Marshall University, Joan C. Edwards School of Medicine
Georgia State University
Iowa State University
Walden University
Old Dominion University
Department of Primary Industries and Regional Development, Western Australia
East Tennessee State University
Virginia Commonwealth University
Gpr75 Deficiency Attenuates High Fat Diet-Driven Obesity And Glucose Intolerance,
2023
NYMC
Gpr75 Deficiency Attenuates High Fat Diet-Driven Obesity And Glucose Intolerance, Sakib Hossain
NYMC Student Theses and Dissertations
Recently, a collaboration between Regeneron Pharmaceuticals and the Schwartzman-Garcia labs at New York Medical College published an exome sequencing study of individuals across the United Kingdom, United States, and Mexico which concluded that individuals possessing non-functioning, truncated mutations to the orphan g protein coupled receptor (GPCR), GPR75, had lower BMI and 54% reduced likelihood of obesity. The present study was undertaken to fully characterize the metabolic phenotype of Gpr75 deficient mice when fed a high fat diet (HFD) and explore potential mechanisms by which GPR75 activation links to increased adiposity and decreased glucose tolerance. After 14 weeks of HFD-feeding we …
An Argument For The Utilization Of Amphibian Stress As An Indicator Of Wetland Condition,
2023
Murray State University
An Argument For The Utilization Of Amphibian Stress As An Indicator Of Wetland Condition, Andrew W. Sisson
Honors College Theses
Traditional forms of rapid wetland condition assessments focus on foliage health, nutrient enrichment, chemical contamination, and surrounding land usage, often overlooking an evaluation of the animals living in the wetland. More intense assessments include the National Wetland Condition Assessment (NWCA) and indices of biotic integrity, which focus on community composition (e.g., diversity and species richness) and abundances. These indices require expertise in species identification and do not provide information about the animal’s fitness. Animal stress physiology, which generally correlates with measures used to quantify animal fitness (e.g., survival, reproduction, and body condition), may provide a complementary rapid assessment method aimed …
Amiodarone-Induced Thyrotoxicosis Type 2 : Utilization Of Color-Flow Doppler Sonography For Diagnosis,
2023
HCA Healthcare
Amiodarone-Induced Thyrotoxicosis Type 2 : Utilization Of Color-Flow Doppler Sonography For Diagnosis, Sam Joseph, Larissa Check, Donald Eagerton
South Atlantic Division Research Day 2023
No abstract provided.
Increasing Efficiency Of Finishing Beef Production: Strategies To Optimize Starch Digestion, Improve Flake Quality, And Reduce Methane Emissions,
2023
University of Kentucky
Increasing Efficiency Of Finishing Beef Production: Strategies To Optimize Starch Digestion, Improve Flake Quality, And Reduce Methane Emissions, Ronald J. Trotta
Theses and Dissertations--Animal and Food Sciences
To continue to meet the demands of increasing food production and environmental sustainability, new strategies are needed to enhance the efficiency of finishing cattle production. A review of the literature identified several nutritional and physiological constraints that limit the ability for cattle to digest starch and absorb glucose from the small intestine. Comparative sequencing analyses revealed a missing region of the sucrase-isomaltase protein which could affect the capacity for starch digestion in cattle. Post-flaking sampling and handling recommendations were generated based on a series of experiments to improve estimates of starch availability and flaking consistency for commercial feedlots and laboratories. …
Diabetes-Related Outcomes Following Use Of Basal-Bolus Insulin Vs Premixed Insulin In A Va Population With Type 2 Diabetes: A Retrospective Chart Review.,
2022
University of Nevada, Las Vegas
Diabetes-Related Outcomes Following Use Of Basal-Bolus Insulin Vs Premixed Insulin In A Va Population With Type 2 Diabetes: A Retrospective Chart Review., Ravisha Bai, Kavita Batra, Charmaine Yap, Kenneth Izuora
School of Medicine Faculty Presentations
No abstract provided.
A Multi-Species Study On Several Types Of Visitor Effects On The Behavior And Physiology Of Animals At The Oregon Zoo,
2022
Portland State University
A Multi-Species Study On Several Types Of Visitor Effects On The Behavior And Physiology Of Animals At The Oregon Zoo, Laurel Berylline Fink
Dissertations and Theses
The visitor effect on zoo animals is one of the expanding research topics in zoo animal research. As visitors are a mandatory feature of zoological institutions, understanding their effects on zoo animals is imperative for maximizing zoo animal welfare. Zoo animals are subject to many anthropogenic influences: visual, olfactory, and audible, for example. This dissertation investigates several of the effects of visitor presence and its relative influence on six mammalian species: cheetahs (Acinonyx jubatus), African painted dogs (Lycaon pictus), Asian elephants (Elephas maximus indicus & Elephas maximus borneensis), giraffes (Giraffa camelopardalis reticulata & …
A Study Of The Effect Of Physiological Stressors On Hypothalamic Regulation Of Reproduction Using An In Vitro System,
2022
University of Tennessee, Knoxville
A Study Of The Effect Of Physiological Stressors On Hypothalamic Regulation Of Reproduction Using An In Vitro System, Lisa L. Amelse
Doctoral Dissertations
Stressors have a negative impact on reproductive efficiency in humans and other animals, which has an economic cost due to infertility treatments for humans and reduced income for food producers. We wished to determine the molecular pathways by which metabolic disturbances and low-level inflammation impact the hypothalamic pituitary gonadal (HPG) axis using an in vitro model. To this end, we used the GT1-7 cell line, an immortalized line expressing the Kiss1R receptor that responds to kisspeptin stimulation with the release of GnRH to assess the impact of stressors on the GnRH-releasing cells. Additionally, we used the KTaV-3 and KTaR-1[A1] …
Effects Of Glucocorticoids Upon Pro-Inflammatory Responses To Acute Sleep Fragmentation,
2022
Western Kentucky University
Effects Of Glucocorticoids Upon Pro-Inflammatory Responses To Acute Sleep Fragmentation, Hunter Weaver
Masters Theses & Specialist Projects
Sleep loss is a common problem in humans who suffer from obstructive sleep apnea. Sleep aids in the regulation of immune responses, some of which induce inflammatory responses. Cytokines regulate the inflammatory process and are released in response to sleep fragmentation (SF) in mice. Glucocorticoids are hormones that are released from the adrenal cortices during a stress response and are considered to be anti-inflammatory and immunosuppressive at high doses but may stimulate immune function on an acute level. The first hypothesis tested was that normal physiological expression of glucocorticoids (Sham) will display increased IL-1β and TNFα expression levels, while high …
Effects Of Sunrise/Sunset Lighting On Corticosterone Levels In Coturnix Quail (Coturnix Coturnix),
2022
University of Arkansas, Fayetteville
Effects Of Sunrise/Sunset Lighting On Corticosterone Levels In Coturnix Quail (Coturnix Coturnix), Hannah Feuerborn
Poultry Science Undergraduate Honors Theses
Both genetics and environment play an important role in the growth, performance and overall welfare of poultry species. Current commercial production practices typically do not mimic the natural environmental conditions of ancestral poultry species, specifically lighting requirements. In nature, poultry species are subjected to natural day length and the slow rising and setting of the sun. This is compared to commercial conditions in which lights are sudden on/off, not mimicking the natural trajectory of the sun in terms of light intensity and exposure. The current study aimed to evaluate the impact of genetics and the effect of sunrise/sunset lighting on …
Collagen Iv-Β1integrin Regulation Of Exocytotic Machinery In Pancreatic Beta-Cell Insulin Secretion,
2022
The University of Western Ontario
Collagen Iv-Β1integrin Regulation Of Exocytotic Machinery In Pancreatic Beta-Cell Insulin Secretion, Malina Barillaro
Electronic Thesis and Dissertation Repository
Diabetes is a prevalent metabolic disease characterized by impaired insulin secretion, action, or both. β1-integrin is a key receptor that regulates cell-ECM interactions and is important in maintaining beta-cell functions, including insulin secretion. However, little is reported about the relationship between β1-integrin and the exocytotic proteins involved in insulin secretion. This study examined the influence of ECM-mediated β1-integrin activation on exocytotic machinery involved in insulin secretion using rat insulinoma (INS-1) cells. Collagen IV (COL IV) promoted INS-1 cell adhesion, spreading, and insulin secretion. Additionally, these cells displayed changes in levels and localization of exocytotic proteins involved in insulin secretion. β1-integrin …
Inflammatory Bowel Disease Causing Retroperitoneal Varicosity Mimicking A Renal Artery Aneurysm: A Novel Case Report And Literature Review,
2022
Alfaisal University, Riyadh, Kingdom of Saudi Arabia
Inflammatory Bowel Disease Causing Retroperitoneal Varicosity Mimicking A Renal Artery Aneurysm: A Novel Case Report And Literature Review, Areez Shafqat, Shameel Shafqat, Belal Nedal Sabbah, Abdullah Shaik, Wael Khalil Alfehaid, Syed Shafqat Ul Islam
Medical College Documents
A 17-year-old female presented to our hospital complaining of bloody diarrhea 4-6 times per day for the past month. She was a known case of inflammatory bowel disease noncompliant to her medications. Abdominal computed tomography revealed an unusually dilated mass in the retroperitoneum at L2 vertebral level connecting the lumbar and left renal veins. The renal artery was visualized separately, and a diagnosis of communicating vein varicosity was made. This lesion can be misleading on imaging, hence our aim to disseminate our findings to practicing radiologists. The differential diagnosis of these lesions include retroperitoneal lymphadenopathy, renal artery aneurysms, and testicular …
Estrogen Regulation Of Daily Metabolic Rhythms In Female Mice,
2022
University of Kentucky
Estrogen Regulation Of Daily Metabolic Rhythms In Female Mice, Oluwabukola Omotola
Theses and Dissertations--Biology
Circadian rhythms are approximately 24-hour cycles of behavior, physiology, and gene expression. In mammals, these circadian rhythms are generated by clocks located in nearly every tissue in the body. The function of circadian clocks is to synchronize physiology and behavior with environmental cycles such as the light-dark cycle. After menopause, when circulating levels of estrogens are very low, women are more susceptible to obesity comorbidities such as metabolic syndrome and cardiovascular disease, suggesting that estrogens regulate these processes. Estrogens could protect females from metabolic dysfunction by regulating circadian rhythms. Consumption of diets that are high in fat contribute to obesity. …
Fertility Control Options For Management Of Free-Roaming Horse Populations,
2022
University of Pennsylvania
Fertility Control Options For Management Of Free-Roaming Horse Populations, Ursula S. Bechert, John W. Turner Jr., Dan L. Baker, Douglas C. Eckery, Jason E. Bruemmer, Candace C. Lyman, Tulio M. Prado, Sarah R. B. King, Mark A. Fraker
Human–Wildlife Interactions
The management of free-roaming horses (Equus ferus) and burros (E. asinus) in the United States has been referred to as a “wicked problem” because, although there are population control options, societal values will ultimately determine what is acceptable and what is not. In the United States, free-roaming equids are managed by different types of organizations and agencies, and the landscapes that these animals inhabit vary widely in terms of access, size, topography, climate, natural resources, flora, and fauna. This landscape diversity, coupled with contemporary socioeconomic and political environments, means that adaptive management practices are needed to …
The Use Of Exogenous Acrp30 As A Promising Amelioratory Compound Regarding Insulin Resistance And Type Ii Diabetes Mellitus,
2022
University of Central Florida
The Use Of Exogenous Acrp30 As A Promising Amelioratory Compound Regarding Insulin Resistance And Type Ii Diabetes Mellitus, Stephen L. Romero
Honors Undergraduate Theses
As numerous bodies of research have characterized the adipocytokine adiponectin (ACRP30) as an anti-diabetic compound, this work serves as an analysis to partly elucidate the potential usage of supplementary adiponectin as a therapeutic compound in the treatment of type II diabetes mellitus. In this work, a meta-analysis was conducted to centralize large amounts of data on adiponectin’s insulin sensitizing characteristics in conjunction with like-minded studies utilizing metformin treatment as the diabetic standard of care. Upon comparison of fasting glucose, fasting insulin, and glucose tolerance test area under the curve reduction percentages, it is quite clear that ACRP30 has significant insulin …
Effects Of Sunrise/Sunset Lighting On Corticosterone Levels In Coturnix Quail (Coturnix Coturnix),
2022
University of Arkansas, Fayetteville
Effects Of Sunrise/Sunset Lighting On Corticosterone Levels In Coturnix Quail (Coturnix Coturnix), Hannah M. Feuerborn, Sara K. Orlowski
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
Both genetics and environment play important roles in the growth, performance, and overall welfare of poultry species. Current commercial production practices typically do not mimic the natural environmental conditions of ancestral poultry species, specifically lighting. The current study aimed to evaluate the impact of genetics and the effect of sunrise/sunset lighting on the stress response of 4 genetic lines of Coturnix quail. The 4 lines utilized in this study included high stress (H), low stress (L), stress control (R), and Arkansas randombred (A) quail lines. Day old chicks from these lines were placed in one of two environmentally controlled rooms. …
Implications Of Population Genetics And Physiological Responses On The Conservation Of Moose (Alces Alces Americana),
2022
University of Vermont
Implications Of Population Genetics And Physiological Responses On The Conservation Of Moose (Alces Alces Americana), Elias Rosenblatt
Graduate College Dissertations and Theses
Wildlife populations around the globe are facing numerous, complex challengesto their persistence, yet conservation efforts are hindered by limited information about these populations and the anthropogenic pressures they face. North American moose (Alces alces americana), despite being of ecological, cultural, and economical importance, inhabit remote landscapes, making population monitoring difficult. At the same time, many moose populations, including in Vermont and eastern North America, have experienced recent declines mainly due to winter tick (Dermacentor albipictus) epizootics. Anthropogenic landscape change and climate-mediated pressures pose future challenges for moose across the southern extent of their distribution. Though impacts of winter tick infestation …
The Exposome, Metabolic Dysfunction And Silicosis: A Pulmonary And Pathophysiology Study,
2022
West Virginia University
The Exposome, Metabolic Dysfunction And Silicosis: A Pulmonary And Pathophysiology Study, Janet A. Thompson
Graduate Theses, Dissertations, and Problem Reports
The exposome encompasses the concept that an individual’s health is a combination of genetic, environmental, and occupational exposures. A worker’s exposomal profile could potentially influence their susceptibility to hazardous occupational exposures. Over 35% of adults in the United States have metabolic dysfunction (MetDys), yet interactions between MetDys and hazardous occupational exposures are generally unknown. MetDys is associated with HFWD-consumption and obesity and induces a chronic low grade systemic inflammation and alters serum adipokine profiles. Silicosis, a progressive inflammatory lung disease, results from occupational inhalation exposure to respirable crystalline silica particles. This research tests the hypothesis “Inflammation resulting from HFWD-induced …
Effects Of Melatonin Implantation On The Activity Levels Of Captive Snow Buntings (Plectrophenax Nivalis),
2022
Western Kentucky University
Effects Of Melatonin Implantation On The Activity Levels Of Captive Snow Buntings (Plectrophenax Nivalis), Zoë Ward
Mahurin Honors College Capstone Experience/Thesis Projects
In vertebrates, melatonin regulates many components of the circadian rhythm; depending on the organism’s location and time of year, the pineal gland will produce melatonin accordingly, controlling the sleep-wake cycle and breeding physiologies. However, locations at the poles in which the sun is above the horizon for multiple days at a time pose unique challenges for the organisms living there. The goal of this study was to examine how the implantation of melatonin in an arctic-breeding songbird affects its activity levels and circadian rhythm. The subject of this study, the snow bunting (Plectrophenax nivalis), is a small songbird …
The Role Of Neuronal Atp-Sensitive Potassium Channels In Learning And Memory,
2021
Washington University in St. Louis
The Role Of Neuronal Atp-Sensitive Potassium Channels In Learning And Memory, Shaul Vladimir Yahil
Arts & Sciences Electronic Theses and Dissertations
ATP-sensitive potassium (KATP) channels link cellular metabolism and membrane excitability in many tissues, including brain and pancreas. Gain-of-function (GOF) mutations to KATP channels cause neonatal diabetes, with some patients exhibiting developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome. Diabetic symptoms have been attributed to loss of membrane excitability and insulin secretion in pancreatic β-cells, though the origin of neurological deficits and the effects of neuronal KATP-GOF mutations more generally remain elusive. In this dissertation, I will present evidence that mice expressing KATP-GOF mutations pan-neuronally (nKATP-GOF) demonstrated sensorimotor and cognitive deficits, whereas hippocampus-specific hKATP-GOF mice exhibited predominantly learning and memory deficits. …
Energetic Cost And Physiological Trade-Offs,
2021
Florida International University
Energetic Cost And Physiological Trade-Offs, Heba A. Ali
FIU Electronic Theses and Dissertations
Understanding how organisms allocate limited resources across physiological systems is a major challenge in biology. This study revealed that high energetic demand of electric signals of male electric fish (Brachyhypopomus gauderio) is matched by a metabolic trade-off with other cellular functions. We used thyroxine (T4) to modulate the fish’s signal metabolism, partitioned the energy budget pharmacologically, and measured energy consumption using oxygen respirometry. In males, total energy consumption was unchanged pre- and post-T4 treatment, while signal metabolism rose and the standard metabolic rate fell in an even trade-off. Total metabolism in females did the opposite. Under T4, the …
