Physiology Commons^™

Comparison Of Two Static Stretching Procedures On Hip Adductor Flexibility And Strength, Brandon Fjerstad, Roger L. Hammer Dr., Adam Hammer, Gavin Connolly, Karen Lomond, Paul O'Connor

International Journal of Exercise Science

International Journal of Exercise Science 11(6): 1074-1085, 2018. It has been shown that acute static stretching (SS) may increase flexibility, improve performance and reduce the risk of muscle strains, but may also result in decreased maximal force output. Literature review revealed little research had specifically been done on the most effective ways to stretch the hip adductor muscles. The purpose was to determine the effects that an acute bout of SS (active vs passive) has on hip adductor flexibility and maintenance of strength. Randomized cross-over study using a 3 X 2 (Condition X Time) repeated measures ANOVA statistical design. Forty …

The Effect Of Active Ankle T1tm Ankle Braces On The Timing Of Muscular Activation In The Leg In Female Varsity Volleyball Players: A Pilot Study, Kylee Kuchta, Sara Potter, Heather Brousseau, Ian Newhouse

International Journal of Exercise Science

International Journal of Exercise Science 11(1): 1086-1095, 2018. The objective was to examine the effect of Active Ankle T1^TM ankle braces on the timing of muscular activation of the upper leg in female volleyball athletes during a one-legged landing task. Fourteen healthy female varsity volleyball athletes participated in this study. Each signed a participant recruitment form, consent form, a Physical Activities Readiness Questionnaire (PAR-Q) and completed the injury screening form. A warm up was completed followed by two practice jumps. Each participant was randomly assigned and counterbalanced to a condition to begin with (no brace or brace). Once the …

Relationships Between Assessments In A Physical Ability Test For Law Enforcement: Is There Redundancy In Certain Assessments?, Karly Cesario, Joe Dulla, Ashley Blood Good, Matthew R. Moreno, J. Jay Dawes, Robert G. Lockie

International Journal of Exercise Science

International Journal of Exercise Science 11(4): 1063-1073, 2018. The purpose of this study was to investigate the relationships between tests incorporated into a physical assessment battery (PAT) for a law enforcement (LEA) to determine if there were redundancies (i.e. tests measuring the same qualities). A retrospective analysis of 226 recruits (196 males, 30 females) was conducted. The PAT consisted of: maximal push-ups and sit-ups completed in 60 s; a 75-yard pursuit run (75PR); maximal revolutions completed on an arm ergometer in 60 s; and a 2.4 km run. A one-way ANOVA (p<0.05) determined if there were significant differences in the PAT data between the sexes. Pearson’s correlations (p<0.05) calculated relationships between each of the tests within the PAT, and males and females were analyzed separately. Further, tests that could potentially measure similar qualities, including upper-body endurance (push-ups/arm ergometer), abdominal endurance (push-ups/sit-ups), and aerobic fitness (arm ergometer/2.4 km run) were investigated further with one-sample t-tests to determine agreement. Males performed better than the females in all tests (p≤0.017). There were significant correlations …

Fitness Profiles In Elite Tactical Units: A Critical Review, Daniel Maupin, Thomas Wills, Robin M. Orr, Benjamin Schram

International Journal of Exercise Science

International Journal of Exercise Science 11(3): 1041-1062, 2018. Elite tactical units complete a variety of demanding tasks and a high level of fitness is required by this population to perform their occupational tasks optimally. The aim of this critical review was to identify and synthesize key findings of studies that have investigated the fitness profiles of elite tactical units. Included studies were critically appraised, using the Downs and Black checklist, and a level of evidence was determined. Relevant data were extracted, tabulated, and synthesized. Fourteen studies were included for review and ranged in percentage quality scores from 46% to 66% …

Reestablishing A Culture Of Water Competency At An Hbcu, Knolan C. Rawlins

International Journal of Aquatic Research and Education

African American children ages 5 – 19 years drown in swimming pools at rates of 5.5 times higher than those of whites (Gilchrist & Parker, 2014). Literature suggested culture is the culprit for this disparity. A fear of water dates to slavery (Pitts, 2007). After slavery was abolished, the memory of drowning remained part of the African American culture. In the twentieth century, the popularity of swimming grew with the increase in public pools. The era of the Jim Crow laws kept African Americans out of public pools (Pitts, 2007). Although the political landscape has shifted since the Jim Crow …

Fars2 Mutations Presenting With Pure Spastic Paraplegia And Lesions Of The Dentate Nuclei, Supreet K. Sahai, Rebecca E. Steiner, Margaret G. Au, John M. Graham, Norikio Salamon, Michael Ibba, Tyler M. Pierson

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Mutations in FARS2, the gene encoding the mitochondrial phenylalanine‐tRNA synthetase (mtPheRS), have been linked to a range of phenotypes including epileptic encephalopathy, developmental delay, and motor dysfunction. We report a 9‐year‐old boy with novel compound heterozygous variants of FARS2, presenting with a pure spastic paraplegia syndrome associated with bilateral signal abnormalities in the dentate nuclei. Exome sequencing identified a paternal nonsense variant (Q216X) lacking the catalytic core and anticodon‐binding regions, and a maternal missense variant (P136H) possessing partial enzymatic activity. This case confirms and expands the phenotype related to FARS mutations with regards to clinical presentation and neuroimaging findings.

Running Economy While Running In Shoes Categorized As Maximal Cushioning, Miles A. Mercer, Tori M. Stone, John C. Young, John A. Mercer

International Journal of Exercise Science

International Journal of Exercise Science 11(2): 1031-1040, 2018. The purpose of the study was to determine if running economy was influenced by wearing maximal cushioning shoes vs. control (neutral cushioning) shoes. Participants (n=10, age=28.2±6.1yrs; mass=68.1±10.2 kg; height=170±6.1 cm) completed two experiments. Each experiment included running conditions wearing control and maximal cushioning shoes. In Experiment 1, participants ran on a treadmill at three speeds in each shoe condition (6 total conditions). The speeds were: 1) preferred speed, 2) preferred speed + 0.447 m·s^-1, and 3) preferred speed - 0.447 m·s^-1. In Experiment 2, participants ran on a …

Comparison Of Physical Activity During Zumba With A Human Or Video Game Instructor, Bridgette Schneekloth, Gregory A. Brown

International Journal of Exercise Science

International Journal of Exercise Science 11(4): 1019-1030, 2018. Using a physically active video game presents an opportunity for a person to engage in exercise in the privacy of their own home, yet still receive some feedback on the quality of their exercise performance. The purpose of this project was to compare the physical activity between participating in a Zumba exercise class led by a human and using a Zumba video game. Eight women (33.0 ± 3.0 y, 34.8 ± 8.1 % body fat) who regularly participated in a Zumba exercise class were measured for heart rate, number of steps taken, …

Aerobic Fitness Is Of Greater Importance Than Strength And Power In The Load Carriage Performance Of Specialist Police, Jeremy Robinson, Adam Roberts, Shane Irving, Robin M. Orr

International Journal of Exercise Science

International Journal of Exercise Science 11(4): 987-998, 2018.Police officers are required to carry external loads as part of their occupation. One means of preparing officers to carry loads is through physical conditioning. The aim of this study was to investigate whether strength, power or aerobic endurance had the greatest association with load carriage performance. Retrospective data from 42 male specialist tactical police officers (mean body weight = 88.8±8.25 kg) informed this study. Baseline data were provided for strength (1 Repetition Maximum [RM] bench press, deadlift, squat and pull-up), lower body power (vertical jump, 10m sprint) and aerobic (‘beep’ test) …

Effect Of A Flying Versus Stationary Start On Wingate Test Outcomes Using An Electromagnetically-Braked Cycle Ergometer In Advanced Resistance-Trained Males, Nicolas W. Clark, Dale R. Wagner, Edward M. Heath

International Journal of Exercise Science

International Journal of Exercise Science 11(4): 980-986, 2018.The purpose of this study was to compare power outputs of the flying start to the stationary start method on an electromagnetically–braked cycle ergometer. Twenty advanced resistance-trained men (age 24.6 ± 4.5 years; 25.4 ± 2.5 kg/m²) volunteered to participate in this study. A counter-balanced, repeated-measures design was utilized to randomly assign participants to either the flying start or the stationary start for their first Wingate test. Paired ttests were used to evaluate mean differences between start methods. Peak power (PP), mean power (MP), total work (TW), peak cadence (PC), …

Effect Of Torpor On Host Transcriptomic Responses To A Fungal Pathogen In Hibernating Bats, Kenneth A. Field, Brent J. Sewall, Jenni M. Prokkola, Gregory G. Turner, Marianne Gagnon, Thomas M. Lilley, J Paul White, Joseph S. Johnson, Christopher L. Hauer, Deeann M. Reeder

Faculty Journal Articles

Hibernation, the use of prolonged torpor to depress metabolism, is employed by mammals to conserve resources during extended periods of extreme temperatures and/or resource limitation. Mammalian hibernators arouse to euthermy periodically during torpor for reasons that are not well understood and these arousals may facilitate immune processes. To determine if arousals enable host responses to pathogens, we used dual RNA‐Seq and a paired sampling approach to examine gene expression in a hibernating bat, the little brown myotis (Myotis lucifugus). During torpor, transcript levels differed in only a few genes between uninfected wing tissue and adjacent tissue infected with …

Targeting Neuropeptides To Bone Fractures For Accelerated Healing, Nicholas A. Young, Jeffery J. Nielsen, Philip S. Low

The Summer Undergraduate Research Fellowship (SURF) Symposium

In patients over the age of 65 especially, bone fractures represent a significant disease burden. Non-invasive drug therapies are not available for bone fractures which represents a problem for this population. Vasoactive intestinal peptide (VIP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), two neuromodulator peptides in the glucagon superfamily, have demonstrated positive regulation of osteoblast proliferation and activity. Using acidic oligopeptides, we have developed ligands that target to and accumulate at fracture sites. These targeting ligands can be synthesized in sequence with bone anabolic peptides to minimize off target effects and increase potency at the fracture site to create safer and …

The Effect Of Different Training Loads On The Lung Health Of Competitive Youth Swimmers, Rachelle D. Davies, Eric C. Parent, Craig D. Steinback, Michael D. Kennedy

International Journal of Exercise Science

International Journal of Exercise Science 11(6): 999-1018, 2018. Airway hyperresponsiveness (AHR), airway inflammation, and respiratory symptoms are common in competitive swimmers, however it is unclear how volume and intensity of training exacerbate these problems. Thus, our purpose was to measure AHR, inflammation, and respiratory symptoms after low, moderate, and high training loads in swimmers. Competitive youth swimmers (n=8) completed nine weeks of training split into three blocks (Low, Moderate, and High intensity). Spirometry at rest and post-bronchial provocation [Eucapnic Voluntary Hyperpnea (EVH)] and Fractional Exhaled Nitric Oxide (FeNO) were completed at the end of each training block. A weekly self-report …

The Role Of Developmental Timing Regulators In Progenitor Proliferation And Cell Fate Specification During Mammalian Neurogenesis, Jennifer S. Romer-Seibert

Graduate School of Biomedical Sciences Theses and Dissertations

Developmental timing is a key aspect of tissue and organ formation in which distinct cell types are generated through a series of steps from common progenitors. These progenitors undergo specific changes in gene expression that signifies both a distinct progenitor type and developmental time point that thereby specifies a particular cell fate at that stage of development. The nervous system is an important setting for understanding developmental timing because different cell types are produced in a certain order and the switch from stem cells to progenitors requires precise timing and regulation. Notable examples of such regulatory molecules include the RNA-binding …

Insight Into Translational Activation In Yeast Mitochondria, Julia Lynn Jones

Graduate School of Biomedical Sciences Theses and Dissertations

Mitochondrial function depends on over a thousand proteins, of which the majority are nuclear DNA-encoded and approximately one percent are mitochondrial DNA-encoded. The mitochondrial DNA of Saccharomyces cerevisiae contains eight protein-encoding genes, seven of which are required for proper function of the respiratory complexes and one encodes a ribosomal protein. The bigenomic nature of the oxidative phosphorylation complexes requires coordinated expression and regulation from both the nuclear and the mitochondrial genomes. It is currently unclear how this regulatory network operates. However, it is thought that nuclear genome-encoded messengers localized to the mitochondria aid in this coordination.

A family of proteins …

Effect Of Morinda Citrifolia (Noni)-Enriched Diet On Hepatic Heat Shock Protein And Lipid Metabolism-Related Genes In Heat Stressed Broiler Chickens, Joshua Flees

Graduate Theses and Dissertations

Heat stress (HS) has been reported to alter fat deposition in broilers, however the underlying molecular mechanisms are not well-defined; therefore, the objectives of the current study were to: (1) determine the effects of acute (2 h) and chronic (3 wk) HS on the expression of key molecular signatures involved in hepatic lipogenic and lipolytic programs; and (2) assess if diet supplementation with dried Noni medicinal plant (0.2% of the diet) modulates these effects. Broilers (n=480 males, 1 d) were randomly assigned to 12 environmental chambers, subjected to two environmental conditions (HS at 35°C vs. thermoneutral condition [TN] at 24°C) …

Body Composition, Muscular Performance, And Free Testosterone Following 12-Weeks Of Protein Supplementation And Resistance Training In Men Aged 35-55, Matthew Steven Stone

Graduate Theses and Dissertations

PURPOSE: The purpose of this study was to investigate the effects of 12 weeks of protein supplementation and Autoregulatory Progressive Resistance Exercise (APRE) training on measures of body composition, muscular performance, and free testosterone in middle-aged men. METHODS: Untrained males (n = 35; 43.3 ± 6.6 years) participated in this study. Lean mass (LM) and fat mass (FM) were measured via Dual Energy X-ray Absorptiometry (DEXA), while strength was measured utilizing one repetition maximum (1RM), endurance measured using maximum repetitions completed (REPS) at 75% 1RM for the bench and leg press, and free testosterone was measured using changes in serum …

Immune Function And Metabolism Of Hibernating North American Bats With White-Nose Syndrome, Briana Nicole Anderson

Graduate Theses/Dissertations

White-nose syndrome (WNS) causes substantial mortality in certain species of hibernating North American bats. The responsible agent is Pseudogymnoascus destructans (Pd), a fungus which causes physiological complications such as increased arousals and energy depletion during the hibernation season. Tricolored bats (Perimyotis subflavus) and northern long-eared bats (Myotis septentrionalis) suffer extensive WNS mortality, while gray bats (Myotis grisescens) and big brown bats (Eptesicus fuscus) are infected, but mortality is rarely observed. It is hypothesized that there is a difference in immune responses and/or hibernation metabolism between these bat species, resulting in this …

Overexpression Of Cyb5r3 And Nqo1, Two Nad+-Producing Enzymes, Mimics Aspects Of Caloric Restriction, Alberto Diaz-Ruiz, Michael Lanasa, Joseph Garcia, Hector Mora, Frances Fan, Alejandro Martin-Montalvo, Andrea Di Francesco, Miguel Calvo-Rubio, Andrea Salvador-Pascual, Miguel A. Aon, Kenneth W. Fishbein, Kevin J. Pearson, Jose Manuel Villalba, Placido Navas, Michel Bernier, Rafael De Cabo

Pharmacology and Nutritional Sciences Faculty Publications

Calorie restriction (CR) is one of the most robust means to improve health and survival in model organisms. CR imposes a metabolic program that leads to increased stress resistance and delayed onset of chronic diseases, including cancer. In rodents, CR induces the upregulation of two NADH‐dehydrogenases, namely NAD(P)H:quinone oxidoreductase 1 (Nqo1) and cytochrome b₅ reductase 3 (Cyb5r3), which provide electrons for energy metabolism. It has been proposed that this upregulation may be responsible for some of the beneficial effects of CR, and defects in their activity are linked to aging and several age‐associated diseases. However, …

The Role Of Perivascular Fibrosis In Post-Stroke Glymphatic Impairment And Cerebral Amyloid Angiopathy, Matthew D. Howe

Dissertations and Theses (Open Access)

In healthy brain tissue, toxic amyloid-β (Aβ) proteins are transported by the pulsatile flow of cerebrospinal fluid (CSF) along perivascular drainage pathways. Ischemic stroke may disrupt this process, leading to a perivascular build-up of Aβ, termed cerebral amyloid angiopathy (CAA). I hypothesize that an abnormal pattern of extracellular matrix deposition within the vascular basement membrane, termed fibrosis, impairs Aβ drainage from the aged brain after stroke. I further hypothesize that inhibition of astrocytic transforming growth factor-β (TGF-β) signaling can reverse these phenotypes. Finally, I also hypothesize that serum biomarkers of perivascular fibrosis can be used to diagnose CAA following intracerebral …