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Opioid Use Disorder: The Timeline For Medication Assisted Therapy, Alexander Cristofori 2021 Arcadia University

Opioid Use Disorder: The Timeline For Medication Assisted Therapy, Alexander Cristofori

Capstone Showcase

Opioid Use Disorder is patterns of opioid use leading to withdrawal, giving up important life events in order to use opioids, and excessive time spent using opioids, to name a few diagnostic criteria. The clinical progression of the disorder involves periods of acute exacerbation and remission that are cyclic in nature. Treatment is most effective when it includes both pharmacological and psychosocial modalities, referred to as medication assisted therapy (MAT). Three drugs used commonly in MAT-based treatment for OUD from oldest to newest include Methadone, Buprenorphine-naloxone, and Naltrexone. Treatment program models that prioritize total abstinence from the addictive substance attached ...


Sexually Dimorphic Oxytocin Receptor-Expressing Neurons In The Anteroventral Periventricular Nucleus Regulates Maternal Behavior, Kaustubh Sharma 2020 Louisiana State University and Agricultural and Mechanical College

Sexually Dimorphic Oxytocin Receptor-Expressing Neurons In The Anteroventral Periventricular Nucleus Regulates Maternal Behavior, Kaustubh Sharma

LSU Doctoral Dissertations

The neurohypophysial hormone oxytocin is involved in the regulation of social behaviors, including social recognition, pair bonding, and sex-specific parental behaviors in a variety of species. Oxytocin triggers these social behaviors by binding to oxytocin receptors (OXTR) in various parts of the brain. Oxytocin-induced sex-typical behavior, therefore, suggests a sexual dimorphic distribution of OXTR in the brain. In recent years, the oxytocin system in the brain received tremendous attention as a potential pharmacological target for treatment of many psychiatric disorders, such as anxiety, autism spectrum disorders, and even sex-specific psychiatric disorder like postpartum depression (PPD). An important problem and a ...


Engineering Creativity: Prior Experience Modulates Electrophysiological Responses To Novel Metaphors, Rafal Jończyk, Gül E. Okudan Kremer, Zahed Siddique, Janet G. van Hell 2020 Adam Mickiewicz University and Pennsylvania State University

Engineering Creativity: Prior Experience Modulates Electrophysiological Responses To Novel Metaphors, Rafal Jończyk, Gül E. Okudan Kremer, Zahed Siddique, Janet G. Van Hell

Industrial and Manufacturing Systems Engineering Publications

Novel metaphorical language use exemplifies human creativity through production and comprehension of meaningful linguistic expressions that may have never been heard before. Available electrophysiological research demonstrates, however, that novel metaphor comprehension is cognitively costly, as it requires integrating information from distantly related concepts. Herein, we investigate if such cognitive cost may be reduced as a factor of prior domain knowledge. To this end, we asked engineering and nonengineering students to read for comprehension literal, novel metaphorical, and anomalous sentences related to engineering or general knowledge, while undergoing EEG recording. Upon reading each sentence, participants were asked to judge whether or ...


Effect Of Ambient Temperature On Recovery Of Surgically Instrumented Sprague-Dawley Rats, Gianna Mangone 2020 James Madison University

Effect Of Ambient Temperature On Recovery Of Surgically Instrumented Sprague-Dawley Rats, Gianna Mangone

Senior Honors Projects, 2020-current

Based on current guidelines for housing rodents after surgical instrumentation, rodents may be housed at temperatures that hinder surgical recovery and cause thermal stress– room temperature (21°C) being one of them. Rodents are often housed at room temperature since this temperature is easy for humans to be caring for them. However, if recovering rodents are thermally stressed, experimental results will be confounded. To address this issue, Sprague-Dawley rats were surgically instrumented with radiotelemtry thermoprobes (Data Sciences, #TA-10F40) to monitor their core temperatures, then housed at one of five temperatures to assess the effect ambient temperature had on multiple aspects ...


Alternative Polyadenylation Modulates Expression Of Pro-Fibrotic Proteins And Contributes To Lung Fibrosis, Junsuk Ko 2020 The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences

Alternative Polyadenylation Modulates Expression Of Pro-Fibrotic Proteins And Contributes To Lung Fibrosis, Junsuk Ko

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects about 5 to 8 million individuals in the world. Despite the high prevalence, there is currently no cure for IPF, and the cause of this disease is still unclear. Our laboratory and collaborators have shown that nudix hydrolase 21 (NUDT21, which is also known as cleavage factor 25, CFIm25) is a key regulator of alternative polyadenylation (APA). NUDT21 depletion causes 3’UTR shortening via APA leading to enhanced mRNA stability and protein translation. This NUDT21 reduction promotes tumor growth in glioblastoma by enhancing expression of oncogenes. Cancer and IPF ...


Amygdala And Neocortical Structural Volume Analysis In The Shank3b Mutant Mouse Model Of Autism Spectrum Disorder, Preet Sawhney 2020 University of Connecticut

Amygdala And Neocortical Structural Volume Analysis In The Shank3b Mutant Mouse Model Of Autism Spectrum Disorder, Preet Sawhney

Honors Scholar Theses

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is characterized by abnormal social behavior, deficits in communication, and motor stereotypy. The SHANK3 gene, responsible for the generation of a scaffolding protein that is integral for the development of synapses, has been identified as one of the primary candidate genes implicated in the disorder. Shank3B is the rodent homolog for this gene. Research has shown that when this gene is disrupted in rodent models (e.g., via knock-out (KO)), ASD-like behaviors result. These include deficits in social interaction, increased anxiety, and repetitive self-grooming. The current study aimed to identify a ...


Ctrp3 And Alcoholic Liver Disease In Female Mice, Callie Root 2020 East Tennessee State University

Ctrp3 And Alcoholic Liver Disease In Female Mice, Callie Root

Undergraduate Honors Theses

C1q TNF Related Protein 3 (CTRP3), is a cytokine that is primarily secreted from adipose tissue, which classifies it as an adipokine. Our previous research has shown that CTRP3 prevents alcoholic fatty liver disease (ALD) in male mice. However, even when accounting for confounding factors such as absolute and relative alcohol intake, females are more sensitive to the effects of consumption compared to male mice. Therefore, the goal of this project was to determine whether CTRP3 prevented ALD in female mice. Methods: Female wild type (WT) and female CTRP3 transgenic over expressing (Tg) mice were fed an ethanol containing liquid ...


Safe Sleep: Developmental Implications For Hospitalized Infants, Katherine Kohlsaat 2020 University of Rhode Island

Safe Sleep: Developmental Implications For Hospitalized Infants, Katherine Kohlsaat

Senior Honors Projects

The rate at which an infant develops both physically and cognitively is significant during sleep, as this is the time when the entire body can dedicate its efforts to this cause. Parents of healthy infants follow the guidelines set by the American Academy of Pediatrics (AAP) relating to safe sleep, and since their introduction in 1992, the rate of Sudden Infant Death Syndrome (SIDS) has decreased by 40% (Center for Disease Control and Prevention, 2016). However, if an infant has been hospitalized since birth due to necessary invasive procedures such as open-heart surgery, these protocols cannot be initially implemented. Common ...


Heat For The Masses: Thermal Ecology Of The Western Tent Caterpillar, Victoria Dahlhoff 2020 University of Montana, Missoula

Heat For The Masses: Thermal Ecology Of The Western Tent Caterpillar, Victoria Dahlhoff

Graduate Student Theses, Dissertations, & Professional Papers

A unique feature of some gregarious, colonial insects is their ability to create external structures that alter environmental conditions for the entire (often family) group. A combination of physical alteration of local microhabitats and behavioral thermoregulation allows many of these animals to actively control their body temperatures, which allows them to regulate energy use and metabolism in variable thermal environments. Here I describe mechanisms of microhabitat modification and thermal regulation in the western tent caterpillar, Malacosoma californicum pluviale. Tent caterpillars build communal silk tents, whose temperatures can rise substantially above ambient air temperature. I experimentally manipulated colony sizes and examined ...


Oxidative Stress Analysis Of Placental Tissue In The Rupp Pregnant Rat, Natalie Ganios 2020 The University of Akron

Oxidative Stress Analysis Of Placental Tissue In The Rupp Pregnant Rat, Natalie Ganios

Williams Honors College, Honors Research Projects

Preeclampsia is a disease associated with a vasoconstrictive phenotype due to disrupted signaling in the vascular endothelial growth factor (VEGF) relaxation pathway. The purpose of these studies is to determine the level of oxidative damage that is occurring in the placenta of the reduced uterine perfusion pressure (RUPP) rat, which serves as a common model for preeclampsia. RUPP and SHAM placenta tissue will be examined for oxidative stress as an indicator of tissue damage associated with the pathologically induced ischemia. Oxidative stress in the placental tissue will be measured by performing the following oxidative stress assays: 8-isoprostane test, TBARS assay ...


Towards A Hybrid Comfortable Passenger Cabin Interior For The Flying V Aircraft, Peter Vink, Thomas Rotte, Shabila Anjani, Chiara Percuoco, Roelof Vos 2020 Delft University of Technology

Towards A Hybrid Comfortable Passenger Cabin Interior For The Flying V Aircraft, Peter Vink, Thomas Rotte, Shabila Anjani, Chiara Percuoco, Roelof Vos

International Journal of Aviation, Aeronautics, and Aerospace

The Flying-V is a V-shaped airplane in development, which uses less fuel due its form. Passengers are in the oval cabin in the wing, which asks for an alternative design to the interior. At the same time there is a demand for more comfortable interiors.

80 students were asked to develop interior design ideas for this Flying V concept. A jury of experts selected four aircraft interior concepts and these were developed and a 1:1 scale mockup was made, with a hybrid interior. It included a chaise longue seats, the group space, beds and ‘staggered’ seats for the middle ...


Physiological Response Of Elasmobrachs During Propofol Immersion, Matthew Levendosky 2020 Georgia Southern University

Physiological Response Of Elasmobrachs During Propofol Immersion, Matthew Levendosky

Electronic Theses and Dissertations

Sensory experiments require anesthesia so the animal is immobilized, however fish anesthetics have shown to depress sensory responses. Newer anesthetics may offer similar anesthetic relief, but differ in means of action so sensory responses may be unaffected. Propofol has been used intravenously on small elasmobranchs but may provide prolonged effects if used as an immersion anesthetic. Objectives of this study were 1. Determine appropriate concentration of anesthetic to minimize induction and recovery for animals anesthetized at a surgical plane of anesthesia and 2. Measure physiological response of the pupil to light stimuli during anesthetic immersion. To address these objectives, I ...


Tracing Nutrient Sources To Lipid Production In Birds And Insects Using Stable Isotope (Δ13c, Δ2h) Tracers: Implications For Nutritional Physiology Of Migratory Species, Libesha Anparasan 2019 The University of Western Ontario

Tracing Nutrient Sources To Lipid Production In Birds And Insects Using Stable Isotope (Δ13c, Δ2h) Tracers: Implications For Nutritional Physiology Of Migratory Species, Libesha Anparasan

Electronic Thesis and Dissertation Repository

Using stable isotope measurements of inert tissues to determine origins and migratory patterns is well established. However, isotopically determining nutritional origins of lipids, the primary fuel of migration, has not been attempted. I explored isotopic links between diet and stored lipids in captive White-throated Sparrows (Zonotrichia albicollis) and true armyworm moths (Mythimna unipuncta) using δ13C and δ2H measurements. Isotopic discrimination between body lipids and diet was established as linear calibration functions. Isotopic uptake following a diet switch in moths was used to trace lipid accumulation over time. Isotopic correlations between breath metabolic by-products of fed and ...


Response Of Early Life Stage Homarus Americanus To Ocean Warming And Acidification: An Interpopulation Comparison, Maura K. Niemisto 2019 University of Maine

Response Of Early Life Stage Homarus Americanus To Ocean Warming And Acidification: An Interpopulation Comparison, Maura K. Niemisto

Electronic Theses and Dissertations

Anthropogenic carbon released into the atmosphere is driving rapid, concurrent increases in temperature and acidity across the world’s oceans, most prominently in northern latitudes. The geographic range of the iconic American lobster (Homarus americanus) spans a steep thermal gradient and one of the most rapidly warming oceanic environments. Understanding the interactive effects of ocean warming and acidification on this species’ most vulnerable early life stages is important to predict its response to climate change on a stage-specific and population level. This study compares the responses of lobster larvae from two sub-populations spanning New England’s north-south temperature gradient (southern ...


Analyzing Physiological Stress Response Using Dermal Swabs In Plethodon Montanus, John Tester 2019 East Tennessee State University

Analyzing Physiological Stress Response Using Dermal Swabs In Plethodon Montanus, John Tester

Undergraduate Honors Theses

Upon exposure to environmental stressors, amphibians such as Plethodon montanus will release corticosterone (CORT) thus causing a behavioral and physiological response to cope with the stress. Currently, there are several invasive ways of collecting CORT in salamanders. However, these techniques typically require euthanasia of the organism. We hypothesized that exposure of P. montanus to stressful handling conditions will result in elevations of CORT that can be detected through dermal swabbing. To test this, two experiments were conducted which involved swabbing the dorsal side of the trunk before and immediately after exposing P. montanus to two different environmental stressors. The first ...


Tracing Nutrient Sources To Lipid Production In Insects Using Stable Isotope (Δ13c, Δ2h) Tracers: Implications For Nutritional Physiology Of Migratory Species., Libesha Anparasan, Keith A. Hobson 2019 The University of Western Ontario

Tracing Nutrient Sources To Lipid Production In Insects Using Stable Isotope (Δ13c, Δ2h) Tracers: Implications For Nutritional Physiology Of Migratory Species., Libesha Anparasan, Keith A. Hobson

Western Research Forum

Using stable isotope measurements of insect tissues to determine origin and migratory patterns is well established. However, isotopically determining nutritional origins of lipids, the primary fuel of migration, has not been as thoroughly researched. We explored isotopic links between diet and stored lipids in laboratory raised True armyworm moths (Mythimna unipuncta) using δ13C and δ2H measurements. Pupae were randomly separated into four groups (n=20) and fed isotopically distinct nectar, each consisting of a combination of high δ13C (C4 sugar), or low δ13C (C3 sugar) carbohydrate, with high δ2H (deuterium ...


Stress And Body Composition Of Juvenile Alligator Snapping Turtles (Macrochelys Temminckii), Brandon Scott Tappmeyer 2019 Missouri State University

Stress And Body Composition Of Juvenile Alligator Snapping Turtles (Macrochelys Temminckii), Brandon Scott Tappmeyer

MSU Graduate Theses

The alligator snapping turtle (Macrochelys temminckii), is a species of conservation concern that is the subject of multiple head-start and reintroduction efforts across its range. In captive propagation programs, producing offspring that are in optimal physiological condition maximizes the likelihood of success after release. The purpose of my study was to compare stress and body composition between one free-ranging reintroduced population and two captive populations. The two captive populations were both housed in southern Oklahoma, but one group was reared indoors whereas the other inhabited outdoor ponds at a national fish hatchery. I used circulating glucocorticoid (corticosterone) concentrations as an ...


Human Anatomy And Physiology I: Course Map With Expected Learning Outcomes, Carlos Liachovitzky 2019 CUNY Bronx Community College

Human Anatomy And Physiology I: Course Map With Expected Learning Outcomes, Carlos Liachovitzky

Open Educational Resources

This document contains a list with all the Anatomy and Physiology I expected learning outcomes organized by topics, and grouped into ten units: 1. Introduction to A&P: body plan & organization; 2. Introduction to A&P: homeostasis; 3. The chemical level of organization; 4. Levels of organization: the cellular level of organization; 5. Levels of organization: the tissue level of organization; 6. Support and movement: integumentary system; 7. Support and movement: skeletal system & articulations; 8. Support and movement: muscular system; 9. Regulation, integration, and control: nervous system; 10. Regulation, integration, and control: special senses

Each learning outcome is referred to a section in the textbook “Anatomy and ...


The Effects Of Salinity On Zootechnical Performance Of Spotted Seatrout (Cynoscion Nebulosus) In Recirculating Aquaculture Systems, Eric Gigli 2019 University of Southern Mississippi

The Effects Of Salinity On Zootechnical Performance Of Spotted Seatrout (Cynoscion Nebulosus) In Recirculating Aquaculture Systems, Eric Gigli

Master's Theses

The spotted seatrout (Cynoscion nebulosus) is a euryhaline finfish candidate for marine aquaculture in the northern Gulf of Mexico. Aquaculture of this species currently uses salinities of 25 psu or greater making production challenging in areas where high salinity water is not available. This study aimed to document the effects of salinity on zootechnical performance of spotted seatrout embryos, early larvae, and juveniles in recirculating aquaculture systems to assist with the development of protocols for low salinity culture.

Embryos obtained from a volitional spawn at 29 psu were incubated at three salinities (12.5, 18.75, or 25 psu) until ...


Thermal Biology Of Temperate And High-Latitude Arachnids, Susan E. Anthony 2019 The University of Western Ontario

Thermal Biology Of Temperate And High-Latitude Arachnids, Susan E. Anthony

Electronic Thesis and Dissertation Repository

Temperate and high latitude terrestrial ecosystems have high thermal variability, and the ectotherms that inhabit these regions must have thermal tolerances that mirror these temperatures. However, the thermal limits of many high-latitude arachnids are unknown, as well as any underlying mechanisms of seasonal plasticity for any arachnid. The objective of my thesis is to measure the thermal tolerances of temperate, Arctic, and sub-Arctic arachnids, and identify if they have thermal plasticity, either seasonally or following acclimation. I collected the high-latitude pseudoscorpion Wyochernes asiaticus streamside from the Yukon Territory, where besides large thermal variability, they are also inundated with spring flooding ...


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