The Effects Of Lipopolysaccharide-Induced Neuroinflammation On Learning And Forgetting In Juvenile Rats, 2016 Seton Hall University
The Effects Of Lipopolysaccharide-Induced Neuroinflammation On Learning And Forgetting In Juvenile Rats, Michele Barry
Seton Hall University Dissertations and Theses (ETDs)
The inability to remember events experienced very early in life is referred to as Infantile Amnesia (IA) and has been observed in both humans and animals. Over the years interest in the phenomenon waned, but has recently increased with the discovery of new neurobiological methods to study brain function (e.g., Callaghan, Li & Richardson, 2014). The neurobiological mechanism behind IA has yet to be determined, but several innovative theories have been developed with these new research methods. The neurogenesis hypothesis theorizes that increased neurogenesis during early development disrupts previously established memories. The hippocampus, an area that mediates both the memory ...
Prenatal Exposure To Social Stress Alters Adult Behavior In Syrian Hamsters, 2016 Neuroscience
Prenatal Exposure To Social Stress Alters Adult Behavior In Syrian Hamsters, Genna Jones
Georgia State Undergraduate Research Conference
No abstract provided.
Dyslexia And Language Impairment Associated Genetic Markers Influence Cortical Thickness And White Matter In Typically Developing Children, John D. Eicher, Jean A. Frazier, David N. Kennedy, Jeffrey R. Gruen, Pediatric Imaging Neurocognition Genetics Study
University of Massachusetts Medical School Faculty Publications
Dyslexia and language impairment (LI) are complex traits with substantial genetic components. We recently completed an association scan of the DYX2 locus, where we observed associations of markers in DCDC2, KIAA0319, ACOT13, and FAM65B with reading-, language-, and IQ-related traits. Additionally, the effects of reading-associated DYX3 markers were recently characterized using structural neuroimaging techniques. Here, we assessed the neuroimaging implications of associated DYX2 and DYX3 markers, using cortical volume, cortical thickness, and fractional anisotropy. To accomplish this, we examined eight DYX2 and three DYX3 markers in 332 subjects in the Pediatrics Imaging Neurocognition Genetics study. Imaging-genetic associations were examined by ...
Roles Of Planar Cell Polarity Proteins In Copa Axon Pathfinding, 2016 Virginia Commonwealth University
Roles Of Planar Cell Polarity Proteins In Copa Axon Pathfinding, Ashley Morgan Purdy
Theses and Dissertations
In zebrafish, CoPA (Commissural Primary Ascending) is the first among ascending commissural axons to pathfind anteriorly and form the spinal commissure. One pathway that guides their anterior growth is the planar cell polarity (PCP) signaling pathway, but it is not fully known how PCP signaling regulates anterior guidance. We examined CoPA pathfinding in various PCP mutants to determine if anterior-posterior (A-P) guidance of CoPAs is dependent on PCP signaling. We found that certain PCP mutants exhibited anterior pathfinding defects, with approximately half of all affected CoPAs migrating incorrectly posteriorly. By using a translation-blocking DCC (Deleted in Colorectal ...
Potential For Aerobic Exercise To Release Growth Factors To Induce Cognitive Changes In Children With Autism Spectrum Disorder, 2016 Virginia Commonwealth University
Potential For Aerobic Exercise To Release Growth Factors To Induce Cognitive Changes In Children With Autism Spectrum Disorder, Maya Harrington
Undergraduate Research Posters
Autism Spectrum Disorder (ASD) is becoming increasingly prevalent among adolescents, and while the number of individuals diagnosed with the disorder grows, there continues to be no cure or even a clear treatment path for ASD. This study analyzes the biological stimulations that create cognitive changes—which are induced by intensive aerobic exercise—within the brains of individuals ages 8-18 diagnosed with autism. I studied journal articles on the current treatments available for ASD, the increasing prevalence of the disease, the cognitive alterations of the autistic brain relative to the brains of individuals without the disease, the release of growth factors ...
Exercise During The Juvenile Period Produces Long Lasting Stress Protection Potentially Subserved By Epigenetic Alterations To The Serotonergic System, 2016 University of Colorado, Boulder
Exercise During The Juvenile Period Produces Long Lasting Stress Protection Potentially Subserved By Epigenetic Alterations To The Serotonergic System, Nicole L. Rumian
Undergraduate Honors Theses
Exercise is capable of producing a myriad of beneficial alterations in brain chemistry and function which can help prevent stress-related psychiatric disorders, such as anxiety and depression. Recent work from our lab demonstrates that 6 weeks of exercise initiated in early life produces lasting protection against stress-induced anxiety and depressive like behaviors, whereas, in adults, this protection is transient and dissipates upon cessation of exercise. Thus, when exercise begins at a young age, the neurobiological improvements remain intact even after exercise has ceased for a period of time. The mechanism underlying this long lasting protection is currently unknown. Furthermore, it ...
Alignment Of Neurochemically Defined Modules In Multimodal Aspects Of The Mouse Inferior Colliculus., 2016 James Madison University
Alignment Of Neurochemically Defined Modules In Multimodal Aspects Of The Mouse Inferior Colliculus., Chris H. Dillingham
Senior Honors Projects
Processing of sound requires precise coordination of various levels of the auditory system. Auditory reflexes and orientation behaviors require interactions with other systems and modalities, emphasizing the importance of highly organized integrative circuits. The inferior colliculus (IC) is a unique midbrain structure in that it exhibits aspects that are specifically arranged for processing auditory cues, as well as regions that handle multisensory inputs and thereby exhibit an entirely different organization. While the central nucleus of the IC (CNIC) is primarily auditory and arranged tonotopically, the lateral cortex (LCIC) is multimodal and exhibits a unique array of modular and extramodular fields ...
Using Spiral Dynamic Theory For Adult Civic Engagement Research And Social Justice Education, 2016 University of Georgia
Using Spiral Dynamic Theory For Adult Civic Engagement Research And Social Justice Education, Lisa R. Brown
Adult Education Research Conference
Empirical civic engagement research based in a South American context. Participants included adult learner populations engaged in revolutionary protests that opposed private for-profit education in Chile. Findings were higher order Spiral Dynamic Theory thinking at the for-profits and lower civic engagement.
Compensatory Mechanisms And T Cell Migration In Mouse Models Of Dopaminergic Loss, 2015 University of Nebraska Medical Center
Compensatory Mechanisms And T Cell Migration In Mouse Models Of Dopaminergic Loss, Kristi M. Anderson
Theses & Dissertations
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and second most common neurodegenerative disorder. PD is characterized by the selective loss of dopaminergic neurons and dopamine neurotransmitter within the substantia nigra and termini in the striatum. Progressive loss of dopaminergic neurons occurs over many years in PD, and by the time movement disorder symptoms manifest, up to 50-70% of dopaminergic neurons have been lost. Several aspects of PD pathology have been described in detail, but a better understanding of PD progression is needed to develop more efficient treatments.
Motor symptoms associated with PD do not manifest until ...
Rna Sequence Analysis Of Human Huntington Disease Brain Reveals An Extensive Increase In Inflammatory And Developmental Gene Expression, 2015 Boston University School of Medicine
Rna Sequence Analysis Of Human Huntington Disease Brain Reveals An Extensive Increase In Inflammatory And Developmental Gene Expression, Adam Labadorf, Andrew Hoss, Valentina Lagomarsino, Jeanne C. Latourelle, Tiffany C. Hadzi, Joli Bregu, Marcy E. Macdonald, James F. Gusella, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Richard H. Myers
Open Access Articles
Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide analysis of mRNA expression in human prefrontal cortex from 20 HD and 49 neuropathologically normal controls using next generation high-throughput sequencing. Surprisingly, 19% (5,480) of the 28,087 confidently detected genes are differentially expressed (FDR < 0.05) and are predominantly up-regulated. A novel hypothesis-free geneset enrichment method that dissects large gene lists into functionally and transcriptionally related groups discovers that the differentially expressed genes are enriched for immune response, neuroinflammation, and developmental genes. Markers for all major brain cell types are observed, suggesting that HD invokes a systemic response in the brain area studied. Unexpectedly, the most strongly differentially expressed genes are a homeotic gene set (represented by Hox and other homeobox genes), that are almost exclusively expressed in HD, a profile not widely implicated in HD pathogenesis. The significance of transcriptional changes of developmental processes in the HD brain is poorly understood and warrants further investigation. The role of inflammation and the significance of non-neuronal involvement in HD pathogenesis suggest anti-inflammatory therapeutics may offer important opportunities in treating HD.
Ethanol Exposure During Synaptogenesis In A Mouse Model Of Fetal Alcohol Spectrum Disorders: Acute And Long-Term Effects On Gene Expression And Behaviour, 2015 The University of Western Ontario
Ethanol Exposure During Synaptogenesis In A Mouse Model Of Fetal Alcohol Spectrum Disorders: Acute And Long-Term Effects On Gene Expression And Behaviour, Morgan L. Kleiber
Electronic Thesis and Dissertation Repository
Alcohol is a neuroactive molecule that is able to exert variable and often detrimental effects on the developing brain, resulting in a broad range of physiological, behavioural, and cognitive phenotypes that characterize ‘fetal alcohol spectrum disorders’ (FASD). Factors affecting the manifestation of these phenotypes include alcohol dosage, timing of exposure, and pattern of maternal alcohol consumption; however, the biological processes that are vulnerable to ethanol at any given neurodevelopmental stage are unclear, as is how their disruption results in the emergence of specific pathological phenotypes later in life.
The research included in this thesis utilizes a C57BL/6J (B6) mouse ...
Relation Of Childhood Home Environment To Cortical Thickness In Late Adolescence: Specificity Of Experience And Timing, 2015 University of Pennsylvania
Relation Of Childhood Home Environment To Cortical Thickness In Late Adolescence: Specificity Of Experience And Timing, Brian B. Avants, Daniel A Hackman, Laura Betancourt, Gwendolyn M. Lawson, Hallam Hurt, Martha J. Farah
What are the long-term effects of childhood experience on brain development? Research with animals shows that the quality of environmental stimulation and parental nurturance both play important roles in shaping lifelong brain structure and function. Human research has so far been limited to the effects of abnormal experience and pathological development. Using a unique longitudinal dataset of in-home measures of childhood experience at ages 4 and 8 and MRI acquired in late adolescence, we were able to relate normal variation in childhood experience to later life cortical thickness. Environmental stimulation at age 4 predicted cortical thickness in a set of ...
An Emerging Role For Prdm Family Genes In Dorsoventral Patterning Of The Vertebrate Nervous System, 2015 University of Massachusetts Medical School
An Emerging Role For Prdm Family Genes In Dorsoventral Patterning Of The Vertebrate Nervous System, Denise A. Zannino, Charles G. Sagerstrom
Open Access Articles
The embryonic vertebrate neural tube is divided along its dorsoventral (DV) axis into eleven molecularly discrete progenitor domains. Each of these domains gives rise to distinct neuronal cell types; the ventral-most six domains contribute to motor circuits, while the five dorsal domains contribute to sensory circuits. Following the initial neurogenesis step, these domains also generate glial cell types-either astrocytes or oligodendrocytes. This DV pattern is initiated by two morphogens-Sonic Hedgehog released from notochord and floor plate and Bone Morphogenetic Protein produced in the roof plate-that act in concentration gradients to induce expression of genes along the DV axis. Subsequently, these ...
Developmental Decline In Neuronal Regeneration By The Progressive Change Of Two Intrinsic Timers, 2015 Cincinnati Children's Hospital Research Foundation
Developmental Decline In Neuronal Regeneration By The Progressive Change Of Two Intrinsic Timers, Yan Zou, Hui Chiu, Anna Zinovyeva, Victor Ambros, Chiou-Fen Chuang, Chieh Chang
Victor R. Ambros
Like mammalian neurons, Caenorhabditis elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7 contributes to a developmental decline in anterior ventral microtubule (AVM) axon regeneration. In older AVM axons, let-7 inhibits regeneration by down-regulating LIN-41, an important AVM axon regeneration-promoting factor. Whereas let-7 inhibits lin-41 expression in older neurons through the lin-41 3' untranslated region, lin-41 inhibits let-7 expression in younger neurons through Argonaute ALG-1. This reciprocal inhibition ensures that axon regeneration is inhibited only in older neurons. These findings show that a let-7-lin-41 regulatory circuit, which was previously ...
Play As The Foundation Of Human Intelligence: The Illuminating Role Of Human Brain Evolution And Development And Implications For Education And Child Development., 2015 University of California, Los Angeles
Play As The Foundation Of Human Intelligence: The Illuminating Role Of Human Brain Evolution And Development And Implications For Education And Child Development., Aaron P. Blaisdell
Journal of Evolution and Health
Children love to play. Why do they find such a frivolous activity so pleasurable and desirable? Perhaps it is not frivolous, but instead is an adaptation designed to guide proper cognitive development in human children. To understand why, I marshal evidence from different fields to build a case for play as a central behavioral mechanism of human brain and cognitive development. I start with a discussion of human evolution, focusing on the evolution of human physiology, tool-use, the human brain, and life-history strategy, and development, and how these are all connected as an adaptive suite. The anthropological and developmental evidence ...
Structure And Composition Of Postsynaptic Densities, 2015 The University of Texas Graduate School of Biomedical Sciences at Houston
Structure And Composition Of Postsynaptic Densities, Madeline Farley
UT GSBS Dissertations and Theses (Open Access)
Communication between neurons within the brain occurs at chemical synapses and is fundamental for all brain functions. Modulation of the strength of communication is controlled by both presynaptic and postsynaptic mechanisms and is termed synaptic plasticity. One postsynaptic structure postulated to regulate synaptic strength is the postsynaptic density (PSD), a large electron dense protein complex located just below the synaptic membrane. The PSD, which is composed of signaling, scaffold and cytoskeletal proteins, supports and organizes neurotransmitter receptors within the synaptic membrane in addition to bridging signaling with the actin cytoskeletal network. The protein composition and structure of PSDs is known ...
Concussion Awareness And Educational Outreach Through A Website And Mobile Application, 2015 Ursinus College
Concussion Awareness And Educational Outreach Through A Website And Mobile Application, Daniel J. Brogan
Neuroscience Summer Fellows
In recent years concussions have become a more apparent problem in youth and adolescent sports. 1 in 5 high school students will sustain a concussion during the season. Due to medical and scientific advances, the diagnosis of concussions is becoming much simpler with key markers that are signs for an injury. Returning to play too soon before an athlete is fully recovered increases the likelihood that serious and irreversible neurological deficits can occur. Symptoms for concussions are necessary to track in order for an athlete to properly report their recovery to a physician. Doctors primarily rely on a patient’s ...
Glypican Is A Modulator Of Netrin-Mediated Axon Guidance, 2015 University of Massachusetts Medical School
Glypican Is A Modulator Of Netrin-Mediated Axon Guidance, Cassandra Blanchette, Paola N. Perrat, Andrea Thackeray, Claire Y. Benard
Open Access Articles
Netrin is a key axon guidance cue that orients axon growth during neural circuit formation. However, the mechanisms regulating netrin and its receptors in the extracellular milieu are largely unknown. Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan, modulates UNC-6/netrin signaling and may do this through interactions with the UNC-40/DCC receptor. We show that developing axons misorient in the absence of LON-2/glypican when the SLT-1/slit guidance pathway is compromised and that LON-2/glypican functions in both the attractive and repulsive UNC-6/netrin pathways. We find that the core LON-2/glypican protein ...
Alcohol Exposure During Development: Impact On The Epigenome, 2015 University of South Carolina - Columbia
Alcohol Exposure During Development: Impact On The Epigenome, A. Perkins, Claudia Lehmann, R. Lawrence, Sandra Kelly
Sandra J. Kelly
No abstract provided.
Ablation Of Retinal Ciliopathy Protein Rpgr Results In Altered Photoreceptor Ciliary Composition, 2015 University of Massachusetts Medical School
Ablation Of Retinal Ciliopathy Protein Rpgr Results In Altered Photoreceptor Ciliary Composition, Kollu N. Rao, Linjing Li, Manisha Anand, Hemant Khanna
Open Access Articles
Cilia regulate several developmental and homeostatic pathways that are critical to survival. Sensory cilia of photoreceptors regulate phototransduction cascade for visual processing. Mutations in the ciliary protein RPGR (retinitis pigmentosa GTPase regulator) are a prominent cause of severe blindness disorders due to degeneration of mature photoreceptors. However, precise function of RPGR is still unclear. Here we studied the involvement of RPGR in ciliary trafficking by analyzing the composition of photoreceptor sensory cilia (PSC) in Rpgr(ko) retina. Using tandem mass spectrometry analysis followed by immunoblotting, we detected few alterations in levels of proteins involved in proteasomal function and vesicular trafficking ...