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Specific Neuroligin3-Alphaneurexin1 Signaling Regulates Gabaergic Synaptic Function In Mouse Hippocampus, Motokazu Uchigashima, Kohtarou Konno, Emily Demchak, Amy Cheung, Takuya Watanabe, David G. Keener, Manabu Abe, Timmy Le, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Yuka Imamura Kawasawa, Masahiko Watanabe, Kensuke Futai 2020 University of Massachusetts Medical School

Specific Neuroligin3-Alphaneurexin1 Signaling Regulates Gabaergic Synaptic Function In Mouse Hippocampus, Motokazu Uchigashima, Kohtarou Konno, Emily Demchak, Amy Cheung, Takuya Watanabe, David G. Keener, Manabu Abe, Timmy Le, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Yuka Imamura Kawasawa, Masahiko Watanabe, Kensuke Futai

University of Massachusetts Medical School Faculty Publications

Synapse formation and regulation require signaling interactions between pre- and postsynaptic proteins, notably cell adhesion molecules (CAMs). It has been proposed that the functions of neuroligins (Nlgns), postsynaptic CAMs, rely on the formation of trans-synaptic complexes with neurexins (Nrxns), presynaptic CAMs. Nlgn3 is a unique Nlgn isoform that localizes at both excitatory and inhibitory synapses. However, Nlgn3 function mediated via Nrxn interactions is unknown. Here we demonstrate that Nlgn3 localizes at postsynaptic sites apposing vesicular glutamate transporter 3-expressing (VGT3+) inhibitory terminals and regulates VGT3+ inhibitory interneuron-mediated synaptic transmission in mouse organotypic slice cultures. Gene expression analysis of interneurons revealed that ...


Circadian Regulation Of The Timing Of Pre-Ovulatory Luteinizing Hormone Surge In Mice And Hamsters, Ajay Kumar 2020 University of Massachusetts Amherst

Circadian Regulation Of The Timing Of Pre-Ovulatory Luteinizing Hormone Surge In Mice And Hamsters, Ajay Kumar

Doctoral Dissertations

Endogenous daily (circadian) oscillators ensure the proper timing of physiological and behavioral processes that are essential to health. A set of core clock genes and their protein products function in transcriptional/translational feedback loops (TTFLs) that time and coordinate vital homeostatic, cognitive, and hormonal processes. A master pacemaker in the suprachiasmatic nucleus (SCN) coordinates circadian function throughout the organism. Investigating the causal role of genetically defined cell types in the suprachiasmatic nucleus for circadian rhythms is essential to understand how an animal’s physiology is temporally organized. This thesis explores the role of molecular clocks within particular cell types in ...


Neurocounseling And The Counseling Profession: Integrating Neuroscience Into The Practice Of Counseling, Sherri Clark 2020 Minnesota State University Moorhead

Neurocounseling And The Counseling Profession: Integrating Neuroscience Into The Practice Of Counseling, Sherri Clark

Dissertations, Theses, and Projects

Neurocounseling integrates Neuroscience into mental health counseling by using psychoeducation, teaching, and illustrations as well as other forms of therapy (CBT, Interpersonal Psychotherapy, Narrative Therapy, etc.) to assist clients in understanding the neurological basis of many mental and behavioral health concerns. Clients can benefit from Neurocounseling as they gain a more comprehensive understanding of the central nervous system and brain function in connection to the body, cognition, mood, and behaviors, also known as the mind and body connection. Neuroplasticity and neurogenesis allow us to understand the brain’s amazing capability to grow and change. Understanding neuroscience allows for more integrated ...


Preventing Neurodegeneration By Controlling Oxidative Stress: The Role Of Oxr1, Michael R. Volkert, David J. Crowley 2020 University of Massachusetts Medical School

Preventing Neurodegeneration By Controlling Oxidative Stress: The Role Of Oxr1, Michael R. Volkert, David J. Crowley

Open Access Publications by UMMS Authors

Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage resulting from ischemia are among the notable neurodegenerative diseases in which oxidative stress occurs shortly before the onset of neurodegeneration. A shared feature of these diseases is the depletion of OXR1 (oxidation resistance 1) gene products shortly before the onset of neurodegeneration. In animal models of these diseases, restoration of OXR1 has been shown to reduce or eliminate the deleterious effects of oxidative stress induced cell death, delay the onset of symptoms, and reduce overall severity. Moreover, increasing OXR1 expression in cells further increases oxidative stress resistance and delays ...


An Objective Method To Assess And Recommend Exertion And Exercise Targets For Return To Play Post Concussion, Joseph F. Clark PhD ATC, Robert E. Mangine PT MEd ATC, Kimberly A. Hasselfeld MS, Violet T. Schramm, Angelo J. Colosimo MD, Aaron Kuehn-Himmler AT MS, Gerald M. Holloway MS ATC, Faniel Fosselman DO MBA, Jon Vincent, Nicole Giordano, Jon G. Divine MD MS 2020 Department of Neurology and Rehabilitation Medicine, University of Cincinnati

An Objective Method To Assess And Recommend Exertion And Exercise Targets For Return To Play Post Concussion, Joseph F. Clark Phd Atc, Robert E. Mangine Pt Med Atc, Kimberly A. Hasselfeld Ms, Violet T. Schramm, Angelo J. Colosimo Md, Aaron Kuehn-Himmler At Ms, Gerald M. Holloway Ms Atc, Faniel Fosselman Do Mba, Jon Vincent, Nicole Giordano, Jon G. Divine Md Ms

NeuroSports

Introduction.

Concussions are of significant concern for athletic trainers, and there is a critical need to objectively and safely allow an athlete to return to play. In sports the objective is return as safely and soon as possible. Exertion is a consideration regarding progressing an athlete back to play. The ability to exert in cardiovascular and strength and conditioning contexts are two critical steps in most return to play protocols. Being able to make objective recommendations is urgently needed, as trial and error leads to unnecessary risk of eliciting symptoms and/or causing setbacks.

Objective.

The object of this paper ...


Quality Of Life Among Injectable And Oral Disease-Modifying Therapy Users In The Pacific Northwest Multiple Sclerosis Registry., Tamela Stuchiner, Lindsay Lucas, Elizabeth Baraban, Kateri Spinelli, Chiayi Chen, Alden Smith, Lobat Hashemi, Stanley Cohan 2020 Providence Multiple Sclerosis Center, Providence Brain and Spine Institute, Providence Health & Services, Portland, OR, USA

Quality Of Life Among Injectable And Oral Disease-Modifying Therapy Users In The Pacific Northwest Multiple Sclerosis Registry., Tamela Stuchiner, Lindsay Lucas, Elizabeth Baraban, Kateri Spinelli, Chiayi Chen, Alden Smith, Lobat Hashemi, Stanley Cohan

Articles, Abstracts, and Reports

BACKGROUND: Nine oral disease-modifying therapies (DMTs) have been approved for the treatment of multiple sclerosis (MS) in the United States. Few studies have examined self-reported quality of life (QoL) and functional status outcomes among patients who switch to oral medications from injectable MS therapies. This study compares self-reported QoL and disability status between participants switching from injectable to oral DMTs, to those who stay on injectable DMTs continuously for the same time period.

METHODS: Longitudinal data were assessed from relapsing MS participants in the Pacific Northwest MS Registry completing a minimum of two surveys between 2012 and 2018 with a ...


A Meta-Analysis Of Brain Dna Methylation Across Sex, Age And Alzheimer’S Disease Points For Accelerated Epigenetic Aging In Neurodegeneration [Preprint], C. Pellegrini, Danielle Fernandes Durso, Maria Giulia Bacalini 2020 IRCCS Institute of Neurological Sciences of Bologna

A Meta-Analysis Of Brain Dna Methylation Across Sex, Age And Alzheimer’S Disease Points For Accelerated Epigenetic Aging In Neurodegeneration [Preprint], C. Pellegrini, Danielle Fernandes Durso, Maria Giulia Bacalini

University of Massachusetts Medical School Faculty Publications

Alzheimer’s disease (AD) is characterized by specific alterations of brain DNA methylation (DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect the epigenetic profiles in the brain, but their contribution to AD-associated DNAm changes has been poorly investigated. In this study we considered publicly available DNAm datasets of 4 brain regions (temporal, frontal, entorhinal cortex and cerebellum) from healthy adult subjects and AD patients, and performed a meta-analysis to identify sex-, age- and AD-associated epigenetic profiles. We showed that DNAm differences between males and females tend to be shared between the ...


Spirituality As A Moderator Between Ptss And Cardiovascular Reactivity, Kriti Sharda 2020 University of Connecticut

Spirituality As A Moderator Between Ptss And Cardiovascular Reactivity, Kriti Sharda

Honors Scholar Theses

Posttraumatic stress symptoms (PTSS) can be distressing and produce robust cardiovascular symptoms, such as increased heart rate and blood pressure, which have been implicated in higher risk of developing cardiovascular disease (CVD). Identifying factors that may reduce symptoms may suggest therapeutic strategies. One such potential factor is spirituality, given that spirituality is associated with both reducing PTSS and with preventing or improving CVD. We sampled 63 young college women who indicated being exposed to unwanted sexual contact. We asked them to write about their experience while we took heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP ...


Inactivation Of Nucleus Reuniens Impairs Spatial Memory In Mice, Miranda Schwabe 2020 University of Wisconsin-Milwaukee

Inactivation Of Nucleus Reuniens Impairs Spatial Memory In Mice, Miranda Schwabe

Theses and Dissertations

Episodic memory is a complex process requiring input from several regions of the brain. Coordinated activity in the Dorsal Hippocampus (DH) and medial Prefrontal Cortex (mPFC) is required for episodic memory consolidation. Our laboratory demonstrated that simultaneous subthreshold chemogenetic inactivation of the dorsal hippocampus (DH) and medial prefrontal cortex (mPFC) impairs the consolidation of object placement (OP) and object recognition (OR) memory in female mice (Tuscher et al., 2018), suggesting that these two brain regions work in concert to promote memory consolidation. However, the mechanisms through which the DH and mPFC interact to promote memory consolidation remain poorly understood. A ...


Data-Driven Approach To Dynamic Resting State Functional Connectivity In Post-Traumatic Stress Disorder, Carissa Weis 2020 University of Wisconsin-Milwaukee

Data-Driven Approach To Dynamic Resting State Functional Connectivity In Post-Traumatic Stress Disorder, Carissa Weis

Theses and Dissertations

Posttraumatic stress disorder (PTSD) is a heterogenous psychological disorder that may result from exposure to a traumatic event. Using functional magnetic resonance imaging (fMRI), symptoms of PTSD have been associated with aberrations in brain networks that emerge in the absence of a given cognitive demand or task, called resting state networks. Most previous research in resting state networks and PTSD has focused on aberrations in the static functional connectivity among specific regions of interest (ROI) in the brain and within canonical networks constrained by a priori hypotheses. However, dynamic fMRI, an approach that examines changes in brain network characteristics over ...


Spatial Patterns Of Correlation Between Cortical Amyloid And Cortical Thickness In A Tertiary Clinical Population With Memory Deficit, Jagan A. Pillai, Mykol Larvie, Jacqueline Chen, Anna Crawford, Jeffery L. Cummings, Stephen E. Jones 2020 Cleveland Clinic Foundation

Spatial Patterns Of Correlation Between Cortical Amyloid And Cortical Thickness In A Tertiary Clinical Population With Memory Deficit, Jagan A. Pillai, Mykol Larvie, Jacqueline Chen, Anna Crawford, Jeffery L. Cummings, Stephen E. Jones

School of Medicine Faculty Publications

© 2020, The Author(s). To estimate regional Alzheimer disease (AD) pathology burden clinically, analysis methods that enable tracking brain amyloid or tau positron emission tomography (PET) with magnetic resonance imaging (MRI) measures are needed. We therefore developed a robust MRI analysis method to identify brain regions that correlate linearly with regional amyloid burden in congruent PET images. This method was designed to reduce data variance and improve the sensitivity of the detection of cortical thickness–amyloid correlation by using whole brain modeling, nonlinear image coregistration, and partial volume correction. Using this method, a cross-sectional analysis of 75 tertiary memory clinic ...


Cortical Iron Disrupts Functional Connectivity Networks Supporting Working Memory Performance In Older Adults, Valentinos Zachariou, Christopher E. Bauer, Elayna R. Seago, Flavius D. Raslau, David K. Powell, Brian T. Gold 2020 University of Kentucky

Cortical Iron Disrupts Functional Connectivity Networks Supporting Working Memory Performance In Older Adults, Valentinos Zachariou, Christopher E. Bauer, Elayna R. Seago, Flavius D. Raslau, David K. Powell, Brian T. Gold

Neuroscience Faculty Publications

Excessive brain iron negatively affects working memory and related processes but the impact of cortical iron on task-relevant, cortical brain networks is unknown. We hypothesized that high cortical iron concentration may disrupt functional circuitry within cortical networks supporting working memory performance. Fifty-five healthy older adults completed an N-Back working memory paradigm while functional magnetic resonance imaging (fMRI) was performed. Participants also underwent quantitative susceptibility mapping (QSM) imaging for assessment of non-heme brain iron concentration. Additionally, pseudo continuous arterial spin labeling scans were obtained to control for potential contributions of cerebral blood volume and structural brain images were used to control ...


Extending Power Series Methods For The Hodgkin-Huxley Equations, Including Sensitive Dependence, James S. Sochacki 2020 James Madison University

Extending Power Series Methods For The Hodgkin-Huxley Equations, Including Sensitive Dependence, James S. Sochacki

CODEE Journal

A neural cell or neuron is the basic building block of the brain and transmits information to other neurons. This paper demonstrates the complicated dynamics of the neuron through a numerical study of the Hodgkin-Huxley differential equations that model the ionic mechanisms of the neuron: slight changes in parameter values and inputted electrical impulses can lead to very different (unexpected) results. The methods and ideas developed for the ordinary differential equations are extended to partial differential equations for Hodgkin-Huxley networks of neurons in one, two and three dimensions.


Modelling The Impact Of Clot Fragmentation On The Microcirculation After Thrombectomy [Preprint], Wahbi K. El-Bouri, Andrew MacGowan, Tamás I. Józsa, Matthew J. Gounis, Stephen J. Payne 2020 University of Oxford

Modelling The Impact Of Clot Fragmentation On The Microcirculation After Thrombectomy [Preprint], Wahbi K. El-Bouri, Andrew Macgowan, Tamás I. Józsa, Matthew J. Gounis, Stephen J. Payne

University of Massachusetts Medical School Faculty Publications

Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy) do not get reperfusion of tissue despite the thrombus being removed. One hypothesis for this ‘no-reperfusion’ phenomenon is micro-emboli fragmenting off the large clot during thrombectomy and occluding smaller blood vessels downstream of the clot location. This is impossible to observe in-vivo and so we here develop an in-silico model based on in-vitro experiments to model the effect of micro-emboli on brain tissue. Through in-vitro experiments we obtain, under a variety of clot consistencies and thrombectomy techniques, micro-emboli distributions post-thrombectomy. Blood flow through the microcirculation is modelled ...


Continuous And Non-Invasive Thermography Of Mouse Skin Accurately Describes Core Body Temperature Patterns, But Not Absolute Core Temperature, Vincent van der Vinne, Carina A. Pothecary, Sian L. Wilcox, Laura E. McKillop, Lindsay A. Benson, Jenya Kolpakova, Shu K. E. Tam, Lukas B. Krone, Angus S. Fisk, Tatiana S. Wilson, Tomoko Yamagata, James Cantley, Vladyslav V. Vyazovskiy, Stuart N. Peirson 2020 University of Oxford

Continuous And Non-Invasive Thermography Of Mouse Skin Accurately Describes Core Body Temperature Patterns, But Not Absolute Core Temperature, Vincent Van Der Vinne, Carina A. Pothecary, Sian L. Wilcox, Laura E. Mckillop, Lindsay A. Benson, Jenya Kolpakova, Shu K. E. Tam, Lukas B. Krone, Angus S. Fisk, Tatiana S. Wilson, Tomoko Yamagata, James Cantley, Vladyslav V. Vyazovskiy, Stuart N. Peirson

Open Access Publications by UMMS Authors

Body temperature is an important physiological parameter in many studies of laboratory mice. Continuous assessment of body temperature has traditionally required surgical implantation of a telemeter, but this invasive procedure adversely impacts animal welfare. Near-infrared thermography provides a non-invasive alternative by continuously measuring the highest temperature on the outside of the body (Tskin), but the reliability of these recordings as a proxy for continuous core body temperature (Tcore) measurements has not been assessed. Here, Tcore (30 s resolution) and Tskin (1 s resolution) were continuously measured for three days in mice exposed to ad libitum and restricted feeding conditions. We ...


Pregnancy Associated Epigenetic Markers Of Inflammation Predict Depression And Anxiety Symptoms In Response To Discrimination, Femke Sluiter, Angela C. Incollingo Rodriguez, Benjamin C. Nephew, Ryan J. Cali, Chris Murgatroyd, Hudson P. Santos Jr. 2020 Manchester Metropolitan University

Pregnancy Associated Epigenetic Markers Of Inflammation Predict Depression And Anxiety Symptoms In Response To Discrimination, Femke Sluiter, Angela C. Incollingo Rodriguez, Benjamin C. Nephew, Ryan J. Cali, Chris Murgatroyd, Hudson P. Santos Jr.

Open Access Publications by UMMS Authors

Latina mothers, who have one of the highest fertility rates among ethnic groups in the United States (US), often experience discrimination. Psychosocial influences during pregnancy, such as discrimination stress, promotes inflammation. However, the role of epigenetic markers of inflammation as a mediator between, and predictor of, maternal discrimination stress and neuropsychiatric outcomes has not been extensively studied. The current study investigates the role of DNA methylation at FOXP3 Treg-cell-specific demethylated region (TSDR), as a marker of regulatory T (Treg) cells that are important negative regulators of inflammation, and the promoter of tumour necrosis factor-alpha (TNF-alpha) gene, an important pro-inflammatory cytokine ...


Historical Trauma Response Scores As A Function Of Unresolved Grief And Substance Use Disorder In American Indian Populations, Andrew R. Saunders 2020 University of Missouri-St. Louis

Historical Trauma Response Scores As A Function Of Unresolved Grief And Substance Use Disorder In American Indian Populations, Andrew R. Saunders

Undergraduate Research Symposium

Abstract

Researchers are interested in the outcomes of interventions, specifically, measuring historical trauma (HT) among American Indian/Alaska Native communities and the long-term distress and substance abuse as a result of historical trauma response (HTR). Previous literature has implicated limitations in the clinical conceptualization of the relationship between intergenerational transfer of HTR and substance abuse. The aim of the current study is to examine treatment efficacy of 50 homosexual, American Indian males randomized to a culturally-adapted juxtaposition of (1) Group Interpersonal Psychotherapy (IPT), (2) Cognitive Processing Therapy (CPT), and (3) Historical Trauma and Unresolved Grief Intervention (HTUG), or (4) waitlisted ...


Insulin Resistance And Oxidative Stress: In Relation To Cognitive Function And Psychopathology In Drug-Naive, First-Episode Drug-Free Schizophrenia, Qi Tao, Yu Miao, Huihui Li, Xiuxia Yuan, Xufeng Huang, Yunpeng Wang, Ole A. Andreassen, Xiaoduo Fan, Yongfeng Yang, Xueqin Song 2020 Zhengzhou University

Insulin Resistance And Oxidative Stress: In Relation To Cognitive Function And Psychopathology In Drug-Naive, First-Episode Drug-Free Schizophrenia, Qi Tao, Yu Miao, Huihui Li, Xiuxia Yuan, Xufeng Huang, Yunpeng Wang, Ole A. Andreassen, Xiaoduo Fan, Yongfeng Yang, Xueqin Song

Open Access Publications by UMMS Authors

Objective: The present study aimed to examine whether insulin resistance and oxidative stress are associated with cognitive impairment in first-episode drug-free schizophrenia (SZ) patients.

Methods: Ninety first-episode SZ patients and 70 healthy controls were enrolled. Fasting insulin (FINS) and markers of oxidative stress [oxidized glutathione (GSSG), superoxide dismutase (SOD), nitric oxide (NO) and uric acid (UA) levels] were measured in serum before pharmacological treatment was initiated. Psychiatric symptoms and cognitive function were assessed with the Positive and Negative Syndrome Scale (PANSS) and MATRICS Consensus Cognitive Battery (MCCB), respectively. In addition, the homeostatic model assessment of insulin resistance (HOMA-IR) was also ...


Examining The Structure Of Symbolic Number Representations In The Parietal Cortex: An Rsa Study, Aymee Alvarez Rivero 2020 The University of Western Ontario

Examining The Structure Of Symbolic Number Representations In The Parietal Cortex: An Rsa Study, Aymee Alvarez Rivero

Electronic Thesis and Dissertation Repository

Previous studies using fMRI adaptation to investigate the neural substrate of symbolic number processing have found ratio-dependent responses in regions of the parietal cortex, suggesting that number symbols are coded by overlapping neuronal populations: the larger the ratio between two numerals, the more their representation overlap. The current study analyzed the distributed patterns of activation associated with numerals presented during this task. I could not find substantial evidence supporting the ratio-dependent structure of the similarity space predicted by the univariate adaptation analyses. I also failed to find evidence in favor of the alternative model that similarities were driven by lexical ...


Sexually Dimorphic Oxytocin Receptor-Expressing Neurons In The Anteroventral Periventricular Nucleus Regulates Maternal Behavior, Kaustubh Sharma 2020 Louisiana State University and Agricultural and Mechanical College

Sexually Dimorphic Oxytocin Receptor-Expressing Neurons In The Anteroventral Periventricular Nucleus Regulates Maternal Behavior, Kaustubh Sharma

LSU Doctoral Dissertations

The neurohypophysial hormone oxytocin is involved in the regulation of social behaviors, including social recognition, pair bonding, and sex-specific parental behaviors in a variety of species. Oxytocin triggers these social behaviors by binding to oxytocin receptors (OXTR) in various parts of the brain. Oxytocin-induced sex-typical behavior, therefore, suggests a sexual dimorphic distribution of OXTR in the brain. In recent years, the oxytocin system in the brain received tremendous attention as a potential pharmacological target for treatment of many psychiatric disorders, such as anxiety, autism spectrum disorders, and even sex-specific psychiatric disorder like postpartum depression (PPD). An important problem and a ...


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