Mental Associations And Music Therapy: Including The History Of Associationism And The Neurology Of Associations, Dianna Rose
Expressive Therapies Capstone Theses
Associations are formed in our minds based upon three elements: sensory experience, emotions, and memories. These associations, unique to each individual, dictate thoughts, beliefs, behaviors, and actions. Some are necessary and supportive, while others can be maladaptive. Established associations can be changed, and new associations can be formed, to align with a client’s goals. The literature presents a strong history of associationism, as well as a body of research that demonstrates the neurological processes of how mental associations are formed. There are also studies showing how music activates the brain. However, there is a lack of research which draws ...
Neurocognitive Risk Factors And Current Intervention Strategies For Survivors Of Pediatric Acute Lymphoblastic Leukemia, Abigail Taber
Senior Honors Theses
The improved survival rate for pediatric cancer patients is one of the greatest triumphs of recent medicine, but the late effects faced by these survivors have been uncovered through this new population of survivors. Many survivors of pediatric acute lymphoblastic leukemia (ALL) experience cognitive deficits in areas such as attention, memory, processing speed, and academic achievement following cancer treatment. Recent research has pointed to chemotherapeutic agents, host risk factors, and genetic predispositions as perpetrators of these deficits, although other factors are also under investigation. Consequently, the search for appropriate interventions for the amelioration of these deficits has dominated the literature ...
Safe Sleep: Developmental Implications For Hospitalized Infants, 2020 University of Rhode Island
Safe Sleep: Developmental Implications For Hospitalized Infants, Katherine Kohlsaat
Senior Honors Projects
The rate at which an infant develops both physically and cognitively is significant during sleep, as this is the time when the entire body can dedicate its efforts to this cause. Parents of healthy infants follow the guidelines set by the American Academy of Pediatrics (AAP) relating to safe sleep, and since their introduction in 1992, the rate of Sudden Infant Death Syndrome (SIDS) has decreased by 40% (Center for Disease Control and Prevention, 2016). However, if an infant has been hospitalized since birth due to necessary invasive procedures such as open-heart surgery, these protocols cannot be initially implemented. Common ...
A Study Of Matr3 And Its Effects On The Neural Progenitor Cells Of Xenopus Laevis Tadpoles, Kendall Branham
Undergraduate Honors Theses
Understanding the genes and mechanisms that regulate the highly important process of neurogenesis in the developing nervous system is crucial to uncovering why disease arises when this system is disrupted. Neural progenitor cells and their multipotent nature allow for the growth of a large pool of stem cells in the early stages of development, but the signal that leads these cells to the irreversible fate of becoming a neuron is unclear. The gene matr3 has been implicated in having a role in the maintenance of undifferentiated neural stem cells but its role needs further investigation to fully reveal how its ...
Innate Immunity In The C. Elegans Intestine Is Programmed By A Neuronal Regulator Of Awc Olfactory Neuron Development, 2020 University of Massachusetts Medical School
Innate Immunity In The C. Elegans Intestine Is Programmed By A Neuronal Regulator Of Awc Olfactory Neuron Development, Kyle J. Foster, Hilary K. Cheesman, Pengpeng Liu, Nicholas D. Peterson, Sarah M. Anderson, Read Pukkila-Worley
Open Access Articles
Olfactory neurons allow animals to discriminate nutritious food sources from potential pathogens. From a forward genetic screen, we uncovered a surprising requirement for the olfactory neuron gene olrn-1 in the regulation of intestinal epithelial immunity in Caenorhabditis elegans. During nematode development, olrn-1 is required to program the expression of odorant receptors in the AWC olfactory neuron pair. Here, we show that olrn-1 also functions in AWC neurons in the cell non-autonomous suppression of the canonical p38 MAPK PMK-1 immune pathway in the intestine. Low activity of OLRN-1, which activates the p38 MAPK signaling cassette in AWC neurons during larval development ...
Effect Of Reduced Neurogenesis On Microglial Activation, 2020 Belmont University
Effect Of Reduced Neurogenesis On Microglial Activation, Amelia Smith
The geriatric population of America has grown exponentially in the past century. Health degradations and expensive medical care are characteristic of this population with many of these costs due to age-related cognitive decline. It is essential to completely understand the mechanisms of normal and abnormal aging in the search for treatments for cognitive decline. A reduction of neurogenesis is a common factor in aging, but this reduction is even more drastic in individuals experiencing cognitive decline. It is unclear what effect reduced neurogenesis has on the extracellular environment, including glial cells. In particular, changes in microglial activation could be related ...
Pornography: Adolescent Brain Development & Addiction, 2020 Dublin City Schools
Pornography: Adolescent Brain Development & Addiction, William K. Canady
National Youth-At-Risk Conference Savannah
This presentation will explain the historical development of pornography. It will highlight three segments: 1- Porn’s impact on brain development of reward pathways, ultimately increasing the appetite for more porn. 2- Porn can be a false substitute for real intimacy, resulting in decreased sexual satisfaction with a real person and increased verbal and physical aggression. 3- Porn promotes sex trafficking, promotes multiple sex partners and reduced STD prevention.
Effects Of Novel Tool Use: Cortical And Functional Measures In Children Using A Prosthetic Simulator, 2020 University of Nebraska at Omaha
Effects Of Novel Tool Use: Cortical And Functional Measures In Children Using A Prosthetic Simulator, Chris Copeland
Student Research and Creative Activity Fair
As of 2005, there were a total of 1.6 million people living with the loss of a limb, with this population projected to double to 3.6 million by 2050 . While prostheses aim to enhance the function of these individuals, it is estimated that 45% of pediatric prosthetic users reject their prosthesis . The literature which describes the neurological control mechanisms of prosthetic use is sparse and often low-powered due to an inadequate number of participants. However, prosthetic simulators may be a solution to chronically low-powered prosthetic-centric studies by serving as functional homologues, though this has yet to ...
Antagonistic Regulation Of Circadian Output And Synaptic Development By Jetlag And The Dyschronic-Slowpoke Complex, 2020 Thomas Jefferson University
Antagonistic Regulation Of Circadian Output And Synaptic Development By Jetlag And The Dyschronic-Slowpoke Complex, Angelique Lamaze, James E.C. Jepson, Oghenerukevwe Akpoghiran, Kyunghee Koh
Department of Neurosciences Faculty Papers
Circadian output genes act downstream of the clock to promote rhythmic changes in behavior and physiology, yet their molecular and cellular functions are not well understood. Here we characterize an interaction between regulators of circadian entrainment, output, and synaptic development in Drosophila that influences clock-driven anticipatory increases in morning and evening activity. We previously showed the JETLAG (JET) E3 ubiquitin ligase resets the clock upon light exposure, whereas the PDZ protein DYSCHRONIC (DYSC) regulates circadian locomotor output and synaptic development. Surprisingly, we find that JET and DYSC antagonistically regulate synaptic development at the larval neuromuscular junction, and reduced JET activity ...
Using An Internal Auditory Stimulus To Activate The Developing Primary Auditory Cortex: A Fetal Fmri Study, 2020 The University of Western Ontario
Using An Internal Auditory Stimulus To Activate The Developing Primary Auditory Cortex: A Fetal Fmri Study, Estee Goldberg
Electronic Thesis and Dissertation Repository
Insight into the rapidly developing brain in utero is scarce. Fetal functional magnetic resonance imaging (fMRI) is a technique used to gain awareness into the developmental process. Previous auditory task-based fMRI studies employed an external sound stimulus directly on the maternal abdomen. However, there has since been recommendation to cease doing so. We sought to investigate a reliable paradigm to study the development of fetal brain networks and postulate that by using an internal stimulus, such as the mother singing, it would result in activation of the fetal primary auditory cortex. Volunteers carrying singleton fetuses with a gestational age of ...
Tissue-Specific Regulation Of Pnmt By Intron Retention During Neural Development, 2020 University of Central Florida
Tissue-Specific Regulation Of Pnmt By Intron Retention During Neural Development, Meeti Mehta
Digital Repository: Showcase of Undergraduate Research Excellence
No abstract provided.
#44 - Effects Of Chemical Vagotomy On The Neonatal Mouse Paraventricular Nucleus Of The Hypothalamus, 2019 Georgia State University
#44 - Effects Of Chemical Vagotomy On The Neonatal Mouse Paraventricular Nucleus Of The Hypothalamus, Aviva Gars, Alexandra Castillo-Ruiz, Benoit Chassaing, Nancy Forger
Georgia Undergraduate Research Conference (GURC)
Birth is marked by a dramatic transition from the sterile womb to a world full of microorganisms that colonize every body surface. We previously found that this colonization exerts rapid effects on brain development, as in mice born in the absence of microbes had increased cell death in the paraventricular nucleus of the hypothalamus (PVN), an effect not seen 12 h prior to expected delivery. The gut microbiota influences the development of many body systems, and communicates bi-directionally with the brain. We hypothesize that the microbiota exerts effects on neuronal cell death via the vagus nerve, which connects the gut ...
In Search Of Psychiatric Kinds: Natural Kinds And Natural Classification In Psychiatry, 2019 The University of Western Ontario
In Search Of Psychiatric Kinds: Natural Kinds And Natural Classification In Psychiatry, Nicholas Slothouber
Electronic Thesis and Dissertation Repository
In recent years both philosophers and scientists have asked whether or not our current kinds of mental disorder—e.g., schizophrenia, depression, bipolar disorder—are natural kinds; and, moreover, whether or not the search for natural kinds of mental disorder is a realistic desideratum for psychiatry. In this dissertation I clarify the sense in which a kind can be said to be “natural” or “real” and argue that, despite a few notable exceptions, kinds of mental disorder cannot be considered natural kinds. Furthermore, I contend that psychopathological phenomena do not cluster together into kinds in the way that paradigmatic natural ...
The Physiology Of Social-Emotional Learning: Integrating Biomarkers Of Self-Regulation Into The Assessment And Implementation Of Programs, Martin E. Blank
Master of Applied Positive Psychology (MAPP) Capstone Projects
In the last two decades, formalized social-emotional learning (SEL) programs in schools have proliferated in response to a staggering increase in mental, social, and emotional challenges for youth. SEL programs differ in their theoretical foundations, though there are commonalities among them. Self-regulation (SR) surfaces as an important pillar. Researchers have relied mostly on self-reporting and teacher questionnaires to measure the effectiveness of these programs to improve SR and other aspects of youth well-being, without explicitly considering the physiological effects of these interventions on the biomarkers of youth. By addressing this gap, program researchers, developers, and educators can reach their stated ...
Micrornas Are Necessary For Bmp-7-Induced Dendritic Growth In Cultured Rat Sympathetic Neurons, 2019 Saint Mary's College of California
Micrornas Are Necessary For Bmp-7-Induced Dendritic Growth In Cultured Rat Sympathetic Neurons, Vidya Chandrasekaran
Role Of A 19s Proteasome Subunit- Psmd10(Gankyrin) In Neurogenesis Of Human Neuronal Progenitor Cells, 2019 Technion - Israel Institute of Technology
Role Of A 19s Proteasome Subunit- Psmd10(Gankyrin) In Neurogenesis Of Human Neuronal Progenitor Cells, Indrajit Sahu, Padma P. Nanaware, Minal Mane, Saim Wasi Mulla, Soumen Roy, Prasanna Venkatraman
Open Access Articles
PSMD10(Gankyrin), a proteasome assembly chaperone, is a widely known oncoprotein which aspects many hall mark properties of cancer. However, except proteasome assembly chaperon function its role in normal cell function remains unknown. To address this issue, we induced PSMD10(Gankyrin) overexpression in HEK293 cells and the resultant large-scale changes in gene expression profile were analyzed. We constituted networks from microarray data of these differentially expressed genes and carried out extensive topological analyses. The overrecurring yet consistent theme that appeared throughout analysis using varied network metrics is that all genes and interactions identified as important would be involved in neurogenesis ...
Integrins Have Cell-Type-Specific Roles In The Development Of Motor Neuron Connectivity, 2019 University of Massachusetts Medical School
Integrins Have Cell-Type-Specific Roles In The Development Of Motor Neuron Connectivity, Devyn Oliver, Emily Norman, Heather Bates, Rachel Avard, Monika Rettler, Claire Y. Benard, Michael M. Francis, Michele L. Lemons
Open Access Articles
Formation of the nervous system requires a complex series of events including proper extension and guidance of neuronal axons and dendrites. Here we investigate the requirement for integrins, a class of transmembrane cell adhesion receptors, in regulating these processes across classes of C. elegans motor neurons. We show alpha integrin/ina-1 is expressed by both GABAergic and cholinergic motor neurons. Despite this, our analysis of hypomorphic ina-1(gm144) mutants indicates preferential involvement of alpha integrin/ina-1 in GABAergic commissural development, without obvious involvement in cholinergic commissural development. The defects in GABAergic commissures of ina-1(gm144) mutants included both premature termination ...
The Association Of Late-Life Depression, Cognitive Functioning, And Sleep Disorder In Aging, 2019 University of Maine
The Association Of Late-Life Depression, Cognitive Functioning, And Sleep Disorder In Aging, Jessica B. Aronis
Electronic Theses and Dissertations
The continuing growth in the demographic of aging individuals in the United States creates concern for diseases of aging that are chronic, notably unipolar depressive disorders. The high rates of depression in the aging population are a concern because of the strong association between late-life depression and cognitive impairment. Poor cognitive functioning is a hallmark of aging related neurological disorders, the most prevalent being Alzheimer’s Disease (AD). Sleep disorder is a core symptom of depression, and is definitively associated with the development of mild cognitive impairment (MCI), the prodrome of AD. MCI is also characterized by similar types of ...
Neurodevelopmental Outcomes Of Infantile Hydrocephalus: An Fmri Case Study, 2019 The University of Western Ontario
Neurodevelopmental Outcomes Of Infantile Hydrocephalus: An Fmri Case Study, Ikhlas Ahmed Hashi
Electronic Thesis and Dissertation Repository
Ventricle dilatation caused by infantile hydrocephalus may result in extensive damage of the posterior cortex (parietal and occipital lobes). We hypothesize that pathological changes in the development of the posterior cortex can be linked to non-verbal learning disabilities in children with previous infantile hydrocephalus. This case study will investigate the neurodevelopmental outcomes of 3 treated hydrocephalus patients, when compared to a group of healthy control children (n = 12). Within the hydrocephalus group, patients displayed differences in non-verbal test performance as well as parietal brain activation during an fMRI number comparison task. We associated these differences with clinical variables such as ...
Relationship Of Maternal And Infant Cortisol Matrices With Later Infant Behavior And Temperament, 2019 University of Massachusetts Amherst