Biological Psychology Commons^™

Preliminary Evidence For Medication Effects On Functional Abnormalities In The Amygdala And Anterior Cingulate In Bipolar Disorder, Hilary P. Blumberg, Nelson H. Donegan, Charles A. Sanislow, Susan Collins, Cheryl Lacadie, Pawel Skudlarski, Ralitza Gueorguieva, Robert K. Fulbright, Thomas H. Mcglashan, John C. Gore, John H. Krystal

Charles A. Sanislow, Ph.D.

RATIONALE: Abnormal amygdala and frontocortical responses to emotional stimuli are implicated in bipolar disorder (BD) and have been proposed as potential treatment targets.

OBJECTIVES: The aim of this study was to investigate amygdala and frontocortical responses to emotional face stimuli in BD and the influences of mood-stabilizing medications on these responses.

METHODS: Functional magnetic resonance imaging was performed while 17 BD participants (5 unmedicated) and 17 healthy comparison (HC) participants viewed faces with happy, sad, fearful, or neutral expressions.

RESULTS: The group by stimulus-condition interaction was significant (p<0.01) for amygdala activation, with the greatest effects in the happy face condition. Relative to HC, amygdala increases were greater in unmedicated BD, but lower in medicated BD. Rostral anterior cingulate (rAC) activation was decreased in unmedicated BD compared to HC; however, BD participants taking medication demonstrated rAC activation similar to HC participants.

CONCLUSIONS: Although the sample sizes were small, these preliminary results suggest that …

Regret And The Control Of Temporary Preferences, Terry Connolly, Jochen Reb

Research Collection Lee Kong Chian School Of Business

Regret is often symptomatic of the defective decisions associated with temporary preference problems. It may also help overcome these defects. Outcome regret can modify the relative utilities of different payoffs. Process regret can motivate search for better decision processes or trap-evading strategies. Heightened regret may thus be functional for control of these self-defeating choices.

The Impact Of The Chip Program On Depression And Well-Being: A Pilot Study, Carmen Diehl Thieszen

Loma Linda University Electronic Theses, Dissertations & Projects

Reliable studies have demonstrated that intensive and comprehensive lifestyle changes can reduce coronary risk, which, in turn, can prevent, postpone, and reverse coronary heart disease (CHD) and affect its underlying atherosclerotic lesions. These well-established studies have focused their interventions on moderating biophysical risk factors. In the past 10 years, however, burgeoning research is supporting the idea that psychological factors, such as depression and well-being, are also important CHD risk factors. Little research has addressed, in a non-subjective way, how an intervention program focused on modifying biophysical risk factors may influence psychological factors. Using the Beck Depression Inventory-Short Form, the Dartmouth …

Using Fmri To Investigate A Component Process Of Reflection: Prefrontal Correlates Of Refreshing A Just-Activated Representation, Marcia K. Johnson, Carol L. Raye, Karen J. Mitchell, Erich J. Greene, William A. Cunningham, Charles A. Sanislow

Charles A. Sanislow, Ph.D.

Using fMRI, we investigated the functional organization of prefrontal cortex (PFC) as participants briefly thought of a single just-experienced item (i.e., refreshed an active representation). The results of six studies, and a meta-analysis including previous studies, identified regions in left dorsolateral, anterior, and ventrolateral PFC associated in varying degrees with refreshing different types of information (visual and auditory words, drawings, patterns, people, places, or locations). In addition, activity increased in anterior cingulate with selection demands and in orbitofrontal cortex when a nonselected item was emotionally salient, consistent with a role for these areas in cognitive control (e.g., overcoming "mental rubbernecking"). …

Avoidant Personality Disorder And Social Phobia: Distinct Enough To Be Separate Disorders?, Elizabeth Ralevski, Charles A. Sanislow, Carlos M. Grilo, Andrew E. Skodol, John G. Gunderson, M. Tracie Shea, Shirley Yen, Donna S. Bender, Mary C. Zanarini, Thomas H. Mcglashan

Charles A. Sanislow, Ph.D.

Objective: Existing evidence from anxiety disorder research indicates that social phobics (SP) with avoidant personality disorder (AVPD) experience more anxiety and show more impairment than patients with SP alone. The purpose of this study was to examine whether in patients diagnosed with AVPD, the co-occurrence of SP adds to its severity. We hypothesized that the addition of SP will not add to the severity of AVPD alone.

Method: Two groups of patients (AVPD = 224; AVPD/SP = 101) were compared at baseline and 2 years later on multiple demographic and clinical variables.

Results: Patients with AVPD and an additional diagnosis …

Extraocular Muscle Activity, Rapid Eye Movements And The Development Of Active And Quiet Sleep, Adele M. H. Seelke, Andrew J. Gall, Karl Æ. Karlsson, Mark S. Blumberg

Faculty Publications

Rapid eye movements (REMs), traditionally measured using the electrooculogram (EOG), help to characterize active sleep in adults. In early infancy, however, they are not clearly expressed. Here we measured extraocular muscle activity in infant rats at 3 days of age (P3), P8 and P14-15 in order to assess the ontogeny of REMs and their relationship with other forms of sleep-related phasic activity. We found that the causal relationship between extraocular muscle twitches and REMs strengthened during the first two postnatal weeks, reflecting increased control of the extraocular muscles over eye movements. As early as P3, however, phasic bursts of extraocular …

Self-Management Strategies Mediate Self-Efficacy And Physical Activity, Amanda Birnbaum, Rod K. Dishman, Robert W. Motl, James F. Sallis, Andrea L. Dunn, Greg J. Welk, Ariane L. Yung, Carolyn C. Voorhees, Jared B. Jobe

Department of Public Health Scholarship and Creative Works

Self-efficacy theory proposes that girls who have confidence in their capability to be physically active will perceive fewer barriers to physical activity or be less influenced by them, be more likely to pursue perceived benefits of being physically active, and be more likely to enjoy physical activity. Self-efficacy is theorized also to influence physical activity through self-management strategies (e.g., thoughts, goals, plans, and acts) that support physical activity, but this idea has not been empirically tested.

The Relationship Between Psychopathology In Caregivers And Their Children With Asthma, Jaime L. Benson

Honors Capstone Projects - All

Asthma is the leading chronic illness among children, and children with asthma have an increased risk not only for physical problems, but also for social and emotional difficulties related to their asthma. These risks are compounded when children have a caregiver who is depressed. The effects of maternal depression for children are complex and have been shown to persist into adolescence and adulthood. This is especially important because children with asthma, who are already at risk for psychopathology, may have increased internalizing and externalizing problems when their primary caregivers have depression or display depressive symptoms. Because depression affects cognitive functioning …

The Neural Substrates Of Infant Sleep In Rats, Karl Æ. Karlsson, Andrew J. Gall, Ethan J. Mohns, Adele M. H. Seelke, Mark S. Blumberg

Faculty Publications

Sleep is a poorly understood behavior that predominates during infancy but is studied almost exclusively in adults. One perceived impediment to investigations of sleep early in ontogeny is the absence of state-dependent neocortical activity. Nonetheless, in infant rats, sleep is reliably characterized by the presence of tonic (i.e., muscle atonia) and phasic (i.e., myoclonic twitching) components; the neural circuitry underlying these components, however, is unknown. Recently, we described a medullary inhibitory area (MIA) in week-old rats that is necessary but not sufficient for the normal expression of atonia. Here we report that the infant MIA receives projections from areas containing …

Why Girls? The Importance Of Developing Gender-Specific Health Promotion Programs For Adolescent Girls, Amanda Birnbaum, Tracy R. Nichols

Department of Public Health Scholarship and Creative Works

Adolescence is a time when many girls begin to develop unhealthy behaviors that can affect myriad short- and long-term health outcomes across their lifespan.2There is evidence that smoking, physical activity, and diet are habituated during adolescence, and some physiologic processes of adolescence, such as peak bone mass development, have direct effects on future health.3-4 Establishing healthy practices, beliefs and knowledge among adolescent girls will decrease morbidity and mortality among adult women and potentially affect the health of men and children through women’s role as healthcare agents. This paper provides a brief review of lifestyle health behaviors among women and girls …

Birth Parents In Adoption: Research, Practice, And Counseling Psychology, Amanda Baden, Mary O'Leary Wiley

Department of Counseling Scholarship and Creative Works

This article addresses birth parents in the adoption triad by reviewing and integrating both the clinical and empirical literature from a number of professional disciplines with practice case studies. This review includes literature on the decision to relinquish one’s child for adoption, the early postrelinquishment period, and the effects throughout the lifespan on birth parents. Clinical symptoms for birth parents include unresolved grief, isolation, difficulty with future relationships, and trauma. Some recent research has found that some birth mothers who relinquish tend to fare comparably to those who do not relinquish on external criteria of well-being (e.g., high school graduation …

Intimacy, Orgasm Likelihood Of Both Partners, Conflict, And Partner Response Predict Sexual Satisfaction In Heterosexual Male And Female Respondents, R. Vernon Haning

Theses, Dissertations and Capstones

Anonymous data provided by 417 female and 179 male sexually active heterosexual respondents showed that in long term sexual relationships sexual satisfaction was positively correlated with two different intimacy variables, the respondent’s orgasm likelihood, and the partner’s orgasm likelihood and negatively correlated with conflict in the relationship. All were significant predictors together in a multiple linear regression model. Empathic sexuality was defined as sexual response modulated by the sexual arousal or lack of arousal of the partner. Of 696 respondents, 90.3% reported empathic turn-on, 68% reported empathic turn-off, and 63.4% reported both empathic turn-on and turn-off, findings significantly different from …

Actions Of A Partial D2-Like Agonist During Low Or High Dopaminergic Tone: A Neurochemical Study Using Preweanling Rats, Shelly Taeko Yoshida

Theses Digitization Project

The neurochemical effects of partial D2-like agonists (i.e., terguride) to alter striatal DOPA accumulation under high and low dopaminergic tone was examined in preweanling rats. The results indicate that terguride has agonist-like (quinpirole-like) effects under a low dopaminergic tone and antagonist-like (haloperidol-like) effects under a high dopaminergic tone during the preweanling period.

Effect Of Preweanling Methylphenidate Exposure On The Induction, Extinction And Reinstatement Of Morphine-Induced Conditioned Place Preference In Rats, Kellie Lynn Kucher

Theses Digitization Project

This study examined the effect of preweanling methyphenidate exposure on later drug reward. We examined the induction, extinction, and reinstatement of morphine induced conditioned place preference (CPP) in rats that received methylphenidate pretreatment during the preweanling period.

Stress Enhancement Of Craving During Sobriety: A Risk For Relapse, Laura O'Dell

Laura Elena O'Dell

No abstract provided.

Epipregnanolone And A Novel Synthetic Neuroactive Steroid Reduce Reduce Alcohol Self-Administration In Rats., Laura O'Dell

Laura Elena O'Dell

No abstract provided.

The Effect Of Early Psychostimulant Treatment On Abuse Liability And Dopamine Receptors, Steven Wayne Villafranca

Theses Digitization Project

Examines whether the reinforcing properties of drugs of abuse were altered in adulthood by methylphenidate, more commonly known as Ritalin. Subjects were 108 rats of Sprague-Dawley descent (Harlan). Methylphenidate, or saline was administered daily to the subjects from the postnatal period (11-20 days old). The rats preference for morphine during early adulthood was measured using conditioned place preference. The number of dopamine D₂ receptors was measured in each rat and the correlation between receptor number and morphine preference was determined. Results indicate that rats pretreated with methylphenidate showed greater preference for morphine than saline pretreated rats and suggests that exposure …

192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis Impair Serial Reversal Learning In Rats, Sara Michelle Cabrera

Theses Digitization Project

In order to assess flexibility in acquiring and using conflicting response rules, rats with selective lesions of the NBM or sham-lesion controls were subjected to serial reversal training in a simple operant discrimination paradigm. The NBM lesion group did not differ from the control group in acquisition of the original rules; the NBM lesion group required more time to master the changes in rules in the first reversal, but not in subsequent reversals.

Cholinergic Basal Forebrain Involvement In The Acquisition Of Differential Reinforcement Of Low Rate Responding Tasks In Rats, Sean Ryan Corley

Theses Digitization Project

It was hypothesized that 192 IgG-saporin lesions of the basal forebrain cholinergic system (BFCS) would disrupt differential reinforcement of low rate (DRL) learning in an uncued DRL task, but would not impair acquisition and performance in the cued version of the task. Results suggest that BFCS lesions impair vigilance to the external cues despite continued practice in the cued DRL, whereas continuous attention to internally produced cues recovers with extended practice in the uncued DRL.

The Effects Of Neonatal Manganese Exposure On Impulsivity, Unlearned Motoric Function, And Reward, Carmela Marie Reichel

Theses Digitization Project

This study examined the effects of low to moderate doses of manganese (0, 250, or 750 _g per day from PD 1-21) on a comprehensive battery of behaviors in rats during the neonatal period, preweanling period, and in adulthood.

The Microfoundations Of Standard Form Contracts: Price Discrimination Vs. Behavioral Bias, Jonathan Klick

All Faculty Scholarship

Standard form contracts, or contracts of adhesion, appear to provide contradictory evidence for the operation of bargaining in the markets where they are common. Non-negotiated contract terms that seemingly benefit sellers to the detriment of buyers call into question the efficiency implications of the Coase Theorem, which forms the foundation of positive law and economics. Proponents of the behavioral school of law and economics have suggested that behavioral biases, observed in experimental contexts, provide the most plausible explanation for standard form contracts. However, price discrimination might provide a more parsimonious explanation for abusive terms in contracts. If there is heterogeneity …

The Effect Of Delta9-Tetrahydrocannabinol (Thc) And Cb1 Antagonists On Sucrose And Quinine Palatability: Direct Measurement With The Taste Reactivity Test, Maegan Jarrett

Theses and Dissertations (Comprehensive)

Anecdotal reports suggest that cannabinoid agonists enhance palatability and that antagonists reduce palatability; however there has been little direct experimental evidence for these claims. The taste reactivity (TR) test is a direct measure of palatability in rats (Grill & Norgren, 1978). In Experiments 1 and 4, the taste reactivity (TR) test was used to evaluate the potential of delta-9-tetrahydrocannabinol (THC) to modify both sucrose and quinine palatability. The TR test revealed that THC (0.5 mg/kg) increases the palatability of sucrose solutions at 120 min post-injection, regardless of the sucrose concentration. THC (0.5 mg/kg) also decreased the aversiveness of the quinine …