Biological Psychology Commons^™

Cognitive Differences In Parkinson’S Disease With Amyloid Positivity And Negativity, Kenya Luna

Electronic Theses, Projects, and Dissertations

In Parkinson’s Disease (PD), research has shifted to investigate how biomarkers commonly seen in Alzheimer’s Disease (AD), such as amyloid beta (AB), may be associated with cognitive functioning in PD. AB is considered a reliable biomarker for AD pathology, however in PD there is a lacking biomarker that can accurately reflect severity of cognitive impairment. AD research has shown an association between low AB and cognitive decline, but the data in PD has mixed results. Most studies that analyze cognitive decline and biomarkers do not use a cutoff level and the few that do have a threshold vary greatly in …

Opioid System's Potential Involvement In Ketamine's Cognitive And Antidepressant-Like Effects In Rats, Fan Zhang

Theses and Dissertations

Depression stands as one of the most pervasive mental health challenges worldwide, including the United States. Conventional antidepressants typically display a delayed onset of therapeutic action (4-8 weeks) and lack efficacy in a substantial portion of patients (over 40% of depressed patients are treatment-resistant). The dissociative anesthetic ketamine, which is a glutamatergic N-methyl-D-aspartate (NMDA) antagonist, has emerged as a promising novel treatment due to its rapid and prolonged antidepressant effects, and it is especially beneficial for treatment-resistant depression. Nevertheless, the precise neurochemical mechanisms underlying ketamine’s antidepressant properties remain elusive, hampering the development of safer and more efficacious treatments. The present …

Neuroanatomy In Mild Cognitive Impairment: Relationship To Functional Skills, Treatment Expectancy, And Comorbid Depression, Sara Rushia

Dissertations, Theses, and Capstone Projects

Mild cognitive impairment (MCI) is a neurocognitive disorder defined by cognitive decline in older adults. Although MCI has been studied for decades, there remain important areas to be explored in order to adequately characterize aspects of this disorder that provide information valuable for possible interventions and disease progression to dementia, including a better understanding of the neuroanatomical variables relevant to this disorder. Such neuroanatomical variables include cortical thickness, hippocampal volume, and white matter hyperintensities (WMHs). This dissertation consists of three separate studies aimed at addressing gaps in the literature on MCI in relation to brain morphometrics and under-studied characteristics involved …

Understanding Across The Senses: Cross-Modal Studies Of Cognition In Cetaceans, Jason N. Bruck, Adam A. Pack

Faculty Publications

Cross-modal approaches to the study of sensory perception, social recognition, cognition, and mental representation have proved fruitful in humans as well as in a variety of other species including toothed whales in revealing equivalencies that suggest that different sensory stimuli associated with objects or individuals may effectively evoke mental representations that are, respectively, object based or individual based. Building on established findings of structural equivalence in the form of spontaneous recognition of complex shapes across the modalities of echolocation and vision and behavior favoring identity echoic–visual cross-modal relationships over associative echoic–visual cross-modal relationships, examinations of transitive inference equivalencies from initially …

Cross-Modal Perception Of Identity By Sound And Taste In Bottlenose Dolphins, Jason N. Bruck, Sam F. Walmsley, Vincent M. Janik

Faculty Publications

While studies have demonstrated concept formation in animals, only humans are known to label concepts to use them in mental simulations or predictions. To investigate whether other animals use labels comparably, we studied cross-modal, individual recognition in bottlenose dolphins (Tursiops truncatus) that use signature whistles as labels for conspecifics in their own communication. First, we tested whether dolphins could use gustatory stimuli and found that they could distinguish between water and urine samples, as well as between urine from familiar and unfamiliar individuals. Then, we paired playbacks of signature whistles of known animals with urine samples from either the same …

The Evolution Of Quantitative Sensitivity, Margaret A H Bryer, Sarah E. Koopman, Jessica F. Cantlon, Steven T. Piantadosi, Evan L. Maclean, Joseph M. Baker, Michael J. Beran, Sarah M. Jones, Kerry E. Jordan, Salif Mahamane, Andreas Nieder, Bonnie M. Perdue, Friederike Range, Jeffrey R. Stevens, Masaki Tomonaga, Dorottya Ujfalussy, Jennifer Vonk

Jeffrey Stevens Publications

The ability to represent approximate quantities appears to be phylogenetically widespread, but the selective pressures and proximate mechanisms favouring this ability remain unknown. We analysed quantity discrimination data from 672 subjects across 33 bird and mammal species, using a novel Bayesian model that combined phylogenetic regression with a model of number psychophysics and random effect components. This allowed us to combine data from 49 studies and calculate the Weber fraction (a measure of quantity representation precision) for each species. We then examined which cognitive, socioecological and biological factors were related to variance in Weber fraction. We found contributions of phylogeny …

Antidepressants, Circadian Rhythms, And Cognition: The Effects Of Ssris And Snris On Circadian Rhythms And Cognitive Performance, Gabriel Gilmore

Masters Theses, 2020-current

It has been well documented that individuals with depression commonly experience sleep disturbances. Decreased sleep quality, diminished sleep efficiency, and increased nighttime awakenings are all typical ailments. Deficits in cognitive functioning often co-occur, including impairments in working memory, learning, inhibition, and set shifting. Many studies have found that upon taking antidepressants (i.e. serotonin agonists), individuals with depression experience normalized sleep and cognitive performance. The impact of antidepressants, especially SSRIs and SNRIs, on sleep stages, particularly REM and slow wave sleep, has been the subject of numerous studies. However, there is currently very limited literature that examines their impact on sleep …

Music And Its Effects On The Brain, Caitlyn Herron

Williams Honors College, Honors Research Projects

This paper will discuss, in short, how music influences our brain, as well as some behavioral and physiological effects as a result. The brain consists of many regions responsible for different cognitive processes, such as learning, memory, recall, speech, and our emotions. It has been found that music helps to facilitate all of these cognitive processes, regardless of its emotional valence or whether the music is active or passive, such as singing or listening to it, respectively. It was discovered that music influences our ability to learn novel concepts related to mathematics, reading, and even language acquisition. It was also …

The Biological, Psychological, Cognitive, And Social Perspectives On Aging: The Design Of A Healthy Aging Program For Older Adults, Melissa Santiago

Dissertations

Aging is an inevitable process, accompanied by changes in physiological, cognitive, psychological, and social facets. Researchers have investigated the physiological, cognitive, psychological, and social risk factors associated with aging and have encouraged the use of physical activity, cognitive training, and dietary interventions to alleviate risk factors. However, holistic programs dedicated to promoting successful aging among older adults are uncommon. This review sought to promote successful aging by identifying physiological, cognitive, psychological, and social risk factors that affect older adults and develop a comprehensive program to holistically mitigate these risk factors. Risk factors associated with unsuccessful aging include the development of …

The Project Talent Twin And Sibling Study: Zygosity And New Data Collection, Carol A. Prescott, Ellen E. Walters, Thalida Em Arpawong, Catalina Zavala, Tara L. Gruenewald, Margaret Gatz

Psychology Faculty Articles and Research

The Project Talent Twin and Sibling (PTTS) study includes 4481 multiples and their 522 nontwin siblings from 2233 families. The sample was drawn from Project Talent, a U.S. national longitudinal study of 377,000 individuals born 1942–1946, first assessed in 1960 and representative of U.S. students in secondary school (Grades 9–12). In addition to the twins and triplets, the 1960 dataset includes 84,000 siblings from 40,000 other families. This design is both genetically informative and unique in facilitating separation of the ‘common’ environment into three sources of variation: shared by all siblings within a family, specific to twin-pairs, and associated with …

Short-Term Abstinence Effects In Experienced Electronic Cigarette Users, Nicholas J. Felicione

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nicotine/tobacco dependence is a problem that negatively affects health at an individual and population level. Nicotine/tobacco dependence may be best assessed by measuring withdrawal symptoms of a nicotine/tobacco user who abstains from use. Withdrawal symptoms experienced by cigarette smokers are well characterized, including deficits in attention and memory, as well as self-reported cravings, urges, and other symptoms. While withdrawal in cigarette smokers has been studied extensively, little is known about dependence and withdrawal associated with newer products, such as electronic cigarettes (ECIGs). ECIGs can deliver nicotine comparably to tobacco cigarettes, indicating that they may have the potential to cause dependence. …

Validation Of The Barkley Deficits Of Executive Functioning Scale-Short Form, Brian Sheble

Dissertations

The Barkley Deficits of Executive Functioning-Short Form (BDEFS-SF) is a short rating scale measuring executive functioning in adults. The BDEFS-SF was developed using the 5 highest loading questions from the BDEFS-LF. Consequently, the psychometric qualities of the BDEFS-SF were not investigated using formal methods. In this study, the psychometric attributes of the BDEFS-SF were examined using two separate but similar groups. The first group of 264 men and women aged 18-35 years old completed the BDEFS-SF via an internet survey. The second group of 36 men and women aged 18-35 years old completed the BDEFS-SF and individualized assessments of executive …

The Immediate And Long-Lasting Cognitive Consequences Of Adolescent Chronic Sleep Restriction, Kerry Howard

Seton Hall University Dissertations and Theses (ETDs)

Adolescence is a critical developmental period. An important change that occurs in adolescence is the neurological maturation for adult-type cognitive abilities. Research has linked adequate sleep quantity to successful learning and memory capabilities. However, due to a shift in sleep timing drive in adolescence, in combination with early awakening for school, the adolescent population is experiencing chronic sleep restriction (CSR). What repercussions to long-term memory capabilities could CSR in adolescence have immediately and are the consequences long-lasting? The present study modeled human adolescent CSR in rats through four hours of sleep deprivation for five days, followed by two days of …

The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber

Wayne State University Dissertations

In the neonatal intensive care unit (NICU) preterm infants are exposed to a multitude of stressors, which include both neonatal pain and reduced maternal care. Clinical and preclinical research has demonstrated that exposure to neonatal pain and reduced maternal care has a profound negative impact on brain and behavioral development. Currently, the biological mechanism by which both of these stressors impacts brain and behavioral outcomes remains widely unknown. To uncover a potential biological mechanism, the current dissertation project utilized a preclinical model of repetitive needle pokes and developed a novel model of reduced maternal care through tea-ball encapsulation. Briefly, rat …

The Effect Of Increased Sleep On The Circadian Rhythm Of Salivary Cortisol Concentrations, Mariah Jacqueline Scott

Seton Hall University Dissertations and Theses (ETDs)

Cortisol is a salivary marker for the hypothalamic-pituitary-adrenal axis (HPA) component of the stress response. The activity of the HPA demonstrates a circadian rhythm. It is well known that sleep deprivation increases cortisol concentrations. In this study, we looked at the effect of an increase of one-hour sleep for one month on the circadian rhythm of the HPA.

Eight college subjects (n=8) collected saliva during their normal sleep wake cycle every 4 hours for 24 hours. Saliva collections were repeated after a month of increase of sleep by 1-hour. The subjects also completed demographic forms that asked for age, sex, …

Effects Of Rhes Prenylation On Mouse Cognition In A 3-Nitropropionic Acid Animal Model Of Huntington's Disease, Diana Hobbs

LSU New Orleans Theses and Dissertations

Located on the short arm of chromosome 4, there exists a gene, IT15, responsible for the trinucleotide CAG expansion involved in the autosomal dominant neurodegenerative disorder known as Huntington’s disease (HD). The brain region associated with the most atrophy, the striatum, leads to expression of severe motor dysfunction, the hallmark feature of HD. To a lesser degree, the cortex and hippocampus show earlier deterioration indicative of the cognitive deficits that occur prior to motor symptom onset. The brain regions associated with HD-induced neuronal death additionally selectively express the protein Rhes - the combination of Rhes and mutant huntingtin being cytotoxic. …

Changes In Cerebral White Matter, Vascular Risk And Cognition Across The Adult Lifespan, Andrew Robert Bender

Wayne State University Dissertations

Numerous studies over the past decade have used diffusion tensor imaging (DTI) to examine associations between age, diffusion and anisotropy measures of cerebral white matter (WM), and cognitive performance. However, few have examined relationships between intra-individual change in DTI measures of WM and cognitive function. It is possible that the extant cross-sectional findings are a poor representation of age-related change in WM and cognition. The present study used latent difference-score modeling (LDM) to assess change over two years in DTI indices fractional anisotropy (FA), radial diffusivity (DR), axial diffusivity (DA) and mean diffusivity (MD). In addition, we examined the effects …

Cognitive And Psychiatric Predictors To Psychosis In Velocardiofacial Syndrome: A 3-Year Follow-Up Study, Kevin M. Antshel, Robert J. Shprintzen, Wanda Fremont, Anne Marie Higgins, Stephen V. Faraone, Wendy R. Kates

Communication Disorders Faculty Publications

Objective: To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS). Method: 70 youth with VCFS, 27 siblings of youth with VCFS and 25 community controls were followed from childhood (Mean age = 11.8 years) into mid-adolescence (mean age 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention and executive functioning as well as measures of parent and clinician ratings of child psychiatric functioning were completed at both time point. Results: Major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder diagnoses increased in the VCFS sample. With very low false positive rates, the best predictor of adolescent prodromal …