Biological Psychology Commons^™

Importance Of The D2 Receptor For One- And Multi-Trial Psychostimulant-Induced Behavioral Sensitization In Preweanling Rats, Martha A. Mohd-Yusof

Electronic Theses, Projects, and Dissertations

The neural mechanisms mediating one-trial and multi-trial behavioral sensitization during early ontogeny are poorly understood. The purpose of this thesis was to assess the importance of D2-like receptors for the induction of cocaine- and methamphetamine-induced one-trial and multi-trial behavioral sensitization during the middle and late preweanling period. In a series of four experiments, rats were injected with saline or the selective dopamine D2-like receptor antagonist raclopride 15 min prior to treatment with the indirect dopamine agonists cocaine or methamphetamine. Acute control groups received two injections of saline. The pretreatment regimens occurred on either PND 16 or PND 20 (one-trial behavioral …

Investigating The Effects Of Copy Number Variants On Reading And Language Performance, Alessandro Gialluisi, Alessia Visconti, Erik G. Willcutt, Shelley D. Smith, Bruce F. Pennington, Mario Falchi, John C. Defries, Richard K. Olson, Clyde Francks, Simon E. Fisher

Psychology: Faculty Scholarship

Background

Reading and language skills have overlapping genetic bases, most of which are still unknown. Part of the missing heritability may be caused by copy number variants (CNVs).

Methods

In a dataset of children recruited for a history of reading disability (RD, also known as dyslexia) or attention deficit hyperactivity disorder (ADHD) and their siblings, we investigated the effects of CNVs on reading and language performance. First, we called CNVs with PennCNV using signal intensity data from Illumina OmniExpress arrays (~723,000 probes). Then, we computed the correlation between measures of CNV genomic burden and the first principal component (PC) score …

The Effects Of Lipopolysaccharide-Induced Neuroinflammation On Learning And Forgetting In Juvenile Rats, Michele Barry

Seton Hall University Dissertations and Theses (ETDs)

The inability to remember events experienced very early in life is referred to as Infantile Amnesia (IA) and has been observed in both humans and animals. Over the years interest in the phenomenon waned, but has recently increased with the discovery of new neurobiological methods to study brain function (e.g., Callaghan, Li & Richardson, 2014). The neurobiological mechanism behind IA has yet to be determined, but several innovative theories have been developed with these new research methods. The neurogenesis hypothesis theorizes that increased neurogenesis during early development disrupts previously established memories. The hippocampus, an area that mediates both the memory …

Do Rats Consume Ethanol To Regulate A Negative Emotion Induced By A Successive Negative Contrast Procedure?, Andrew Dieterich

Seton Hall University Dissertations and Theses (ETDs)

According to the self-medication hypothesis, individuals may consume drugs or alcohol, or engage in other behaviors in order to reduce a negative emotional state (Khantzian, 1985; Gross, 2013; Crum et al., 2013). Rats experiencing a negative state induced by various stressors (Bertholomey et al., 2010), or a decrease or loss in reward value of a sucrose solution (Manzo et al., 2015; Manzo et al., 2014) demonstrate increased consumption of alcohol. I used successive (SNC) and anticipatory negative contrast (ANC) procedures to further examine this hypothesis and the previous findings (Manzo et al., 2015), that rats increase consumption and preference for …

Working Memory Impairments In Chromosome 22q11.2 Deletion Syndrome: The Roles Of Anxiety And Stress Physiology, Ashley F. P. Sanders

LSU New Orleans Theses and Dissertations

Stress and anxiety negatively impact the working memory system by competing for executive resources. Broad memory deficits have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing children (M = 11.10 years, SD = 2.95). Results indicate reduced post-stress RSA recovery and overall increased levels of cortisol in children with 22q11.2DS. Additionally, anxiety mediated the relationship between 22q11.2DS and visuospatial working memory impairment. However, there was no indication that stress response physiology mediated this association. …

Hormonal Correlates Of P50 Suppression In Socially Anxious Young Adults, Andrea M. Tountas

LSU New Orleans Theses and Dissertations

Ten to 15% of the population is temperamentally shy and have elevated physiological stress responses to novel social situations. Yet, the neural mechanisms underlying this personality trait are not fully understood (Beaton et al., 2009; Schmidt et al., 1997). Efficiently attending to, acting on, and remembering relevant stimuli and filtering out less important information is critical given the sheer volume of sensory and perceptual stimuli the brain is exposed to.

Relevant stimuli that garner attention are remembered and consolidated with existing memories. Stimuli that do not warrant extended attention are ignored or habituated to in a process underpinned by cortical …

An Analysis Of Canine Processing Of Stimulus Compounds Varying In Light And Sound Intensity, Katherine O. Compitus

Theses and Dissertations

A dog was trained to respond deferentially to two light-sound compounds. The dog was then tested with combinations of additional light and sound intensities. The dog appeared to use the information provided by both stimulus dimensions. This research is relevant to the understanding of information processing, specifically categorization and generalization.

The Effects Of Chronic Partial Sleep Deprivation And Chronic Voluntary Alcohol Consumption On Δfos B Accumulation, Kristian Ponder

Masters Theses, 2010-2019

The present study explores the relation between sleep restriction and alcohol use and the neural substrates that result from chronic behaviors. Accumulation of the transcription factors ΔFosB is suggested as a possible outcome of chronic behaviors, such as addiction. Sleep is discussed as possible mediating factor in the relationship between ΔFosB and chronic alcohol consumption. There were four experimental groups in this study: Control (C), Sleep Deprivation only (SD), Alcohol Exposure only (AO), and both sleep deprivation and alcohol exposure (B). Levels of ΔFosB accumulation in the Nucleus Accumbens (NAc) revealed a significant main effect of sleep deprivation, but no …

The Effect Of Descriptive Norms On Resistance Exercise Self-Efficacy In College-Aged Females 2016, Justin Kompf

Master's Theses

Resistance training is a form of physical activity that provides substantial health benefits. Despite these widespread benefits, participation in resistance training is considerably low, particularly among females. To engage in a skill-related activity such as resistance training, individuals need to have confidence in their abilities. Self-efficacy is a cognitive construct that is used to describe situation-specific self-confidence. Descriptive norms are a type of social norm that describes the behavior of others. Descriptive norms have been useful in positively changing health related behaviors. The exact mechanism of how descriptive norms alter behavior is unknown. However, it has been show in research …

The Effects Of Antipsychotic Treatment Upon Nicotine Associative Reward In A Neonatal Quinpirole Model Of Schizophrenia, Adam Ray Denton

Undergraduate Honors Theses

Research has revealed that schizophrenics are significantly more likely to smoke cigarettes than the general population, and consume nicotine products at a much more prevalent rate. Further exacerbating this issue, it has been previously demonstrated in clinical populations that the type of antipsychotic treatment administered (typical versus atypical) may result in either an increase or a decrease of already heightened smoking behavior within the schizophrenic population. With these clinical issues in mind, the present study sought to examine the effects of antipsychotic treatment upon the associative reward of nicotine within the neonatal quinpirole model of schizophrenia. We found that treatment …

Daily Bidirectional Relationships Between Sleep And Mental Health Symptoms In Youth With Emotional And Behavioral Problems, Tori R. Van Dyk, Ronald W. Thompson, Timothy D. Nelson

Department of Psychology: Faculty Publications

Objective The present study examined the daily, bidirectional relationships between sleep and mental health symptoms in youth presenting to mental health treatment. Methods Youth aged 6 to 11 (36% female, 44% European American) presenting to outpatient behavioral health treatment (N = 25) were recruited to participate in the study. Children and parents completed daily questionnaires regarding the child’s sleep, mood, and behavior for a 14-day period, while youth wore an actigraph watch to objectively measure sleep. Results Examining between- and within-person variance using multilevel models, results indicate that youth had poor sleep duration and quality and that sleep and mental …

Effects Of Optogenetic Activation And Pharmacological Modulation Of Dopamine Neurons, Remington J. Rice

All NMU Master's Theses

This study explored the use of optogenetic tools to better understand treatments used for schizophrenia. The “positive” symptoms (e.g., hallucinations, paranoia, etc.) of schizophrenia may come from overexpression of dopamine in mesolimbic dopamine neurons. Positive symptoms can be produced in healthy volunteers treated with amphetamine, a psychostimulant drug and dopamine releaser. Conversely, antipsychotic drugs may reduce positive symptoms by blocking dopamine receptors. This study used optogenetics to explore how drugs that alter neurotransmission, might alter behaviors occurring from activation of mesolimbic dopamine (DA) neurons in the ventral tegmental area (VTA). Light-induced activation of DA neurons in the VTA in male …

The Contribution Of A Polygenic Risk Score To Individual Differences In Aggressive Behavior: The Moderating And Mediating Roles Of Stressful Events, Christa C. Christ

Department of Psychology: Dissertations, Theses, and Student Research

Although aggression can be beneficial in certain situations (e.g. playing sports, self-defense), excessive and inappropriate aggression can lead to adverse physical and psychological health outcomes in both perpetrators and victims. Genetic susceptibility to negative environments can increase the likelihood of aggressive behavior in the context of situational risk factors. Low efficiency of serotonin neurotransmission and exposure to stress appear to play a prominent role in the etiology of aggressive behavior. A set of three studies assessed the contribution of polygenic risk (TPH2 rs4570625, SLC6A4 5-HTTLPR+rs25531, HTR1B rs13212041, MAOA uVNTR) to aggressive behavior, including alcohol-related aggression, in university students at varying …

Evaluation Of The Discriminable Stimulus Effects Of 0.3 Mg/Kg 3, 4‑Methylenedioxypyrovalerone (Mdpv) And 1.0 Mg/Kg 4-Methylmethcathinone (4-Mmc) Using A Drug Discrimination Procedure In Male Sprague-Dawley Rats, Michael Berquist

Research and Creative Activities Poster Day

Experimental investigations into the behavioral and neurochemical effects of illicit β-ketophenethylamines (synthetic cathinones, “bath salts”) has increased in recent years. Two cathinone derivatives in particular, MDPV and mephedrone (4-MMC), have received a considerable amount of research attention given their relative popularity among users at the turn of the 21st century. Researchers investigating MDPV and 4-MMC have devoted much of their attention toward evaluating the drugs’ reinforcing efficacy, rewarding effects, receptor binding profiles, and effects on ambulatory responses.

There exist few published studies that have evaluated the discriminable stimulus effects of MDPV and 4-MMC using rodent drug discrimination procedures. To date, …

Previous Exposure To Lsd Fails To Enhance The Psychomotor Stimulant Effects Of D-Amphetamine In Male Sprague-Dawley Rats, Keli Herr

Research and Creative Activities Poster Day

• The hallucinogenic effects of lysergic acid diethylamide (LSD) have been largely attributed to its high affinity for 5-HT2A receptors. However, LSD also has a high affinity at several other monoamine receptors (Nichols, 2004; Passie et al., 2008).
• The contribution of dopaminergic mechanisms to LSD’s behavioral effects have not been investigated to the same extent that serotonergic mechanism have been studied. Some authors have hypothesized that chronic treatment of rats with LSD may produce a persistent behavioral state characterized by sensitivity to dopamine agonists (Marona-Lewicka and Nichols, 2007).
• Repeated exposure to psychostimulant drugs is known to produce progressive increases in locomotor …

Effect Of Apoe E4 Variant On Progression From Mild Cognitive Impairment To Alzheimer’S Disease, Brad P. Taylor

Butler Journal of Undergraduate Research

Alzheimer’s disease is a very prevalent and fatal disorder in older adults, and Mild Cognitive Impairment is often seen as a precursor to Alzheimer’s disease. Alzheimer’s disease is a form of Dementia that is characterized by loss of cognitive abilities while aging. It is ultimately fatal. Mild Cognitive Impairment is more of an intermediate stage between normal mental decline with aging and the more serious decline of dementia. The ApoE E4 gene has been shown to be highly correlated with a greater likelihood of acquiring late-onset Alzheimer’s disease. This study looked to see the effect that the ApoE E4 gene …

The Effects Of Chronic Partial Sleep Deprivation On Alcohol Consumption And Delta Fos B Accumulation, Kristian Ponder

Showcase of Graduate Student Scholarship and Creative Activities

The present study explores the relation between sleep restriction and alcohol use and the neural substrates that result from chronic behaviors, such as transcription factors. Transcription factor activity is suggested as a possible outcome of chronic behaviors, such as addiction. Sleep is discussed as possible mediating factor in the relationship between specific transcription factors and alcohol. Analysis will focus on brain areas related to both sleep and reward.

Effects Of Acute Stress And Ethanol Consumption On Il-1Β In Female Long Evans Rats: A Pilot Study, Kristin R. Creel

Honors Theses

Background: Acute stress elicits many physiological, behavioral, and neurological responses, and many studies have aimed to better our understanding of these responses and their effects. However, a majority of preclinical studies have used male test subjects, despite growing evidence that males and females have different responses to acute and chronic stressors. This study thus aims to evaluate the ability of three different acute stressors to cause a physiological stress response in adult and adolescent female subjects.

Methods: In this preliminary investigation, Female Long Evans rats (N=12) underwent three acute stressors over the course of three consecutive days. In order, these …

Suprachiasmatic Nucleus And Subparaventricular Zone Lesions Disrupt Circadian Rhythmicity But Not Light-Induced Masking Behavior In Nile Grass Rats, Andrew J. Gall, Dorela D. Shuboni, Lily Yan, Antonio A. Nunez, Laura Smale

Faculty Publications

The ventral subparaventricular zone (vSPVZ) receives direct retinal input and influences the daily patterning of activity in rodents, making it a likely candidate for the mediation of acute behavioral responses to light (i.e., masking). We performed chemical lesions aimed at the vSPVZ of diurnal grass rats (Arvicanthis niloticus) using N-methyl-D,L-aspartic acid (NMA), a glutamate agonist. Following NMA lesions, we placed grass rats in various lighting conditions (e.g., 12:12 light-dark, constant dark, constant light); presented a series of light pulses at circadian times (CT) 6, 14, 18, and 22; and placed them in a 7-h ultradian cycle to assess behavioral masking. …

Nature As A Buffer: The Physiological Effects Of Exposure To Nature On Stress, Tyler J. Stading, Jeffrey R. Stevens

UCARE: Research Products

Exposure to images of nature following a stressful event can reduce physiological measures associated with stress. The objectives of this study was to determine whether exposure to nature before the stressor can buffer the stress response. We varied whether nature or urban images were viewed before or after a stressor and measured galvanic skin response in our participants. We describe how order of presenting the stressor influences nature’s calming effect on physiology.

“My Logic Is Undeniable”: Replicating The Brain For Ideal Artificial Intelligence, Samuel C. Adams

Senior Honors Theses

Alan Turing asked if machines can think, but intelligence is more than logic and reason. I ask if a machine can feel pain or joy, have visions and dreams, or paint a masterpiece. The human brain sets the bar high, and despite our progress, artificial intelligence has a long way to go. Studying neurology from a software engineer’s perspective reveals numerous uncanny similarities between the functionality of the brain and that of a computer. If the brain is a biological computer, then it is the embodiment of artificial intelligence beyond anything we have yet achieved, and its architecture is advanced …

A Systems Approach To Stress And Resilience In Humans: Mindfulness Meditation, Aging, And Cognitive Function, Barry S. Oken

Dissertations and Theses

Psychological stress is common and contributes to many physical and mental health problems. Its effects are mediated by a complex neurobiological system centering in the brain with effectors including autonomic nervous system, hypothalamic-pituitary-adrenal axis, inflammatory system, and gene expression. A stressor pushes the human physiological system away from its baseline state towards a lower utility state. The physiological system may return towards the original state but may be shifted to a lower utility state. While some physiological changes induced by stressors may benefit health, chronic stressors usually have negative effects on health. In contrast to this stressor effect is the …

Stress And Suicidal Behavior: A Cognitive, Behavioral, And Biological Integrative Approach, Jorge Valderrama

Dissertations, Theses, and Capstone Projects

Suicide is one of the leading causes of death in young adults in the United States. Previous research has established distal and proximal life stress as a strong risk factor for suicidal behavior. However, how stress impacts suicidal behavior via interactive cognitive and biological mechanisms has not been thoroughly examined. The present research sought to better understand the relationship between stress and suicidal behavior via altered neurobiological functioning, maladaptive cognitions, and deficits in executive functioning. The first study found a relationship between the brooding subtype of rumination and trait impulsivity in the forms of negative urgency, lack of premeditation, and …

Status Signaling And The Characterization Of A Chirp-Like Signal In The Weakly Electric Fish Steatogenys Elegans, Caitlin E. Field

Dissertations, Theses, and Capstone Projects

Sensory systems are critical to both exploratory and communicatory processes, the study of which is critical to our understanding of how animals perceive and respond to their environments. In weakly electric fishes the electrosensory system is utilized for both of these purposes. One type of communication, status signaling, is widespread across taxa and frequently hormonally modulated. This hormonal modulation keeps the signal honest, wherein the status of the sender and the production of the status signal itself are both hormone dependent. We investigated exploratory and communicatory strategies of the electromotor system in pulse-type gymnotiforms, with a focus on status communication …

A Mouse Model Of Toluene Abstinence-Induced Pathology, Sean Callan

Wayne State University Dissertations

The intentional misuse of volatile solvents is a persistent public health concern. Limited self-report data suggests that chronic inhalant abusers experience withdrawal symptoms including anxiety and seizure symptoms. However, these symptoms have never been explored in a preclinical model and are not considered part of the DSM-V criteria for an Inhalant Use Disorder. For this experiment, 76 young adult male Swiss Webster mice were exposed to either 5,000 ppm toluene vapor or air (0 ppm) for 24 consecutive hours beginning on postnatal day (PND) 30. Following the 24 hour exposure, mice were allowed to recover for 3 hours before behavioral …

Intertemporal Similarity: Discounting As A Last Resort, Jeffrey R. Stevens

Jeffrey Stevens Publications

Standard models of intertemporal choice assume that individuals discount future payoffs by integrating reward amounts and time delays to generate a discounted value. Alternative models propose that, rather than integrate across them, individuals compare within attributes (amounts and delays) to determine if differences in one attribute outweigh differences in another attribute. For instance, Leland (2002) and Rubinstein (2003) propose models that 1) compare the two reward amounts to determine whether they are similar, 2) compare the similarity of the two time delays, and then 3) make a decision based on these similarity judgments. Here, I tested discounting models against attribute-based …

Human Vision Inspires Cortisol And Immune Behaviors, J. Forrest Olsen

Departmental Honors Projects

Ten-minute slideshows of disease stimuli were presented to human participants who donated saliva samples before and after its completion. Much to our surprise, this research found cortisol decreased upon the visual perception of a disease threat, a response depicting the physiological consequences of Behavior Immune System activation. Even subliminal exposure to disease stimuli, totaling only 0.5 seconds over the ten-minute slideshow, was found to elicit a cortisol response.

The Domain Specificity Of Intertemporal Choice In Pinyon Jays, Jeffrey R. Stevens, Bryce Kennedy, Dina Morales, Marianna Burks

Jeffrey Stevens Publications

When choosing between a piece of cake now versus a slimmer waistline in the future, many of us have difficulty with self-control. Food-caching species, however, regularly hide food for later recovery, sometimes waiting months before retrieving their caches. It remains unclear whether these long-term choices generalize outside of the caching domain. We hypothesized that the ability to save for the future is a general tendency that cuts across different situations. To test this hypothesis, we measured and experimentally manipulated caching to evaluate its relationship with operant measures of self-control in pinyon jays (Gymnorhinus cyanocephalus). We found no correlation …

Discriminative Stimulus Properties Of 1.25 Mg/Kg Clozapine In Rats: Mediation By Serotonin 5-Ht2 And Dopamine D4 Receptors, Adam J. Prus, Laura Wise, Alan L. Pehrson, Scott D. Philibin, Benny Bang-Andersen, Jørn Arnt, Joseph H. Porter

Journal Articles

The atypical antipsychotic drug clozapine remains one of most effective treatments for schizophrenia, given a lack of extrapyramidal side effects, improvements in negative symptoms, cognitive impairment, and in symptoms in treatment-resistant schizophrenia. The adverse effects of clozapine, including agranulocytosis, make finding a safe clozapine-like a drug a goal for drug developers. The drug dis- crimination paradigm is a model of interoceptive stimulus that has been used in an effort to screen experimental drugs for clozapine-like atypical antipsychotic effects. The present study was conducted to elucidate the receptor-mediated stimulus properties that form this clozapine discriminative cue by testing selective receptor ligands …

The Relationship Between Physical Fitness And School Performance In Middle School Girls, Jamie Anne Donnelly

Walden Dissertations and Doctoral Studies

Past research has indicated a significant relationship between physical fitness and standardized test scores; however, the relationship between physical fitness and other aspects of school performance has yet to be empirically examined in a population specifically composed of middle school girls. This study examined several factors that contribute to school success, such as classroom behavior, attendance, and grades, in relation to physical fitness among a group of adolescent girls. It was specifically designed to examine the statistical relationship between physical fitness, as measured by the Fitnessgram, and quantitative data on school performance including grades, standardized test scores, school behavior, and …