Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Experimental Analysis of Behavior (4)
- Medicine and Health Sciences (4)
- Mental and Social Health (4)
- Clinical Psychology (3)
- Developmental Psychology (3)
-
- Life Sciences (3)
- Substance Abuse and Addiction (3)
- Animal Studies (1)
- Applied Behavior Analysis (1)
- Behavior and Behavior Mechanisms (1)
- Behavioral Medicine (1)
- Biology (1)
- Cognition and Perception (1)
- Cognitive Neuroscience (1)
- Cognitive Psychology (1)
- Development Studies (1)
- Health Psychology (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Mental Disorders (1)
- Neuroscience and Neurobiology (1)
- Neurosciences (1)
- Other Mental and Social Health (1)
- Other Psychology (1)
- Pharmacology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Psychiatric and Mental Health (1)
- Keyword
-
- Rats Physiology (14)
- Rats Physiology. (11)
- Cocaine (5)
- Rats -- Physiology (5)
- Dopamine Receptors (4)
-
- Drug abuse Animal models (4)
- Rats Behavior Experiments (4)
- Alzheimer's disease Animal models (3)
- Cocaine Physiological effect (3)
- Conditioned response (3)
- Conditioned response -- Rats (3)
- Dopaminergic mechanisms (3)
- Immunohistochemistry (3)
- Learning disabilities (3)
- Methylphenidate Side effects (3)
- Neurotransmitter receptors (3)
- Opioids Receptors (3)
- Rats as laboratory animals (3)
- Acetylcholine Receptors (2)
- Addiction (2)
- Adolescence (2)
- Amphetamines Physiological effect (2)
- Attention-deficit hyperactivity disorder Treatment (2)
- Basal ganglia Diseases Animal models (2)
- Conditioned place preference (CPP) (2)
- Depression (2)
- Dopamine -- Receptors (2)
- Dopamine -- Receptors -- Effect of drugs on (2)
- Dopamine Agonists (2)
- Drug abuse Forecasting (2)
- Publication Year
- Publication
- Publication Type
Articles 1 - 30 of 46
Full-Text Articles in Biological Psychology
Impact Of Perinatal Escitalopram Exposure On Adolescent Behavior, Jessica Bezenah - Bottorff
Impact Of Perinatal Escitalopram Exposure On Adolescent Behavior, Jessica Bezenah - Bottorff
Electronic Theses, Projects, and Dissertations
Escitalopram (EST), a selective serotonin reuptake inhibitor (SSRI), is an antidepressant frequently used during pregnancy, yet there is limited knowledge of its long-term effects on maternal use. Past studies suggest that maternal exposure may adversely affect the fetus, which may be due to the hyperserotonergic environment caused by the nature of SSRIs during early development. Modifications of the serotonergic system in offspring during certain critical periods of development may result in long-term behavioral and cognitive changes in adulthood. Further, recent human studies have demonstrated that prenatal exposure to SSRIs in humans may increase susceptibility to autism spectrum disorder (ASD) and …
Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor
Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor
Electronic Theses, Projects, and Dissertations
Serotonin has been found to regulate several cognitive and physiological functions, and its role in depression and other neuropsychiatric disorders has been a focus of research. More specifically, a wealth of research regarding serotonin focuses on serotonergic medications in the treatment of neuropsychiatric disorders, such as depression and anxiety, and stimulates the 5-HT1A and 5-HT1B receptors. Within the last decade, there has been an increase in prescriptions of psychotropic medication for children, however, the efficacy and adverse effects of these drugs have not been evaluated in younger populations. While antidepressants reduce symptoms of depression in adults, they are …
Cerebrospinal Fluid Biomarkers Not Associated With Neurologic Compromise Among Mild Cognitively Impaired Reverters With Parkinson's Disease, Cameron Ryczek
Cerebrospinal Fluid Biomarkers Not Associated With Neurologic Compromise Among Mild Cognitively Impaired Reverters With Parkinson's Disease, Cameron Ryczek
Electronic Theses, Projects, and Dissertations
Parkinson's Disease (PD) is a neurodegenerative disease characterized by motor (e.g. tremors) and non-motor symptoms (e.g. cognitive impairment). PD patients' change in cognitive functioning can be observed using the following classifications: cognitively intact, mild cognitive impairment (MCI), or dementia (PDD). MCI has many subtypes, one of which is MCI reversion which is defined as those with MCI at one time point reverting to cognitively intact later. While there is limited research into the utility of MCI reversion and its relationship with cerebrospinal fluid (CSF) biomarkers in PD, this study will begin to elucidate this relationship. To this end, data from …
Serotonin 1b/1a Receptor Modulation On Behavioral Flexibility In C57bl/6j Mice, Brandon L. Oliver
Serotonin 1b/1a Receptor Modulation On Behavioral Flexibility In C57bl/6j Mice, Brandon L. Oliver
Electronic Theses, Projects, and Dissertations
Pharmacological activation of the 5-HT1B and 1A receptors has been implicated in OCD-like behaviors in rodents such as increased perseverative circling, checking behaviors, and locomotor stereotypy. However, little is understood about the effects of 5-HT1B and 1A receptor activation on behavioral inflexibility, a common symptom associated with OCD. The present study utilized the 5-HT1B/1A receptor agonist RU24969 at 0.01, 0.1, and 1.0 mg/kg to test three hypotheses. The first hypothesis predicted RU24969 would lead to a dose-dependent impairment on behavioral flexibility in C57BL/6J mice. It was also predicted that male C57BL/6J mice would be more inflexible than female C57BL/6J mice …
Effects Of Neonatal Ethanol Exposure In Normal And Dopamine Deficient Rats, Jessica Luz Razo
Effects Of Neonatal Ethanol Exposure In Normal And Dopamine Deficient Rats, Jessica Luz Razo
Electronic Theses, Projects, and Dissertations
Attention deficit hyperactivity disorder (ADHD) is a common developmental disorder characterized by impulsivity, inattention, and hyperactivity. In rodents, neonatal 6-OHDA lesions is an established model of ADHD because it produces symptoms of hyperactivity and cognitive deficits that improve following psychostimulant treatment. Recently, early alcohol exposure in rodents has also been suggested as a model of ADHD due to the high prevalence of ADHD in children exposed prenatally to alcohol. However, children exposed to prenatal alcohol differ in symptoms from children with idiopathic ADHD, suggesting that ADHD caused by prenatal alcohol exposure may be a special subtype of ADHD or a …
Biological Siblings: Can You Trust Them With Your Mate?, Elisha Barron
Biological Siblings: Can You Trust Them With Your Mate?, Elisha Barron
Electronic Theses, Projects, and Dissertations
Recent studies suggest that genes may influence human mate preferences. What would this mean for same-sex siblings who share genes? Might they also share mate preferences and engage in mate poaching or would social norms and strong sibling bonds discourage such behaviors? We hypothesized that siblings would perceive their mate preferences to be more similar to their sibling’s than to an average person of their same gender. It was also hypothesized that the association between perceived sibling mate preferences and sibling mate poaching would be moderated by sibling closeness and sibling competition. Additionally, it was hypothesized that sibling mate competition …
Scope Of Attention Variation As A Function Of Anxiety And Depression, Kathleen O'Donnell
Scope Of Attention Variation As A Function Of Anxiety And Depression, Kathleen O'Donnell
Electronic Theses, Projects, and Dissertations
As a social species, correct emotional perception is so vital, that the human brain has evolved a mechanism to control attentional choices by exerting a narrowed field of perception during danger, called the scope of attention (SoA). The SoA determines what information will be focused on or ignored by blocking the perception of non-relevant items and increasing selective focus on danger; even if danger is merely a sad-face. The emotional items blocked from perception cannot be remembered because they were never perceived. But, attention-control to emotional stimuli also varies with mood, as seen in mood-disorders. A mood-disorder’s effect upon the …
Age-Dependent Effects Of Eedq On Cocaine-Induced Locomotor Activity And D2 Receptor Supersensitivity, Angie Teran
Age-Dependent Effects Of Eedq On Cocaine-Induced Locomotor Activity And D2 Receptor Supersensitivity, Angie Teran
Electronic Theses, Projects, and Dissertations
The neurochemical changes occurring between the preweanling period and adolescence could be crucial for understanding the role development plays in the manifestation of psychotic behaviors. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) fully attenuates the DA agonist-induced behaviors of adult rats, while potentiating the DA agonist-induced locomotor activity of preweanling rats. My specific hypotheses were as follows: (1) Systemically administered EEDQ would block the cocaine-induced locomotor activity of adult rats. (2) Systemically administered EEDQ would potentiate the cocaine-induced locomotion of preweanling rats. (3) EEDQ would increase the Emax values (a measure of D2 receptor sensitivity) of preweanling rats, but not adolescent or adult rats. …
Evidence-Based Teaching Strategies For Behavioral Neuroscience And Biological Psychology Classes, Richard Addante
Evidence-Based Teaching Strategies For Behavioral Neuroscience And Biological Psychology Classes, Richard Addante
Q2S Enhancing Pedagogy
Courses in Behavioral Neuroscience and Biological Psychology were taught while implementing evidence based teaching practices and several additional innovations. Students engaged in think-pair-share activities, group projects, and novel innovations of assignments including incentivized exam re-earns and creating modern memes of neuroscience content. Students exhibited evidence of learning, enjoyment, and teaching effectiveness.
Cannabinoid-Induced Behavioral Sensitization In Adolescent Sprague-Dawley Rats, Michelle Stone
Cannabinoid-Induced Behavioral Sensitization In Adolescent Sprague-Dawley Rats, Michelle Stone
Electronic Theses, Projects, and Dissertations
Adolescent cannabis use has grown because of increased availability and higher societal acceptance. This increase in cannabis use is problematic as adolescents who experiment with cannabis are more likely to abuse cannabis and experiment with other illicit drugs such as cocaine. The reason for the greater susceptibility to drugs use is unclear and may be the result of altered drug sensitivity after cannabis exposure. Thus, the present investigation used the behavioral sensitization paradigm to examine the behavioral response of early adolescent rats to the cannabinoid agonist CP 55,940 (CP) or cocaine after repeated cannabinoid administration. It was hypothesized that: (1) …
Effects Of Nicotine Exposure On Methamphetamine Oral Self-Administration, Extinction, And Reinstatement In Adolescent Rats, Zachary Robert Harmony
Effects Of Nicotine Exposure On Methamphetamine Oral Self-Administration, Extinction, And Reinstatement In Adolescent Rats, Zachary Robert Harmony
Electronic Theses, Projects, and Dissertations
Adolescence is a vulnerable developmental period in regards to drug initiation and use. The gateway hypothesis suggests that adolescent cigarette smoking may result in a heightened risk for methamphetamine use. However, little is understood about the role of nicotine on adolescent methamphetamine addiction. The aim of the present study was to determine whether early, late, or continuous adolescent nicotine exposure would alter oral methamphetamine self-administration, extinction, or reinstatement. A total of 164 male and female Sprague-Dawley rats were pretreated with saline or nicotine (0.16, or 0.64 mg/kg, sc) beginning on postnatal day (PD) 25 for 10 consecutive days. On PD …
The Importance Of Serotonergic And Adrenergic Receptors For The Induction And Expression Of One-Trial Cocaine-Induced Behavioral Sensitization, Krista N. Rudberg
The Importance Of Serotonergic And Adrenergic Receptors For The Induction And Expression Of One-Trial Cocaine-Induced Behavioral Sensitization, Krista N. Rudberg
Electronic Theses, Projects, and Dissertations
Addiction is a complex process in which behavioral sensitization may be an important component. While the behavioral effects of sensitization are well established, the intricate neurobiology of the phenomenon is still largely unknown. Dopamine systems mediate the induction of behavioral sensitization in adult rats, but there is a large amount of evidence showing that other neurotransmitter systems also modulate the induction process. For example, the α1b-adrenergic and 5-HT2A receptor systems are known to modulate the sensitized responding of adult rats, but the roles that these receptor systems play in the induction and expression of behavioral sensitization during the preweanling …
Importance Of The D2 Receptor For One- And Multi-Trial Psychostimulant-Induced Behavioral Sensitization In Preweanling Rats, Martha A. Mohd-Yusof
Importance Of The D2 Receptor For One- And Multi-Trial Psychostimulant-Induced Behavioral Sensitization In Preweanling Rats, Martha A. Mohd-Yusof
Electronic Theses, Projects, and Dissertations
The neural mechanisms mediating one-trial and multi-trial behavioral sensitization during early ontogeny are poorly understood. The purpose of this thesis was to assess the importance of D2-like receptors for the induction of cocaine- and methamphetamine-induced one-trial and multi-trial behavioral sensitization during the middle and late preweanling period. In a series of four experiments, rats were injected with saline or the selective dopamine D2-like receptor antagonist raclopride 15 min prior to treatment with the indirect dopamine agonists cocaine or methamphetamine. Acute control groups received two injections of saline. The pretreatment regimens occurred on either PND 16 or PND 20 (one-trial behavioral …
Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant
Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant
Electronic Theses, Projects, and Dissertations
A problematic connection has been reported between those who use nicotine related products alone or in combination with ADHD medications, like methylphenidate (MPH), in late childhood or early adolescence and the increased likelihood of later marijuana abuse in adulthood. Pre-clinical studies have found that the use of nicotine during the early adolescence period produces enduring changes to the endocannabinoid system in the brain. Since CB agonists, like marijuana, exert their effect through the eCB system, it is possible that early nicotine use may alter the rewarding nature of CB agonists in adulthood. In addition, MPH has also been shown to …
Preweanling Exposure To Selective Catecholamine Transporter Inhibitors Differentially Effects Morphine-Induced Antinociception In Adulthood, Joseph Marco Valentine
Preweanling Exposure To Selective Catecholamine Transporter Inhibitors Differentially Effects Morphine-Induced Antinociception In Adulthood, Joseph Marco Valentine
Theses Digitization Project
The purpose of this project is to determine how early methylphenidate exposure alters opioid receptor functioning in adulthood. To this end, we will administer selective monoamine transporter inhibitors for dopamine and norepinephrine (GBR-12904 and atomoxetine) during preweanling period and assess opioid function in adult rats by testing morphine-induced antinociception using the hot-plate and tail-flick tasks. In order to assess the effects of methylphenidate use on brain functions during development, investigations have been conducted in rats using ages roughly analogous to early and late childhood.
Adolescent And Adult Nicotine Exposure On The Acquisition Of Methamphetamine Self-Administration And The Reinstatement Of Extinguished Methamphetamine-Seeking In Male Rats, Joseph Allan Pipkin
Adolescent And Adult Nicotine Exposure On The Acquisition Of Methamphetamine Self-Administration And The Reinstatement Of Extinguished Methamphetamine-Seeking In Male Rats, Joseph Allan Pipkin
Theses Digitization Project
This study sought to determine the individual and combined contribution of adolescent and adult nicotine exposure on METH self-administration and METH-seeking behavior in male rats. Nicotine is a commonly abused substance among adolescents and is believed to be a "gateway" to other drugs of abuse. In support of the gateway hypothesis, cigarette smoking during adolescence is related to increased methamphetamine (METH) use in adulthood.
Monoamine Modulation Of Separation-Induced Ultrasonic Vocalizations In Preweanling F344 And Sd Rats, Cynthia Elizabeth Britt
Monoamine Modulation Of Separation-Induced Ultrasonic Vocalizations In Preweanling F344 And Sd Rats, Cynthia Elizabeth Britt
Theses Digitization Project
The purpose of this study was to determine if Fischer 344 (F344) rats, a strain which naturally shows deficits in social communication during adolescence, could be used as a model of the social communication deficits observed in autism. Thus, the goal was to determine if F344 rats would also show fewer emissions of isolated-induced ultrasonic vocalizations (an early onset form of social interaction) as compared to SD rats. Subjects consisted of 142 F344 rat pups (67 male and 75 female). Subjects were treated according to the "Guide for the Care and Use of Mammals in Neuroscience and Behavioral Research" under …
Role Of The Ventral Tegmental Area And Nucleus Accumbens For The One-Trial Behavioral Sensitization Of The Preweanling Rat, Alexandria Grace Pothier
Role Of The Ventral Tegmental Area And Nucleus Accumbens For The One-Trial Behavioral Sensitization Of The Preweanling Rat, Alexandria Grace Pothier
Theses Digitization Project
Behavioral sensitization is defined as an increase in behavioral responding that occurs after repeated administration of a psychostimulant. Behavioral sensitization is an important component of the addiction process that is mediated by different brain regions. In this thesis, lidocaine was used to determine those brain areas mediating one-trial behavioral sensitization in preweanling rats.
Paradoxical Behavior Effects Of Dopamine Receptor Inactivation In Preweanling Rats: Role Of The Dorsal Striatum, Taleen Siran Der-Ghazarian
Paradoxical Behavior Effects Of Dopamine Receptor Inactivation In Preweanling Rats: Role Of The Dorsal Striatum, Taleen Siran Der-Ghazarian
Theses Digitization Project
The purpose of this thesis was to: a) investigate the effects of intrastriatally administered N-ethoxycarbonyl-2ethoxy-1, 2-dihydroquinoline (EEDQ) on nonselective dopamine agonists (NPA) -induced locomotor activity in preweanling and adult rats; b) determine which dopamine receptor subtype (D1- or D2-like) is responsible for modulating EEDQ's paradoxical behavioral effects in preweanling rats; and c) examine the magnitude of EEDQ-induced D1- and D2-like receptor inactivation in both adult and preweanling rats. Subjects were 252 male and female rat pups of Sprague-Dawley descent (Charles River Laboratories, Hollister, CA, USA), born and raised at California State University, San Bernardino (CSUSB).
Ontogeny Of One-Trial Behavioral Sensitization In Preweanling, Adolescent, And Adult Rats: Differential Effects Of Cocaine And Methamphetamine, Olga Olia Kozanian
Ontogeny Of One-Trial Behavioral Sensitization In Preweanling, Adolescent, And Adult Rats: Differential Effects Of Cocaine And Methamphetamine, Olga Olia Kozanian
Theses Digitization Project
The purpose of this thesis was to assess the ontogeny of cocaine- and methamphetamine-induced one-trial locomotor sensitization in preweanling, adolescent, and adult rats. Subjects were 336 male and female rats of Sprague-Dawley descent that were raised at California State University, San Bernardino (CSUSB).
Persistence Of One-Trial Cocaine-Induced Behavioral Sensitization And Conditioned Activity In Preweanling Rats, Anthony Michael Cortez
Persistence Of One-Trial Cocaine-Induced Behavioral Sensitization And Conditioned Activity In Preweanling Rats, Anthony Michael Cortez
Theses Digitization Project
The purpose of this thesis was to determine the persistence of one-shot context-specific and context-independent behavioral sensitization by administering a single pretreatment injection of cocaine or saline in either the home cage or a novel test chamber on PD 19 or PD 79. In order to examine the persistence of conditioned activity, adult rats were given an injection of saline after 1, 3, or 5 abstinence days. Preweanling rats were given an injection of saline after only 1 abstinence day.
Environmental Enrichment Attenuates Nucleus Basalis Lesion Induced Impairments To Attention, Brandee Leianne Kinney-Hurd
Environmental Enrichment Attenuates Nucleus Basalis Lesion Induced Impairments To Attention, Brandee Leianne Kinney-Hurd
Theses Digitization Project
This experiment examined the effects of environmental enrichment on performance in an attention-dependent learning task in rats with selective lesions of the cholinergic nucleus basalis magnocellularis (NBM). The findings demonstrate that environmental enrichment can enhance attention-dependent learning performance in normal animals as well as attenuating NBM lesion-induced impairments otherwise seen following rearing in standard conditions.
Effects Of Chronic Paroxetine And Fluoxetine Treatment On Markers Of Suicidal Behavior In Adolescent Rats, Leslie Renee Horn
Effects Of Chronic Paroxetine And Fluoxetine Treatment On Markers Of Suicidal Behavior In Adolescent Rats, Leslie Renee Horn
Theses Digitization Project
Major depression is a common problem in adolescents. Unfortunately, one of the most effective antidepressants in adults, the selective serotonin reuptake inhibitor (SSRI) paroxetine, is not clinically effective in pediatric populations. There are many variables that increase the risk of suicide including genetic, social, psychological, and biological factors, making the evaluation of the effect of SSRIs on suicidal behavior difficult to assess in human adolescents. The goal of the present investigation was to compare the effects of paroxetine and fluoxetine in adolescent rats on markers associated with depression and suicidal behavior in humans.
Consequences Of Early Methylphenidate Exposure On Opioid System Functioning In Adult Rats, Matthew Scott Herbert
Consequences Of Early Methylphenidate Exposure On Opioid System Functioning In Adult Rats, Matthew Scott Herbert
Theses Digitization Project
Methylphenidate is the preferred treatment for attention-deficit hyperactivity disorder in preschool-aged children, even though few human studies have assessed the long-term consequences of early methyphenidate use. In rats, exposure to methylphenidate during a developmental period that approximates early childhood increases morphine-induced antinociception in adulthood. However, because morphine activates three distinct opioid receptors it is unknown which receptor is resonsible for this methylphenidate effect. The purpose of the present study was to assess the long-term effects of early methylphenidate exposure on DAMGO- and U50, 488-induced antinociception, a mu-opioid and kappa-opioid selective agonist.
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Theses Digitization Project
Infusions of the nonselective dopamine agonist R( - ) propylnorapomorphine (NPA) into the dorsal striatum of preweanling rats atteuates kappa opioid-mediated locomotor activity. The purpose of this thesis was to ascertain which dopamine receptor subtype (D1 or D2) is responsible for this effect. It was hypothsized that a) D1, but not D2, receptors in the dorsal striatum underlie NPA's ability to attenuate the kappa opioid-mediated locomotor activity of preweanling rats, and b) microinjectng SKF38393 (a D1 agonist), and not quinpirole (a D2 agonist), would attenuate kappa opioid-mediated locomotion.
Effects Of Early Amphetamine Exposure On Memory, Wendy Ann Holmquist
Effects Of Early Amphetamine Exposure On Memory, Wendy Ann Holmquist
Theses Digitization Project
The purpose of the current study was to determine if rat pups treated with amphetamine (AMPH) during a critical time of hippocamal development would exhibit deficits in spatial learning and memory when tested in the Morris water maze during adolescence. Exposure to amphetamine during early postnatal development induces long-term reductions in protein kinase A (PKA) activity. Because PKA activity is known to regulate the production of brain derived neurotrophic factor (BDNF), and reductions in BDNF are associated with memory deficits, it was hypothesized that early exposure to amphetamine would lead to declines in both BDNF levels and memory performance. The …
Acetylcholine Levels In The Prefrontal Cortex And Hippocampus During Trace And Delay Conditioning, Mary Melissa Flesher
Acetylcholine Levels In The Prefrontal Cortex And Hippocampus During Trace And Delay Conditioning, Mary Melissa Flesher
Theses Digitization Project
The goal of this experiment was to examine the pattern of ACh release in mPFC and HPC during performance in trace and delay appetitive conditioning.
Importance Of The Kappa Opoid System For Ultrasonic Vocalizations Of Young Rats: Role Of Peripherally-Versus Centrally-Located Kappa Opioid Receptors, James Roy Osburn
Importance Of The Kappa Opoid System For Ultrasonic Vocalizations Of Young Rats: Role Of Peripherally-Versus Centrally-Located Kappa Opioid Receptors, James Roy Osburn
Theses Digitization Project
The purpose of this thesis was to determine whether the kappa opioid receptors modulating ultrasonic vocalizations production are located in the central and/or peripheral nervous system.
The Effects Of Acute Posttraining Injections Of Cocaine On Spatial Memory In C57bl/6 Mice, Sergio Diaz IñIguez
The Effects Of Acute Posttraining Injections Of Cocaine On Spatial Memory In C57bl/6 Mice, Sergio Diaz IñIguez
Theses Digitization Project
The purpose of this study was to investigate the effects of cocaine on spatial memory consolidation using the Morris water maze. Specifically, male and female C57BL/6 mice were trained on a spatial water task, and then administered a single posttraining injection of saline or cocaine (1.25, 2.5, 5.0, or 20.0 mg/kg).
The Effects Of (Rs)-Mcpg On Amphetamine-Induced Sensitization In Neonatal Rats, Fiona Yeuk-Lun Choi
The Effects Of (Rs)-Mcpg On Amphetamine-Induced Sensitization In Neonatal Rats, Fiona Yeuk-Lun Choi
Theses Digitization Project
The purpose of the study was to investigate the role of metabotropic glutamate receptors (mGluR) in the ontogeny of amphetamine-induced behavioral sensitization. Eleven-day-old rat pups were given five daily bilateral infusions of the mGluR antagonist, (RS)-methyl-4-carboxyphenylglycine (MCPG) followed by a systemic injection of amphetamine and locomotor activity was measured. It was hypothesized that rats receving amphetamine pretreatment and an amphetamine challenge would exhibit a significant increase in activity, indicating short-term behavioral sensitization. As predicted, repeated amphetamine administration during the pretreatment phase produced progressively enhanced locomotor activity, indicating the development of behavioral sensitization. The effect of MCPG on locomotor activity appears …