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2015

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Articles 1 - 30 of 411

Full-Text Articles in Physiology

Using Detection Dogs And Rspf Models To Assess Habitat Suitability For Bears In Greater Yellowstone, Jon P. Beckmann, Lisette P. Waits, Aimee Hurt, Alice Whitelaw, Scott Bergen Dec 2015

Using Detection Dogs And Rspf Models To Assess Habitat Suitability For Bears In Greater Yellowstone, Jon P. Beckmann, Lisette P. Waits, Aimee Hurt, Alice Whitelaw, Scott Bergen

Western North American Naturalist

In the northern U.S. Rockies, including the Greater Yellowstone Ecosystem (GYE), connectivity is a concern because large carnivores have difficulties dispersing successfully between protected areas. One area of high conservation value because of its importance for connecting the GYE to wilderness areas of central Idaho is the Centennial Mountains and surrounding valleys (2500 km2) along the Idaho–Montana border just west of Yellowstone National Park. The current expansion of grizzly bears (Ursus arctos) and other large carnivore populations outside protected areas of Yellowstone National Park and Grand Teton National Park has placed a greater emphasis on potential linkage zones …

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Alternative Use Of Dna Binding Domains By The Neurospora White Collar Complex Dictates Circadian Regulation And Light Responses, Bin Wang, Xiaoying Zhou, Jennifer J. Loros, Jay C. Dunlap Dec 2015

Alternative Use Of Dna Binding Domains By The Neurospora White Collar Complex Dictates Circadian Regulation And Light Responses, Bin Wang, Xiaoying Zhou, Jennifer J. Loros, Jay C. Dunlap

Dartmouth Scholarship

In the Neurospora circadian system, the White Collar complex (WCC) of WC-1 and WC-2 drives transcription of the circadian pacemaker gene frequency (frq), whose gene product, FRQ, as a part of the FRQ-FRH complex (FFC), inhibits its own expression. The WCC is also the principal Neurospora photoreceptor; WCC-mediated light induction of frq resets the clock, and all acute light induction is triggered by WCC binding to promoters of light-induced genes. However, not all acutely light-induced genes are also clock regulated, and conversely, not all clock-regulated direct targets of WCC are light induced; the structural determinants governing the shift …

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Correlations Between Quantitative Fat–Water Magnetic Resonance Imaging And Computed Tomography In Human Subcutaneous White Adipose Tissue, Aliya Gifford, Ronald C. Walker, Theodore F. Towse, E Brian Welch Dec 2015

Correlations Between Quantitative Fat–Water Magnetic Resonance Imaging And Computed Tomography In Human Subcutaneous White Adipose Tissue, Aliya Gifford, Ronald C. Walker, Theodore F. Towse, E Brian Welch

Peer Reviewed Articles

Beyond estimation of depot volumes, quantitative analysis of adipose tissue properties could improve understanding of how adipose tissue correlates with metabolic risk factors. We investigated whether the fat signal fraction (FSF) derived from quantitative fat–water magnetic resonance imaging (MRI) scans at 3.0 T correlates to CT Hounsfield units (HU) of the same tissue. These measures were acquired in the subcutaneous white adipose tissue (WAT) at the umbilical level of 21 healthy adult subjects. A moderate correlation exists between MRI- and CT-derived WAT values for all subjects, R2=0.54, p<0.0001, with a slope of −2.6, (95% CI [−3.3,−1.8]), indicating that a decrease of 1 HU equals a mean increase of 0.38% FSF. We demonstrate that FSF estimates obtained using quantitative fat–water MRI techniques correlate with CT HU values in subcutaneous WAT, and therefore, MRI-based FSF could be used as an alternative to CT HU for assessing metabolic risk factors.

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Interaction Between Angiotensin Ii And Bdnf In Modulating Sympathetic Nerve Activity, Bryan K. Becker Dec 2015

Interaction Between Angiotensin Ii And Bdnf In Modulating Sympathetic Nerve Activity, Bryan K. Becker

Theses & Dissertations

Over activation of the sympathetic nervous system is prevalent in many forms of cardiovascular disease such as chronic heart failure (CHF) and hypertension. Although increased neuronal renin-angiotensin system activity in presympathetic neurons has been well implicated in mediating this sympatho-excitation, many of the neuronal effects of angiotensin II (Ang II) signaling remain poorly understood. One particular mechanism of Ang II-mediated increases in presympathetic neuronal activity is through reductions in voltage-gated K+ currents. Another pathway that has profound effects on neuronal K+ currents and that has been previously implicated in Ang II-signaling is brain-derived neurotrophic factor (BDNF) activity through …

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Longevity Of Mineral Supplements Within The Soil And Associated Use By White-Tailed Deer, Brian C. Peterson, Keith D. Koupal, Andrew K. Schissel, Cody M. Siegel Dec 2015

Longevity Of Mineral Supplements Within The Soil And Associated Use By White-Tailed Deer, Brian C. Peterson, Keith D. Koupal, Andrew K. Schissel, Cody M. Siegel

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Humans have baited wildlife such as white-tailed deer (Odocoileus virginianus) for generations with the primary purpose of increasing hunting harvest success. Baiting regulation changes are often considered by state management agencies as they pertain to hunting opportunity, fair chase, and disease risk. Cervids require a variety of minerals to supplement biological processes, especially sodium (Na), calcium (Ca), and phosphorus (P). We developed artificial mineral supplement sites set in front of trail cameras to monitor deer use. Pooled soil samples were collected at mineral sites and compared to the surrounding area to determine the longevity of elevated minerals levels …

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Using Hexoskin Wearable Technology To Obtain Body Metrics In A Trail Hiking Setting, Jeffrey Montes, Tori M. Stone, Jacob W. Manning, Damon Mccune, Debra K. Tacad, Jack C. Young, Mark Debeliso Phd, James W. Navalta Dec 2015

Using Hexoskin Wearable Technology To Obtain Body Metrics In A Trail Hiking Setting, Jeffrey Montes, Tori M. Stone, Jacob W. Manning, Damon Mccune, Debra K. Tacad, Jack C. Young, Mark Debeliso Phd, James W. Navalta

International Journal of Exercise Science

International Journal of Exercise Science 8(4): 425-430, 2015. Use of wearable technology to obtain various body metrics appears to be a trending phenomenon. However there is very little literature supporting the notion that these apparatuses can be used for research purposes in the field. The purpose of this study was to utilize Hexoskin wearable technology shirts (HxS) to obtain data in a pilot study using a trail hiking situation. Ten individuals (male, n = 4, female n = 6) volunteered to participate. On the first day, volunteers completed two approximately flat trail hikes at a self-preferred pace with a 15-minute …

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A New Method For Shear Wave Speed Estimation In Shear Wave Elastography, Aaron J. Engel, Gregory R. Bashford Dec 2015

A New Method For Shear Wave Speed Estimation In Shear Wave Elastography, Aaron J. Engel, Gregory R. Bashford

Biomedical Imaging and Biosignal Analysis Laboratory

Visualization of mechanical properties of tissue can aid in noninvasive pathology diagnosis. Shear wave elastography (SWE) measures the elastic properties of soft tissues by estimation of local shear wave propagation speed. In this paper, a new robust method for estimation of shear wave speed is introduced which has the potential for simplifying continuous filtering and real-time elasticity processing. Shear waves were generated by external mechanical excitation and imaged at a high frame rate. Three homogeneous phantoms of varying elastic moduli and one inclusion phantom were imaged. Waves propagating in separate directions were filtered and shear wave speed was estimated by …

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Countermovement Jump Performance Changes Over The Course Of Collegiate Basketball Pre-Season Associated With Block Periodization Model Of Strength And Conditioning Program, Nobuhisa Yoshida, Caleb D. Bazyler, Takahiro Unebasami, Stephen Wells, Zachary Whitman, Danielle Lee, Mallory Stellhorn, Kimitake Sato, Michael H. Stone Dec 2015

Countermovement Jump Performance Changes Over The Course Of Collegiate Basketball Pre-Season Associated With Block Periodization Model Of Strength And Conditioning Program, Nobuhisa Yoshida, Caleb D. Bazyler, Takahiro Unebasami, Stephen Wells, Zachary Whitman, Danielle Lee, Mallory Stellhorn, Kimitake Sato, Michael H. Stone

ETSU Faculty Works

No abstract provided.

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Analysis Of Changes In Muscle Architecture And Explosive Ability In Ncaa Division I Volleyball Players, Caleb D. Bazyler, Jacob R. Goodin, Conrad Rapp, Mark Disanto, Frank Smith, Michael H. Stone Dec 2015

Analysis Of Changes In Muscle Architecture And Explosive Ability In Ncaa Division I Volleyball Players, Caleb D. Bazyler, Jacob R. Goodin, Conrad Rapp, Mark Disanto, Frank Smith, Michael H. Stone

ETSU Faculty Works

Abstract available in the 10th Annual Coaches and Sport Science College .

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Application Of Principal Components Analysis In Kinetics Study For Isometric Squat, Junshi Liu, Caleb D. Bazyler, Christopher B. Taber, Tony Pustina, Satoshi Mizuguchi Dec 2015

Application Of Principal Components Analysis In Kinetics Study For Isometric Squat, Junshi Liu, Caleb D. Bazyler, Christopher B. Taber, Tony Pustina, Satoshi Mizuguchi

ETSU Faculty Works

Abstract available in the 10th Annual Coaches and Sport Science College .

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Calcium Signaling And Ca2+/Calmodulin-Dependent Kinase Ii Activity In Epithelial To Mesenchymal Transition, Melissa Ann Mcneil Dec 2015

Calcium Signaling And Ca2+/Calmodulin-Dependent Kinase Ii Activity In Epithelial To Mesenchymal Transition, Melissa Ann Mcneil

Theses and Dissertations

Epithelial to mesenchymal transition (EMT) is an important process in embryonic development, tissue repair, inflammation, and cancer. During EMT, epithelial cells disassemble cell-cell adhesions, lose apicobasal polarity, and initiate migratory and invasive processes that allow individual cells to colonize distant sites. It is the means by which non-invasive tumors progress into malignant, metastatic carcinomas. In vitro, EMT occurs in two steps. First, cells spread out, increasing in surface area and pushing the colony borders out. Then cells contract, pulling away from neighboring cells and rupturing cell-cell junctions, resulting in individual highly migratory cells. Recent discoveries indicate that calcium signaling is …

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Cardiovascular Regulation And Effects Of Respiratory Motor Training In Patients With Chronic Spinal Cord Injury., Bonnie Legg Ditterline Dec 2015

Cardiovascular Regulation And Effects Of Respiratory Motor Training In Patients With Chronic Spinal Cord Injury., Bonnie Legg Ditterline

Electronic Theses and Dissertations

This dissertation attempts to discover the mechanisms between cardiovascular and respiratory motor control post spinal cord injury (SCI): in normal, non-injured (NI) persons, cardiovascular regulation is dependent upon respiration, but there is nothing that suggests the mechanism for this relationship post-SCI. Thus we hoped to evaluate various aspects of cardiovascular regulation to further illustrate how this relationship is changed or unchanged by SCI. Chapter I describes the anatomy and physiology of the spine, respiratory system, and cardiovascular system in a NI person, and then describes how the function of these systems is changed by SCI. In addition, we describe therapies …

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Autophagy And Its Potential Role In Stress And Feed Efficiency Using Avian Lines, Alissa Laura Piekarski Dec 2015

Autophagy And Its Potential Role In Stress And Feed Efficiency Using Avian Lines, Alissa Laura Piekarski

Graduate Theses and Dissertations

Autophagy is a highly conserved cellular mechanism that is responsible for the degradation and recycling of damaged organelles. Recently, autophagy has been involved in critical roles during overall development of the organism and degradation of damaged cellular components. This pathway has witnessed dramatic growth in the last few years and has been extensively studied in yeast and mammals, however, there is a paucity of information in avian (non-mammalian) species. First, we characterized genes involved in the autophagy pathway in male and female Jungle Fowl to determine gender and tissue specific differences. Secondly, tissue and genotype differences in Japanese quail selected …

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Third Ventricle Width As A Metric For Fast And Efficient Detection Of Atrophy In Traumatic Brain Injury, Christopher Scott Finuf Dec 2015

Third Ventricle Width As A Metric For Fast And Efficient Detection Of Atrophy In Traumatic Brain Injury, Christopher Scott Finuf

Theses and Dissertations

In an average year more than 1.7 million people will experience a traumatic brain injury (TBI) in the United States. It is known that atrophy occurs across a spectrum for TBI patients, ranging from mild to severe. Current conventional magnetic resonance imaging (MRI) methods are inconsistent in detecting this atrophy on the milder end of the spectrum. Also more contemporary imaging tools, although efficient, are too time consuming for clinical applicability. It is for these reasons that a quick and efficient measurement for detecting this atrophy is needed by clinicians. The measuring of third ventricle width had the potential to …

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Effects Of Rapamycin Treatment On Neurogenesis And Synaptic Reorganization In The Dentate Gyrus After Controlled Cortical Impact Injury In Mice, Corwin R. Butler, Jeffery A. Boychuk, Bret N. Smith Nov 2015

Effects Of Rapamycin Treatment On Neurogenesis And Synaptic Reorganization In The Dentate Gyrus After Controlled Cortical Impact Injury In Mice, Corwin R. Butler, Jeffery A. Boychuk, Bret N. Smith

Physiology Faculty Publications

Post-traumatic epilepsy (PTE) is one consequence of traumatic brain injury (TBI). A prominent cell signaling pathway activated in animal models of both TBI and epilepsy is the mammalian target of rapamycin (mTOR). Inhibition of mTOR with rapamycin has shown promise as a potential modulator of epileptogenesis in several animal models of epilepsy, but cellular mechanisms linking mTOR expression and epileptogenesis are unclear. In this study, the role of mTOR in modifying functional hippocampal circuit reorganization after focal TBI induced by controlled cortical impact (CCI) was investigated. Rapamycin (3 or 10 mg/kg), an inhibitor of mTOR signaling, was administered by intraperitoneal …

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Changes In Intragastric Temperature Reflect Changes In Heat Stress Following Tepid Fluid Ingestion But Not Ice Slurry Ingestion, Christopher J. Stevens, Ben Dascombe Nov 2015

Changes In Intragastric Temperature Reflect Changes In Heat Stress Following Tepid Fluid Ingestion But Not Ice Slurry Ingestion, Christopher J. Stevens, Ben Dascombe

Journal of Human Performance in Extreme Environments

This study examined the effects of fluid and ice slurry ingestion on the relationship between intragastric temperature and rectal temperature in humans during physical activity. The purpose was to identify a technique to quantify changes in heat stress in situations when temperature probes are not feasible and when time constraints do not allow for a period long enough for an indigestible temperature capsule to reach the lower gastrointestinal tract. Eight moderately trained male runners inserted a rectal probe and ingested a telemetric capsule before randomized, crossover, pre-exercise ingestion of 7.5 mL x kg-1 x BM-1tepid fluid (22°C) …

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Hepatic Nutrient And Hormonal Regulation Of The Pancreatic-Derived Factor (Pander) Promoter, Whitney Ratliff Nov 2015

Hepatic Nutrient And Hormonal Regulation Of The Pancreatic-Derived Factor (Pander) Promoter, Whitney Ratliff

USF Tampa Graduate Theses and Dissertations

PANcreatic-DERived factor (PANDER, FAM3B) has been shown to regulate glycemic levels via interactions with both pancreatic islets and the liver. Although PANDER is predominantly expressed from the endocrine pancreas, recent work has provided sufficient evidence that the liver may also be an additional tissue source of PANDER production. At physiological levels, PANDER is capable of disrupting insulin signaling and promoting increased hepatic glucose production. As shown in some animal models, strong expression of PANDER, induced by viral delivery within the liver, induces hepatic steatosis. However, no studies to date have explicitly characterized the transcriptional regulation of PANDER from the liver. …

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Chemical-Free Technique To Study The Ultrastructure Of Primary Cilium, Ashraf M. Mohieldin, Wissam A. Aboualaiwi, Min Gao, Surya M. Nauli Nov 2015

Chemical-Free Technique To Study The Ultrastructure Of Primary Cilium, Ashraf M. Mohieldin, Wissam A. Aboualaiwi, Min Gao, Surya M. Nauli

Pharmacy Faculty Articles and Research

A primary cilium is a hair-like structure with a width of approximately 200 nm. Over the past few decades, the main challenge in the study of the ultrastructure of cilia has been the high sensitivity of cilia to chemical fixation, which is required for many imaging techniques. In this report, we demonstrate a combined high-pressure freezing (HPF) and freeze-fracture transmission electron microscopy (FFTEM) technique to examine the ultrastructure of a cilium. Our objective is to develop an optimal high-resolution imaging approach that preserves cilia structures in their best natural form without alteration of cilia morphology by chemical fixation interference. Our …

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Bdnf Contributes To Angiotensin Ii-Mediated Reductions In Peak Voltage-Gated K+ Current In Cultured Cath.A Cells., Bryan K. Becker, Han-Jun Wang, Changhai Tian, Irving H. Zucker Nov 2015

Bdnf Contributes To Angiotensin Ii-Mediated Reductions In Peak Voltage-Gated K+ Current In Cultured Cath.A Cells., Bryan K. Becker, Han-Jun Wang, Changhai Tian, Irving H. Zucker

Journal Articles: Cellular & Integrative Physiology

Increased central angiotensin II (Ang II) levels contribute to sympathoexcitation in cardiovascular disease states such as chronic heart failure and hypertension. One mechanism by which Ang II increases neuronal excitability is through a decrease in voltage-gated, rapidly inactivating K(+) current (IA); however, little is known about how Ang II signaling results in reduced IA. Brain-derived neurotrophic factor (BDNF) has also been demonstrated to decrease IA and has signaling components common to Ang II. Therefore, we hypothesized that Ang II-mediated suppression of voltage-gated K(+) currents is due, in part, to BDNF signaling. Differentiated CATH.a, catecholaminergic cell line treated with BDNF for …

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The Anatomy Of Porcine And Human Larynges: Structural Analysis And High Resolution Magnetic Resonance Imaging Of The Recurrent Laryngeal Nerve, Nena Lundgreen Mason Nov 2015

The Anatomy Of Porcine And Human Larynges: Structural Analysis And High Resolution Magnetic Resonance Imaging Of The Recurrent Laryngeal Nerve, Nena Lundgreen Mason

Theses and Dissertations

The recurrent laryngeal nerve (RLN) innervates all the intrinsic muscles of the larynx that are responsible for human vocalization and language. The RLN runs along the tracheoesophageal groove bilaterally and is often accidentally damaged or transected during head and neck surgical procedures. RLN palsy and vocal cord paralysis are the most common and serious post op complications of thyroid surgeries. Patients who suffer from RLN injury can develop unilateral or bilateral vocal fold paralysis (BVFP). Theoretically, selective reinnervation of the posterior cricoarytenoid muscle would be the best treatment for BVFP. The phrenic nerve has been shown in several studies to …

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Effects Of Prenatal Environment Are Revealed By Post-Natal Challenges: Embryonic Hormone Exposure, Adrenocortical Function And Food In Seabird Chicks, Z. Morgan Benowitz-Fredericks, Jannik Schultner, Alexander S. Kitaysky Nov 2015

Effects Of Prenatal Environment Are Revealed By Post-Natal Challenges: Embryonic Hormone Exposure, Adrenocortical Function And Food In Seabird Chicks, Z. Morgan Benowitz-Fredericks, Jannik Schultner, Alexander S. Kitaysky

Faculty Journal Articles

The interaction between prenatal environments and postnatal environments is an important source of phenotypic variability. We examined the ability of prenatal steroid exposure and postnatal energy restriction to explain adrenocortical function and fledging age in captive seabird chicks. We proposed and tested two hypotheses: (1) the strength of prenatal effects is attenuated by challenging postnatal environments (postnatal override) and (2) the strength of prenatal effects increases with the severity of postnatal challenges (postnatal reveal). We reared common murre (Uria aalge) chicks and measured prenatal exposure to corticosterone (CORT) and testosterone (T) from allantoic waste. Adrenocortical function was assessed after 10 …

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Steroid Receptor Isoform Expression In Drosophila Nociceptor Neurons Is Required For Normal Dendritic Arbor And Sensitivity, Aidan L. Mcparland, Taylor L. Follansbee, Gwendolyn D. Vesenka, Alexandra E. Panaitiu, Geoffrey K. Ganter Oct 2015

Steroid Receptor Isoform Expression In Drosophila Nociceptor Neurons Is Required For Normal Dendritic Arbor And Sensitivity, Aidan L. Mcparland, Taylor L. Follansbee, Gwendolyn D. Vesenka, Alexandra E. Panaitiu, Geoffrey K. Ganter

Biology Student Publications

Steroid hormones organize many aspects of development, including that of the nervous system. Steroids also play neuromodulatory and other activational roles, including regulation of sensitivity to painful stimuli in mammals. In Drosophila, ecdysteroids are the only steroid hormones, and therefore the fly represents a simplified model system in which to explore mechanisms of steroid neuromodulation of nociception. In this report, we present evidence that ecdysteroids, acting through two isoforms of their nuclear ecdysone receptor (EcR), modulate sensitivity to noxious thermal and mechanical stimuli in the fly larva. We show that EcRA and EcRB1 are expressed by third instar larvae in …

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P53: "The Wall Watcher", Nektarios Barabutis, John D. Catravas Oct 2015

P53: "The Wall Watcher", Nektarios Barabutis, John D. Catravas

Bioelectrics Publications

No abstract provided.

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An Unattended Mask Makes An Attended Target Disappear, Arielle A. Veenemans, Patrick Cavanagh Oct 2015

An Unattended Mask Makes An Attended Target Disappear, Arielle A. Veenemans, Patrick Cavanagh

Dartmouth Scholarship

In pattern masking, the target and mask are presented at the same location and follow one another very closely in time. When the observer attends to the target, he or she must also attend to the mask, as the switching time for attention is quite slow. In a series of experiments, we present mask–target–mask sequences staggered in time and location (Cavanagh, Holcombe, & Chou, 2008) that allow participants to attentively track the target location without attending to the masks. The results show that the strength of masking is on average unaffected by the removal of attention from the masks. Moreover, …

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Rfx Transcription Factors Are Essential For Hearing In Mice, Ran Elkon, Beatrice Milon, Laura Morrison, Manan Shah, Sarath Vijayakumar, Manoj Racherla, Carmen C. Leitch, Lorna Silipino, Shadan Hadi, Michèle Weiss-Gayet, Emmanuèle Barras, Christoph D. Schmid, Aouatef Ait-Lounis, Ashley Barnes, Yang Song, David J. Eisenman, Efrat Eliyahu, Gregory I. Frolenkov, Scott E. Strome, Bénédicte Durand, Norann A. Zaghloul, Sherri M. Jones, Walter Reith, Ronna Hertzano Oct 2015

Rfx Transcription Factors Are Essential For Hearing In Mice, Ran Elkon, Beatrice Milon, Laura Morrison, Manan Shah, Sarath Vijayakumar, Manoj Racherla, Carmen C. Leitch, Lorna Silipino, Shadan Hadi, Michèle Weiss-Gayet, Emmanuèle Barras, Christoph D. Schmid, Aouatef Ait-Lounis, Ashley Barnes, Yang Song, David J. Eisenman, Efrat Eliyahu, Gregory I. Frolenkov, Scott E. Strome, Bénédicte Durand, Norann A. Zaghloul, Sherri M. Jones, Walter Reith, Ronna Hertzano

Physiology Faculty Publications

Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate and current stem cell and gene delivery protocols result only in immature HC-like cells. Importantly, although the transcriptional regulators of embryonic HC development have been described, little is known about the postnatal regulators of maturating HCs. Here we apply a cell type-specific functional genomic analysis to the transcriptomes of auditory and vestibular sensory epithelia from early postnatal mice. We identify RFX transcription factors as essential and evolutionarily conserved regulators of the HC-specific transcriptomes, and detect Rfx1,2,3,5 and 7 in the developing HCs. …

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Topological Data Analysis For Discovery In Preclinical Spinal Cord Injury And Traumatic Brain Injury, Jessica L. Nielson, Jesse Paquette, Aiwen W. Liu, Cristian F. Guandique, C. Amy Tovar, Tomoo Inoue, Karen-Amanda Irvine, John C. Gensel, Jennifer Kloke, Tanya C. Petrossian, Pek Y. Lum, Gunnar E. Carlsson, Geoffrey T. Manley, Wise Young, Michael S. Beattie, Jacqueline C. Bresnahan, Adam R. Ferguson Oct 2015

Topological Data Analysis For Discovery In Preclinical Spinal Cord Injury And Traumatic Brain Injury, Jessica L. Nielson, Jesse Paquette, Aiwen W. Liu, Cristian F. Guandique, C. Amy Tovar, Tomoo Inoue, Karen-Amanda Irvine, John C. Gensel, Jennifer Kloke, Tanya C. Petrossian, Pek Y. Lum, Gunnar E. Carlsson, Geoffrey T. Manley, Wise Young, Michael S. Beattie, Jacqueline C. Bresnahan, Adam R. Ferguson

Physiology Faculty Publications

Data-driven discovery in complex neurological disorders has potential to extract meaningful syndromic knowledge from large, heterogeneous data sets to enhance potential for precision medicine. Here we describe the application of topological data analysis (TDA) for data-driven discovery in preclinical traumatic brain injury (TBI) and spinal cord injury (SCI) data sets mined from the Visualized Syndromic Information and Outcomes for Neurotrauma-SCI (VISION-SCI) repository. Through direct visualization of inter-related histopathological, functional and health outcomes, TDA detected novel patterns across the syndromic network, uncovering interactions between SCI and co-occurring TBI, as well as detrimental drug effects in unpublished multicentre preclinical drug trial data …

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Prediction Of Maximal Oxygen Consumption From Rating Of Perceived Exertion (Rpe) Using A Modified Total-Body Recumbent Stepper, John P. Mcculloch, Douglas J. Lorenz, Michael A. Kloby, Matthew D. Love, Daniela G.L. Terson De Paleville Phd Oct 2015

Prediction Of Maximal Oxygen Consumption From Rating Of Perceived Exertion (Rpe) Using A Modified Total-Body Recumbent Stepper, John P. Mcculloch, Douglas J. Lorenz, Michael A. Kloby, Matthew D. Love, Daniela G.L. Terson De Paleville Phd

International Journal of Exercise Science

International Journal of Exercise Science 8(4): 414-424, 2015. Exercise training is crucial to improve cardiovascular health and quality of life in people with spinal cord injuries (SCI). A key limitation is the lack of validated submaximal tests to evaluate and predict cardiovascular fitness in this population. The purpose of this study was to validate a submaximal test to predict maximal oxygen consumption for individuals with SCI. Ten able-bodied participants and two individuals with SCI completed a rating of perceived exertion (RPE)-based submaximal oxygen consumption test and a graded maximal oxygen consumption test on a NuStep T4 recumbent stepper. Prediction of …

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Assessment Of Dietary Behaviors, Body Composition, And Cardiovascular Disease Risk Among College Club Rugby Team, Carly R. Macdougall, Gytis Balilionis, Svetlana Nepocatych Oct 2015

Assessment Of Dietary Behaviors, Body Composition, And Cardiovascular Disease Risk Among College Club Rugby Team, Carly R. Macdougall, Gytis Balilionis, Svetlana Nepocatych

International Journal of Exercise Science

International Journal of Exercise Science 8(4): 403-413, 2015. The purpose of this study was to evaluate dietary behaviors, body composition, and potential cardiovascular disease (CVD) risk factors among college club rugby team players. 15 athletes completed demographics, three 24-hour dietary recalls, body composition and blood lipid profile assessments following an overnight fast. Mean ± SD age of participants was 20 ± 1 years; weight 81 ± 16 kg; BMI 25.7 ± 3.2 kg/m2; body fat 13 ± 5%; total cholesterol 133 ± 37 mg/dl; high-density lipoprotein 49 ± 18 mg/dl; low-density lipoproteins 77 ± 26 mg/dl; triglycerides 86 …

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The Influence Of Short-Term Quercetin Supplementation On Peak Oxygen Uptake During Simulated Altitude Exposure In Trained Cyclists, Justin A. Carlstrom Oct 2015

The Influence Of Short-Term Quercetin Supplementation On Peak Oxygen Uptake During Simulated Altitude Exposure In Trained Cyclists, Justin A. Carlstrom

International Journal of Exercise Science

International Journal of Exercise Science 8(4): 394-402, 2015. Endurance performance and peak oxygen uptake (VO2peak) decline as altitude increases. Some data exist suggesting that quercetin supplementation improves aerobic capacity in trained and untrained individuals at sea-level (normobaric normoxic conditions). Few studies have examined the effects of quercetin on endurance performance during simulated altitude exposure (normobaric hypoxic conditions). The purpose of this study was to determine the effects of consuming 1000 mg·day-1 of quercetin for two weeks on cycling VO2peak in healthy trained male cyclists performing under normobaric normoxic and hypoxic conditions (NP and HP, respectively). Fourteen …

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Efficacy Of Vibration Exercise As A Warm-Up Modality For Overground Sprinting, Victoria Moddie, Amanda C. Benson, Brett A. Gordon, Noel Lythgo Oct 2015

Efficacy Of Vibration Exercise As A Warm-Up Modality For Overground Sprinting, Victoria Moddie, Amanda C. Benson, Brett A. Gordon, Noel Lythgo

International Journal of Exercise Science

International Journal of Exercise Science 8(4): 385-393, 2015. This study investigated the efficacy of vibration exercise (VbX) as a warm-up modality for maximal overground sprinting. Ten national level sprinters participated in a randomized crossover design (14.0 ± 7.4 days washout period). A VbX warm-up was compared to a warm-up involving sprint-specific exercises (control condition). The VbX warm-up involved 10 ´ 1 minute bouts delivered by a Galileo 900 side-alternating plate (frequency = 26 Hz, peak-to-peak displacement = 9 mm) with 30 s rest between bouts (total time = 15 minutes). The sprint-specific warm-up involved jogging, dynamic exercises and sprinting drills …

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