Physiology Commons^™

Analysis Of Serotonin And Postural Instability In Parkinson’S Disease, Sandra Kuniyoshi

Loma Linda University Electronic Theses, Dissertations & Projects

Postural instability is one of the most debilitating symptoms of Parkinson’s disease and the best clinical prognostic indicator of progressive disease. Significant differences in neuropathology, neurochemistry, response to L-dopa therapy and stereotactic surgery as well as prognosis have been identified in subtypes when patients with predominant postural instability and gait difficulty (PIGD)/Type B were differentiated from those with predominant symptoms of tremor and rigidity/Type A. Postural instability is resistant to the therapeutic effects of L-dopa, despite its continued efficacy on other Parkinson’s symptomatology, implicating the nondopaminergic mechanism of postural instability in Parkinson’s disease. Patients with significant postural instability and gait …

The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Elizabeth Gillard, Arshad Khan, Rickinder Grewal, Bara Mouradi, Stefany Wolfsohn, B. Stanley

Selected Works Temporary Series

No abstract provided.

The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Gillard, Arshad Khan, Rickinder Grewal, Bara Mouradi, Stefany Wolfsohn, B. Stanley

Departmental Papers (Biology)

No abstract provided.

A Kinematic And Kinetic Analysis Of First, Fourth, And Fifth Positions In The Classical Ballet Method, Mary Sue Hill

Masters Theses

The problem of the study was to compare electromyography (EMG) responses, ground reaction forces, and torques on female college-age dancers' knees in selected positions. Subjects were 18 female dancers, aged 18 to 30 years, with 6 subjects from each of three levels: Ballet Technique I, II, and III. The rectus femoris, vastus lateralis, and vastus medialis were analyzed in a grande plie in three positions, (1) first, (2) fourth, and (3) fifth, with two phases: (1) eccentric, and (2) concentric. No differences in force or EMG data were found for the concentric phases of the three positions. Significant differences were …

Physiological Effects Of Varying Power Output In A Cycling Time Trial, Mark Alan Liedl

Human Movement Studies & Special Education Theses & Dissertations

During a bicycle time trial, varying power slightly to counter external conditions may result in improved performance [Swain, 1997], but it is not known if such power variations result in added physiological stress. Thus, the purpose of this study was to determine if variable power (VP) cycling produced greater physiological stress than constant power (CP) cycling of the same mean intensity. Eight trained male cyclists (age 28 ± 2 yr, mass 74.4 ± 2.3 kg, VO_2max 4.24 ± 0.13 L•min^-1, weekly training 277 ± 44 km) performed three 1 h ergometer trials. The first trial was performed …

The Role Of Glycoconjugates In Mediating Human Fertilization And Induction Of Fetomaternal Tolerance, Manish S. Patankar

Theses and Dissertations in Biomedical Sciences

Using the hemizona assay (HZA), a in vitro sperm-egg binding assay, we show that specific glycoconjugates known to inhibit immune cell interactions mediated by the selectins, potently block human sperm-egg binding. The selectin ligand sialyl Lewis^x inhibits sperm binding in the HZA by 60% at a concentration of 1 mg/ml. Our data indicates that glycodelin-A, a endometrial glycoprotein known to block sperm-egg binding in the HZA at low concentrations expresses unusual fucosylated lacdiNAc type glycans. The fucosylated lacdiNAc type sugars have been previously shown to be 15-20 fold more potent ligands of E-selectin. Glycodelin-S a seminal plasma glycoform of …

Randomly Amplified Polymorphic Dna Analysis (Rapd) Of Artemisia Subgenus Tridentatae Species And Hybrids, E. Durant Mcarthur, Joann Mudge, Renée Van Buren, W. Ralph Andersen, Stewart C. Sanderson, David G. Babbel

Great Basin Naturalist

Species of Artemisia (subgenus Tridentatae) dominate much of western North America. The genetic variation that allows this broad ecological adaptation is facilitated by hybridization and polyploidization. Three separate studies were performed in this group using randomly amplified polymorphic DNA (RAPD). Fifty-seven 10-mer primers generated nearly 400 markers from genomic DNA obtained from leaf tissue. These studies were (1) a measure of the variability of plants within and between populations and between subspecies using 5 A. tridentata ssp. wyomingensis populations, 2 A. cana ssp. cana populations, and 1 A. cana ssp. viscidula population; (2) an examination of the hypothesis that …

Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Elizabeth Gillard, Arshad Khan, Bara Mouradi, Omkar Nalamwar, B. Stanley

Selected Works Temporary Series

No abstract provided.

Effects Of Xenoestrogens And Cytochrome P450 Aromatase Inhibitors On Sexual Differentiation In Medaka (Oryzias Latipes), John Stewart Gilman Edmunds

MUSC Theses and Dissertations

Several classes of environmental contaminants have been demonstrated to disrupt reproductive function in wild populations and laboratory animals through interactions with endocrine pathways. Primary targets for these endocrine active contaminants are steroid hormone receptors and steroidogenic enzymes. The first study tests the hypothesis that aromatase represents a major target for environmental contaminants which disrupt reproductive function. The results indicate that the biosynthesis of estrogens can be inhibited by certain pesticides and that aromatase represents a target for contaminants disrupting reproductive function. The second study develops an estrogen sensitive and specific reporter gene assay responsive to steroid hormones and several estrogenic …

Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Gillard, Arshad Khan, Bara Mouradi, Omkar Nalamwar, B. Stanley

Departmental Papers (Biology)

No abstract provided.

Cloning And Characterization Of A Novel Ion Channel, Jung-Ha Lee

Dissertations

No abstract provided.

Immunocytochemical Study Of Apoptosis Signaling In Nb2 Lymphoma Cells, Angelo P. Guanzon

Theses and Dissertations

In the absence of mitogen, administration of Dexamethasone (Dex) induces apoptosis, or programmed-cell death in the Nb2 lymphoma cell. Addition of prolactin (Prl), on the other hand, blocks this effect. As a model for apoptosis, we were able to investigate this Dex-Prl interaction by means of a morphological approach: one that could be visualized under a light microscope. This approach allowed us to achieve several aims. First, we were able to develop a method of cell quantification befitting a morphological study based upon the hemacytometer. Second, with Trypan Blue exclusion, we were able to verify Dex/Prl-responsiveness in the Nb2 cells. …

Whole Body I=In Vivo Vascular Compliance In Two Amphibians, Bufo Marinus And Rana Cate, Todd Micheal Hoagland

Dissertations and Theses

The mean circulatory filling pressure (MCFP), vascular compliance (C) and unstressed volume (USV) were measured in Bufo marinus and Rana catesbeiana, using an in vivo preparation. Capacitance curves were constructed by varying total vascular volume and then measuring MCFP. These capacitance curves enable the extrapolation of USV and the measurement of vascular compliance. The MCFP, C, and USV were 8.6 ± 0.2 (mmHg), 3.7 (ml· mmHg-1 · kg- 1 ) and 2.5 (ml), respectively, in B. marinus. The MCFP, C, and USV were 9.5 ± 0.1 (mmHg), 2.2 (ml· mmHg-1 · kg- 1 ) and 14.2 (ml), respectively, …

Reliability Of The Modified-Modified Schober Method Of Measuring Lumbar Range Of Motion, Mira H. Mariano

Rehabilitation Sciences Theses & Dissertations

The purpose of this study was to determine the reliability of the Modified-modified Schober (MMS) method of measuring lumbar flexion and extension on subjects with low back pain. Thirty patients (19 females, 11 males) between the ages of 18 to 61 years (mean=40.0, SD=l 1.7) were measured by two physical therapists who each had six years of orthopedic experience.

Each subject was evaluated twice, in random order, by each tester using the MMS method. Trials 1 and 2 were used to calculate intratester reliability for each tester and intertester reliability was calculated between the two testers. Intraclass correlation coefficients (ICCs) …

Interaction Of Acth And Estradiol In The Regulation Of Growth, Differentiation, And Steroidogenic Maturation Of The Baboon Fetal Adrenal Gland, Maria Gomez Leavitt

Theses and Dissertations in Biomedical Sciences

The present study determined whether the growth of, as well as ACTH receptor and P-450 enzyme messenger ribonucleic acid and/or protein levels in the baboon fetal adrenal are dependent upon fetal pituitary ACTH during mid and late gestation and the mechanism by which placental estrogen modulates ACTH actions. Administration of betamethasone (3mg/day) to baboon mothers on days 60-99 of gestation and to the fetus (0.6 mg/, n = 4) or to the fetus (0.6mg) and mother (6 mg/ml; n = 4) every other day between days 150-164 of gestation (term = 184 days) decreased (P $53β-hydroxysteroid dehydrogenase-isomerase (3β-HSD(+)ctochrome P450 17α-hydroxylase, …

Effect Of Cocaine On Rabbit Renin Angiotensin System: Cocaine Detection In Adult And Fetal Tissue And Adult Plasma Using Ion Mobility Spectrometry, Barbara Belinda Guinn

Biological Sciences Theses & Dissertations

Ion mobility spectrometry (IMS) was used to detect cocaine and/or the metabolite ecgonine methyl ester (EME) in tissue and plasma samples from male, maternal, and fetal New Zealand White (NZW) rabbits. EME was consistently detected in all adult plasma samples 5 minutes after the injection of cocaine hydrochloride (cocaine•HCI, 2 mg/kg). EME was also in the liver, kidneys, testicles, and ovaries. Five minutes after the injection of cocaine•HCI, the male arterial pressure (MAP) increased from a mean control value of 79 ± 3.2 mmHg to 88 ± 4.1 mmHg, and the pCO₂ increased from a control value of28 ± …

Effect Of Resistance Training On Lipid Profile And Body Composition In Premenopausal Women, Bharathi Prabhakaran

Human Movement Studies & Special Education Theses & Dissertations

This study examined the effects of 14 weeks of resistance training on lipid levels and body fat percentage (BF%) in healthy, sedentary premenopausal women. Twenty four women (mean ± SD: age:27 ± 6.5 yrs, weight 66.2 ± 12.3 kg) participated in the study. The subjects were randomly placed in either a control (CON) group or in an exercise (EXER) group. The EXER group participated in a supervised 45-50 minute resistance training session (85% of 1-RM) for 14 weeks, 3 times per week on non-consecutive days. The CON group did not participate in any physical activity. The subjects were asked not …

Endothelial Nitric Oxide Synthase And Growth Factor Regulation Of Flow-Mediated Vascular Remodeling, David Anthony Tulis

Theses and Dissertations in Biomedical Sciences

This study was designed to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control vessels. Neither mean carotid nor local mesenteric arterial pressures changed significantly pre- to post-ligation. The primary flow-mediated force in both vessels was shear stress with possible involvement of acute stretch-induced wall stress in the ileal artery. Significant luminal expansion and medial wall hypertrophy occurred in the ileal and second-order arteries in a time-dependent …

Cellular Responses In Escherichia Coli To Lethal And Sublethal Doses Of Ozone, Indira Ruth Komanapalli

Loma Linda University Electronic Theses, Dissertations & Projects

Ozone is a major component of photochemical smog. High levels of this pollutant, sufficient to affect human health are found in many urban areas worldwide. Though limited studies in humans are supported by extensive findings from animal experiments, a difficulty in interpreting the results of these experiments has lead to an ambiguity on the biochemical mechanism of ozone toxicity. To elucidate the mechanism by which ozone causes cell damage and eventual cell death we conducted a comprehensive study using Escherichia coli K-12 as a model.

Studies on the comparative inactivation of bacteriophage lambda (λ), Escherichia coli, and Candida albicans …

Genomic Diversity In Staphylococcus Aureus, Bret Max Barton

Loma Linda University Electronic Theses, Dissertations & Projects

Staphylococcus aureus chromosomal DNA from 125 methicillin-resistant and 10 methicillin-sensitive clinical isolates was digested with rare-cutting restriction endonucleases and subjected to pulsed-field gel electrophoresis (PFGE). Thirty-nine distinct genomic macrorestriction patterns (GPs) were identified using SmaI; 29 of these patterns are from methicillin-resistant S. aureus (MRSA).

A dendrogram showing percent similarity among the patterns was constructed which revealed the considerable genomic diversity of the collection even though the isolates had been obtained during outbreaks. The majority of the MRSA formed one broad group with two outbreak subclasses. However, 8 of the 29 MRSA GPs (28%) were diverse.

Digestion with Csp …

Density, Distribution, And Habitat Of Flammulated Owls In Idaho, Craig Groves, Terry Frederick, Glenn Frederick, Eric Atkinson, Melonie Atkinson, Jay Shepherd, Gregg Servheen

Great Basin Naturalist

From 1990 to 1992 we surveyed for Flammulated Owls (Otus flammeolus) in 3 areas in Idaho: Salmon National Forest (SNF), Payette National Forest and adjacent Hells Canyon National Recreation Area (PNF-HCNRA), and Nez Perce National Forest (NPNF). We also collected and summarized information on all historic and modern records of Flammulated Owls in Idaho. Flammulated Owls were detected on 65% of 68 routes (2–16 km in length) surveyed at densities ranging from 0.04 to 1.25 singing males/40 ha. Owls were detected on survey routes as early as 10 May and as late as 23 July. Mean percent canopy …

Erratum

Great Basin Naturalist

No abstract provided.

Diplostomiasis In Native And Introduced Fishes From Yellowstone Lake, Wyoming, Victor H. Inchausty, Michael Foutz, Richard A. Heckmann, Claudete Ruas, Paulo Ruas

Great Basin Naturalist

Totals of 101 native Yellowstone cutthroat (Oncorhynchus clarki bouvieri), 27 introduced lake trout (Salvelinus namaycush), and 40 introduced longnose sucker (Catostomus catostomus) from Yellowstone Lake, Wyoming, USA, were examined for eye flukes. Metacercariae of the trematode fluke Diplostomum were in vitreous humor and/or lens of 94% of Yellowstone cutthroat trout, 92% of lake trout, and 78% of longnose sucker. Longnose sucker had 7% prevalence of infection in both lens and vitreous humor of metacercariae, while Yellowstone cutthroat trout had 3% and lake trout 8%. Diplostomum spathaceum was in lens tissue of 5% of infected …

Receptor Kinase Gene Expression In Olfactory Receptor Neurons, Michael Moore

Honors Capstones

No abstract provided.

Changes In Spinal Height Supine And Walking In Subjects With And Without Lower Back Pain, Dave Gregory

Rehabilitation Sciences Theses & Dissertations

Purpose: The purpose of this study was to develop and test a device that could be used in clinical situations to measure spinal height in subjects with lower back pain.

Introduction: Spinal height measurement provides information on the impact of spinal loading on the intervertebral disc. The stadiometer is presently the most accurate device for this purpose but users of the device must be trained to be measured. This excludes untrainable subjects such as those with lower back pain. For this study, a new ins1rument was developed combining aspects of the stadiometer and other devices to produce a simpler method …

Natural Variability Of Vegetation, Soils, And Physiography In The Bristlecone Pine Forest Of The Rocky Mountains, Brigitte M. Ranne, William L. Baker, Tom Andrews, Michael G. Ryan

Great Basin Naturalist

Pinus aristata Engelm. forest vegetation in Colorado was studied to determine vegetation composition and the relationship between vegetation and environment. Species percent cover, tree size class, and environmental variables were recorded for 49 plots. Previously collected data for 4 plots from New Mexico were included. Environmental variables included latitude, longitude, elevation, slope, aspect, topographic position, parent material, percent rock cover, mean rock size, litter depth, estimated plot age class, and evidence of anthropogenic disturbance. Soils were analyzed for texture, depth, and percent carbon and nitrogen. Pinus aristata foliage was analyzed for percent nitrogen and phosphorus. Direct and indirect gradient analyses …

Effects Of Lipoproteins On Cyclo-Oxygenase And Lipoxygenase Pathways In Human Platelets, S A. Saeed, R A. Memon, A H. Gilani, B H. Shah

Department of Biological & Biomedical Sciences

The products of arachidonic acid (AA) metabolism in platelets play an important role in platelet shape change, adhesion and aggregation which may participate in the pathogenesis of ischemic heart disease and thrombosis. Since lipoproteins are also involved in the pathogenesis of thrombo-embolic disorders, the effect of human lipoproteins (HDL, LDL, VLDL) on AA metabolism in human platelets was investigated. Lipoproteins were separated by density gradient zonal ultracentrifugation. The effects of lipoproteins on production of AA metabolites in human platelets i.e., thromboxane A2 (TXA2) and hydroxy-eicosatetraenoic acids (HETEs) were examined using radiometric thin layer chromatography coupled with automated data integrator system. …

Lectin Binding Affinities Of Egg Coats And Sperm Of The Freshwater Zebra Mussel, Dreissena Polymorpha, Kathryn Margaret Kreimborg

Honors Capstones

No abstract provided.

Electrophysiological Effects Of Lysoplasmenylcholine On Rabbit Ventricular Myocytes, Ray Caldwell

Theses and Dissertations

Myocardial ischemia activates a phospholipase A2 that targets plasmalogen phospholipids and liberates 1-0-alkenyl-Iysoplasmenylcholine (LPLC) in preference to 1-0- acyl-Iysophosphatidylcholine (LPC). Although LPC is a pro arrhythmic ischemic metabolite, the effect of LPLC on cardiac electrophysiology is unknown. At the lowest doses investigated, LPLC induced spontaneous contractions in otherwise quiescent rabbit ventricular myocytes significantly faster than LPC. Spontaneous contractions developed with median times of 16.4 (n = 64), 27.4 (n = 36), and >60 min (n = 25) during exposure to 5, 2.5, and 1 JlM LPLC compared with 38.0 (n = 48) and >60 min (n = 29) for 5 …

Ankle Injuries And Ankle Strength, Flexibility, And Proprioception In College Basketball Players, Kristen A. Payne, Kris E. Berg, Richard W. Latin

Health and Kinesiology Faculty Publications

Injuries to the ankle joint are among the most common of all sport-related injuries. Figures range from 10% to 30% of all injuries and from 5% to 20% of all time-loss injuries.1-9 Athletes participating in sports such as football, soccer, basketball, and volleyball are especially at risk for this type of injury, largely because of the running and jumping involved. In 1977, Garrick3 reported that during any single year of a 6-year period at the University of Washington, at least 16% of all time-loss injuries for all sports involved ankle sprains.