Biological Psychology Commons^™

The Biopsychosocial Model And Clinical Decision Science In The Age Of Black Lives Matter: A Clinical Reflection, Abdul-Rahman M. Suleiman, Samer Ilayan

Clinical Research in Practice: The Journal of Team Hippocrates

The author reflects on the biopsychosocial considerations of elevated blood pressure in teenage African American youth during the era of Black Lives Matter (BLM). Parallels are drawn between Dr. Engel’s biopsychosocial model and clinical decision science.

The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber

Wayne State University Dissertations

In the neonatal intensive care unit (NICU) preterm infants are exposed to a multitude of stressors, which include both neonatal pain and reduced maternal care. Clinical and preclinical research has demonstrated that exposure to neonatal pain and reduced maternal care has a profound negative impact on brain and behavioral development. Currently, the biological mechanism by which both of these stressors impacts brain and behavioral outcomes remains widely unknown. To uncover a potential biological mechanism, the current dissertation project utilized a preclinical model of repetitive needle pokes and developed a novel model of reduced maternal care through tea-ball encapsulation. Briefly, rat …

Analgesia Followed By Long-Term Hyperalgesia Generated By Disinhibition Of The Basolateral Amygdala, Derek Atchley

Wayne State University Theses

Stress produces bimodal effects on pain peception. During exposure to a stressor pain responses are inibited (i.e. stress-induced analgesia). However, following long-term exposure to a stressor increases in responsiveness to painful stimuli may develop (i.e. stress-induced hyperalgesia). Here I evaluated how a key component of the subcortical defense circuit and target of stress hormones contributes to the development of both stress-induced analgesia and hyperalgesia. Bicuculline methiodide, a GABAA antagonist, injected into the basolateral amygdala was used to mimic the neural effects of a stressor or threat exposure. Immediately following injection pain responsiveness was decreased as measured by vocalizations after discharge …

A Mouse Model Of Toluene Abstinence-Induced Pathology, Sean Callan

Wayne State University Dissertations

The intentional misuse of volatile solvents is a persistent public health concern. Limited self-report data suggests that chronic inhalant abusers experience withdrawal symptoms including anxiety and seizure symptoms. However, these symptoms have never been explored in a preclinical model and are not considered part of the DSM-V criteria for an Inhalant Use Disorder. For this experiment, 76 young adult male Swiss Webster mice were exposed to either 5,000 ppm toluene vapor or air (0 ppm) for 24 consecutive hours beginning on postnatal day (PND) 30. Following the 24 hour exposure, mice were allowed to recover for 3 hours before behavioral …

Changes In Cerebral White Matter, Vascular Risk And Cognition Across The Adult Lifespan, Andrew Robert Bender

Wayne State University Dissertations

Numerous studies over the past decade have used diffusion tensor imaging (DTI) to examine associations between age, diffusion and anisotropy measures of cerebral white matter (WM), and cognitive performance. However, few have examined relationships between intra-individual change in DTI measures of WM and cognitive function. It is possible that the extant cross-sectional findings are a poor representation of age-related change in WM and cognition. The present study used latent difference-score modeling (LDM) to assess change over two years in DTI indices fractional anisotropy (FA), radial diffusivity (DR), axial diffusivity (DA) and mean diffusivity (MD). In addition, we examined the effects …

Self-Construal Moderates Testosterone Reactivity To Competitive Outcomes, Keith Welker

Wayne State University Dissertations

Previous research shows that testosterone reactivity to competitive outcomes predicts aggressive behavior in men. However, some studies have failed to find these effects, and it has been suggested that individual differences moderate the relationships between competitive outcomes, testosterone fluctuations, and aggressive behavior. The current research examined whether one individual difference--self-construal--would moderate these effects. In Study 1, participants were assigned to win or lose a competitive video game and engaged in a reactive aggression task. Results indicated that increases in testosterone in response to winning and decreases in response to losing occurred in men with independent, not interdependent, self-construals. These changes …

Understanding The Role Of Nutritional Stress In The Adult And Developing Zebra Finch, Jessica Bayley Thompson

Wayne State University Dissertations

Songbirds are particularly susceptible to stress during the sensitive period for song learning. Thus the developmental stress hypothesis (DSH) proposes that adult song reflects a male's early life environment during this period. Nutritional stress (NS) has been shown to cause deficits in song learning and adult song output that are salient to females. Female song birds consistently prefer control males over those raised under NS, yet the effects NS on females are still unclear. The hypothalamic-pituitary-adrenal axis (HPA) has been implicated in this process. However, evidence directly linking HPA functioning to the deficits due to NS have inconsistently shown elevations …

Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (Taeniopygia Guttata), Kimberly Anne Laplante

Wayne State University Dissertations

Stress and affiliative social relationships are bi-directionally related. It is well understood that social relationships can buffer the physiological response to a stressor. Conversely, there is some evidence to suggest that stress can affect the propensity to form a pair bond. Data from humans and prairie voles, monogamous rodents, suggest that activation of the hypothalamic-pituitary-adrenal axis (HPA) in males increases attraction for females. Across species, females are understudied, but evidence from the prairie vole suggests HPA activation impairs formation of partner preference, the first step in establishing a pair bond. Across taxa there is evidence that formation and maintenance of …

Sex Differences In The Dopaminergic Regulation Of Courtship, But Not Pairing Behaviors In Zebra Finches, Erin Marie Lowrey

Wayne State University Theses

Dopamine is one of the key ingredients in the glue that cements social bonds in vertebrates. The D2 dopamine receptor has been implicated in the regulation of monogamous pair bonding in the prairie vole. While dopamine affects courtship behaviors in the male zebra finch, the behavioral role of dopamine acting at D2 receptors in both males and females deserves further attention. We hypothesized that the D2 receptor would regulate courtship and pairing behaviors in the male and female zebra finch. Sixteen males and females were tested using a repeated measures design. On day 1, the zebra finches were injected with …

Effects Of Sex, Free Testosterone, And Androgen Receptor Cag Repeat Number On Spatial Cognition And Virtual Navigation Performance, Nicole Therese Nowak

Wayne State University Dissertations

The male advantage typically found on some measures of spatial cognition (e.g., mental rotations) has been approached for three decades from the perspective that androgens contribute to this sex difference. To date, evidence to support the notion that androgens affect spatial cognition in healthy young individuals is balanced by evidence to the contrary. The present study sought to clarify the association between androgens and spatial performance by extending our measurements of androgenicity to include both a measure of circulating testosterone as well as a receptor-specific marker.

The aims of this dissertation were to assess the effects of sex, testosterone, and …

The Contribution Of Genes And Hormones To The Sexual Differention Of The Zebra Finch Song System, Jessica Bayley Thompson

Wayne State University Theses

Recent studies in the zebra finch suggest the sexual differentiation of the song system and singing behavior may not be solely driven by steroid hormones organizing the brain, and may be genetically driven. In fact, genes and hormones might act together to produce sexual differentiation of the brain. To test this hypothesis, animals were implanted with a 1mm pellet containing 50ug of 17b-estradiol or a blank pellet on the third day post-hatching. At post-hatch day 25, the brains were collected and a double label fluorescence in situ hybridization protocol using biotin and digoxigenin-tagged mRNA probes was used to simultaneously label …

Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet

Wayne State University Dissertations

Activation of the dopaminergic mesolimbic reward circuitry that originates in the ventral tegmental area (VTA) is postulated to preferentially suppress affective reactions to noxious stimuli (affective analgesia, AA). VTA dopamine neurons are activated via cholinergic inputs, and we have observed that microinjections of the acetylcholine agonist carbachol suppressed vocalizations of rats that occur following administration of brief (1 sec) tail-shocks (vocalization afterdischarges = VAD). VADs are a validated rodent model of pain affect. In addition, the capacity of carbachol to support reinforcement appears to be regionally dependent within VTA. Ikemoto and Wise (2002) reported that carbachol was self-administered in the …