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Biological Psychology Commons

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2016

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Articles 1 - 30 of 80

Full-Text Articles in Biological Psychology

If It Feels Good, View It: Selective Exposure And Desensitization Moderate The Association Between Video Gameplay And Pleasure-Oriented Aggression, Mejdy M. Jabr Dec 2016

If It Feels Good, View It: Selective Exposure And Desensitization Moderate The Association Between Video Gameplay And Pleasure-Oriented Aggression, Mejdy M. Jabr

University of New Orleans Theses and Dissertations

A number of studies have indicated that violent video gameplay is associated with higher levels of aggression, and desensitization to violent content contributes to this association. Utilizing a rapid serial visual presentation (RSVP) task, the current study used event-related potentials (ERPs) to investigate selective attention (N1 activation), cognitive control (N2 activation), and desensitization (P3 activation) as neurocognitive mechanisms potentially underlying the association between gameplay and subtypes of aggression. Results showed video game players and non-players differed significantly in brain activation when engaged with violent imagery. N1 and P3 amplitude moderated the association between gameplay and pleasure-oriented aggression. Follow-up analyses further …


Habitat Use By Bottlenose Dolphins, Tursiops Truncatus, In Roanoke Sound, North Carolina, Shauna Marisa Mcbride Dec 2016

Habitat Use By Bottlenose Dolphins, Tursiops Truncatus, In Roanoke Sound, North Carolina, Shauna Marisa Mcbride

Dissertations

Information on the habitat use of a species is important to develop conservation efforts and management strategies for that species. Roanoke Sound, North Carolina is primarily a seasonal habitat for bottlenose dolphins, Tursiops truncatus, from late spring to early fall, but little information is known about how dolphins use this area. Transect survey data and opportunistic survey data collected by the Outer Banks Center for Dolphin Research from 2009 to 2015 were used to analyze dolphin habitat use. The objectives of this project were to: 1) identify areas that were important to dolphins, 2) determine which behaviors were observed …


The Importance Of Serotonergic And Adrenergic Receptors For The Induction And Expression Of One-Trial Cocaine-Induced Behavioral Sensitization, Krista N. Rudberg Dec 2016

The Importance Of Serotonergic And Adrenergic Receptors For The Induction And Expression Of One-Trial Cocaine-Induced Behavioral Sensitization, Krista N. Rudberg

Electronic Theses, Projects, and Dissertations

Addiction is a complex process in which behavioral sensitization may be an important component. While the behavioral effects of sensitization are well established, the intricate neurobiology of the phenomenon is still largely unknown. Dopamine systems mediate the induction of behavioral sensitization in adult rats, but there is a large amount of evidence showing that other neurotransmitter systems also modulate the induction process. For example, the α1b-adrenergic and 5-HT2A receptor systems are known to modulate the sensitized responding of adult rats, but the roles that these receptor systems play in the induction and expression of behavioral sensitization during the preweanling …


If Or When? Uncertainty's Role In Anxious Anticipation, Kenneth P. Bennett Dec 2016

If Or When? Uncertainty's Role In Anxious Anticipation, Kenneth P. Bennett

Theses and Dissertations

Uncertainty is often associated with subjective distress and a potentiated anxiety response. Occurrence uncertainty (OU), or the inability to predict if a threat will occur, has never been compared experimentally with temporal uncertainty (TU), or the inability to predict when a threat will occur. The current study aimed to 1) directly compare the eye-blink startle responsivity of OU and TU, 2) develop a more effective task for isolating uncertain anticipation, and 3) better understand the relationship between individual differences in the intolerance of uncertainty and uncertain anticipation startle responsivity. The novel study showed that OU anticipation is more anxiety provoking …


The Neural Correlates Of Emotion Reactivity And Regulation In Young Children With Adhd, Claudia I. Lugo-Candelas Nov 2016

The Neural Correlates Of Emotion Reactivity And Regulation In Young Children With Adhd, Claudia I. Lugo-Candelas

Doctoral Dissertations

Attention-deficit hyperactivity disorder (ADHD) is the most frequently occurring pediatric neurobehavioral disorder. Although emotion reactivity and regulation are frequently impaired in ADHD, few studies have examined these factors in preschool aged children with ADHD, and none have explored the neural correlates of emotion reactivity and regulation in this group though event-related potentials (ERPs). Children aged 4 to 7 with (n = 24) and without (n = 30) ADHD symptoms completed an attention task composed of four blocks: baseline, frustration, suppression, and recovery. In the frustration and suppression blocks, negative affect was induced by false negative feedback. During the …


Marijuana Use Is Associated With Behavioral Approach And Depressive Symptoms In Adolescents And Emerging Adults, Natasha E. Wright, Danny Scerpella, Krista M. Lisdahl Nov 2016

Marijuana Use Is Associated With Behavioral Approach And Depressive Symptoms In Adolescents And Emerging Adults, Natasha E. Wright, Danny Scerpella, Krista M. Lisdahl

Psychology Faculty Articles

Background

Repeated CB1 binding due to THC results in downregulation of the endocannabinoid system in cortex and limbic regions, perhaps disrupting frontolimbic functioning. This is particularly a concern in young adults who are still undergoing neurodevelopment in frontal and limbic regions. Such disruptions may be linked to increased depressive symptoms, anxiety symptoms, and executive dysfunction, and decreased behavioral approach.

Objectives

Here we examine the influence of young adult marijuana use on anxiety, depressive symptoms, behavioral approach, and executive dysfunction. The influence of alcohol and gender were also assessed.

Methods

84 participants (42 MJ, 42 controls) aged 18–25 were balanced for …


Perceptions Of Peer Sexual Behavior: Do Adolescents Believe In A Sexual Double Standard?, Michael Young, Susan Cardenas, Joseph Donnelly, Mark J. Kittleson Nov 2016

Perceptions Of Peer Sexual Behavior: Do Adolescents Believe In A Sexual Double Standard?, Michael Young, Susan Cardenas, Joseph Donnelly, Mark J. Kittleson

Department of Public Health Scholarship and Creative Works

BACKGROUND

The purpose of the study was to (1) examine attitudes of adolescents toward peer models having sex or choosing abstinence, and (2) determine whether a “double standard” in perception existed concerning adolescent abstinence and sexual behavior.

METHODS

Adolescents (N = 173) completed questionnaires that included 1 of 6 randomly assigned vignettes that described male and female peer models 3 ways: (1) no information about model's sexual behavior, (2) model in love but choosing abstinence, and (3) model in love and having sex. Participants read the vignette to which they had been assigned and responded to statements about the peer …


Using Auditory Feedback To Improve Striking For Mixed Martial Artists, Frank Krukauskas Krukauskas Nov 2016

Using Auditory Feedback To Improve Striking For Mixed Martial Artists, Frank Krukauskas Krukauskas

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to evaluate, auditory feedback as a training procedure to increase the effectiveness of throwing a "right cross.” Auditory feedback was evaluated in multiple baselines across behaviors design with 4 mixed martial arts students, two males and two females, 25-54 years old. The percentage of correct steps of the right crosses.” was stable .during baseline for all participants improved substantially following the introduction of the auditory feedback, and maintained at 90 percent or more for all participants during follow-up.


Connecting Psychopathology Meta-Structure And Mechanisms, Charles A. Sanislow Oct 2016

Connecting Psychopathology Meta-Structure And Mechanisms, Charles A. Sanislow

Charles A. Sanislow, Ph.D.

No abstract provided.


Alleged Insanity: Frank Johnson Sr., Racial Injustice, And The Failure Of The Mental Health Care System In South Carolina, Jonathon P. Johnson Oct 2016

Alleged Insanity: Frank Johnson Sr., Racial Injustice, And The Failure Of The Mental Health Care System In South Carolina, Jonathon P. Johnson

Senior Theses

This thesis is about Frank Johnson Sr. and the circumstances that led to his downfall as a farmer and father of six, to his tragic death in the isolation of a racially segregated mental institution 18 miles away from his home. Using his life and incarceration at the South Carolina State Park mental health facility, I argue that racial injustice contributed to his tragic death and the woefully inadequate treatment thousands of African Americans in South Carolina received during Jim Crow. Additionally, I argue that the tragic circumstances around my great grandfather’s institutionalization and death were part of an enduring …


Effects Of Auditory Vection Speed And Directional Congruence On Perceptions Of Visual Vection, Isabella Alexis Gagliano Oct 2016

Effects Of Auditory Vection Speed And Directional Congruence On Perceptions Of Visual Vection, Isabella Alexis Gagliano

Psychology Theses & Dissertations

Spatial disorientation is a major contributor to aircraft mishaps. One potential contributing factor is vection, an illusion of self-motion. Although vection is commonly thought of as a visual illusion, it can also be produced through audition. The purpose of the current experiment was to explore interactions between conflicting visual and auditory vection cues, specifically with regard to the speed and direction of rotation. The ultimate goal was to explore the extent to which aural vection could diminish or enhance the perception of visual vection. The study used a 3 × 2 within-groups factorial design. Participants were exposed to three levels …


The Effect Of Increased Sleep On The Circadian Rhythm Of Salivary Cortisol Concentrations, Mariah Jacqueline Scott Oct 2016

The Effect Of Increased Sleep On The Circadian Rhythm Of Salivary Cortisol Concentrations, Mariah Jacqueline Scott

Seton Hall University Dissertations and Theses (ETDs)

Cortisol is a salivary marker for the hypothalamic-pituitary-adrenal axis (HPA) component of the stress response. The activity of the HPA demonstrates a circadian rhythm. It is well known that sleep deprivation increases cortisol concentrations. In this study, we looked at the effect of an increase of one-hour sleep for one month on the circadian rhythm of the HPA.

Eight college subjects (n=8) collected saliva during their normal sleep wake cycle every 4 hours for 24 hours. Saliva collections were repeated after a month of increase of sleep by 1-hour. The subjects also completed demographic forms that asked for age, sex, …


Updating The Research Domain Criteria, Charles A. Sanislow Sep 2016

Updating The Research Domain Criteria, Charles A. Sanislow

Charles A. Sanislow, Ph.D.

No abstract provided.


Observational Assessment Of Empathy In Parent-Child Verbal Exchanges And Their Influence On Child Behavior, Patty Carambot Sep 2016

Observational Assessment Of Empathy In Parent-Child Verbal Exchanges And Their Influence On Child Behavior, Patty Carambot

Dissertations, Theses, and Capstone Projects

Empathy, the ability to both experientially share in and understand others’ thoughts, behaviors, and feelings, is vital for human adaptation. Deficits in empathy development have implications across the lifespan for the development of prosocial behavior, social functioning, mental health disorders, and risk for antisocial behavior (e.g., Guajardo, Snyder, & Petersen, 2009; Moreno, Klute & Robinson, 2008). In light of these societal and individual burdens, it is imperative to foster and strengthen the development of this ability early in life to prevent or ameliorate such negative outcomes. This type of prevention can take a variety of forms, but parent and child …


Ptsd From Childhood Trauma As A Precursor To Attachment Issues, Christy Owen Sep 2016

Ptsd From Childhood Trauma As A Precursor To Attachment Issues, Christy Owen

Fidei et Veritatis: The Liberty University Journal of Graduate Research

The past 20 years have been turbulent regarding Reactive Attachment Disorder (RAD), with conflicting research about its causes, effects, treatment, and prognosis. The current diagnostic criteria in the DSM-5 fails to adequately address this disorder. A number of deviant and maladaptive behaviors common amongst children with RAD are not even mentioned in the diagnostic criteria. As such, the diagnostic definition is almost unidentifiable or incompatible with real-life conduct manifestations of the disorder. Rather, this author contends that RAD is foundationally a unique and extreme form of Posttraumatic Stress Disorder (PTSD) from Early Childhood Trauma. The child endured unspeakable neglect and/or …


The Bilingual Brain, Victoria A. James Sep 2016

The Bilingual Brain, Victoria A. James

Journal of Counseling and Psychology

This literature review explores the neurocognitive effects of the bilingual brain. Many areas of bilingualism are examined such as age of acquisition, which is when the second language is attained, and memory. The three types of bilingual memory are implicit memory, which is procedural memory, explicit memory, which is declarative memory, and episodic memory, which is autobiographical memory. In relation to the bilingual brain, cognition, control, and /lateralization are also reviewed. Finally, second language (L2) learning strategies are considered. The objective of this study is to obtain an understanding on how two or more languages are acquired and processed in …


Emotion Moderates The Association Between Htr2a (Rs6313) Genotype And Antisaccade Latency, Mark S. Mills, Olivia Wieda, Scott F. Stoltenberg, Michael Dodd Sep 2016

Emotion Moderates The Association Between Htr2a (Rs6313) Genotype And Antisaccade Latency, Mark S. Mills, Olivia Wieda, Scott F. Stoltenberg, Michael Dodd

Department of Psychology: Faculty Publications

The serotonin system is heavily involved in cognitive and emotional control processes. Previous work has typically investigated this system’s role in control processes separately for cognitive and emotional domains, yet it has become clear the two are linked. The present study, therefore, examined whether variation in a serotonin receptor gene (HTR2A, rs6313) moderated effects of emotion on inhibitory control. An emotional antisaccade task was used in which participants looked toward (prosaccade) or away (antisaccade) from a target presented to the left or right of a happy, angry, or neutral face. Overall, antisaccade latencies were slower for rs6313 C allele homozygotes …


Reactivity And Recovery Among Oif/Oef/Ond Combat Veterans: Do Those With Subthreshold Ptsd Differ From Veterans With And Without Ptsd?, Paula Castro-Chapman Aug 2016

Reactivity And Recovery Among Oif/Oef/Ond Combat Veterans: Do Those With Subthreshold Ptsd Differ From Veterans With And Without Ptsd?, Paula Castro-Chapman

USF Tampa Graduate Theses and Dissertations

This study expanded the current literature by assessing PTSD in relation to reactivity and recovery from negative emotional arousal among OEF/OIF/OND Veterans. Cardiac impedance was employed during a speech task and a trauma imagery procedure. Those in the PTSD-S group displayed lower SBP and higher TPR reactivity relative to the PTSD- and PTSD+ groups; lower CO reactivity relative to the PTSD+ group; and more CO recovery than those in the PTSD+ group to the trauma task. For speech task, Veterans in the PTSD-S group exhibited lower HR reactivity for both speech preparation and delivery than those in the PTSD- group. …


Neural Mechanisms Of Action Switching Moderate The Relationship Between Effortful Control And Aggression, Eric L. Rawls Aug 2016

Neural Mechanisms Of Action Switching Moderate The Relationship Between Effortful Control And Aggression, Eric L. Rawls

University of New Orleans Theses and Dissertations

Aggression and violence are social behaviors that exact a significant toll on human societies. Individuals with aggressive tendencies display deficits in effortful control, particularly in affectively charged situations. However, not all individuals with poor effortful control are aggressive. This study uses event-related potentials (ERPs) to decompose the chronology of cognitive functions underlying the link between effortful control and aggression. Specifically, this study investigates which ERPs moderate the effortful control - aggression association. We examined three successive ERP components (P2, N2 and P3) for stimuli that required effortful control. Results indicated that N2 activation, but not P2 or P3 activation, moderated …


Investigating The Role Of Testosterone Signaling At Androgen Receptors In Resiliency To Social Stress, Catherine Tucker Clinard Aug 2016

Investigating The Role Of Testosterone Signaling At Androgen Receptors In Resiliency To Social Stress, Catherine Tucker Clinard

Doctoral Dissertations

Social experience can alter how individuals cope with stressful events and contribute to individual differences in stress vulnerability. We have previously tested dominant and subordinate male Syrian hamsters (Mesocricetus auratus) in a conditioned defeat model and found that dominant individuals show reduced defeat-induced changes in behavior compared to subordinates. Dominant hamsters also show increased neural activation following social defeat stress in brain regions that regulate social behavior and coping with stress, including the medial amygdala (MeA). Because winning aggressive encounters generates a surge in plasma testosterone and androgen receptors are abundant in the MeA, we tested whether testosterone …


Therapy Dogs In The College Classroom: The Effect Of Dogs On Stress, Anxiety, And Spanish L2 Phonological Learning And Performance, Elaine Maralee Henry Aug 2016

Therapy Dogs In The College Classroom: The Effect Of Dogs On Stress, Anxiety, And Spanish L2 Phonological Learning And Performance, Elaine Maralee Henry

Doctoral Dissertations

Anxiety and stress invoked by the second language classroom setting has the ability to cause numerous detrimental physiological changes which impair the learning process. A more natural, “immersion” type atmosphere is often desired when teaching a second language; however, this is not typically possible with college classes. Therefore, the addition of therapy dogs to college second language classes may be a beneficial solution since therapy dogs are frequently cited as having the ability to lower stress and anxiety in many different settings. Stroking and interacting with a dog may reduce many markers of stress, including blood pressure, heart rate, and …


An Investigation Of Short-Term Plasticity In Human Motor Cortex, Matthew Alan Gannon Aug 2016

An Investigation Of Short-Term Plasticity In Human Motor Cortex, Matthew Alan Gannon

Graduate Theses and Dissertations

Transcranial magnetic stimulation (TMS) produces a transient magnetic field that activates underlying cortical tissue by eliciting an electrical discharge of the neurons in the targeted area. Repetitive TMS (rTMS) uses patterns of repetitive TMS pulses and has been reliably shown to produce changes in the state of cortical excitability outlasting the time of stimulation. One such protocol that has demonstrated states of increased excitability is intermittent theta burst stimulation (iTBS). This method applies high-frequency bursts (50Hz) of pulses every 200 ms in trains of ten bursts. The effects of and differences between rTMS protocols have been investigated since gaining popularity …


Perseverance: Psychospiritual And Genetic Perspectives, Tony N. Jelsma, Arielle Johnston, Bruce Vermeer Jul 2016

Perseverance: Psychospiritual And Genetic Perspectives, Tony N. Jelsma, Arielle Johnston, Bruce Vermeer

Faculty Work Comprehensive List

Perseverance constitutes a quality that motivates humankind to press onward usually in the face of significant adversity and resistance. Perseverance is also important in the Christian life. The apostle Paul, using athletic training metaphors, frequently urges his readers to persevere in the faith, even describing his own life as a fight and a race (2 Tim.4:7). Yet, certain groups of people seem to possess a greater measure of perseverance than others have. We are therefore led to ask, “Can our ability to persevere be, in God’s providence, at least partly genetically influenced?”


The Contribution Of The Pineal Gland On Daily Rhythms And Masking In Diurnal Grass Rats, Arvicanthis Niloticus, Dorela D. Shuboni, Amna A. Agha, Thomas K. H. Groves, Andrew J. Gall Jul 2016

The Contribution Of The Pineal Gland On Daily Rhythms And Masking In Diurnal Grass Rats, Arvicanthis Niloticus, Dorela D. Shuboni, Amna A. Agha, Thomas K. H. Groves, Andrew J. Gall

Faculty Publications

Melatonin is a hormone rhythmically secreted at night by the pineal gland in vertebrates. In diurnal mammals, melatonin is present during the inactive phase of the rest/activity cycle, and in primates it directly facilitates sleep and decreases body temperature. However, the role of the pineal gland for the promotion of sleep at night has not yet been studied in non-primate diurnal mammalian species. Here, the authors directly examined the hypothesis that the pineal gland contributes to diurnality in Nile grass rats by decreasing activity and increasing sleep at night, and that this could occur via effects on circadian mechanisms or …


Examination Of Methamphetamine Reinstatement In Female And Male Rats: A Pre-Clinical Model Of Relapse, Steven T. Pittenger Jun 2016

Examination Of Methamphetamine Reinstatement In Female And Male Rats: A Pre-Clinical Model Of Relapse, Steven T. Pittenger

Department of Psychology: Dissertations, Theses, and Student Research

Methamphetamine (meth) dependence is often characterized by persistent and chronic relapse (i.e., return to drug use). There is growing pre-clinical and human evidence suggesting females are at greater risk to relapse. The set of studies presented in this dissertation extended this limited evidence by identifying sex-dependent neural substrates correlated with meth-triggered reinstatement (Experiment 1) and by examining sex-differences in reinstatement triggered by drugs of abuse that are commonly co-abused with meth (Experiment 2). Female and male rats were trained to self-administer meth, received subsequent extinction sessions, and then tested for reinstatement. In Experiment 1, rats were perfused following reinstatement testing …


Importance Of The D2 Receptor For One- And Multi-Trial Psychostimulant-Induced Behavioral Sensitization In Preweanling Rats, Martha A. Mohd-Yusof Jun 2016

Importance Of The D2 Receptor For One- And Multi-Trial Psychostimulant-Induced Behavioral Sensitization In Preweanling Rats, Martha A. Mohd-Yusof

Electronic Theses, Projects, and Dissertations

The neural mechanisms mediating one-trial and multi-trial behavioral sensitization during early ontogeny are poorly understood. The purpose of this thesis was to assess the importance of D2-like receptors for the induction of cocaine- and methamphetamine-induced one-trial and multi-trial behavioral sensitization during the middle and late preweanling period. In a series of four experiments, rats were injected with saline or the selective dopamine D2-like receptor antagonist raclopride 15 min prior to treatment with the indirect dopamine agonists cocaine or methamphetamine. Acute control groups received two injections of saline. The pretreatment regimens occurred on either PND 16 or PND 20 (one-trial behavioral …


Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant Jun 2016

Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant

Electronic Theses, Projects, and Dissertations

A problematic connection has been reported between those who use nicotine related products alone or in combination with ADHD medications, like methylphenidate (MPH), in late childhood or early adolescence and the increased likelihood of later marijuana abuse in adulthood. Pre-clinical studies have found that the use of nicotine during the early adolescence period produces enduring changes to the endocannabinoid system in the brain. Since CB agonists, like marijuana, exert their effect through the eCB system, it is possible that early nicotine use may alter the rewarding nature of CB agonists in adulthood. In addition, MPH has also been shown to …


The Effects Of Lipopolysaccharide-Induced Neuroinflammation On Learning And Forgetting In Juvenile Rats, Michele Barry May 2016

The Effects Of Lipopolysaccharide-Induced Neuroinflammation On Learning And Forgetting In Juvenile Rats, Michele Barry

Seton Hall University Dissertations and Theses (ETDs)

The inability to remember events experienced very early in life is referred to as Infantile Amnesia (IA) and has been observed in both humans and animals. Over the years interest in the phenomenon waned, but has recently increased with the discovery of new neurobiological methods to study brain function (e.g., Callaghan, Li & Richardson, 2014). The neurobiological mechanism behind IA has yet to be determined, but several innovative theories have been developed with these new research methods. The neurogenesis hypothesis theorizes that increased neurogenesis during early development disrupts previously established memories. The hippocampus, an area that mediates both the memory …


Do Rats Consume Ethanol To Regulate A Negative Emotion Induced By A Successive Negative Contrast Procedure?, Andrew Dieterich May 2016

Do Rats Consume Ethanol To Regulate A Negative Emotion Induced By A Successive Negative Contrast Procedure?, Andrew Dieterich

Seton Hall University Dissertations and Theses (ETDs)

According to the self-medication hypothesis, individuals may consume drugs or alcohol, or engage in other behaviors in order to reduce a negative emotional state (Khantzian, 1985; Gross, 2013; Crum et al., 2013). Rats experiencing a negative state induced by various stressors (Bertholomey et al., 2010), or a decrease or loss in reward value of a sucrose solution (Manzo et al., 2015; Manzo et al., 2014) demonstrate increased consumption of alcohol. I used successive (SNC) and anticipatory negative contrast (ANC) procedures to further examine this hypothesis and the previous findings (Manzo et al., 2015), that rats increase consumption and preference for …


Working Memory Impairments In Chromosome 22q11.2 Deletion Syndrome: The Roles Of Anxiety And Stress Physiology, Ashley F. P. Sanders May 2016

Working Memory Impairments In Chromosome 22q11.2 Deletion Syndrome: The Roles Of Anxiety And Stress Physiology, Ashley F. P. Sanders

University of New Orleans Theses and Dissertations

Stress and anxiety negatively impact the working memory system by competing for executive resources. Broad memory deficits have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing children (M = 11.10 years, SD = 2.95). Results indicate reduced post-stress RSA recovery and overall increased levels of cortisol in children with 22q11.2DS. Additionally, anxiety mediated the relationship between 22q11.2DS and visuospatial working memory impairment. However, there was no indication that stress response physiology mediated this association. …