2020 Houston Methodist Hospital

Acute Physiologic Effects Of Performing Yoga In The Heat On Energy Expenditure, Range Of Motion, And Inflammatory Biomarkers, Bradley Lambert, Katherine Miller, Domenica Delgado, Kalyan Chaliki, Joshua Lee, Guillermo Bauza, Francesca Taraballi, David Dong, Ennio Tasciotti, Joshua Harris, Patrick Mcculloch

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 802-817, 2020. Performing yoga in a heated environment (HY) is a popular exercise mode purported to improve range of motion (ROM), body composition, and aerobic fitness. The purpose of this investigation was to compare a session of HY to room temperature yoga (RTY) with regards to ROM, oxygen consumption, caloric expenditure, and biomarkers of acute stress and inflammation. Sixteen experienced yoga practitioners (F14, M2; 40 ± 11yr; 22.6 ± 1.8 kg/m2) completed a 1-hour standardized Bikram sequence in HY (105⁰F, 40⁰C) and RTY (74⁰F, 23.3⁰C) conditions (order of conditions randomized ...


Switching Off The Pancreatic Islet: Complex Network Analysis Of Multicellular Clusters, Janita Patwardhan 2020 University of Maryland - Baltimore County

Switching Off The Pancreatic Islet: Complex Network Analysis Of Multicellular Clusters, Janita Patwardhan

Biology and Medicine Through Mathematics Conference

No abstract provided.


Swimming Pool Environment And Respiratory Health Issues Experienced By Masters Swimmers: Results From A Literature Review And Survey Of United States Masters Swimming Clubs, Jody C. Gan, Julia Snegg, William Harder 2020 American University

Swimming Pool Environment And Respiratory Health Issues Experienced By Masters Swimmers: Results From A Literature Review And Survey Of United States Masters Swimming Clubs, Jody C. Gan, Julia Snegg, William Harder

International Journal of Aquatic Research and Education

After three members of a Masters adult swim club died of lung cancer, both a literature review and survey were conducted with representatives from 746 United States Masters Swimming clubs to explore a possible relationship between swimming and cancers of the respiratory tract. Six other clubs reported known cancers of the respiratory tract among club members, but none of the other 740 clubs reported a similar cluster of lung cancer. More clubs reported cases of chronic respiratory infections and widespread complaints about air quality. While no studies exploring a relationship between swimming and lung cancer could be found in the ...


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