Biological Psychology Commons^™

Clinician Perspectives On Fistula Mental Health, Victoria K. Leonard

Doctoral Dissertations

Background – Obstetric fistula is a childbirth injury caused by prolonged labor that leads to stillbirth and incontinence, spurring social exclusion and isolation. These layers of trauma put women with fistula at great risk for psychological suffering, which has profound negative socioeconomic impacts on them, their families, and communities. This study captured treatment as usual at Comprehensive Community Based Rehabilitation in Tanzania (CCBRT), the country’s largest provider of fistula care.

Method – Improving holistic fistula treatment requires engaging the clinicians who care for women with fistula. This study aimed to investigate the training, beliefs, and treatment approaches of nurses and …

A Child On Stand: The Impact Of Experiencing Trauma On Children’S Testimonial Efficacy In Legal Proceedings, Morgan Sweger

Williams Honors College, Honors Research Projects

Children who are victims of physical, sexual, emotional, or verbal abuse are nearly always left deeply traumatized by such events. In extreme cases, abused children may be asked to testify against their abuser(s) in legal proceedings, recounting their trauma in front of a room full of strangers. For some, the trauma of abuse may influence a child’s ability to effectively recall and describe their experiences and for others, the process of participating in legal proceedings creates deeper wounds. Research has aimed to understand whether children lack the ability to contribute sufficient testimonies during investigations of abuse and how these investigations …

An Ewas Of Dementia Biomarkers And Their Associations With Age, African Ancestry, And Ptsd, Mark W. Miller, Erika J. Wolf, Xiang Zhao, Mark W. Logue, Sage E. Hawn

Psychology Faculty Publications

Background

Large-scale cohort and epidemiological studies suggest that PTSD confers risk for dementia in later life but the biological mechanisms underlying this association remain unknown. This study examined this question by assessing the influences of PTSD, APOE ε4 genotypes, DNA methylation, and other variables on the age- and dementia-associated biomarkers Aβ40, Aβ42, GFAP, NfL, and pTau-181 measured in plasma. Our primary hypothesis was that PTSD would be associated with elevated levels of these markers.

Methods

Analyses were based on data from a PTSD-enriched cohort of 849 individuals. We began by performing factor analyses of the biomarkers, the results of which …

Refining The Scope Of Genetic Influences On Alcohol Misuse Through Environmental Stratification And Gene-Environment Interaction, Jeanne E. Savage, Christiaan A. De Leeuw, Josefin Werme, Spit For Science Working Group, Danielle M. Dick, Danielle Posthuma, Sophie Van Der Sluis

Psychology Faculty Publications

Background

Gene-environment interaction (G X E) is likely an important influence shaping individual differences in alcohol misuse (AM), yet it has not been extensively studied in molecular genetic research. In this study, we use a series of genome-wide gene-environment interaction (GWEIS) and in silico annotation methods with the aim of improving gene identification and biological understanding of AM.

Methods

We carried out GWEIS for four AM phenotypes in the large UK Biobank sample (N = 360,314), with trauma exposure and socioeconomic status (SES) as moderators of the genetic effects. Exploratory analyses compared stratified genome-wide association (GWAS) and GWEIS modeling approaches. …

Identifying Trauma Related Predictors Of Dissociation In Maltreated Youth, Amanda L. Mraz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Maltreated youth who experience traumatic dissociation are at an increased risk for various psychopathological difficulties. Much is still unknown about the machinations behind experiences of dissociation post-trauma. This study aimed to identify variables that place maltreated youth at risk for experiencing traumatic dissociation (e.g., dissociative amnesia, absorption and imaginative involvement, passive influence, depersonalization and derealization, and total adolescent dissociative experiences symptoms (A-DES)). Investigatory variables included demographic (e.g., age, gender, and racial identity), cognitive (e.g., resiliency and posttraumatic cognitions), and psychological (e.g., posttraumatic stress disorder symptoms (PTSD) and anxiety) factors. Classification and regression tree (CART) analysis was utilized to observe the …

Borderline Personality Symptoms And Relationship Threat: The Moderating Role Of Perceived Parental Rejection, Elsa Baumgartner

Departmental Honors & Graduate Capstone Projects

Individuals with borderline personality disorder (BPD) often perceive relationship threats more intensely, resulting in increased emotional reactivity. However, this link has never been examined with physiological measures in “real time,” nor have reports of perceived parental rejection ever been investigated as a potential moderator of this link. To fill this gap, the present study induced romantic relationship threat, after which participants completed an emotional reactivity task while electroencephalography data were recorded. Results reveal that higher levels of BPD features were associated with increased emotional reactivity, indicated by larger late positive potential (LPP) amplitudes, to negative stimuli in the face of …

Dancing The Storm: Neurobiological Correlates Of Trauma-Related Psychopathology In Youth Resettled As Refugees, And The Efficacy Of Creative Arts And Movement Therapies To Address Trauma-Related Psychopathology, Lana Ruvolo Grasser

Wayne State University Dissertations

Exposure to stress and trauma activates key adaptive pathways, including the sympathetic adrenomedullary system and the immune system, which can result in long-term health impacts of trauma especially when experienced during sensitive developmental periods. Alterations in these systems are measurable through non-invasive methods including skin conductance response (SCR), fear potentiated startle (FPS), and inflammation. Research regarding the impact of trauma, and more specifically posttraumatic stress disorder, has primarily focused on adults, and there is a paucity of neurobiological research in displaced populations—like refugees—who may experience higher rates of trauma exposure and related psychopathology. The present study measured SCR to a …

Antecedents Of Borderline Personality Disorder And Antisocial Personality Disorder: An Examination Of Gene X Environment Interactions, Amy L. Medina

Dissertations, Theses, and Capstone Projects

Current thinking suggests that genotypes associated with impulse-control disorders and negative emotionality, such as monoamine oxidase-a (MAOA), interact with negative early environmental factors like childhood maltreatment and develop into the disorders know as Borderline Personality Disorder (BPD) and Antisocial Personality Disorder (ASPD). Using existing data from a prospective cohort design study of the consequences of child abuse and neglect, participants (N = 896 represent individuals with documented histories of child abuse and neglect and a matched comparison group that were followed up into adulthood and interviewed. A subsample of 631 participants gave permission for DNA extraction and analyses during …

Adult And Juvenile Rats Differentially Express Mpfc Glua2 Following Traumatic Memory Retrieval, Edgar Rodriguez

Theses and Dissertations

To advance our understanding of how traumatic memories are modulated between adults and juveniles, we characterize the AMPAr subunits, GluA1, GluA2, GluA3 in the mPFC of rodents following traumatic memory retrieval.

GluA2 was differentially expressed in adults but not juveniles rats. There were no changes in GluA1 or GluA3 expression

Estradiol And Daily Affective Experiences In Trauma-Exposed Women, Jenna Rieder

Dissertations, Theses, and Capstone Projects

People who experience trauma can develop enduring trauma-related symptoms. In daily life, post-trauma symptoms (e.g., elevated physiological arousal) can be triggered by affectively salient cues in the environment, especially by cues that act as trauma reminders. Trauma exposure is associated with enduring changes in two biological stress systems: the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. In women, activity in both systems is additionally modulated by fluctuations in levels of sex hormones (e.g., estradiol), which could influence physiological responses to trauma reminders. Additionally, previous work has linked the sex hormone estradiol with affect, suggesting that menstrual cycle might …

Efficaciousness Of Mindfulness Interventions For Trauma Using Psychophysiological Measures: A Review, Sherief Y. Eldeeb

Scholarly Undergraduate Research Journal at Clark (SURJ)

In recent decades the efficaciousness of mindfulness has been proven in a wide variety of contexts, but some crucial populations remain understudied. This review critically examines the literature on mindfulness in individuals with trauma using psychophysiological measures. Psychophysiological measures offer critical insight into this intersection of mindfulness and trauma due to the known somatic components in each, as well as serving as an objective response. Mindfulness-based treatments seem to show great promise in treating trauma, however there are significant limitations in the literature. Future studies should standardize the minimum length of treatment, utilize gender-balanced and ethnically diverse samples, and introduce …

Social Work Trauma Interventions: Dialectical Behavioral Therapy, Kassie Baumann

Senior Honors Theses

According to Lynne Weilart (2013), in her article on the reasons why people seek out therapy, trauma is the number one reason people attend counseling. Many different trauma-informed approaches are designed specifically to address the consequences of trauma and to facilitate healing. Some of these approaches are as follows: Cognitive Behavioral Therapy (CBT); Dialectical Behavioral Therapy (DBT);Mentalization Based Therapy (MBT); Trauma Systems Therapy (TST); Trauma Assessment Pathway (TAP); and Attachment, Self-Regulation, and Competency (ARC) (de Arellano, Danielson, Ko, & Sprauge, 2008). The effectiveness of each trauma intervention will be examined. DBT is one of these trauma interventions that is growing …

Neural Hypervigilance In Trauma-Exposed Women, Seungyeon A. Yoon

Dissertations, Theses, and Capstone Projects

Trauma-exposed people often experience hypervigilance, which is a tonic condition of elevated alertness and excessive scanning for potential threat. A cardinal feature of hypervigilance is that no actual threat is needed to evoke or maintain the over-alertness and heightened affective response. However, most neuroimaging research in trauma to date has only focused on reactivity to an actual threat. Thus, the overarching aim of this dissertation was to investigate neural signatures and salivary markers of post-trauma hypervigilance in the absence of threat that can cause impairment in daily functioning and contribute to developing other trauma-related symptoms such as heightened threat reactivity. …

Cognitive Functioning During Conflict In Intimate Partner Relationships Between Traumatized And Non-Traumatized Samples, Kylie N. Coleman

Doctor of Psychology (PsyD)

Significant differences have been found in neural connectivity of the brain in frontal, central, temporal, and parietal areas of individuals who experienced childhood trauma compared to those who had not (Cook, Ciorciari, Varker, & Devilly, 2009). This study investigated the relationship between the number of distressing and traumatic life experiences and participants’ neural responses to observing simulated conflict in intimate relationship. Graduate students (n = 11) answered conflict resolution and emotional activation questions while watching a simulated, escalating marital conflict. The participants’ neural responses were recorded via EEG mean power data from frontal and temporal brain regions. Heart rate (bpm) …

Ptsd From Childhood Trauma As A Precursor To Attachment Issues, Christy Owen

Fidei et Veritatis: The Liberty University Journal of Graduate Research

The past 20 years have been turbulent regarding Reactive Attachment Disorder (RAD), with conflicting research about its causes, effects, treatment, and prognosis. The current diagnostic criteria in the DSM-5 fails to adequately address this disorder. A number of deviant and maladaptive behaviors common amongst children with RAD are not even mentioned in the diagnostic criteria. As such, the diagnostic definition is almost unidentifiable or incompatible with real-life conduct manifestations of the disorder. Rather, this author contends that RAD is foundationally a unique and extreme form of Posttraumatic Stress Disorder (PTSD) from Early Childhood Trauma. The child endured unspeakable neglect and/or …

The Impact Of Childhood Trauma As Moderated By Ptsd, Relationship With Caregiver, And Rumination, Aislyn M. Allen

USC Aiken Psychology Theses

The current study explored the relationship between childhood trauma and deliberate rumination, as well as PTSD symptomology, psychological and physiological functioning. Participants consisted of 55 undergraduate students, ages 18-23; who completed measures about a specific traumatic event, psychological functioning, parental attachment, PTSD symptoms, deliberate rumination, childhood maltreatment, and a demographics questionnaire. Reported childhood trauma was a specifically identified traumatic life event, child maltreatment, or having a parent with a substance abuse or mental disorder. Following completion of measures, participants were asked to answer questions while heart rate, heart rate variability, and electrodermal activity were monitored. Results indicated there was relation …

Attachment: The Antidote To Trauma, Joshua Straub

Faculty Publications and Presentations

Trauma and loss in life are inevitable. And all too often the traumatic experience itself can be enough to paralyze the mental, emotional, and spiritual state of any given person. Unable to interpret the traumatic experience, many instead are left defined by it. Helping clients discern the objective experience and their subjective reactions to it will help free them from the emotions and beliefs that subsequently control their lives. Based on the most relevant attachment theory research and clinical techniques, this workshop teaches the attentional strategies necessary to helping clients overcome trauma.