Psychedelics Can Save: The Scientific And Social Case For Rescheduling Psychedelic Compounds, 2021 University of Tennessee, Knoxville
Psychedelics Can Save: The Scientific And Social Case For Rescheduling Psychedelic Compounds, Galen M. Fader
Chancellor’s Honors Program Projects
No abstract provided.
The Neurobiological Relationship Between Childhood Maltreatment And Major Depressive Disorder (Mdd), 2021 Pepperdine University
The Neurobiological Relationship Between Childhood Maltreatment And Major Depressive Disorder (Mdd), Morgan Clinton
Childhood maltreatment compromises healthy development, impacts neurobiology, and is associated with lasting alterations to emotional perception, processing, and regulation. Most significantly, childhood maltreatment increases the risk for later development of emotional disorders such as major depressive disorder (MDD). The stress associated with both childhood maltreatment and MDD can lead to lasting alterations to the fronto-limbic circuitry. Using functional and structural magnetic resonance imaging, researchers have observed hippocampal atrophy and amygdala hyperresponsiveness in participants who’ve experienced both childhood maltreatment and MDD. Furthermore, researchers have also observed increased connectivity between the hippocampus and amygdala in victims of childhood maltreatment. Because childhood ...
Landmark-Guided T-Maze Learning In The Wolf Spider Tigrosa Helluo, 2021 Susquehanna University
Landmark-Guided T-Maze Learning In The Wolf Spider Tigrosa Helluo, Tiffany Guth
Senior Scholars Day
Wolf spiders can learn spatial navigation through simple maze tasks. It remains unclear if spatial learning is acquired through idiothetic information (i.e. self-referential movement cues) or if they use allothetic cues (e.g. external landmarks) to navigate. Spiders may also use specific types of landmarks to navigate known as reference frames. A reference frame is an environmental shape or boundary that provides a framework for spatial localization. Using a modified water T-maze, we recorded the ability of adult female Tigrosa helluo wolf spiders to correctly navigate toward a target reward. We measured variation in spatial learning of the target ...
Npy Expression Of Low-Birth Weight Offspring In Nutrient-Restricted Utero, 2021 Susquehanna University
Npy Expression Of Low-Birth Weight Offspring In Nutrient-Restricted Utero, Janine Levandowski, Holly Young
Senior Scholars Day
No abstract provided.
B12: The T Cell Co-Receptor Cd5 Alters Mouse Behavior And Gut Microbiome Composition, 2021 Brigham Young University
B12: The T Cell Co-Receptor Cd5 Alters Mouse Behavior And Gut Microbiome Composition, Kyle Reaveley
Annual Research Symposium
No abstract provided.
Autism Treatments: Beyond Applied Behavioral Analysis Therapy, 2021 Grand Valley State University
Autism Treatments: Beyond Applied Behavioral Analysis Therapy, Sarah Samosiuk
This literature review dicusses the efficacy of mindfulness as a potential treatment option for individuals with autism spectrum disorder (ASD). It differs from other treatment options as it works to reduce the symptoms of ASD by reducing the stress and anxiety that cause the symptoms. I discuss the neuroscience behind the autistic mind and give a multitude of studies showing the power of mindfulness. Researchers have only scratched the surface of the possibilities that mindfulness could achieve in this field and hopefully this movement can gain traction so that this kind of help is available to all of those who ...
Anhedonia And Its Intervention In Depressive Adults: New Developments Based On Research Domain Criteria (Rdoc) In Mental Illnesses, 2021 Faculty of Psychology, Southwest University, Chongqing 400715, China
Anhedonia And Its Intervention In Depressive Adults: New Developments Based On Research Domain Criteria (Rdoc) In Mental Illnesses, J. Mao, J. Yuan
Stress and Brain
Anhedonia, as one of the core symptoms of depression, is of great significance for the diagnosis and treatment of depression. Traditionally, anhedonia has been referred to as "loss of pleasure" , while the recent research emphasizes that anhedonia is a complex and multidimensional construct based on reward processing impairment. Exploring different manifestations of anhedonia and developing the corresponding interventions have become indispensable in the current research of depression. Based on the positive valence system of the Research Domain Criteria (RDoC), this paper firstly demonstrates that the anhedonia of depressive adults are mainly characterized by the impairments in anticipatory pleasure, incentive motivation ...
Exposure To Single Prolonged Stress Fails To Induce Anxiety-Like Behavior In Mice, 2021 Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China
Exposure To Single Prolonged Stress Fails To Induce Anxiety-Like Behavior In Mice, W-J. You, Y. He, W-Z. Liu, Yu-Ge Zhu, Ping Hu, Bing-Xing Pan, Wen-Hua Zhang
Stress and Brain
Single prolonged stress (SPS) is a well-established and most frequently used rat model to induce post-traumatic stress disorder (PTSD)-like symptoms, which helps to understand the neurobiological mechanisms as well as developing novel therapeutic strategies for PTSD. However, whether such stress model works efficiently in mice remains unknown. In the present study, we established a mouse SPS (mSPS) model by exposing C57BL/6J mice to a series of multimodal stressors on a single day, then the anxiety-like behavior was measured by open-field test, elevated plus maze test, dark-light box, and novelty-suppressed feeding test. Our results showed that mSPS had no ...
Pornography: Social, Emotional And Mental Implications Among Adolescents, 2021 Dublin City Schools
Pornography: Social, Emotional And Mental Implications Among Adolescents, William Kelly Canady
National Youth Advocacy and Resilience Conference
This presentation will explain the historical development of pornography. It will highlight four segments: 1- Porn’s impact on brain development of reward pathways, ultimately increasing the appetite for more porn. 2- Porn can be a false substitute for real intimacy, resulting in decreased sexual satisfaction with a real person and increased verbal and physical aggression. 3- Porn promotes sex trafficking, promotes multiple sex partners and reduced STD prevention. 4- A review of interventions available to assist clients in navigating a lifestyle away from pornography.
Cognitive Changes Caused By Lps-Induced Neuroinflammation, 2021 The Graduate Center, City University of New York
Cognitive Changes Caused By Lps-Induced Neuroinflammation, Nancy De La Torre
Dissertations, Theses, and Capstone Projects
The brain performs cognitive processes finely orchestrated by timely precise action of neurons. Neurons functioning at their highest standard communicate with each other through perfectly functioning synapses. Microglia, as part of the immune system assist synaptic processing and have the ability to affect cognition. Indeed, microglia play a role in cognition. To investigate the link between microglia and cognition we utilized lipopolysaccharide (LPS) to pharmacologically activate microglia. LPS, normally present in the environment on the wall of Gram-negative bacteria is a pharmacological agent used to cause microglia activation in mice. LPS is a typical model to study changes induced by ...
Influence Of 2,5-Dimethoxy-4-Iodoamphetamine (Doi) On Ethanol Preference And Consumption In C57bl/6 Male Mice, 2021 Virginia Commonwealth University
Influence Of 2,5-Dimethoxy-4-Iodoamphetamine (Doi) On Ethanol Preference And Consumption In C57bl/6 Male Mice, Alaina M. Jaster, Sam Gottlieb, Michael Miles, Javier González-Maeso
Graduate Research Posters
Substance use disorders (SUD) account for a large number of mental health diagnosis in the United States and around the world. Approximately 13.6 million adults 26 or older and 5.1 million young adults (ages 18-24) battled with a SUD in 2017. Alcohol Use Disorder (AUD) alone effects nearly 6% of the adult population within the United States. This creates a substantial burden on the individual, with alcohol being the third-leading cause of preventable death in the United States. Few treatments for AUD exist, with no new FDA-approved therapeutic treatments within the last 15 years. Additionally, the limited treatments ...
The Inevitability Of Collision: Creating Empathy Through Fiction, 2021 Regis University
The Inevitability Of Collision: Creating Empathy Through Fiction, Danielle Beckman
While the stigma for mental illnesses has greatly declined in the last decade, there is still a disconnect between individuals without neurological illnesses and those with neurological illnesses, especially those that cause individuals to lose contact with reality. The goal of this interdisciplinary paper is to create empathy for these individuals, specifically people with schizophrenia, Alzheimer disease, and post-traumatic amnesia. Through a collection of four stories told from the perspective of these unreliable narrators, I used fiction writing techniques from the field of cognitive literary studies such as gapping and defamiliarization to create more empathy in the reader. In reading ...
Probation Officer’S Experiences Regarding Juvenile Delinquency And Alternatives To Detention Centers, Bailey Rodriguez
Walden Dissertations and Doctoral Studies
With a shift in focus from punitive measures to rehabilitation within the juvenile justice system, it is imperative that the efficacy of alternative resources is more closely examined. Given the existing research that highlights adolescent development and the negative or neutral impacts detention centers impose on juveniles, the conversation has now shifted to the use of alternative resources or alternatives to detention. The question now, however, is whether or not these alternatives are sufficient enough to ensure the safety of the community, victims, and the well-beings of the juveniles, when a violent crime has been committed. This study, which was ...
Manipulating The Perineuronal Net In The Deep Cerebellar Nucleus, 2021 West Virginia University
Manipulating The Perineuronal Net In The Deep Cerebellar Nucleus, Deidre E. O'Dell
Graduate Theses, Dissertations, and Problem Reports
Perineuronal nets (PNN) are a type of specialized extracellular matrix in the central nervous system. The PNN forms during postnatal development but the ontogeny of the PNN has yet to be elucidated. Studying the PNN in the rat brain may allow us to further understand the PNN’s role in development, learning, and memory. The PNN is fully developed in the deep cerebellar nuclei (DCN) of rats by post-natal day 18. By using enzymatic digestion of the PNN with chondroitinase ABC (ChABC), we studied how digestion of the PNN affects cerebellar-dependent eyeblink conditioning (EBC) and performed electrophysiological recordings from DCN ...
Opioid Use Disorder: The Timeline For Medication Assisted Therapy, 2021 Arcadia University
Opioid Use Disorder: The Timeline For Medication Assisted Therapy, Alexander Cristofori
Opioid Use Disorder is patterns of opioid use leading to withdrawal, giving up important life events in order to use opioids, and excessive time spent using opioids, to name a few diagnostic criteria. The clinical progression of the disorder involves periods of acute exacerbation and remission that are cyclic in nature. Treatment is most effective when it includes both pharmacological and psychosocial modalities, referred to as medication assisted therapy (MAT). Three drugs used commonly in MAT-based treatment for OUD from oldest to newest include Methadone, Buprenorphine-naloxone, and Naltrexone. Treatment program models that prioritize total abstinence from the addictive substance attached ...
Neurocounseling And The Counseling Profession: Integrating Neuroscience Into The Practice Of Counseling, 2020 Minnesota State University Moorhead
Neurocounseling And The Counseling Profession: Integrating Neuroscience Into The Practice Of Counseling, Sherri Clark
Dissertations, Theses, and Projects
Neurocounseling integrates Neuroscience into mental health counseling by using psychoeducation, teaching, and illustrations as well as other forms of therapy (CBT, Interpersonal Psychotherapy, Narrative Therapy, etc.) to assist clients in understanding the neurological basis of many mental and behavioral health concerns. Clients can benefit from Neurocounseling as they gain a more comprehensive understanding of the central nervous system and brain function in connection to the body, cognition, mood, and behaviors, also known as the mind and body connection. Neuroplasticity and neurogenesis allow us to understand the brain’s amazing capability to grow and change. Understanding neuroscience allows for more integrated ...
Spirituality As A Moderator Between Ptss And Cardiovascular Reactivity, 2020 University of Connecticut
Spirituality As A Moderator Between Ptss And Cardiovascular Reactivity, Kriti Sharda
Honors Scholar Theses
Posttraumatic stress symptoms (PTSS) can be distressing and produce robust cardiovascular symptoms, such as increased heart rate and blood pressure, which have been implicated in higher risk of developing cardiovascular disease (CVD). Identifying factors that may reduce symptoms may suggest therapeutic strategies. One such potential factor is spirituality, given that spirituality is associated with both reducing PTSS and with preventing or improving CVD. We sampled 63 young college women who indicated being exposed to unwanted sexual contact. We asked them to write about their experience while we took heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP ...
Historical Trauma Response Scores As A Function Of Unresolved Grief And Substance Use Disorder In American Indian Populations, 2020 University of Missouri-St. Louis
Historical Trauma Response Scores As A Function Of Unresolved Grief And Substance Use Disorder In American Indian Populations, Andrew R. Saunders
Undergraduate Research Symposium
Researchers are interested in the outcomes of interventions, specifically, measuring historical trauma (HT) among American Indian/Alaska Native communities and the long-term distress and substance abuse as a result of historical trauma response (HTR). Previous literature has implicated limitations in the clinical conceptualization of the relationship between intergenerational transfer of HTR and substance abuse. The aim of the current study is to examine treatment efficacy of 50 homosexual, American Indian males randomized to a culturally-adapted juxtaposition of (1) Group Interpersonal Psychotherapy (IPT), (2) Cognitive Processing Therapy (CPT), and (3) Historical Trauma and Unresolved Grief Intervention (HTUG), or (4) waitlisted ...
Sexually Dimorphic Oxytocin Receptor-Expressing Neurons In The Anteroventral Periventricular Nucleus Regulates Maternal Behavior, 2020 Louisiana State University and Agricultural and Mechanical College
Sexually Dimorphic Oxytocin Receptor-Expressing Neurons In The Anteroventral Periventricular Nucleus Regulates Maternal Behavior, Kaustubh Sharma
LSU Doctoral Dissertations
The neurohypophysial hormone oxytocin is involved in the regulation of social behaviors, including social recognition, pair bonding, and sex-specific parental behaviors in a variety of species. Oxytocin triggers these social behaviors by binding to oxytocin receptors (OXTR) in various parts of the brain. Oxytocin-induced sex-typical behavior, therefore, suggests a sexual dimorphic distribution of OXTR in the brain. In recent years, the oxytocin system in the brain received tremendous attention as a potential pharmacological target for treatment of many psychiatric disorders, such as anxiety, autism spectrum disorders, and even sex-specific psychiatric disorder like postpartum depression (PPD). An important problem and a ...
A C. Elegans Neuron Both Promotes And Suppresses Motor Behavior To Fine Tune Motor Output [Preprint], 2020 University of Queensland
A C. Elegans Neuron Both Promotes And Suppresses Motor Behavior To Fine Tune Motor Output [Preprint], Zhaoyu Li, Jiejun Zhou, Khursheed A. Wani, Teng Yu, Elizabeth A. Ronan, University Of Michigan - Ann Arbor, Jianfeng Liu, X.Z. Shawn Xu
University of Massachusetts Medical School Faculty Publications
How neural circuits drive behavior is a central question in neuroscience. Proper execution of motor behavior requires the precise coordination of many neurons. Within a motor circuit, individual neurons tend to play discrete roles by promoting or suppressing motor output. How exactly neurons function in specific roles to fine tune motor output is not well understood. In C. elegans, the interneuron RIM plays important yet complex roles in locomotion behavior. Here, we show that RIM both promotes and suppresses distinct features of locomotion behavior to fine tune motor output. This dual function is achieved via the excitation and inhibition of ...