Physiology Commons^™

Map Kinases Couple Hindbrain-Derived Catecholamine Signals To Hypothalamic Adrenocortical Control Mechanisms During Glycemia-Related Challenges, Arshad Khan, Kimberly Kaminski, Graciela Sanchez-Watts, Todd Ponzio, J. Kuzmiski, Jaideep Bains, Alan Watts

Selected Works Temporary Series

No abstract provided.

Map Kinases Couple Hindbrain-Derived Catecholamine Signals To Hypothalamic Adrenocortical Control Mechanisms During Glycemia-Related Challenges, Khan, Kimberly Kaminski, Graciela Sanchez-Watts, Todd Ponzio, J. Kuzmiski, Jaideep Bains, Alan Watts

Departmental Papers (Biology)

No abstract provided.

C-Met Initiates Epithelial Scattering Through Transient Calcium Influxes And Nfat-Dependent Gene Transcription, Peter R. Langford

Theses and Dissertations

Hepatocyte growth factor (HGF) signaling drives epithelial cells to scatter by breaking cell-cell adhesions and migrating as solitary cells, a process that parallels epithelial-mesenchymal transition. HGF binds and activates the c-Met receptor tyrosine kinase, but downstream signaling required for scattering remains poorly defined. This study addresses this shortcoming in a number of ways.A high-throughput in vitro drug screen was employed to identify proteins necessary in this HGF-induced signaling. Cells were tested for reactivity to HGF stimulation in a Boyden chamber assay. This tactic yielded several small molecules that block HGF-induced scattering, including a calcium channel blocker. Patch clamping was used …

Multisensory Integration In Shark Feeding Behavior, Jayne M. Gardiner

USF Tampa Graduate Theses and Dissertations

Multimodal sensory input directs simple and complex behaviors in animals. Most research to date has been limited to studies of individual senses rather than multiple senses working together, leading to important advances in our comprehension of the sensory systems in isolation, but not their complementary and alternative roles in difficult behavioral tasks, such as feeding. In the marine environment, a prey item might emit an odor, create a hydrodynamic disturbance, such as from gill movements or swimming, be visible to the predator, produce a sound, and/or produce a weak electrical field. Therefore, the goal of this study was to investigate …

Chronic Hindlimb Ischemia Impairs Functional Vasodilation And Vascular Reactivity In Mouse Feed Arteries, Trevor R. Cardinal, Kyle R. Struthers, Thomas J. Kesler, Matthew D. Yocum, David T. Kurjiaka, James B. Hoying

Peer Reviewed Articles

Vasodilation of lower leg arterioles is impaired in animal models of chronic peripheral ischemia. In addition to arterioles, feed arteries are a critical component of the vascular resistance network, accounting for as much as 50% of the pressure drop across the arterial circulation. Despite the critical importance of feed arteries in blood flow control, the impact of ischemia on feed artery vascular reactivity is unknown. At 14 days following unilateral resection of the femoral–saphenous artery–vein pair, functional vasodilation of the profunda femoris artery was severely impaired, 11 ± 9 versus 152 ± 22%. Although endothelial and smooth muscle-dependent vasodilation were …

Impact Of Collateral Enlargement On Smooth Muscle Phenotype, Alexander Jerome Bynum

Master's Theses

Peripheral Artery Disease is a very serious disease characterized by an arterial occlusion due to atherosclerotic plaques. In response to an arterial occlusion, arteriogenesis occurs, causing smooth muscle cells to transition from a contractile to synthetic state. Also following an arterial occlusion, functional impairment was seen in the collateral circuit. An immunofluorescence protocol was developed in order to assess the impact of collateral enlargement (arteriogenesis) on smooth muscle phenotype at various time points. Smooth muscle α-actin was used to mark all smooth muscle cells, Ki-67 was used to label proliferating smooth muscle cells, and a fluorescent nuclear stain was used …

The Effect Of Physical Activity On The Insulin Response To Frequent Meals, Michael E. Holmstrup

Exercise Science - Dissertations

Long, uninterrupted bouts of sedentary behavior are thought to negatively influence insulin sensitivity, and may impact metabolic function regardless of adherence to general physical activity guidelines. The purpose of this study was to determine the combined effect of physical activity (1 h continuous exercise v. intermittent exercise throughout the day) and meal consumption on glucose excursions, insulin secretion, and appetite markers in obese individuals with prediabetes. Methods: Eleven healthy, obese subjects (>30 kg/m2) with prediabetes underwent 3, 12 h study days including sedentary behavior (SED), exercise (EX; 1h morning exercise, 60-65% VO2 max), and physical activity (PA; 12 hourly, …

Systematics Of Protosteloid Amoebae, Lora Lindley Shadwick

Graduate Theses and Dissertations

Because of their simple fruiting bodies consisting of one to a few spores atop a finely tapering stalk, protosteloid amoebae, previously called protostelids, were thought of as primitive members of the Eumycetozoa sensu Olive 1975. The studies presented here have precipitated a change in the way protosteloid amoebae are perceived in two ways: (1) by expanding their known habitat range and (2) by forcing us to think of them as amoebae that occasionally form fruiting bodies rather than as primitive fungus-like organisms. Prior to this work protosteloid amoebae were thought of as terrestrial organisms. Collection of substrates from aquatic habitats …

Store-Operated Calcium Channels In The Function Of Intracardiac Neurons, Timetria Bonds

USF Tampa Graduate Theses and Dissertations

Proper autonomic regulation of mammalian cardiac function is dependent upon very complex and precise communication among the intracardiac ganglia and individual neurons within the ganglia. An array of neuromodulators is found within the ganglia that direct neuronal activity by modulating the movement of calcium. The current study determines that opioidergic agonists, which have been found to contribute to severe cardiac disease states and intracellular calcium mobilization, are also responsible for changes in the function of the intracardiac neuron via their effects on store-operated calcium channels (SOCs).

Previous studies suggest that phosphorylation plays a role in SOC regulation. Using Fura-2 calcium …

The Short-Term Effect Of Whole Body Vibration Training On Physical Capabilities On Active Young Recreational Athletes, Esteban Martinez Ballester, Ivan Chulvi Dr

International Journal of Exercise Science: Conference Proceedings

In recent years, whole body vibration (WBV) has been the subject of a great amount of research towards improving physical capabilities as a postactivation potentiation because the muscle spindle’s sensitivity can be increased (Rittweger, 2010). Typically, WBV is realized by the subject above the platform in squat position while the platform oscillates at differences intensities and amplitudes. Previous reports have shown that WBV produces preconditioning effects that lead an increase of power and flexibility (Jacobs & Burns, 2009), but controversial data exists that have shown no positive effect if an optimal dosage is not used in a controlled manner (Wilcock …

Discriminating Between Copers And Those With Chronic Ankle Instability With Clinical Outcomes, Erik A. Wikstrom, Jessica Plante

International Journal of Exercise Science: Conference Proceedings

Introduction: Chronic ankle instability (CAI) is a common consequence of lateral ankle sprains and a leading cause of post-traumatic ankle osteoarthritis. Despite a history of a lateral ankle sprain, there are some individuals (copers) who appear to have a mechanism that allows them to avoid recurrent lateral ankle sprains and giving way episodes. To date, research has identified differences in perceptual (e.g. self-assessed disability), mechanical (e.g. ligament laxity), and sensorimotor (e.g. balance) outcomes between copers and those with CAI. However, the vast majority of these outcomes are considered research and/or laboratory based and thus impractical for most clinicians to use …

Comparing Dominant And Non-Dominant Torque And Work Using Biodex 3 Isokinetic Protocol For Knee Flexors And Extensors, Joshua Sparks, Jeremy Carter, Kelly Brooks

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION. There is often a misconception when looking at comparing dominant and non-dominant limbs of any sort. Although there will be a lack of control in non-dominant limbs compared to dominant, the amount of torque and power associated with each limb may be equal; even so, there may be an instance of bilateral deficit, where even though the dominant limb may be used to do work on a specific limb, the non-dominant limb may still receive strength benefits. PURPOSE. The main purpose of this study is to directly relate ability (torque and total work) in both dominant and non-dominate limbs …

Influences On Pulmonary And Muscular V’O2-Kinetics, Uwe Drescher, Uwe Hoffmann

International Journal of Exercise Science: Conference Proceedings

Introduction

Muscular and respiratory V’O2-kinetics are influenced by many factors. At cellular level muscular V’O2 (V’O2musc) is affected by O2-delivery and O2-consumption. Further, these factors can be divided into muscle perfusion, capillary density, enzyme activity, mitochondrial proliferation, muscle fiber composition and some more.

Focusing on the difference between V’O2resp and V’O2musc the venous blood volume, the venous O2-stores and the dynamics of cardiac output can be identified as influences. These influences result in a time delay and a distortion of V’O2resp. Usually exercise step responses are used for estimating V’O2resp-kinetics. But it has to be recognized, that V’O2resp may be …

Micro-Fracture Simulation In Human Vertebral Body Due To Weight Lifting, Harcharan S. Ranu

International Journal of Exercise Science: Conference Proceedings

Abstract Lumbar vertebrae are a heavily loaded component of the human body. They are subjected to repetitive loading in daily activities. However, limited information on failure mechanism of lumbar vertebrae are available to date. Thus, the need to develop an analytical model to predict stress-fracture characteristics of vertebral body. A linear elastic fracture mechanics approach has been considered and a mathematical model has been proposed so that the predictions can be made more easily related to the occurrence of injury. Study reveals that for a person weighing 1334 N and lifting a weight of 345 kg during squat exercise causes …

Injury Simulation In Female Gymnasts, Harcharan S. Ranu

International Journal of Exercise Science: Conference Proceedings

Abstract Female gymnasts often place un-physiological extreme repetitive loading on their bodies during the common maneuvers characteristic of this sport. Thus, it was necessity to provide quantitative and qualitative analyses of impact behavior of feet of gymnasts. The response of fracture or injury due to jumping is also important in designing safety equipment related to sports. A linear elastic fracture mechanics approach has been used for this analysis. Typical behavior of crack growth rate for a force of F= 6.1 KN and m being 1.25, revealed that 6 landings were sufficient to initiate micro-fracture of bone due to landing after …

A Leucine-Enriched Diet Enhances Overload-Induced Growth And Markers Of Protein Synthesis In Aged Rat Skeletal Muscle, Rengfei Shi, Hoke Whitworth, William Mixon, Scott E. Gordon

International Journal of Exercise Science: Conference Proceedings

Introduction: The hypertrophic response to overload in fast-twitch skeletal muscle is impaired in aged humans and rats, and impaired protein synthesis pathway activation is hypothesized to be a contributing factor. Muscle growth occurs when protein synthesis exceeds protein degradation. Dietary supplementation of the essential amino acid leucine has been shown to enhance protein synthesis in both young and aged skeletal muscle. Leucine acts in part by activating mammalian target of rapamycin (mTOR; a key upstream regulator of protein synthesis pathways) as well as by attenuating the activation of 5'-AMP-activated protein kinase (AMPK; a negative regulator of mTOR and protein synthesis). …

A Leucine-Enriched Diet Enhances Overload-Induced Growth And Suppresses Markers Of Protein Degradation In Aged Rat Skeletal Muscle, Scott E. Gordon, William Mixon, Hoke Whitworth, Rengfei Shi

International Journal of Exercise Science: Conference Proceedings

Introduction: The hypertrophic response to overload in fast-twitch skeletal muscle is impaired in aged humans and rats, and upregulation of protein degradation pathways are hypothesized to be a contributing factor. Muscle growth occurs when protein synthesis is greater than protein degradation. Dietary supplementation of the essential amino acid leucine has been shown to reduce protein degradation in both young and aged skeletal muscle. Specifically, leucine acts in part by attenuating 5'-AMP-activated protein kinase (AMPK) activation as well as the translocation of the forkhead box transcription factor 3A (FoxO3, known to promote transcription of mRNAs encoding degradation pathway proteins) to the …

Isokinetic Muscle Strength And Fatigue Evaluation Following A Combined Aerobic And Resistance Training Program On A Gravity Independent Flywheel Device, Joshua A. Cotter, Tomasz Owerkowicz, Alvin M. Yu, Marinelle L. Camilon, Theresa Hoang, Per A. Tesch, Vincent J. Caiozzo, Gregory R. Adams

International Journal of Exercise Science: Conference Proceedings

Exposure to microgravity imposes changes on the musculoskeletal and cardiovascular systems leading to decreases in aerobic capacity, muscular strength, and muscular fatigue (1). Anti-gravity muscles, those that play a postural role in a standard gravity environment such as the soleus and quadriceps, are most affected by microgravity (2) with nearly all musculature affected with extended spaceflight (3). The multi-mode exercise device (M-MED) is a gravity independent device that provides both high force resistance type and low force aerobic type modes of exercise. Consequently, the M-MED has the ability to enhance both skeletal muscle function through resistance training exercises as well …

Genetic Regulation Of Myofiber Hypertrophy?, Anna Thalacker-Mercer, Xiangqin Cui, Michael Stec, Edward Merritt, Marcas Bamman

International Journal of Exercise Science: Conference Proceedings

Introduction. Progressive, resistance exercise training (RT) induces skeletal muscle hypertrophy, increases strength, power, and quality of muscle, and is potentially the most promising method to regenerate and re-grow muscle in populations suffering from involuntary atrophy. However, we have previously shown that there is a large degree of intersubject variability for myofiber hypertrophy in response to RT with adults having no response [-16μm2 (mean myofiber growth), Non], a modest response (1111μm2, Mod), or an extreme hypertrophic response (2475μm2, Xtr). Underlying mechanisms for this differential growth response are largely unknown. Therefore, the purpose of this study was to determine whether differences in …

Effects Of Multivitamin Supplementation On Heart Rate Response In Aerobically Untrained College Aged Students, Greg A. Ryan, Charles P. Katica, Stacy H. Bishop, Robert L. Herron, Andy M. Bosak, Mark Sloniger

International Journal of Exercise Science: Conference Proceedings

Multivitamin use is increasingly prevalent in the US among most every population. Yet, previous research noted no performance benefits among individuals following a supplementation period. This study focused on the potential physiological benefits from a three week multivitamin supplementation period using 24 (20.9 ± 2.6yr) aerobically untrained college aged students. Subjects were divided equally into three groups (placebo = PL, multivitamin = MV, control = CL) and asked to perform separate eight minute bouts of exercise, consisting of six min of moderate (60%VO2max) intensity followed immediately by two min of high (85%VO2max) intensity exercise on a cycle ergometer. Following the …

Effect Of Treadmill Versus Elliptical Exercise On Calcaneal Stiffness Index Among College Age Females, Kelly Maloney, Sandie Walker, Stephanie M. Otto Ph.D.

International Journal of Exercise Science: Conference Proceedings

Osteoporosis is a disease that affects many older individuals, resulting in a decrease in bone density. Involvement in impact loading sports has been associated with greater stiffness index (SI) of the calcaneus when compared to non-impact sports and abstinence from sports. However, comparisons between the effectiveness of impact and non-impact exercise equipment on calcaneal SI is less clear. The purpose of this study was to examine the effect of treadmill versus elliptical exercise on calcaneal SI.

Daily Physical Activity And Bone Health Among High School Students, Stephanie M. Otto Ph.D., Don Morgan Ph.D., Richard S. Farley Ph.D., Jwa K. Kim Ph.D., Dana K. Fuller Ph.D., Jennifer L. Caputo Ph.D.

International Journal of Exercise Science: Conference Proceedings

With advancements in healthcare and public education, life expectancy is increasing and the prevalence of age related health conditions such as osteoporosis are rising. It is well known that children and adolescents who engage in healthy behaviors are more likely to carry those behaviors into adulthood. More specifically, children and adolescents who engage in weight bearing physical activity have higher bone density and are less likely to develop osteoporosis later in life. Furthermore, technology that measures daily physical activity is improving and individuals are interested in the amount of activity they and their children should participate in to remain healthy. …

Body Composition And Physical Fitness Of Students In High School Vs. Students Enrolled In High School Sports Academia Programs, Gunnhildur Hinriksdóttir, Frosti Sigurðsson, Anna S. Ólafsdóttir, Ragnar Bjarnason, Sigurbjörn Á. Arngrímsson

International Journal of Exercise Science: Conference Proceedings

In recent years more and more high schools in Iceland are offering sports academia programs. These programs are intended for teenage athletes in various sports who have the potential of becoming elite athletes. The sports academia programs make it easier for these student athletes to focus on training for their sport while attending high school, and thereby, enable them to get a good education and enhance their athletic potential. These programs also have the potential to reduce drop-out in sports because it is easier for the students to balance athletics and academics. Nevertheless, sports performance is not necessarily linked to …

Body Composition, Physical Activity And Fitness In Children With Moderate-To-Severe Intellectual Disability, Sigurbjorn A. Arngrimsson, Ingi T. Einarsson

International Journal of Exercise Science: Conference Proceedings

Introduction: The prevalence of overweight and obesity has been rising in most parts of the world over the past two decades (1, 2). This rise could pose even a greater problem for people with intellectual disability (ID) because they are more likely to be obese than people without ID (3). Furthermore, research has shown that a sedentary lifestyle is more prevalent among people with ID than otherwise healthy people in modern society (4). In the general population, the adverse effects of obesity on health begin early in life and physical inactivity and adiposity are associated with metabolic diseases and cancers …

The Physiological Stress Response To Anaerobic Exercise Is Altered Following Sodium Bicarbonate Supplementation, Dan J. Peart, Richard Kirk, Angela Hillman, Bryna Chrismas, Leigh Madden, Jason Siegler, Rebecca Vince

International Journal of Exercise Science: Conference Proceedings

Sodium bicarbonate (NaHCO3) is a nutritional aid that is proposed to enhance performance by reducing the state of exercise induced acidosis, however research is currently equivocal. Despite this, most research still focuses on its effects upon performance, and not whether the reduced acidosis impacts upon any other factors related to exercise. There is some research to suggest that such a reduction in [H+] can attenuate a number of physiological stress pathways such as stress hormones (1, 4), heat shock protein 72 (HSP72) and oxidative stress (3), suggesting a potential role in exercise recovery. However there are some limitations with this …

Lactic Acid: A Great Help For The Canoeing Coach., Flavia Bruttini M.D., Serena Benzo M.D., Daniele Bronzini, Luca Nicolasi, Antonio Mortara, Ioanna Nakou M.D., Marco Vescovi M.D., Monica Vescovi M.D.

International Journal of Exercise Science: Conference Proceedings

Six athletes who are practicing canoe kayak (n. 4) and canadese (n. 2, Mirko and Enrico) were submitted to an incremental test of 1000 meters which was repeated three times with an increasing speed. The test was carried out at the river named Ticino, in an area with constant water depth and no current.

Dragon Boat: Customizing The Training Plan, Flavia Bruttini, Serena Benzo M.D., Stefano Loddo, Ioanna Nakou M.D., Marco Vescovi M.D., Monica Vescovi M.D.

International Journal of Exercise Science: Conference Proceedings

Athlete’s muscle function during Dragon Boat practice requires activation of a complex kinetic chain (composed of a great number of muscles of all sizes, starting from dorsal muscles, abdominal muscles and muscles of the limbs). The Dragon Boat competition includes, during the sporting year, races with length spanning from about 40 seconds (200 meters) up to 10 minutes (2000 meters) and beyond, in specific distances (long distances).

Low Back Pain And Kayak: A Short Report, Stefano Loddo, Serena Benzo M.D., Flavia Bruttini M.D., Ioanna Nakou M.D., Marco Vescovi M.D., Monica Vescovi M.D.

International Journal of Exercise Science: Conference Proceedings

During the winter Kayak training remarkable weights are frequently used in the gym, suitable for the preparation, the structure, but mainly the goals of the individual

Ergometer And Dragon Boat, Stefano Loddo, Marco Vescovi M.D., Flavia Bruttini M.D., Ioanna Nakou M.D., Mario Segagni, Serena Benzo M.D., Monica Vescovi M.D.

International Journal of Exercise Science: Conference Proceedings

Dragon Boat is an activity that requires a participation of a large amount of muscles. The muscle groups involved are in order of involvement: the dorsal and abdominal muscles, biceps and triceps in the upper limbs and femoral quadriceps and gastrocnemius in the lower limbs. The athlete’s muscle building is based on strengthening exercises with weight lifting that involves both upper and lower limbs, with a particular attention to the heart. The paddle position, the rotation and the twisting of the body is taken into account. Racing and boat outings are integrated into the preparation. However the paddling technique exercises …

Children’S Winter Training In Kayak: A Multilateral Approach, Marco Vescovi M.D., Serena Benzo M.D., Daniele Bronzini, Flavia Bruttini M.D., Antonio Mortara, Ioanna Nakou M.D., Monica Vescovi M.D.

International Journal of Exercise Science: Conference Proceedings

Children’s approach to Kayak as a sport takes place at about the age of ten. The winter weather conditions of the Northern Italian valley do not usually permit training at the river for a long period of time. Additionally the weather increases the risk of the boat to turn over in case of imperfect control. For this reason we have elaborated a training scheme in which going out on the boat starts in April when the temperature (both of the water and the atmosphere) begins to raise.