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381— Virtual Community Outreach For Elementary School Children In R-Kids After-School Program: A Novel Way To Teach Students About Neuroscience, Lucia Verrelli, Natasha Cotrupi, Julia Hoyt, Daniella Quiroz, Terence Bazzett 2021 SUNY Geneseo

381— Virtual Community Outreach For Elementary School Children In R-Kids After-School Program: A Novel Way To Teach Students About Neuroscience, Lucia Verrelli, Natasha Cotrupi, Julia Hoyt, Daniella Quiroz, Terence Bazzett

GREAT Day

Applications in Neuroscience (NEUR215) offers an opportunity for community outreach within the Neuroscience major. Students enrolled in NEUR215 create neuroscience-based activities designed to foster an excitement for science and to promote higher education in elementary school students recruited through the R-Kids after-school enrichment program. Four one-hour live sessions were held via Zoom with 2-5 R-Kids participants attending each session. Due to the COVID-19 pandemic, all lessons were transitioned virtually during the fall 2020 semester, and effective teaching strategies in a virtual environment were explored. The results of this investigation showed that online learning can be both fun and effective. Inviting ...


355— Topographical Individualized Neuromarkers In The Analysis Of The Brain Functioning Of Social-Emotional Development, Maya Pellitteri, Daniella Leone, Emma Piwko, Michael Schulz, Sarina Singh, Bradley Taber-Thomas 2021 SUNY Geneseo

355— Topographical Individualized Neuromarkers In The Analysis Of The Brain Functioning Of Social-Emotional Development, Maya Pellitteri, Daniella Leone, Emma Piwko, Michael Schulz, Sarina Singh, Bradley Taber-Thomas

GREAT Day

Topographical Individualized Neuromarkers (TIN) are spatially arranged patterns of brain function used to develop novel brain markers of social-emotional functioning and development. The current study focuses on developing markers of risk for psychological problems in children. We are expanding on previous research that indicates the brains of shy children differ from the brains of non-shy children, where shy children present with a topographical pattern of brain function that may be considered an internally hypervigilant neuromarker (Taber-Thomas et al., 2016). Using the online software, Neurosynth, we will extend our research into neuromarkers for other disorders using publicly available data. This program ...


The Sellar Barrier’S: An Important New Concept In Pituitary Surgery., Juan F. Villalonga, ALVARO CAMPERO 2021 LINT, Facultad de Medicina, Universidad Nacional de Tucumán, Tucumán, Argentina

The Sellar Barrier’S: An Important New Concept In Pituitary Surgery., Juan F. Villalonga, Alvaro Campero

Archives of Neurosurgery

The sellar barrier's concept was created by our team in Tucumán in 2019. There are currently 3 well-defined subtypes: strong, weak and mixed. Published case series studies indicate that there is a strong correlation between radiological, intraoperative findings and risk of cerebrospinal fluid (CSF) leakage. Patients with weak sellar barrier have more risk of intraoperative CSF leak. The strong sellar barrier is a protective factor for intraoperative CSF leak. The sellar barrier's concept is useful for clinical-surgical practice and for the physician-patient relationship.


Suprameatal Tubercle Classification; Its Implementation On Clinical Cases, Humberto Reyna Mendez, Jose Alfredo Espinosa Mora, Laura Ubaldo Reyes, Alberto Angeles Castellanos, Ignacio Mora Magaña, Mauro Alberto Segura Lozano, Rachel Blue, John YK Lee, Diego Mendez Rosito 2021 Centro Medico Nacional 20 de Noviembre, ISSSTE. Mexico City

Suprameatal Tubercle Classification; Its Implementation On Clinical Cases, Humberto Reyna Mendez, Jose Alfredo Espinosa Mora, Laura Ubaldo Reyes, Alberto Angeles Castellanos, Ignacio Mora Magaña, Mauro Alberto Segura Lozano, Rachel Blue, John Yk Lee, Diego Mendez Rosito

Archives of Neurosurgery

Abstract:

Background: The suprameatal tubercle (SMT) is a variable prominence of the petrosal surface of the temporal bone that lies above the internal acoustic meatus. An enlarged SMT may present an obstacle during surgeries of the posterior fossa, including microvascular decompression or by itself cause trigeminal neuralgia.

Methods: Based on our prior study of 200 temporal bones, its data collection and establishing a classification of the SMT this extension study exemplifies its clinical application.

Results: According to the classification of the SMT four selected cases are clinically and anatomically correlated to exemplify the utility of this classification.

Conclusion: The SMT ...


Endoscopic–Assisted Surgery For Cerebello Pontine Angle Pathology: Technical Note And Surgical Results In A Series Of Patients, Jaime Jesus Martinez Anda, Pablo David Guerrero Suarez, Diego Pineda Martínez, Rafael Avendaño Pradel, Ernesto Javier Jurado Delgado, Ricardo Santiago Villlagrana Sánchez, Juan Carlos Cisneros Lesser, Carolina De la Llata Segura, Rogelio Revuelta Gutiérrez 2021 Neurosurgery Department, Toluca Medical Center of Social Security Institute of the State of Mexico and Provinces, State of Mexico, Mexico

Endoscopic–Assisted Surgery For Cerebello Pontine Angle Pathology: Technical Note And Surgical Results In A Series Of Patients, Jaime Jesus Martinez Anda, Pablo David Guerrero Suarez, Diego Pineda Martínez, Rafael Avendaño Pradel, Ernesto Javier Jurado Delgado, Ricardo Santiago Villlagrana Sánchez, Juan Carlos Cisneros Lesser, Carolina De La Llata Segura, Rogelio Revuelta Gutiérrez

Archives of Neurosurgery

Objectives: Endoscopic–assisted surgery combined with the operating microscope has been described for several surgical techniques and pathologies of the cerebellopontine angle (CPA). The use of an endoscope allows for a panoramic view of the CPA cistern and a high degree of maneuverability in narrow cisternal spaces that enable the surgeon to deal with most CPA lesions safely. We performed an observational study to describe the surgical anatomy and technique for endoscopic-assisted CPA surgery, describing our experience in a case series of patients with CPA pathology. Methods: Anatomical and surgical technique description of endoscopic-assisted surgery for CPA pathology, based on ...


B12: The T Cell Co-Receptor Cd5 Alters Mouse Behavior And Gut Microbiome Composition, Kyle Reaveley 2021 Brigham Young University

B12: The T Cell Co-Receptor Cd5 Alters Mouse Behavior And Gut Microbiome Composition, Kyle Reaveley

Annual Research Symposium

No abstract provided.


Mental Fatigue: Examining Cognitive Performance And Driving Behavior In Young Adults, Abigail F. Helm 2021 University of Massachusetts Amherst

Mental Fatigue: Examining Cognitive Performance And Driving Behavior In Young Adults, Abigail F. Helm

Doctoral Dissertations

Mental fatigue causes an increase in task-based EEG theta and alpha power and a decrease in performance (for a review, see Tran et al., 2020). However, little is known about the emergence of mental fatigue in resting state EEG recordings and whether the progression of mental fatigue over time is influenced by individual differences. The current dissertation examined the utility of resting state EEG as a measure of mental fatigue by testing whether EEG power changed in young adults over the course of a cognitively demanding battery of tasks. The current dissertation also tested how this measure of mental fatigue ...


Sound In Color, Amber Rhodes 2021 Belmont University

Sound In Color, Amber Rhodes

Honors Theses

“Sound in Color” is an interactive audio-visual experience designed to explore the relationship between sound, color, and emotions. Taking place on the Massey Concert Hall stage, the project is inspired by synesthesia and incorporates research on color psychology. Participants are invited to select an emotion and color. As the user hums into a microphone, they hear their emotions expressed through sound in their headphones and watch as the lights on stage respond to their vocal cues.


Autism Treatments: Beyond Applied Behavioral Analysis Therapy, Sarah Samosiuk 2021 Grand Valley State University

Autism Treatments: Beyond Applied Behavioral Analysis Therapy, Sarah Samosiuk

Honors Projects

This literature review dicusses the efficacy of mindfulness as a potential treatment option for individuals with autism spectrum disorder (ASD). It differs from other treatment options as it works to reduce the symptoms of ASD by reducing the stress and anxiety that cause the symptoms. I discuss the neuroscience behind the autistic mind and give a multitude of studies showing the power of mindfulness. Researchers have only scratched the surface of the possibilities that mindfulness could achieve in this field and hopefully this movement can gain traction so that this kind of help is available to all of those who ...


Music And The Brain: A Review Of Neuroscientific And Clinical Applications, Jacqueline LaRivee 2021 Merrimack College

Music And The Brain: A Review Of Neuroscientific And Clinical Applications, Jacqueline Larivee

Honors Senior Capstone Projects

My research examines the relationship between neuroscience and music, exploring its clinical applications. I extensively review the specific neuroanatomic structures implicated in musical perception. Knowing the function of each brain structure as it relates to musical perception provides insight as to how music is able to elicit certain physical and emotional responses. As music interacts with the human brain, it is also able to provide social, cognitive, and emotional benefits. Given these benefits, my research argues that music is an effective therapeutic intervention for vulnerable populations. I examine the impact of music therapy on preterm infants, hearing impaired individuals, intellectually ...


Receptors And Channels Associated With Alcohol Use: Contributions From Drosophila, Kristin M. Scaplen, Emily Petruccelli 2021 Bryant University

Receptors And Channels Associated With Alcohol Use: Contributions From Drosophila, Kristin M. Scaplen, Emily Petruccelli

Applied Psychology Journal Articles

Alcohol Use Disorder (AUD) is a debilitating disorder that manifests as problematic patterns of alcohol use. At the core of AUD’s behavioral manifestations are the profound structural, physiological, cellular, and molecular effects of alcohol on the brain. While the field has made considerable progress in understanding the neuromolecular targets of alcohol we still lack a comprehensive understanding of alcohol’s actions and effective treatment strategies. Drosophila melanogaster is a powerful model for investigating the neuromolecular targets of alcohol because flies model many of the core behavioral elements of AUD and offer a rich genetic toolkit to precisely reveal the ...


Use Of A Zebrafish Model To Identify Anticonvulsant Properties Of Cannabinoid And Terpenoid Extracts And Mixtures, Courtney Murr 2021 Louisiana State University

Use Of A Zebrafish Model To Identify Anticonvulsant Properties Of Cannabinoid And Terpenoid Extracts And Mixtures, Courtney Murr

LSU Master's Theses

Epilepsy is a complex group of neurological disorders affecting approximately 65 million people worldwide. Animal models reveal the activation of cannabinoid receptor 1 and cannabinoid receptor 2 reduces the severity of seizures associated with epilepsy. Trials of phytocannabinoids in mammals demonstrate their efficacy of reducing the severity of epileptic seizures. Numerous terpenoid compounds are present in Cannabis plants but most have yet to be clinically investigated. The goal of this research was to use zebrafish (Danio rerio) to identify the potential anticonvulsive properties of phytocannabinoid and terpenoid compounds. During acute cannabinoid exposures, 7-days-post-fertilization (7 dpf) zebrafish larvae were exposed to ...


Comparative Effects Of Event Detection Methods On The Analysis And Interpretation Of Ca2+ Imaging Data, Austin Neugornet, Bernadette O’Donovan, Pavel I. Ortinski 2021 University of Kentucky

Comparative Effects Of Event Detection Methods On The Analysis And Interpretation Of Ca2+ Imaging Data, Austin Neugornet, Bernadette O’Donovan, Pavel I. Ortinski

Neuroscience Faculty Publications

Calcium imaging has gained substantial popularity as a tool to profile the activity of multiple simultaneously active cells at high spatiotemporal resolution. Among the diverse approaches to processing of Ca2+ imaging data is an often subjective decision of how to quantify baseline fluorescence or F0. We examine the effect of popular F0 determination methods on the interpretation of neuronal and astrocyte activity in a single dataset of rats trained to self-administer intravenous infusions of cocaine and compare them with an F0-independent wavelet ridgewalking event detection approach. We find that the choice of the processing method ...


Anhedonia And Its Intervention In Depressive Adults: New Developments Based On Research Domain Criteria (Rdoc) In Mental Illnesses, J. Mao, J. Yuan 2021 Faculty of Psychology, Southwest University, Chongqing 400715, China

Anhedonia And Its Intervention In Depressive Adults: New Developments Based On Research Domain Criteria (Rdoc) In Mental Illnesses, J. Mao, J. Yuan

Stress and Brain

Anhedonia, as one of the core symptoms of depression, is of great significance for the diagnosis and treatment of depression. Traditionally, anhedonia has been referred to as "loss of pleasure" , while the recent research emphasizes that anhedonia is a complex and multidimensional construct based on reward processing impairment. Exploring different manifestations of anhedonia and developing the corresponding interventions have become indispensable in the current research of depression. Based on the positive valence system of the Research Domain Criteria (RDoC), this paper firstly demonstrates that the anhedonia of depressive adults are mainly characterized by the impairments in anticipatory pleasure, incentive motivation ...


Exposure To Single Prolonged Stress Fails To Induce Anxiety-Like Behavior In Mice, W-J. You, Y. He, W-Z. Liu, Yu-Ge Zhu, Ping Hu, Bing-Xing Pan, Wen-Hua Zhang 2021 Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China

Exposure To Single Prolonged Stress Fails To Induce Anxiety-Like Behavior In Mice, W-J. You, Y. He, W-Z. Liu, Yu-Ge Zhu, Ping Hu, Bing-Xing Pan, Wen-Hua Zhang

Stress and Brain

Single prolonged stress (SPS) is a well-established and most frequently used rat model to induce post-traumatic stress disorder (PTSD)-like symptoms, which helps to understand the neurobiological mechanisms as well as developing novel therapeutic strategies for PTSD. However, whether such stress model works efficiently in mice remains unknown. In the present study, we established a mouse SPS (mSPS) model by exposing C57BL/6J mice to a series of multimodal stressors on a single day, then the anxiety-like behavior was measured by open-field test, elevated plus maze test, dark-light box, and novelty-suppressed feeding test. Our results showed that mSPS had no ...


Creatine Supplementation On Cognitive Performance Following Exercise In Female Muay Thai Athletes, Lawert A.M. Pires, Scott C. Forbes, Darren G. Candow, Marco Machado 2021 University of Iguaçu

Creatine Supplementation On Cognitive Performance Following Exercise In Female Muay Thai Athletes, Lawert A.M. Pires, Scott C. Forbes, Darren G. Candow, Marco Machado

NeuroSports

BACKGROUND: Creatine supplementation has some beneficial effects on cognitive processing in healthy adults, including athletes; however the effects on cognitive function following exhaustive exercise in athletes is unknown. Therefore, the purpose was to determine the effects of 28 days of creatine supplementation on tasks of cognitive performance immediately following exhaustive exercise in Muay Thai female athletes compared to placebo. METHODS: Using a repeated measures, double-blind, placebo controlled design, 26 female Muay Thai athletes (age: 26 ± 5 years; body mass: 65.1 ± 6.6 kg; height: 162 ± 5 cm; training experience: 2.6 ± 0.6 years) were randomized to supplement with ...


The Effects Of Myelin On Macrophage Activation Are Phenotypic Specific Via Cpla2 In The Context Of Spinal Cord Injury Inflammation, Timothy J. Kopper, Bei Zhang, William M. Bailey, Kara E. Bethel, John C. Gensel 2021 University of Kentucky

The Effects Of Myelin On Macrophage Activation Are Phenotypic Specific Via Cpla2 In The Context Of Spinal Cord Injury Inflammation, Timothy J. Kopper, Bei Zhang, William M. Bailey, Kara E. Bethel, John C. Gensel

Physiology Faculty Publications

Spinal cord injury (SCI) produces chronic, pro-inflammatory macrophage activation that impairs recovery. The mechanisms driving this chronic inflammation are not well understood. Here, we detail the effects of myelin debris on macrophage physiology and demonstrate a novel, activation state-dependent role for cytosolic phospholipase-A2 (cPLA2) in myelin-mediated potentiation of pro-inflammatory macrophage activation. We hypothesized that cPLA2 and myelin debris are key mediators of persistent pro-inflammatory macrophage responses after SCI. To test this, we examined spinal cord tissue 28-days after thoracic contusion SCI in 3-month-old female mice and observed both cPLA2 activation and intracellular accumulation of lipid-rich myelin debris ...


Residual And Compensatory Changes Of Resting-State Eeg In Successful Recovery After Moderate Tbi, Galina V. Portnova, Irina N. Girzhova, Olga V. Martynova 2021 Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Science, Moscow 117485, Russia;The Pushkin State Russian Language Institute, Moscow 117485, Russia

Residual And Compensatory Changes Of Resting-State Eeg In Successful Recovery After Moderate Tbi, Galina V. Portnova, Irina N. Girzhova, Olga V. Martynova

Brain Science Advances

Purpose: Even in years after recovery from moderate traumatic brain injury (moderate TBI), patients complain about residual cognitive impairment and fatigue. We hypothesized that non-linear and linear resting-state electroencephalography (rsEEG) features might also reflect neural underpinnings of these deficits. Methods: We analyzed a 10-minute rsEEG in 77 moderate TBI-survivors and 151 healthy volunteers after cognitive and psychological assessment. The rsEEG analysis included linear measures, such as power spectral density and peak alpha frequency, and non-linear parameters such as Higuchi fractal dimension, envelope frequency, and Hjorth complexity. Results: The patients with moderate TBI had higher scores for fatigue and sleepiness and ...


Intrathecal Administration Of Neuronostatin Induces An Antinociceptive Effect In A Mouse Visceral Pain Model, Tingji Shao, Shaobin Yang, Peng Yu 2021 The Department of Pharmacy, Gansu Provincial Hospital, Lanzhou 730000, Gansu, China

Intrathecal Administration Of Neuronostatin Induces An Antinociceptive Effect In A Mouse Visceral Pain Model, Tingji Shao, Shaobin Yang, Peng Yu

Brain Science Advances

Neuronostatin (NST) is a peptide encoded by the somatostatin gene that serves important physiological functions in diverse tissues. Previous studies have shown that intracerebroventricular administration of NST induces antinociceptive effects and hyperalgesic effects as determined by the tail immersion assay and formalin test, respectively. In the present study, we aimed to evaluate the effects of intrathecal (i.t.) injection of NST on nociception in a model of visceral pain, and determine possible mechanisms of action in mice. NST (1, 3, 6, or 12 nmol) was administered to mice, leading to a dose-dependent antinociceptive effect as determined by the acetic acid-induced ...


Neurological Diseases Caused By Coronavirus Infection Of The Respiratory Airways, Waqas Ahmed, Adeel Khan, Wish Hal Sundar, Humaira Naseem, Wanghao Chen, Jia Feng, Samran Durrani 2021 Department of Neurosurgery, Neuroscience Center, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510310, Guangdong, China;School of Medicine, Southeast University, Nanjing 210009, Jiangsu, China

Neurological Diseases Caused By Coronavirus Infection Of The Respiratory Airways, Waqas Ahmed, Adeel Khan, Wish Hal Sundar, Humaira Naseem, Wanghao Chen, Jia Feng, Samran Durrani

Brain Science Advances

Infections of the central nervous system (CNS) infections are critical problems for public health. They are caused by several different organisms, including the respiratory coronaviruses (CoVs). CoVs usually infect the upper respiratory tract causing the common cold. However, in infants, and in elderly and immunocompromised persons, they can also affect the lower respiratory tract causing pneumonia and various syndromes of respiratory distress. CoVs also have neuroinvasive capabilities because they can spread from the respiratory tract to the CNS. Once infection begins in the CNS cells, it can cause various CNS problems such as status epilepticus, encephalitis, and long-term neurological disease ...


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