Physiology Commons^™

The Role Of Pulmonary Stretch Receptor Afferents In Swallow-Breathing Coordination: A Comparison Of Central Respiratory Rhythm Versus Mechanical Ventilation On Swallow In A Decerebrate Feline Model, Kofi-Kermit A. Horton

USF Tampa Graduate Theses and Dissertations

Swallowing is an essential motor act that coordinates the movement of food or saliva from the mouth through the pharynx and into the esophagus while protecting the upper airways from aspiration of those materials. Disordered swallowing, or dysphagia, results when bolus movement from the oropharyngeal phase into the esophageal phase is uncoordinated. Dysphagia directly causes or increases the risk of aspiration during swallowing in many clinical pathologies including Parkinson’s disease, Alzheimer’s disease, cerebrovascular incidents (stroke) in addition to being prevalent among the elderly population. The coordination between breathing and swallowing is mediated through the interaction of the swallow and respiratory …

Mechanisms Of Fatigability In People With Type 2 Diabetes And Prediabetes, Jonathon William Senefeld

Dissertations (1934 -)

Dynamic fatiguing exercise of limb muscles is the basis of exercise training and a cornerstone of management of type 2 diabetes mellitus (T2D) and prediabetes. Little is known however, about the fatigability of limb muscles (the acute exercise induced reduction in force or power) and the involved mechanisms in people with T2D and prediabetes. Current evidence suggests that people with T2D have reduced muscle strength and power, are more fatigable after static contractions, and have physical impairments affecting activities of daily living. However, impaired function in people with T2D compared with controls is larger for dynamic than static tasks. The …

Elucidating The Role Of The Transcriptional Co-Activator Camta1 In Cardiac Development, Nate Batey, Zach Frederich, Morgan Fronk, Nate Jenkins, Jonathon Hill

Journal of Undergraduate Research

Congenital Heart Disease (CHD) is the most common type of birth defect in the United States, causing more first-year infant deaths than any other birth defect (1). While the causes of CHD are varied, genetic defects are known to play a significant role. Identifying and studying genes involved in embryonic heart development can enhance understanding of the genetic factors in CHDs. The camta1 gene is a promising candidate due to its transient expression in heart morphogenesis and its relationship to camta2 , the only other member of its family in vertebrates and a known player in adult heart failure (2,3).

Spinal Control Of Locomotion: Individual Neurons, Their Circuits And Functions, Marie-Pascale Côté, Lynda M. Murray, Maria Knikou

Publications and Research

Systematic research on the physiological and anatomical characteristics of spinal cord interneurons along with their functional output has evolved for more than one century. Despite significant progress in our understanding of these networks and their role in generating and modulating movement, it has remained a challenge to elucidate the properties of the locomotor rhythm across species. Neurophysiological experimental evidence indicates similarities in the function of interneurons mediating afferent information regarding muscle stretch and loading, being affected by motor axon collaterals and those mediating presynaptic inhibition in animals and humans when their function is assessed at rest. However, significantly different muscle …

Ecophysiology Of Oxygen Supply In Cephalopods, Matthew A. Birk

USF Tampa Graduate Theses and Dissertations

Cephalopods are an important component of many marine ecosystems and support large fisheries. Their active lifestyles and complex behaviors are thought to be driven in large part by competition with fishes. Although cephalopods appear to compete successfully with fishes, a number of their important physiological traits are arguably inferior, such as an inefficient mode of locomotion via jet propulsion and a phylogenetically limited means of blood-borne gas transport. In active shallow-water cephalopods, these traits result in an interesting combination of very high oxygen demand and limited oxygen supply. The ability to maintain active lifestyles despite these metabolic constraints makes cephalopods …

Acute Cardiometabolic Responses To Medicine Ball Interval Training In Children, Avery D. Faigenbaum, Jie Kang, Nicholas A. Ratamess, Anne C. Farrell, Nicole Ellis, Ira Vought, Jill Bush

International Journal of Exercise Science

International Journal of Exercise Science 11(4): 886-899, 2018. Medicine ball interval training (MBIT) has been found to be an effective exercise modality in fitness programs, yet the acute physiological responses to this type of this exercise in youth are unknown. The purpose of this study was to examine the acute cardiometabolic responses to MBIT in children. Fourteen children (mean age 10.1 ± 1.3 yr) were tested for peak oxygen uptake (VO₂peak) on a treadmill and subsequently (> 48 hours later) performed a progressive 10 min MBIT protocol of 5 exercises (EX): standing marches (EX1), alternating lunges (EX2), squat …

Returners Exhibit Greater Jumping Performance Improvements During A Peaking Phase Compared With New Players On A Volleyball Team, Caleb D. Bazyler, Satoshi Mizuguchi, Ashley A. Kavanaugh, John J. Mcmahon, Paul Comfort, Michael H. Stone

ETSU Faculty Works

Purpose: To determine if jumping-performance changes during a peaking phase differed among returners and new players on a female collegiate volleyball team and to determine which variables best explained the variation in performance changes.

Methods: Fourteen volleyball players were divided into 2 groups—returners (n = 7) and new players (n = 7)—who completed a 5-wk peaking phase prior to conference championships. Players were tested at baseline before the preseason on measures of the vastus lateralis cross-sectional area using ultrasonography, estimated back-squat 1-repetition maximum, countermovement jump height (JH), and relative peak power on a force platform. Jumping performance, rating of perceived …

“Seeing” Beyond The Knees: Inflammation In The Eye As A Result Of Mechanical Stress, Michael Goodman, David Kooyman

Journal of Undergraduate Research

A correlation between Osteoarthritis (OA), affecting over 27 million people in the US [1], and metabolic syndrome (MS), affecting over 340 million people worldwide [2], becomes strikingly important as the search for an effective treatment for OA continues. Increasing evidence has shown that OA is linked to systemic inflammation and MS. With MS comes other substantial comorbidities, including diabetic retinopathy (DR). Ocular inflammation promoted through mechanically induced OA would provide evidence that mechanical stress can be a factor leading to systemic inflammation. Such results would have profound impacts upon the way we view OA as a metabolic disorder, leading to …

Rage Functions During Secondhand Smoke-Induced Bronchopulmonary Dysplasia, Brent Kimber, Dr. Paul Reynolds

Journal of Undergraduate Research

Bronchopulmonary Dysplasia (BPD) is a common respiratory disease among pre-term infants or newborns exposed to harmful toxins during pregnancy or at birth. This leads to several respiratory diseases later in life such as chronic obstructive pulmonary disorder (COPD) or asthma. However, research on the effects of cigarette smoke in utero has many gaps. This project focuses on developing a transgenic mouse model that mimics the pulmonary morphologies and characteristics of BPD. This model will then be used for further research and potentially discover new therapeutic methods for BPD. The transgenic mouse was established using a modified genetic scheme whereby the …

Measurement Of Lumbar Multifidus Asymmetry In Amateur Cricket Pace Bowlers Using Real-Time Ultrasound, Matthew Toumazou, Carol A. Flavell, Susan J. Gordon

International Journal of Exercise Science

International Journal of Exercise Science 11(3): 875-885, 2018. Objectives: To determine if lumbar multifidus asymmetry existed between the fifth lumbar (L5) and 1^stsacral (S1) spinal level in a group of amateur cricket pace bowlers and a healthy non-cricketing group of males, and to determine if there were significant differences between groups in lumbar multifidus asymmetry at rest, on contraction, or during activation. Design: A prospective single blinded cross-sectional study. Methods: Forty healthy participants were recruited to two groups: an amateur cricket pace bowling group (n=20) and a non-cricketing group (n=20). Bilateral real-time ultrasound imaging of lumbar multifidus was …

Apoe And Alzheimer’S Disease: Neuroimaging Of Metabolic And Cerebrovascular Dysfunction, Jason A. Brandon, Brandon C. Farmer, Holden C. Williams, Lance A. Johnson

Physiology Faculty Publications

Apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for late onset Alzheimer’s Disease (AD), and is associated with impairments in cerebral metabolism and cerebrovascular function. A substantial body of literature now points to E4 as a driver of multiple impairments seen in AD, including blunted brain insulin signaling, mismanagement of brain cholesterol and fatty acids, reductions in blood brain barrier (BBB) integrity, and decreased cerebral glucose uptake. Various neuroimaging techniques, in particular positron emission topography (PET) and magnetic resonance imaging (MRI), have been instrumental in characterizing these metabolic and vascular deficits associated with this important AD risk factor. In …

An "Exercise" In Cardiac Metabolism, Stephen C. Kolwicz Jr.

Health Sciences Faculty Publications

Research has demonstrated that the high capacity requirements of the heart are satisfied by a preference for oxidation of fatty acids. However, it is well known that a stressed heart, as in pathological hypertrophy, deviates from its inherent profile and relies heavily on glucose metabolism, primarily achieved by an acceleration in glycolysis. Moreover, it has been suggested that the chronically lipid overloaded heart augments fatty acid oxidation and triglyceride synthesis to an even greater degree and, thus, develops a lipotoxic phenotype. In comparison, classic studies in exercise physiology have provided a basis for the acute metabolic changes that occur during …

Effects Of Very Short-Term Dynamic Constant External Resistance Exercise On Strength And Barbell Velocity In Untrained Individuals, M. Travis Byrd, Haley C. Bergstrom

International Journal of Exercise Science

International Journal of Exercise Science 11(1): 867-874, 2018.This study examined the effect of an upper body dynamic constant external resistance (DCER) exercise (barbell bench press [BP]), using the very short-term training (VST) model on strength and barbell velocity. Ten (5 females, 5 males) subjects (mean ± SD age: 21.4 ± 2.8 yrs; height: 1.75 ± 0.12 m; body mass: 83 ± 8.8 kg) completed two pre-test visits (pre-test 1 and pre-test 2) to serve as the within subjects control, three training visits, and one post-test visit. The subject’s 1 repetition maximum (1RM) for the BP as well as the …

Codon Usage Revisited: Lack Of Correlation Between Codon Usage And The Number Of Trna Genes In Enterobacteria, Joaquín Rojas, Gabriel Castillo, Lorenzo Eugenio Leiva, Sara Elgamal, Omar Orellana, Michael Ibba, Assaf Katz

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

It is widely believed that if a high number of genes are found for any tRNA in a rapidly replicating bacteria, then the cytoplasmic levels of that tRNA will be high and an open reading frame containing a higher frequency of the complementary codon will be translated faster. This idea is based on correlations between the number of tRNA genes, tRNA concentration and the frequency of codon usage observed in a limited number of strains as well as from the fact that artificially changing the number of tRNA genes alters translation efficiency and consequently the amount of properly folded protein …

Effects Of Instability On Core Muscle Activation In A Side Bridge, Erin E. Kishman

Masters Theses

Training the musculature of the core continues to be perceived as an essential component of conditioning and rehabilitation settings (11). A popular way to train the core is with the use of instability devices, such as Swiss ball or suspension trainer. However, there is limited research on the effects of these devices on core muscle activity. The purpose of this study was to examine core muscle activity during side bridge variations with and without instability devices (Floor, Swiss Ball, and TRX) through electromyography (EMG) of the rectus abdominis, external oblique, erector spinae, and latissimus dorsi. 39 participants performed three variations …

Transcriptional Correlates Of Proximal-Distal Identify And Regeneration Timing In Axolotl Limbs, S. Randal Voss, David Murrugarra, Tyler B. Jensen, James R Monaghan

Neuroscience Faculty Publications

Cells within salamander limbs retain memories that inform the correct replacement of amputated tissues at different positions along the length of the arm, with proximal and distal amputations completing regeneration at similar times. We investigated the possibility that positional memory is associated with variation in transcript abundances along the proximal-distal limb axis. Transcripts were deeply sampled from Ambystoma mexicanum limbs at the time they were administered fore arm vs upper arm amputations, and at 19 post-amputation time points. After amputation and prior to regenerative outgrowth, genes typically expressed by differentiated muscle cells declined more rapidly in upper arms while cell …

Biology Of Exosomes And Their Microrna Cargos In Human And Bovine Milk, Amy Lynn Leiferman

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Exosomes are small, cargo-containing vesicles secreted by cells to facilitate intercellular communication. Of exosome cargos, microRNAs are especially interesting because of their involvement in gene regulation. Recently, our lab has shown that exosomes and their microRNA cargo are absorbed through the diet and elicit effects exogenously. Human and animal milk contain exosomes, which may have implications in infant and adult nutrition. There is evidence that bovine milk exosomes enhance growth of murine C2C12 myotube cell cultures, but whether this translates to muscle in vivo is unknown. The USDA National Nutrient Database for Standard Reference is lacking up-to-date information about human …

"Understanding Lgbtq+ Intimate Partner Violence & Challenges In, Dr. Juanita Yates

Dissertations

This research project is a focus on Intimate Partner Violence (IPV) within LGBTQ+

community and the challenges associated with seeking family support. IPV is defined as a violent

or aggressive behavior within the home, typically involving the violent abuse of an intimate spouse

or partner. However, IPV can happen on the street, in one’s home or even in a public place. Those

exposed to IPV can be children, men and women. IPV is a prevalent issue in our society (Bright

2008). According to Ristock (2005), violence in LGBTQ+ relationships may be referred to as

partner violence, relationship violence, or LGBTQ+ …

Effects Of Omega-3s And Vitamin E Prophylactic Diets And The Implications Of Lipid Transport In Spinal Cord Injury, Kathia Cordero-Caban

Loma Linda University Electronic Theses, Dissertations & Projects

Traumatic injury to the central nervous system (CNS) presents a devastating problem to our society. Although current interventions are promising, no effective treatments are available. The neural membrane fatty acid composition is markedly altered during the first few days after spinal cord injury (SCI). SCI results in autonomic dysfunction, paralysis, spasticity, and significant chronic neuropathic pain. The trauma leads to significantly increased levels of free radical and oxidative stress that contribute to obstructing tissue healing and recovery. A growing body of evidence shows that administration of hydrophobic molecules such as Vitamin E and long-chain omega-3 polyunsaturated fatty acids (ω3PUFAs) are …

Disruption Of Synchronous Behavior In Pancreatic Islets Via Hub Cells, Janita Patwardhan

Biology and Medicine Through Mathematics Conference

No abstract provided.