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Articles 1 - 30 of 45
Full-Text Articles in Biological Psychology
Exposure To The Trier Social Stress Test Enhances Central Detail Memory, Reduces False Memory, And Results In Intrusive Memories That Last For Days, Mercedes L. Stanek, Kayla Boaz, Taylor D. Niese, Kristen E. Long, Matthew S. Risner, John G. Blasco, Koen N. Suzelis, Kelsey M. Siereveld, Boyd R. Rorabaugh, Phillip R. Zoladz
Exposure To The Trier Social Stress Test Enhances Central Detail Memory, Reduces False Memory, And Results In Intrusive Memories That Last For Days, Mercedes L. Stanek, Kayla Boaz, Taylor D. Niese, Kristen E. Long, Matthew S. Risner, John G. Blasco, Koen N. Suzelis, Kelsey M. Siereveld, Boyd R. Rorabaugh, Phillip R. Zoladz
ONU Student Research Colloquium
Recent work has used a modified version of the well-known laboratory stressor, the Trier Social Stress Test (TSST), to study participant memory for a stressful experience. The paradigm is useful because, unlike most studies examining stress effects on memory, it allows investigators to measure what participants remember about the stressor, not unrelated information. It also presents an opportunity to model other stress-related symptoms, such as intrusive memories, but these have yet to be assessed with this paradigm. Intrusive memories have been notoriously difficult to measure in laboratory settings; most of this research involves participants watching arousing videos and subsequently reporting …
A Preliminary Timeline Of The Midbrain Development In The Monodelphis Domestica Animal Model, Ismael Perez, John L. Vandeberg, Mario Gil
A Preliminary Timeline Of The Midbrain Development In The Monodelphis Domestica Animal Model, Ismael Perez, John L. Vandeberg, Mario Gil
Research Colloquium
Introduction: The Brazilian short-tailed opossum (Monodelphis Domestica) is an understudied animal model compared to the Mus musculus that has been identified as a perfect candidate to study neurodevelopment (Baggott, L. & Moore, H., 1990). What makes the Monodelphis Domestica a perfect specimen for neurodevelopment is that the embryo develops outside the pouch of the mother providing easy noninvasive access to track changes across different developmental stages (Mate et al., 1994).
Objective: The objective of the study is to compare the area and volume in the development of the Monodelphis’s midbrain across three different developmental stages. Our research is beneficial because …
Sex Differences In Stress Reactivity And Responses To Novelty In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Nicole Altamirano, Joseph Rafac, Katelynn Renteria, John L. Vandeberg, Mario Gil
Sex Differences In Stress Reactivity And Responses To Novelty In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Nicole Altamirano, Joseph Rafac, Katelynn Renteria, John L. Vandeberg, Mario Gil
Research Colloquium
Introduction: Investigating how exposures to stress and novel environments influence behavior is important for translational research that aims to improve mental health. Previous studies have focused on reactions to novelty and revealed changes in defense reactions and exploratory behavior. (Pisula et al., 2012).
Objective: The focus of the present study is to investigate sex differences in behavioral responses to novel environments and restraint stress in the gray short-tailed opossums (Monodelphis domestica). Using the Monodelphis is innovative because it is a non-traditional animal model that is ideal for developmental research.
Methods: Using AnyMaze video tracking software, animals’ behaviors (6 males, 6 …
The Impact Of Biological Sex On Motor Function And Responses To Novel Environments In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Ismael Perez, Sasawan Heingraj, Katelynn Renteria, Cristian M. Botello, Joseph C. Cantu, John L. Vandeberg, Mario Gil
The Impact Of Biological Sex On Motor Function And Responses To Novel Environments In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Ismael Perez, Sasawan Heingraj, Katelynn Renteria, Cristian M. Botello, Joseph C. Cantu, John L. Vandeberg, Mario Gil
Research Symposium
Background: Understanding the different stress reactions in different environments can help us understand stress factors. Studying animal behavior is important for translational research for mental health improvement.
Previous literature has shown that stress is a risk factor for higher cancer incidence and poorer cancer survival. (Klejbor & Turlejski., 2012), as well as mental health outcomes. Understanding of how stress is related to cancer can help improve therapeutic outcomes as preventive measures (Glaser et al., 1987).
Methods: Using the Rota Rod apparatus, 12 animals (3 males, 9 females) were tested at 36 rpm for a maximum of 400 seconds (Madroñal et …
A Neurodevelopmental Perspective To Improve Innovation In Preventive Treatment Of Substance Use Disorders, Ismael Perez, John Vandeberg, Mario Gil
A Neurodevelopmental Perspective To Improve Innovation In Preventive Treatment Of Substance Use Disorders, Ismael Perez, John Vandeberg, Mario Gil
Research Symposium
Background: Midbrain dopaminergic neurons have been associated with substance use disorders (Blaess & Ang, 2015). Understanding their neurodevelopment during early stages of life is fundamental for innovating preventive care treatments. The animal model Monodelphis domestica has been proposed as an excellent candidate to study neurodevelopmental changes due to the ease of access to see changes in their embryonic development (Mate et al., 1994). The purpose of our study is to inform how brain cells, including and especially dopaminergic neurons, mature by quantifying their number during early development. Additionally, the study aims to compare different midbrain areas and track neurodevelopmental changes …
Low-Dose Psilocybin Enhances Novel Object Recognition But Not Inhibitory Avoidance In Adult Rats, Claire E. Miller, Colin R. Del Valle, Margaret M. Naylor, Heather R. Sparkman, Connor M. Cruea, Rachel E. Rice, Brooke E. Bramlage, Lillianna P. Puppel, Madison L. Brown, Aleece K. Al-Olimat, Elizabeth S. Dietz, Phillip R. Zoladz
Low-Dose Psilocybin Enhances Novel Object Recognition But Not Inhibitory Avoidance In Adult Rats, Claire E. Miller, Colin R. Del Valle, Margaret M. Naylor, Heather R. Sparkman, Connor M. Cruea, Rachel E. Rice, Brooke E. Bramlage, Lillianna P. Puppel, Madison L. Brown, Aleece K. Al-Olimat, Elizabeth S. Dietz, Phillip R. Zoladz
ONU Student Research Colloquium
Given the recently renewed interest in using psychedelics to aid in the treatment of psychological disorders, we aimed to examine the impact of psilocybin, a 5-HT2A agonist, on learning and memory in rodents. Previous work has demonstrated that psilocybin and other 5-HT2A agonists can enhance fear conditioning, fear extinction, and novel object recognition (NOR). Thus, we predicted that low doses of psilocybin would enhance inhibitory avoidance (IA) and NOR memory. In the first experiment, adult male and female Sprague-Dawley rats underwent step-through IA training (involving 0.45, 0.65, or 1 mA scrambled footshock) and were injected intraperitoneally (i.p.) with …
Psilocybin Prevents Symptoms Of Hyperarousal And Enhances Novel Object Recognition In Rats Exposed To The Single Prolonged Stress Paradigm, Colin R. Del Valle, Heather R. Sparkman, Margaret M. Naylor, Connor M. Cruea, Rachel E. Rice, Claire E. Miller, Brooke E. Bramlage, Lillianna P. Puppel, Madison L. Brown, Aleece K. Al-Olimat, Elizabeth S. Dietz, Phillip R. Zoladz
Psilocybin Prevents Symptoms Of Hyperarousal And Enhances Novel Object Recognition In Rats Exposed To The Single Prolonged Stress Paradigm, Colin R. Del Valle, Heather R. Sparkman, Margaret M. Naylor, Connor M. Cruea, Rachel E. Rice, Claire E. Miller, Brooke E. Bramlage, Lillianna P. Puppel, Madison L. Brown, Aleece K. Al-Olimat, Elizabeth S. Dietz, Phillip R. Zoladz
ONU Student Research Colloquium
Pharmacotherapy for stress-related psychological disorders remains inadequate. Patients who are treated with conventional pharmacological agents frequently report negligeable symptom reduction, and, in most cases, less than 50% experience full remission. Clearly, there is a need for additional pharmaceutical research into both established and novel approaches to alleviate these conditions. Over the past several years, there has been a renewed interest in the use of psychedelics to aid in the treatment of psychological disorders. Several studies have reported promising results in patients with major depression, anxiety disorders, and post-traumatic stress disorder (PTSD) following treatment with psychedelic agents such as lysergic acid …
Tunnel Vision, False Memories, And Intrusive Memories Following Exposure To The Trier Social Stress Test, Chloe N. Cordes, Cassidy L. Pfister, Kayla M. Boaz, Taylor D. Niese, Sydney L. Parker, Kristen E. Long, Mercedes L. Stanek, Matthew S. Risner, John G. Blasco, Koen N. Suzelis, Kelsey M. Siereveld, Shannon B. Carnes, Boyd R. Rorabaugh, Phillip R. Zoladz
Tunnel Vision, False Memories, And Intrusive Memories Following Exposure To The Trier Social Stress Test, Chloe N. Cordes, Cassidy L. Pfister, Kayla M. Boaz, Taylor D. Niese, Sydney L. Parker, Kristen E. Long, Mercedes L. Stanek, Matthew S. Risner, John G. Blasco, Koen N. Suzelis, Kelsey M. Siereveld, Shannon B. Carnes, Boyd R. Rorabaugh, Phillip R. Zoladz
ONU Student Research Colloquium
Most research examining the impact of stress on learning and memory has exposed participants to a stressor and measured how it affects learning and memory for unrelated material (e.g., list of words). Such work has been helpful, but it has not been the most translational to the human condition. When considering phenomena such as intrusive memories in post-traumatic stress disorder (PTSD) or an eyewitness's memory for a crime, it is most useful to know what an individual remembers about the stress experience itself, not unrelated information. In prior work, investigators used a modified version of the Trier Social Stress Test …
Impact Of Acute Stress, Sex, And Childhood Maltreatment On Fear Learning And Fear Generalization In A Fear-Potentiated Startle Paradigm, Kayla M. Boaz, Chloe N. Cordes, Cassidy L. Pfister, Taylor D. Niese, Sydney L. Parker, Kristen E. Long, Mercedes L. Stanek, Boyd R. Rorabaugh, Seth D. Norrholm, Phillip R. Zoladz
Impact Of Acute Stress, Sex, And Childhood Maltreatment On Fear Learning And Fear Generalization In A Fear-Potentiated Startle Paradigm, Kayla M. Boaz, Chloe N. Cordes, Cassidy L. Pfister, Taylor D. Niese, Sydney L. Parker, Kristen E. Long, Mercedes L. Stanek, Boyd R. Rorabaugh, Seth D. Norrholm, Phillip R. Zoladz
ONU Student Research Colloquium
Many researchers approach the etiology of trauma-, stressor-, and anxiety-related mental disorders from the perspective of classical conditioning processes gone awry. According to this view, abnormal associative relationships between conditioned and unconditioned stimuli may underlie pathological anxiety and result in unusually intense fear memories or fear memories that cannot be properly extinguished. Recent work has expanded on this view by showing that many psychological disorders involving pathological anxiety are associated with an exaggerated form of stimulus generalization, leading individuals with such disorders to respond with fear and anxiety to a variety of contexts and cues that should not be threatening. …
"Alcohol Is Not Fun Anymore!": A Study Of Alcohol Expectancies During Covid-19, Sara Mcfarland, Katie Ison, Heather Kissel Phd, Ty Brumback Phd
"Alcohol Is Not Fun Anymore!": A Study Of Alcohol Expectancies During Covid-19, Sara Mcfarland, Katie Ison, Heather Kissel Phd, Ty Brumback Phd
Posters-at-the-Capitol
College parties normalize alcohol use and students develop expectations about drinking due to peer influence and previous experience with alcohol. Our study investigated changes in alcohol expectancies by collecting cross-sectional data on predictors of alcohol use in young adults before and after the start of the pandemic. Data for 46 participants (mean age=20.74, 72% female) were collected prior to March 2020, while data for an additional 26 participants (mean age=19.27, 80.8% female) were collected starting in 2021. During the laboratory session, participants completed surveys and a structured clinical interview. We examined responses from the Alcohol Expectancy Questionnaire (AEQ). This self-report …
Understanding The Contributions Of Hormonal Contraceptives And Cortisol Levels To Fear Learning In Women, Sahil Bardai
Understanding The Contributions Of Hormonal Contraceptives And Cortisol Levels To Fear Learning In Women, Sahil Bardai
Symposium of Student Scholars
Women are twice as likely to be diagnosed with an anxiety disorder than men. Eighty-five percent of women in the US will use hormonal contraceptives at some point in their lifetime. Women who use hormonal contraceptives show heightened startle reactivity to a threatening stimulus. Previous results from our lab showed a significant increase in fear-potentiated startle (FPS) in women who were on hormonal contraceptives compared to women who were naturally cycling. These results stayed consistent throughout three acquisition trials. Others have shown that the use of OCPs (oral contraceptive pills) is related to the dysregulation of the HPA-axis and elevated …
The Effects Of The Aromatase Inhibitor, Letrozole, On Lithium Chloride (Licl)-Induced Conditioned Disgust Behaviour (Anticipatory Nausea) In Male Rats, Vangel Matic
Undergraduate Student Research Internships Conference
Anticipatory Nausea (AN) is a form of classical conditioning in which the effects of a nausea-inducing toxin become associated with a specific environmental context. AN is often experienced by individuals receiving chemotherapy treatment, whereby the emetic effects of the chemotherapy agents become associated with the treatment context (i.e. hospital, clinic), such that exposure to the context alone can cause an individual to experience nausea and potentially withdraw from treatment. Chemotherapy-associated AN is suggested to have a higher incidence in females compared to males.
AN can be represented in a rodent model (conditioned disgust) through the occurrence of conditioned gaping behaviour …
Substance Use Disorders, Cognitive Dysfunction, And Neurodivergence In Emerging Adulthood, David Posada, Jordyn Hebert
Substance Use Disorders, Cognitive Dysfunction, And Neurodivergence In Emerging Adulthood, David Posada, Jordyn Hebert
Symposium of Student Scholars
Substance Use Disorders, Cognitive Dysfunction, and Neurodivergence in Emerging Adulthood
Posada, D., Herbert, J., Weingast, L., Holliday, E.
Cognitive functioning in college students with substance use disorders (SUD) has been widely researched, however, discussions have largely concentrated on executive functions (EF) such as working memory, flexible thinking, and self-control. Literature on the relationship between cognitive dysfunction and SUD has largely underreported the influence of Attention Deficit/Hyperactivity Disorders (ADD/ADHD) and other neurodivergent characteristics. The current review explores the state of the literature on the relationship between neurodivergence, cognitive dysfunction, and SUD in emerging adulthood. More specifically, it speculates whether college students …
Oxytocin Does Not Mediate Lithium Chloride (Licl)-Induced Non-Social Environmentally Conditioned Disgust Behaviour (Anticipatory Nausea) In Male Rats, Vangel Matic
Undergraduate Student Research Internships Conference
Introduction. Anticipatory Nausea (AN) is a form of classical conditioning in which the effects of a nausea-inducing substance, such as lithium chloride (LiCl), become associated with a social or environmental context. In rats, AN can be measured by the frequency of conditioned gaping behaviour, displayed when rats are re-exposed to a context previously associated with LiCl. Oxytocin (OT) may be involved in the mediation of socially conditioned disgust, though its role in mediating non-social environmentally conditioned disgust is unclear. The purpose of the present study was to investigate the role of OT in mediating environmentally conditioned disgust. It was hypothesized …
249— The Role Of The Indirect Basal Ganglia Pathway In A Mouse Model Of Repetitive Circling Behavior, Gavin Vaughan, Allison R. Bechard
249— The Role Of The Indirect Basal Ganglia Pathway In A Mouse Model Of Repetitive Circling Behavior, Gavin Vaughan, Allison R. Bechard
GREAT Day Posters
Repetitive behaviors are associated with a variety of disorders in humans and are diagnostic for autism spectrum disorders. Repetitive behaviors can be modeled in rodents. In our previous experiments, we have been able to reduce repetitive circling behaviors in mice using a ketogenic diet. The mechanisms behind the ketogenic diet are still under investigation. Previous investigations have indicated that the ketogenic diet plays a role in neurotransmitter functioning. This study sought to investigate the potential role of neurotransmitters in repetitive behaviors by investigating how three drugs (L-741,626, a dopamine receptor antagonist; CGS21680, an adenosine agonist; & CDPPB, a glutamate positive …
258— Differential Response To Cocaine In Mice Exposed To Stress, Gavin Vaughan, Melissa Herman, Isabel Ross, Katie Bugbee, April Rowell, Jennifer Bodzon, Allison R. Bechard Ph.D.
258— Differential Response To Cocaine In Mice Exposed To Stress, Gavin Vaughan, Melissa Herman, Isabel Ross, Katie Bugbee, April Rowell, Jennifer Bodzon, Allison R. Bechard Ph.D.
GREAT Day Posters
Exposure to trauma is a risk factor for substance use disorders. Using a mouse model of PTSD, we tested the effects of exposure to a stressor (synthetic fox pheromone: TMT) on response to cocaine. Cocaine induced locomotion and cocaine seeking behavior in a conditioned place preference (CPP) were assessed. TMT was an effective stressor, indicated by freezing behavior, which is a known fear response in mice. In both males and females, TMT-exposed mice showed a greater locomotor response to cocaine compared to control mice, resulting in the interaction between time and TMT treatment. TMT-exposed males, but not females, were overall …
The Relationship Among Social Support, Stress, And Inflammatory Markers Among College Students: A Correlational Study, Bailey Bryant
The Relationship Among Social Support, Stress, And Inflammatory Markers Among College Students: A Correlational Study, Bailey Bryant
Campus Research Day
The relationship between psychological factors and the immune system is a relatively new area of study. Nevertheless, it has been found that significant relationships do exist among these variables; prolonged exposure to maladaptive forms of these variables may lead to the development or expression of inflammation. There is, however, a lack of studies that look at more than one variable in relationship to inflammation at a time. Thus, this study analyzes the correlation among social support, stress, and inflammatory markers among college students.
Keywords: mood, stress, inflammation, inflammatory markers, IL-6, social support, susceptibility
The Relationship Among Social Support, Stress, And Inflammatory Markers Among College Students: A Correlational Study, Bailey Bryant
The Relationship Among Social Support, Stress, And Inflammatory Markers Among College Students: A Correlational Study, Bailey Bryant
Campus Research Day
The relationship between psychological factors and the immune system is a relatively new area of study. Nevertheless, it has been found that significant relationships do exist among these variables; prolonged exposure to maladaptive forms of these variables may lead to the development or expression of inflammation. There is, however, a lack of studies that look at more than one variable in relationship to inflammation at a time. Thus, this study analyzes the correlation among social support, stress, and inflammatory markers among college students.
161— The Effects Of Environment On The Development Of Cocaine-Seeking, Gavin Vaughan, Akane Ichiki, Shreyya Malik, Allison R. Bechard
161— The Effects Of Environment On The Development Of Cocaine-Seeking, Gavin Vaughan, Akane Ichiki, Shreyya Malik, Allison R. Bechard
GREAT Day Posters
Cocaine addiction is a major individual and societal issue. This study aimed to investigate the environmental and social factors that influence the development of cocaine addiction. Mice were reared in either standard housing or enriched housing. Cocaine preference was measured using the Conditioned Place Preference paradigm, in which subjects are conditioned to associate an injection of cocaine (20mg/kg. I.P.) with a particular side of a 3 chambered arena. Subjects reared in enriched environments displayed increased preference for cocaine in cue primed tests. All subjects displayed cocaine preference in cocaine primed tests. This may be attributed to the enhanced memory that …
416— The Effects Of Early Life Trauma On Anxiety And Alcohol Use Is Modified By Environment, Katie Kompanijec, Keara Mullin, Gavin Vaughan, Melissa Herman, Allison Bechard
416— The Effects Of Early Life Trauma On Anxiety And Alcohol Use Is Modified By Environment, Katie Kompanijec, Keara Mullin, Gavin Vaughan, Melissa Herman, Allison Bechard
GREAT Day Posters
Early life trauma is a risk factor for later anxiety and alcohol use disorders. However, the role of the post-trauma environment on the development of such disorders is not well understood. In the present study we investigated experience-dependent changes in anxiety and alcohol use after exposure to early trauma. Young mice (day 23) were exposed to a predator odor (synthetic fox pheromone, TMT) and then reared in either standard (SE) or enriched environments (EE). Adolescent anxiety and conditioned fear were reduced in EE-males, but not EE-females. Adult mice were then tested for their preference to drink alcohol. Alcohol intake escalated …
130— Reducing Stereotypic Behavior With A Ketogenic Diet, Anna Beltramini, Andrew Guido, Alicia Bauers, Joe Spano
130— Reducing Stereotypic Behavior With A Ketogenic Diet, Anna Beltramini, Andrew Guido, Alicia Bauers, Joe Spano
GREAT Day Posters
Now a popular fad diet, the ketogenic diet (KD) is a high-fat, low-carb diet that for decades has been used for treatment of intractable epilepsy. Recent therapeutic applications of KD in animal models include treatment of dementia, obsessive-compulsive disorder, and autism. These disorders are associated with stereotypic behaviors (repetitive, invariant behaviors with no apparent function) that are life-impairing and stigmatizing. However, little is known about their underlying mechanisms and no effective pharmacological treatments are available. Here, we present a novel application of KD to reduce stereotypic behavior in an inbred strain of mice (FVBN/J) that displays a prominent repetitive circling …
159— The Effects Of Trauma On The Response To Cocaine, Gavin Vaughan, Melissa Herman, Katie Kompanijec, Maren Hogan, Annaclaire Modico, Keara Mullin, Allison R. Bechard Ph.D.
159— The Effects Of Trauma On The Response To Cocaine, Gavin Vaughan, Melissa Herman, Katie Kompanijec, Maren Hogan, Annaclaire Modico, Keara Mullin, Allison R. Bechard Ph.D.
GREAT Day Posters
Exposure to adverse events is a risk factor for substance use disorder. We modeled this in an inbred strain of mice by exposing adult males to a predator odor (a synthetic fox pheromone, TMT) and then assessing 1. Cocaine-induced locomotion, and 2. Conditioned place preference (CPP) of cocaine. TMT was an effective stressor as indicated by freezing behavior, an absence of movement that is an instinctive fear response in mice. Interestingly, in a 1-hour baseline locomotor test, TMT-exposed (TMT+) mice were more active than non-exposed (TMT-) mice. In addition, following a cocaine (10 mg/kg) injection (i.p.) TMT+ mice showed a …
Is The Relationship Between Early Life Stress And Attachment Modulated By Dna Methylation Of The Oxytocin Receptor Gene?, Lidia Boghean
Is The Relationship Between Early Life Stress And Attachment Modulated By Dna Methylation Of The Oxytocin Receptor Gene?, Lidia Boghean
UNO Student Research and Creative Activity Fair
Early life stress (ELS) has been linked to endocrine dysregulation, insecure attachment styles, and adult psychopathology. The enduring effects of ELS are likely regulated by epigenetic mechanisms in which the environment influences gene transcription and protein expression. We investigated oxytocin receptor gene (OXTR) methylation as a potential underlying mechanism by which early life stress affects stress reactivity and attachment later in life in a dog model system. 47 dog-owner dyads were grouped by dog early life history (ELS and non-ELS) and provided blood and saliva samples. Dyads participated in a behavioral attachment paradigm. ELS dogs showed increased methylation at one …
Mouse Performance On A Novel Touchscreen Continuous Performance Task Is Dependent On Signaling In The Prelimbic Cortex, Tyler D. Dexter, Daniel Palmer, Amy C. Reichelt, Anita Taksokhan, Lisa M. Saksida, Tim J. Bussey
Mouse Performance On A Novel Touchscreen Continuous Performance Task Is Dependent On Signaling In The Prelimbic Cortex, Tyler D. Dexter, Daniel Palmer, Amy C. Reichelt, Anita Taksokhan, Lisa M. Saksida, Tim J. Bussey
Western Research Forum
Attention is the cognitive processing that facilitates the ability to target and attend to relevant environmental stimuli, while filtering out irrelevant or distracting stimuli. Control over selective attention is theorized to be dependent on organized neural communication that stems from the medial prefrontal cortex (mPFC). To evaluate selective and sustained attention, mice were trained on the novel touchscreen rodent continuous performance task (rCPT), a task designed to emulate the human CPT. In the rodent version, images are continuously presented on a touchscreen, where mice have been trained to selectively respond to one image type while suppressing responses to all others. …
Blood, Meth, And Tears: The Super Soldiers Of World War Ii, Nicholas Racine
Blood, Meth, And Tears: The Super Soldiers Of World War Ii, Nicholas Racine
MAD-RUSH Undergraduate Research Conference
Day and night, soldiers in World War II were physically and mentally strained by fatigue and psychiatric distress. Consequently, many soldiers were left exhausted and demoralized. War efforts hinged on soldiers succeeding in missions, thus a fast-acting solution was needed. Development of the psychostimulant drugs Benzedrine and Pervitin in the 1920s and 30s spurred enthusiasm among scientists, the media, the public, and various governments. Potent and powerful, these drugs exert effects that promote wakefulness, elevated mood, and improved field performance. Governments quickly began researching use of stimulants to improve their war efforts. By the early 40s, both drugs had millions …
The Effects Of Relationships On Ans Function And Wellness, Olivia M. Maples
The Effects Of Relationships On Ans Function And Wellness, Olivia M. Maples
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
The quality of relationships and social networks plays a vital role on well-being (Feeney & Collins, 2015). Social support is linked to positive biological profiles in that social support protects against the negative effects of changes in cardiovascular, neuroendocrine, and immune function. Furthermore, when exploring Autonomic Nervous System (ANS) function, higher heart rate variability has been shown to reflect a psychophysiological state compatible with social interaction (Quintana, Guastella, Outhred, Hickie, & Kemp, 2012). Social support has been shown to buffer against the negative effects of life stressors (Cohen & Wills, 1985), and ultimately, mortality (Holt-Lunstad, Smith, & Layton, 2010). In …
Acute Social Defeat-Induced Neuroinflammation In The Vmpfc Of Syrian Hamsters Via Microglial Activation, Thomas Clarity
Acute Social Defeat-Induced Neuroinflammation In The Vmpfc Of Syrian Hamsters Via Microglial Activation, Thomas Clarity
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Research suggests causal relationships between neuroinflammation and stress-related psychopathologies. Exposure to moderate or chronic psychological stress in rodents leads to increased activation of microglia, the brain’s resident immune cells. The ventral medial prefrontal cortex (vmPFC) is a key limbic region involved in top-down regulation of psychological stress and mediates the deleterious effects of microglial activity following prolonged restraint stress. While there is a growing body of literature indicating that chronic social defeat increases microglial activity in the vmPFC, there has been little research investigating the effects of acute social defeat stress. Here, we used an acute social defeat paradigm in …
What Makes A Good Therapy Dog? Identifying Factors Associated With Calm Behavior In Therapy Dogs, Kristen Cunningham, Zachary L. Darwish, Rosemary Strasser
What Makes A Good Therapy Dog? Identifying Factors Associated With Calm Behavior In Therapy Dogs, Kristen Cunningham, Zachary L. Darwish, Rosemary Strasser
UNO Student Research and Creative Activity Fair
Dogs offer a variety of benefits to society, including the use of therapy dogs to provide therapeutic and physiological benefits, enhancing the lives of a wide range of recipients. Unlike service or emotional support animals, therapy dogs provide support to a multitude of individuals, often in hospitals, schools, nursing homes, or other venues. While many studies have examined behavioral assessments of service dog programs, little research has investigated the factors that make a good therapy dog. Therapy dogs must undergo strategic training before becoming certified. The present study seeks to illuminate what factors might distinguish therapy dogs from pet dogs …
An Investigation Of Stimulants: Reviewing Their Effects On The Brain, Including Memory And Microglia, Michael Douchey
An Investigation Of Stimulants: Reviewing Their Effects On The Brain, Including Memory And Microglia, Michael Douchey
UNO Student Research and Creative Activity Fair
Stimulants are a class of drugs that have a variety of effects on the brain, including changes in receptor activity in the brain areas responsible for- memory, attention, emotion, motor control, and the reward pathway. Stimulants may be generally classified by their availability. For example, prescription stimulants, which include drugs such as methylphenidate (Concerta™, Ritalin™) and mixed amphetamine salts (Adderall™), must be prescribed by medical professionals. Another regulated stimulant, albeit one available without a prescription, is nicotine; a highly addictive chemical that is age-restricted by the U.S. federal government. Nicotine is found in tobacco products, and in tobacco-free alternatives including …
Marmosets Respond Consistently To Threats Across Contexts, Sarah Carp
Marmosets Respond Consistently To Threats Across Contexts, Sarah Carp
UNO Student Research and Creative Activity Fair
Behavioral traits, such as how adventurous an individual is, can vary both across individuals and within an individual across contexts. However, there is evidence that individuals are stable across time in how they respond to certain stimuli. This consistency in behavioral responses to similar environments is termed a behavioral syndrome, or set of correlated behavior. We assessed the degree to which individual marmoset monkeys were consistent across four behavioral tests that measured different aspects of novelty seeking. The four tasks included exposure to a novel object in a familiar environment, exposure to a novel environment, behavioral flexibility in response to …