Physiology Commons^™

An Investigation Into Fatigue Management: Effects Of Two Different Loading Protocols On Markers Of Inflammation And The Endocrine Response, Jake Bernards

Electronic Theses and Dissertations

The purposes of this dissertation were to 1) determine the effectiveness of the neutrophillymphocyte ratio (NLR) as an athlete monitoring tool in resistance training and 2) determine if repetition maximum or relative intensity loading scheme is superior in managing fatigue through the hormonal, inflammatory, and performances response throughout a 10-week periodized resistance training program. Results from the dissertation give merit to continued research regarding the use of NLR as a monitoring tool to help determine the degree of recovery. Furthermore, results from this dissertation lead to questioning the effectiveness of using a repetition maximum (RM) loading scheme within a periodized …

Grapevine Vein Clearing Virus: Epidemiological Patterns And Construction Of A Clone, Cory Von Keith

Graduate Theses/Dissertations

Grapevine vein clearing virus (GVCV) is a recently discovered virus belonging to the Badnavirus genus. Characteristic to its name, the virus is associated with a disease where symptoms manifest as pronounced vein-clearing, resulting in severe berry deformation and vine decline in susceptible grape varieties. Sustainable production of wine is dependent on healthy plants. The associated disease is mainly found in Midwest vineyards. Attempts were made in this thesis to provide evidence of causality of the virus to the associated disease and to infer the historical path and migration pattern of GVCV. Conclusions and discussions will provide grape producers with the …

Role Of Ataxia-Telangiectasia Mutated Kinase In Cardiac Autophagy And Glucose Metabolism Under Ischemic Conditions, Patsy Thrasher

Electronic Theses and Dissertations

Ataxia-telangiectasia mutated kinase (ATM), a serine/threonine kinase primarily located in the nucleus, is typically activated in response to DNA damage. Individuals with mutations in ATM gene develop a disease called Ataxia telangiectasia (AT). These individuals are more susceptible to ischemic heart disease and metabolic disorder. Our lab has previously shown that ATM plays a critical role in β-adrenergic receptor (β-AR) - and myocardial infarction (MI)-stimulated myocyte apoptosis and cardiac remodeling. This study tested the hypothesis that ATM plays a critical role in cardiac autophagy and glucose metabolism following MI and ischemia, respectively. Early during MI (4 hours after its onset) …

Unique Osmoregulatory Morphology In Primitive Sharks: An Intermediate State Between Holocephalan And Derived Shark Secretory Morphology, Matthew Eric Larsen

Electronic Theses and Dissertations

Discovery of an unusual rectal gland in the Atlantic sixgill shark, Hexanchus vitulus, led to examination of rectal glands in 29 species of epipelagic and deep-sea sharks. Eight of 14 deep-sea species of sharks had digitiform glands that were previously assumed to be characteristic of elasmobranchs (N=281; mean width-length ratio ± SD = 0.18 ± 0.07). Hematoxylin-and-eosin stained sections from deep-sea sharks were similar to those from shallow water sharks. Glands from the family Somniosidae were kidney bean-shaped (N = 3; mean width-length ratio ± SD = 0.46 ± 0.05); whereas those from the families Echinorhinidae and Hexanchidae appeared lobulate …

When Is Experiential Avoidance Harmful In The Moment? Examining Global Experiential Avoidance As A Moderator, Michael E. Levin, Jennifer Krafft, Benjamin G. Pierce, Sarah Potts

Psychology Faculty Publications

Background and Objectives: Although experiential avoidance has been shown to predict a wide range of mental health problems, there has been minimal research to-date on the more immediate effects of engaging in experiential avoidance in the moment or the moderators that predict when it is more or less harmful.

Methods: An ecological momentary assessment (EMA) study was conducted with 70 undergraduate students who completed assessments three times a day, over seven days as well as a baseline assessment of global questionnaires.

Results: Both greater global experiential avoidance and momentary experiential avoidance independently predicted greater momentary negative affect, lower positive affect, …

Association Between Bone-Specific Physical Activity Scores And Pqct-Derived Measures Of Bone Strength And Geometry In Healthy Young And Middle-Aged Premenopausal Women., Sojung Kim, Breanne S Baker, Pragya Sharma-Ghimire, Debra A Bemben, Michael G Bemben

College of Science & Mathematics Departmental Research

The aim of this study was to determine if bone-specific physical activity questionnaire (BPAQ) scores were positively related to bone health in healthy young and middle-aged premenopausal women. The total BPAQ was a stronger predictor of bone strength and bone mineral density of hip in young women as compared to middle-aged premenopausal women.

PURPOSE: The purpose of this study was to determine whether the BPAQ scores were predictive indices of volumetric BMD (vBMD), bone strength, and bone geometry in young and middle-aged premenopausal women.

METHODS: Healthy young (n = 60) and middle-aged premenopausal women (n = 54) between the ages …

Musculoskeletal Flexibility And Quality Of Life: A Feasibility Study Of Homeless Young Adults In Los Angeles County, Marina A. Marmolejo, Makda Medhanie, Heather Tarleton

International Journal of Exercise Science

International Journal of Exercise Science 11(4): 968-979, 2018. Proper musculoskeletal health is dependent on the efficient inner workings of muscles, tendons, ligaments, joints, and bones. The homeless experience can be physically debilitating to these tissues and anatomical structures. This feasibility study aims to explore how to answer the overarching question: do the lived experiences of homeless young adults negatively affect their musculoskeletal health? Questionnaires were distributed to assess the demographic characteristics, physical activity, health behaviors, and sleep patterns of 40 homeless young adults and 45 university students in Los Angeles County. Participants also completed supervised stretch tests to assess musculoskeletal …

Autophagy Is Stimulated By Acute High Intensity Interval Exercise In Human Skeletal Muscle And Electrical Pulse Stimulation In C2c12 Myotubes In Vitro, Kurt A. Escobar

Health, Exercise, and Sports Sciences ETDs

Purpose: 1) To compare the effects of an acute bout of HIIT exercise (treadmill running) on autophagy to MICT exercise in human skeletal muscle 3 hours post exercise, and 2) to test an in vitro model of muscle contraction-induced autophagy using electrical pulse stimulation in C2C12 myotubes. Methods: Study 1: Ten recreationally active males and females completed a bout of high intensity interval training (HIIT) exercise and moderate intensity continuous exercise (MICT) exercise in a fasted state. Muscle biopsies from the vastus lateralis were taken pre and 3 hours post-exercise. Muscle tissue was analyzed for protein expression of markers of …

Division I Female Cross-Country Runners’ Perception Of Eating Behaviors And Attitudes Toward Health: A Pilot Study, Laurie Stickler, Marissa Thomas, Laura Kate Morse

International Journal of Exercise Science

International Journal of Exercise Science 11(3): 941-956, 2018.The complexity behind nutritional decisions and the impact of these decisions on overall health (both physical and emotional) in the Division I female runner is not yet well understood. Thus, the purpose of this study was to explore the perspectives of female collegiate cross-country runners from a Division I school on eating behaviors and attitudes toward health. In this qualitative study, six NCAA Division I female collegiate cross-country runners participated in individual interviews. Through qualitative analysis, three themes (Nutritional Views, Identity as a Runner, and Psychological Factors) and 11 subthemes emerged. The …

An Investigation Of The Differences Between Perceived Vs. Measured Body Composition, Social Physique Anxiety, And Overall Appearance Satisfaction Among College Students, Cherilyn N. Mclester, Courtenay S. Hicks, Lauren Miller, John R. Mclester

International Journal of Exercise Science

International Journal of Exercise Science 11(5): 957-967, 2018. The purpose of this study was to examine the differences between body composition, social physique anxiety (SPA) and appearance satisfaction among college students by sex and BMI. A secondary purpose was to assess levels of appearance satisfaction before and after body composition testing and discover any differences between perceived body fat percentage (BF%) and weight versus actual measurements.Participants included 212 college students (93 males, 119 females), 22.0 ± 2.2 years. They answered a demographic questionnaire, the Social Physique Anxiety Scale (SPAS), post-assessment questions, and underwent body composition testing via dual energy x-ray …

The Effectiveness Of Myplate And Paleolithic-Based Diet Recommendations, Both With And Without Exercise, On Aerobic Fitness, Muscular Strength And Anaerobic Power In Young Women: A Randomized Clinical Trial, Collin Popp, Michelle Bohan Brown, Elliot D Jesch, William C. Bridges

International Journal of Exercise Science

International Journal of Exercise Science 11(2): 921-933, 2018. The purpose of this study was to evaluate the effectiveness of recommending a MyPlate or a Paleolithic-based diet, both with and without exercise, on aerobic fitness, strength, and anaerobic power over eight weeks. Participants (n=20) were randomized to one of four groups, (1) a MyPlate diet (MP), (2) Paleolithic-based diet (PD), (3) MyPlate and exercise (MP + Ex), and (4) Paleolithic-based diet and exercise (PD + Ex). The exercise included two days of unsupervised aerobic and resistance exercise. At baseline and final, absolute and relative peak oxygen consumption (absVO_2peak and relVO …

No Performance Or Affective Advantage Of Drinking Versus Rinsing With Water During A 15-Km Running Session In Female Runners, Lauren Shaver, Eric K. O'Neal, Eric E. Hall, Svetlana Nepocatych

International Journal of Exercise Science

International Journal of Exercise Science 11(2): 910-920, 2018. The advantage of ingesting fluids during endurance exercise lasting < 90 min has recently been challenged, but literature confirming or disputing this case is limited, particularly for female athletes. This study examined the effects of consuming water versus mouth rinsing with water during a running time trial. Recreationally active female runners (n = 19) completed two, 15-km time trials on an outdoor course in temperate environment (~20ºC; 87% RH) separated by at least one week in a randomized cross-over study design. Participants consumed 355 ml of water (DW) during their run or mouth rinsed (MR) with water from a handheld water bottle every 3 km for 5 s with physiological, perceptual, and affective variables assessed. DW or MR did not affect completion time (79.8 ± 8.1 min and 79.2 ± …

Concurrent Validity Of The Virtusense® Gait Analysis System For The Quantification Of Spatial And Temporal Parameters Of Gait, Andrew J. Strubhar, Patrick Tan, Laura Storage, Melissa Peterson

International Journal of Exercise Science

International Journal of Exercise Science 11(1): 934-940, 2018. The VirtuSense^Ⓡ (VS) is a new single camera 3D movement-capturing device that has gait analysis capabilities in its arsenal of functional programs. The Gait Analysis System with the VS has not been formally validated. The purpose of the study was to assess the concurrent validity of the VirtuSense^Ⓡ (VS) Gait Analysis System by comparing it to two standards, the GAITRite^Ⓡ (GR) computerized gait mat and manual pedograph (PG). Twenty-seven healthy, young adults performed 4 walking trials at a self-selected pace on a level surface. In 3 trials, stride length, …

Validity Of Critical Velocity Concept For Weighted Sprinting Performance, Nathan D. Dicks, Tammy V. Joe, Kyle J. Hackney, Robert W. Pettitt

International Journal of Exercise Science

International Journal of Exercise Science 11(4): 900-909, 2018. We investigated the validity of a recently developed equation for predicting sprinting times of various tactical loads based upon the performance of a running 3-min all-out exercise test (3MT). Thirteen recreationally trained participants completed the running 3MT to determine critical velocity (CV) and finite running capacity for running velocities exceeding CV (D’). Two subsequent counterbalanced loaded sprints of 800 and 1000 m distances with 20 and 15% of their body mass, respectively, were evaluated. Estimated times (t, sec) for running 800 and 1000 m with a tactical load was derived …

Down Regulation Of Vestibular Balance Stabilizing Mechanisms To Enable Transition Between Motor States, Romain Tisserand, Chris J. Dakin, Machiel H. F. Van Der Loos, Elizabeth A. Croft, Timothy J. Inglis, Jean-Sebastien Blouin

Kinesiology and Health Science Faculty Publications

The neural control of transition between posture and movement encompasses the regulation of reflex-stabilizing mechanisms to enable motion. Optimal feedback theory suggests that such transitions require the disengagement of one motor control policy before the implementation of another. To test this possibility, we investigated the continuity of the vestibular control of balance during transitions between quiet standing and locomotion and between two standing postures. Healthy subjects initiated and terminated locomotion or shifted the distribution of their weight between their feet, while exposed to electrical vestibular stimuli (EVS). The relationship between EVS and ground reaction forces was quantified using time-frequency analyses. …

Maternal-Fetal Interactions And The Induction Of Preeclampsia By Growth Arrest-Specific 6 (Gas6)/Axl Signaling, Todd Dunaway, Paul Reynolds

Journal of Undergraduate Research

Preeclampsia (PE) is a complicated obstetric complication characterized by increased blood pressure and decreased trophoblast invasion. PE is one of the leading causes of maternal and fetal morbidity and mortality in developed countries. The growth arrest-specific 6 (Gas6) protein is known to induce different responses in cells including prevention of apoptosis and enhanced cell migration and invasion. This protein is secreted in response to growth arrest and it is increased in the serum of PE patients. This discovery suggests a mechanistic role for the Gas6 signaling pathway during PE progression. Gas6 binds to the AXL tyrosine kinase receptor and AXL-mediated …

Physiological Differences Between Low Versus High Skeletal Muscle Hypertrophic Responders To Resistance Exercise Training: Current Perspectives And Future Research Directions, Michael D. Roberts, Cody T. Haun, Christopher B. Mobley, Petey W. Mumford, Matthew A. Romero, Paul A. Roberson, Christopher G. Vann, John J. Mccarthy

Physiology Faculty Publications

Numerous reports suggest there are low and high skeletal muscle hypertrophic responders following weeks to months of structured resistance exercise training (referred to as low and high responders herein). Specifically, divergent alterations in muscle fiber cross sectional area (fCSA), vastus lateralis thickness, and whole body lean tissue mass have been shown to occur in high versus low responders. Differential responses in ribosome biogenesis and subsequent protein synthetic rates during training seemingly explain some of this individual variation in humans, and mechanistic in vitro and rodent studies provide further evidence that ribosome biogenesis is critical for muscle hypertrophy. High responders may …

Loss Of Marv1 Promotes Chop Signaling In Mouse Liver, Shad Anthony Mitchell

Graduate School of Biomedical Sciences Theses and Dissertations

Metabolic syndrome (MetS) is a term used to define a set of metabolic diseases: obesity, type 2 diabetes (T2D), hyperlipidemia, hypertension, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic hepatosteatosis (NASH). Those with MetS have a higher incidence of cardiovascular disease and stroke. Current drug treatments for MetS treat the individual pathologies associated with the diseases, rather than directly targeting MetS as a whole. We hypothesize that the inhibition of a ubiquitous lipid transporter known as ARV1 can improve pathologies associated with MetS. To test this hypothesis, we utilized liver tissue from mARV1 knockout mice fed a high-fat diet and examined …

Identifying Kif Subtype That Mediates Axonal Targeting Of Kv7 Channels, Allison Houghton, Jennifer Walters, Mary Hong, Dhruv Joshi, Hee Jung Chung

PRECS 2018

Early-onset Benign Familial Neonatal Epilepsy (BFNE) and Epileptic Encephalopathy (EE), are associated with mutations in neuronal KCNQ/Kv7 channel subunits Kv7.2 and Kv7.3. Kv7 channels are voltage-dependent potassium channels. Enriched at the axonal plasma membrane, they pump potassium ions out of the neurons and inhibit repetitive or burst firing of action potentials. A single neuronal Kv7 channel is a heterotetramer composed of two Kv7.2 and two Kv7.3 subunits. BFNE and EE mutations in Kv7.2 and Kv7.3 lead to decreased surface expression along the axon, which means less potassium ions are moved across the axonal membrane where action potentials are generated and …

Local Adaptation Signatures In Thermal Performance Of The Temperate Coral Astrangia Poculata, Hannah Elise Aichelman

Biological Sciences Theses & Dissertations

The Northern Star Coral (Astrangia poculata) is an understudied temperate scleractinian coral that provides unique opportunities to understand the roles of phenotypic plasticity and local adaptation in coral physiological tolerance limits. Astrangia poculata inhabits hard bottom ecosystems from the northwestern Atlantic to the Gulf of Mexico and withstands an annual temperature range up to 20°C. Additionally, A. poculata is facultatively symbiotic and co-occurs in both symbiotic (“brown”) and aposymbiotic (“white”) states. Here, brown and white A. poculata were collected from Virginia (VA) and Rhode Island (RI), USA and exposed to heat (18-32°C) and cold (18-6°C) temperature assays during …