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Exploring Tactile Art-Making With Deafblind Students And Their Families: An Opportunity For Creative Play, Alice Rodgers 2021 Lesley University

Exploring Tactile Art-Making With Deafblind Students And Their Families: An Opportunity For Creative Play, Alice Rodgers

Expressive Therapies Capstone Theses

The impact of a deafblind diagnosis on an individual’s mental health and the well-being of the family involved can be profound. However, current research and available literature for the mental health treatment and therapy practices of deafblind persons and their families is limited (Kyzar et al., 2016; “WFDB Global Report 2018,” n.d.). This thesis used the Leeds Family Psychology and Therapy Service principles (Leeds FPTS) and the Expressive Therapies Continuum with established deafblind teaching strategies to facilitate an original arts-based community project entitled: “Things We Like.” This project provided an opportunity for deafblind students (ages three to 22 ...


Vitamin B12 Deficiency Does Not Stimulate Amyloid-Beta Toxicity In A Ceanorhabditis Elegans Model Of Alzheimer’S Disease, Opeyemi F. Showemimo 2021 East Tennessee State University

Vitamin B12 Deficiency Does Not Stimulate Amyloid-Beta Toxicity In A Ceanorhabditis Elegans Model Of Alzheimer’S Disease, Opeyemi F. Showemimo

Electronic Theses and Dissertations

Alzheimer’s disease (AD) is symptomized by amyloid-beta plaques in the brain and accounts for more than 65 percent of dementia cases. Vitamin B12 (cobalamin) deficiency can result in similar cognitive impairment and roughly 15% of the elderly are vitamin B12 deficient. Vitamin B12 deficiency results in the accumulation of toxic methylmalonic acid and homocysteine. Hyperhomocysteinemia is a strong risk factor for AD. To test if vitamin B12 deficiency stimulates amyloid-beta toxicity, Caenorhabditis elegans expressing amyloid-beta in muscle were fed either vitamin B12-deficient OP50-1 or vitamin B12-rich HT115(DE3) E. coli bacteria. Increased amyloid-beta toxicity was found in worms fed ...


Using Deep Learning For Children Brain Image Analysis, Rafael Toche Pizano 2021 University of Arkansas, Fayetteville

Using Deep Learning For Children Brain Image Analysis, Rafael Toche Pizano

Computer Science and Computer Engineering Undergraduate Honors Theses

Analyzing the correlation between brain volumetric/morphometry features and cognition/behavior in children is important in the field of pediatrics as identifying such relationships can help identify children who may be at risk for illnesses. Understanding these relationships can not only help identify children who may be at risk of illnesses, but it can also help evaluate strategies that promote brain development in children. Currently, one way to do this is to use traditional statistical methods such as a correlation analysis, but such an approach does not make it easy to generalize and predict how brain volumetric/morphometry will impact ...


How The Covid-19 Pandemic Has Affected Physical Activity, Sleep And Mental Health In University Students, Faculty And Staff And To Examine The Relationship Between These Variables, Zachary Parisi 2021 University of Arkansas, Fayetteville

How The Covid-19 Pandemic Has Affected Physical Activity, Sleep And Mental Health In University Students, Faculty And Staff And To Examine The Relationship Between These Variables, Zachary Parisi

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Increased physical activity has been shown to be beneficial in decreasing stress. This project will expand on this knowledge while also studying college students, a demographic that has been less studied. This study will also examine the impact of COVID-19 on these variables. COVID-19 changed many peoples’ activities of daily life, and possibly physically activity levels, due to public health measures such as lockdowns and remote learning. Purpose: The purpose of this study is to examine how the COVID-19 pandemic has affected physical activity, sleep, and mental health in university students, faculty and staff and to examine the relationship ...


Psychedelics Can Save: The Scientific And Social Case For Rescheduling Psychedelic Compounds, Galen M. Fader 2021 University of Tennessee, Knoxville

Psychedelics Can Save: The Scientific And Social Case For Rescheduling Psychedelic Compounds, Galen M. Fader

Chancellor’s Honors Program Projects

No abstract provided.


Mental Fatigue: Examining Cognitive Performance And Driving Behavior In Young Adults, Abigail F. Helm 2021 University of Massachusetts Amherst

Mental Fatigue: Examining Cognitive Performance And Driving Behavior In Young Adults, Abigail F. Helm

Doctoral Dissertations

Mental fatigue causes an increase in task-based EEG theta and alpha power and a decrease in performance (for a review, see Tran et al., 2020). However, little is known about the emergence of mental fatigue in resting state EEG recordings and whether the progression of mental fatigue over time is influenced by individual differences. The current dissertation examined the utility of resting state EEG as a measure of mental fatigue by testing whether EEG power changed in young adults over the course of a cognitively demanding battery of tasks. The current dissertation also tested how this measure of mental fatigue ...


Anhedonia And Its Intervention In Depressive Adults: New Developments Based On Research Domain Criteria (Rdoc) In Mental Illnesses, J. Mao, J. Yuan 2021 Faculty of Psychology, Southwest University, Chongqing 400715, China

Anhedonia And Its Intervention In Depressive Adults: New Developments Based On Research Domain Criteria (Rdoc) In Mental Illnesses, J. Mao, J. Yuan

Stress and Brain

Anhedonia, as one of the core symptoms of depression, is of great significance for the diagnosis and treatment of depression. Traditionally, anhedonia has been referred to as "loss of pleasure" , while the recent research emphasizes that anhedonia is a complex and multidimensional construct based on reward processing impairment. Exploring different manifestations of anhedonia and developing the corresponding interventions have become indispensable in the current research of depression. Based on the positive valence system of the Research Domain Criteria (RDoC), this paper firstly demonstrates that the anhedonia of depressive adults are mainly characterized by the impairments in anticipatory pleasure, incentive motivation ...


Exposure To Single Prolonged Stress Fails To Induce Anxiety-Like Behavior In Mice, W-J. You, Y. He, W-Z. Liu, Yu-Ge Zhu, Ping Hu, Bing-Xing Pan, Wen-Hua Zhang 2021 Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China

Exposure To Single Prolonged Stress Fails To Induce Anxiety-Like Behavior In Mice, W-J. You, Y. He, W-Z. Liu, Yu-Ge Zhu, Ping Hu, Bing-Xing Pan, Wen-Hua Zhang

Stress and Brain

Single prolonged stress (SPS) is a well-established and most frequently used rat model to induce post-traumatic stress disorder (PTSD)-like symptoms, which helps to understand the neurobiological mechanisms as well as developing novel therapeutic strategies for PTSD. However, whether such stress model works efficiently in mice remains unknown. In the present study, we established a mouse SPS (mSPS) model by exposing C57BL/6J mice to a series of multimodal stressors on a single day, then the anxiety-like behavior was measured by open-field test, elevated plus maze test, dark-light box, and novelty-suppressed feeding test. Our results showed that mSPS had no ...


Pornography: Social, Emotional And Mental Implications Among Adolescents, William Kelly Canady 2021 Dublin City Schools

Pornography: Social, Emotional And Mental Implications Among Adolescents, William Kelly Canady

National Youth Advocacy and Resilience Conference

This presentation will explain the historical development of pornography. It will highlight four segments: 1- Porn’s impact on brain development of reward pathways, ultimately increasing the appetite for more porn. 2- Porn can be a false substitute for real intimacy, resulting in decreased sexual satisfaction with a real person and increased verbal and physical aggression. 3- Porn promotes sex trafficking, promotes multiple sex partners and reduced STD prevention. 4- A review of interventions available to assist clients in navigating a lifestyle away from pornography.


Is Motor Excitability Modulated By Isochronous Rhythms?, Syed Z. Raza 2021 The University of Western Ontario

Is Motor Excitability Modulated By Isochronous Rhythms?, Syed Z. Raza

Electronic Thesis and Dissertation Repository

Humans perceive and synchronize to regularity in auditory temporal sequences. Auditory regularity activates motor areas, but how the timing of motor responses relates to the regularity is unclear. Thus, we examined whether motor excitability, an index of motor activity, fluctuated to an isochronous sequence and characterized the timing of these fluctuations. Participants heard isochronous tones followed by a short silence, during which they imagined the tones continuing. Using single pulse transcranial magnetic stimulation (TMS), we indexed excitability throughout the sequence. Cosine models were fit to constructed excitability timecourses to quantify periodicity of the excitability fluctuations. Motor excitability did not fluctuate ...


Effects Of Mindfulness Meditation On Selective, Sustained Attention, Brain Neural Oscillations, And Short-Term Memory, Anamaria Guzman 2021 University of Nebraska - Lincoln

Effects Of Mindfulness Meditation On Selective, Sustained Attention, Brain Neural Oscillations, And Short-Term Memory, Anamaria Guzman

Honors Theses, University of Nebraska-Lincoln

The following extended literature review and research proposal study started initially as a complete research proposal but, due to the challenges COVID-19 has brought, it has become a stand-alone piece of work without data collection. The goal is to synthesize a broad range of literature and previous research on mindfulness meditation and its effects on attention, memory, and brain activity and thus, offering a new perspective and a proposed research path on this subject. This proposed research study, besides previous studies, indicates that mindfulness meditation is expected to improve and enhance selective and sustained attention, which results in better attentional ...


Cognitive Changes Caused By Lps-Induced Neuroinflammation, Nancy De La Torre 2021 The Graduate Center, City University of New York

Cognitive Changes Caused By Lps-Induced Neuroinflammation, Nancy De La Torre

Dissertations, Theses, and Capstone Projects

The brain performs cognitive processes finely orchestrated by timely precise action of neurons. Neurons functioning at their highest standard communicate with each other through perfectly functioning synapses. Microglia, as part of the immune system assist synaptic processing and have the ability to affect cognition. Indeed, microglia play a role in cognition. To investigate the link between microglia and cognition we utilized lipopolysaccharide (LPS) to pharmacologically activate microglia. LPS, normally present in the environment on the wall of Gram-negative bacteria is a pharmacological agent used to cause microglia activation in mice. LPS is a typical model to study changes induced by ...


Caffeine Modulation Of Attention And Focus In Task Performance, Claudia R. Berger 2021 The Graduate Center, City University of New York

Caffeine Modulation Of Attention And Focus In Task Performance, Claudia R. Berger

Dissertations, Theses, and Capstone Projects

Caffeine has been a heavily researched drug for decades given its prevalence in global consumption, as well as its large impacts on metabolic and executive function research alike. The present study aims to combine a behavioral study (Experiment 1) with a feasibility study (Experiment 2) to test the impacts of variable caffeine consumption on task performance. For both studies, participants filled out a questionnaire regarding caffeine use. Experiment 1 examined whether caffeine modulated attention in an online behavioral task in which participants were asked to identify a target (e.g., female “ahpa”). Participants were tested twice once after consuming 12 ...


Influence Of Demographic, Clinical, And Neuroimaging Variables On Neuropsychological Recovery Trajectories After Moderate-To-Severe Traumatic Brain Injury, Elizabeth J. Leif 2021 The Graduate Center, City University of New York

Influence Of Demographic, Clinical, And Neuroimaging Variables On Neuropsychological Recovery Trajectories After Moderate-To-Severe Traumatic Brain Injury, Elizabeth J. Leif

Dissertations, Theses, and Capstone Projects

Traumatic brain injury (TBI) is prevalent in people of all ages and all walks of life. Cognitive deficits are common after TBI and the recovery patterns are known to be variable across individuals. The current study investigates diffuse axonal injury (DAI), cerebral blood flow (CBF), and focal lesions, in addition to post-traumatic amnesia (PTA), as possible predictors of cognitive trajectory in moderate-to-severe TBI patients. Cognitive trajectory was evaluated with a battery of neuropsychological tests that were combined into three domains: processing speed, verbal learning, and executive function. Patients (N=44) were tested three times at 3, 6, and 12 months ...


Prediction Of Alzheimer’S Disease-Specific Phospholipase C Gamma-1 Snv By Deep Learning-Based Approach For High-Throughput Screening, Sung Hyun Kim, Sumin Yang, Key Hwan Lim, Euiseng Ko, Hyun Jun Jang, Mingon Kang, Pann Ghill Suh, Jae Yeol Joo 2021 Neurodegenerative Disease Research Group

Prediction Of Alzheimer’S Disease-Specific Phospholipase C Gamma-1 Snv By Deep Learning-Based Approach For High-Throughput Screening, Sung Hyun Kim, Sumin Yang, Key Hwan Lim, Euiseng Ko, Hyun Jun Jang, Mingon Kang, Pann Ghill Suh, Jae Yeol Joo

Computer Science Faculty Publications

© 2021 National Academy of Sciences. All rights reserved. Exon splicing triggered by unpredicted genetic mutation can cause translational variations in neurodegenerative disorders. In this study, we discover Alzheimer’s disease (AD)-specific single-nucleotide variants (SNVs) and abnormal exon splicing of phospholipase c gamma-1 (PLCγ1) gene, using genome-wide association study (GWAS) and a deep learning-based exon splicing prediction tool. GWAS revealed that the identified single-nucleotide variations were mainly distributed in the H3K27ac-enriched region of PLCγ1 gene body during brain development in an AD mouse model. A deep learning analysis, trained with human genome sequences, predicted 14 splicing sites in human PLCγ1 ...


Internal And External Challenges To Culpability, Stephen J. Morse 2021 University of Pennsylvania Carey Law School

Internal And External Challenges To Culpability, Stephen J. Morse

Faculty Scholarship at Penn Law

This article was presented at “Guilty Minds: A Virtual Conference on Mens Rea and Criminal Justice Reform” at Arizona State University’s Sandra Day O’Connor College of Law. It is forthcoming in Arizona State Law Journal Volume 53, Issue 2.

The thesis of this article is simple: As long as we maintain the current folk psychological conception of ourselves as intentional and potentially rational creatures, as people and not simply as machines, mental states will inevitably remain central to ascriptions of culpability and responsibility more generally. It is also desirable. Nonetheless, we are in a condition of unprecedented internal ...


Cognitive Abilities In Hearing Loss: Perceived And Performance Abilities Of Adults Related To Attention, Memory, And Social Cognition, Karah Gottschalk 2021 University of Kentucky

Cognitive Abilities In Hearing Loss: Perceived And Performance Abilities Of Adults Related To Attention, Memory, And Social Cognition, Karah Gottschalk

Theses and Dissertations--Gerontology

Hearing loss is the most common sensory deficit noted in aging adults. It is commonly known to reduce an individual’s ability to detect, identify, and localize sounds and speech and to cause issues in communication. However, there are other less commonly discussed impacts that hearing loss has beyond the auditory system. Literature suggests a correlation between hearing loss and cognition in aging adults. Similar to hearing loss, the domains of cognition experience performance and functional changes across the life span. In an aging adult, changes related to cognition are also suggested to be associated with hearing loss. This study ...


How Does Direct Volunteering Affect The Onset Of Alzheimer’S Dementia In Elderly Patients With Preexisting Cardiac Comorbidities?, Sneha R. Gade 2021 Virginia Commonwealth University

How Does Direct Volunteering Affect The Onset Of Alzheimer’S Dementia In Elderly Patients With Preexisting Cardiac Comorbidities?, Sneha R. Gade

Undergraduate Research Posters

Alzheimer's Dementia is a disease that affects memory, thinking, and behavior. The Alzheimer's Association reported Alzheimer's as the sixth-leading cause of death in the United States, and a cure does not exist. Donepezil, a cholinesterase inhibitor drug, is frequently prescribed to treat Alzheimer's disease. Still, patients must continuously take the medication for years to receive any measurable improvement in quality of life after developing Alzheimer's Dementia. Further, research shows prolonged use of Donepezil can lead to other health problems, such as QTc prolongation, for cardiac disease patients. Therefore, the effectiveness of non-drug interventions, such as ...


Bilingualism: A Way To Delay The Onset Of Alzheimer’S Disease And Fight The Global Burden Of Disease It Imposes, Abigail Wester 2021 Regis University

Bilingualism: A Way To Delay The Onset Of Alzheimer’S Disease And Fight The Global Burden Of Disease It Imposes, Abigail Wester

Student Publications

Dementia is the second leading cause of death (accounts for 16.5%) and the leading cause of dependency and disability worldwide (GBD 2016 Neurology Collaborators, 2019). This burden associated with dementia falls heavily on family members, communities, and the individuals themselves. When looking at global dementia cases, the numbers are on the rise and expected to triple by 2050 (World Health Organization, 2019; Robinson, Stephan, & Magklara, 2019). The most common type of dementia is Alzheimer’s Disease (AD), which accounts for 60-80% of all dementia cases (DeTure & Dickson, 2019). Characterized by memory impairment and cognitive decline, AD later impacts behavior, speech, visuospatial orientation, and the motor system (DeTure & Dickson, 2019). Specifically, it leads to atrophy of the brain in multimodal association cortices, limbic lobe structures, gyri in frontal and temporal cortices, posterior cortical areas, the amygdala, and hippocampus (DeTure & Dickson, 2019). One way to delay the onset of AD is through lifelong bilingualism. In addition to other brain changes, increased grey matter can be found in the temporal lobe and orbitofrontal cortex (Abutalebi et al., 2015). This increased grey matter builds-up at a young age and is maintained throughout a lifetime. This allows it to act as a defense against neuroanatomical changes and atrophy commonly associated with AD (Abutalebi et al., 2015; Green & Abutalebi, 2016). More specifically, bilingualism has been found to delay AD development by an average of 4.7 years (Brini et al., 2019).


Diversifying Participation: The Rarity Of Reporting Racial Demographics In Neuroimaging Research, Madeline Goldfarb 2021 Claremont Colleges

Diversifying Participation: The Rarity Of Reporting Racial Demographics In Neuroimaging Research, Madeline Goldfarb

Pitzer Senior Theses

Background: Functional neuroimaging techniques have been instrumental to progress in the cognitive and behavioral sciences; however, their increasing prevalence has evoked conversations concerning limitations associated with reproducibility and bias (Gilmore et al., 2017). While the literature has explored several mechanisms driving issues of replicability, few discussions have considered the effects of confounding social and environmental variables such as age, sex, socioeconomic status, and race (Sauce & Matzel, 2013). The prevailing racial, cultural, and socioeconomic bias in scientific research and the methodological limitations of EEG perpetuate racial and ethnic homogeneity in participation, eliciting qualms regarding the generalizability of findings (Henrich et al ...


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