Pharmacology, Toxicology and Environmental Health Commons^™

What Influences Trust In And Understanding Of Clinical Trials? An Analysis Of Information And Communication Technology Use And Online Health Behavior From The Health Information National Trends Survey, Aurora Occa, Allison S. Merritt, Allison Leip, Jerod L. Stapleton

UK CARES Faculty Publications

Background: Using information and communication technologies to seek, discuss, and share health-related information influences people’s trust and knowledge of several health practices. However, we know little about the associations between individuals’ information and communication technology use and their perceptions of trust and knowledge of clinical trials. Examining these associations may lead to the identification of target audiences and channels for developing effective educational interventions and campaigns about clinical trials.

Methods: In this study, we analyzed Health Information National Trends Survey data to document perceptions of clinical trial-related knowledge and trust that were recently added as questions in this annual national …

Environmental Health And Impact Of Workload On Errors For Wildland Fire Personnel, Michael Bryan Held

Masters Theses

"This thesis offers an analysis of how environmental health and workload affect wildland fire dispatchers and firefighters, combining results from two studies. The first study, "Environmental Health of Wildland Firefighters: A Scoping Review," performs a scoping review of scientific literature that examines the unique environmental health challenges wildland firefighters face. The review points out the increased risks to safety, health, and well-being from more exposure to natural hazards, identifying key research gaps and priorities. It stresses the need to broaden the geographic and demographic scope of studies, improve analytical methods, and increase research funding and focus for wildland firefighters.

The …

Evaluating Superfund Effectiveness And Community Engagement: Smurfit-Stone Mill Case Study, Abigail M. Sherwood

Undergraduate Theses, Professional Papers, and Capstone Artifacts

The Smurfit-Stone Mill operated in Frenchtown, MT from 1957 until 2010, releasing toxic pollutants into the Clark Fork River and surrounding areas. Despite environmental protests since the 1960s, substantive action to remedy environmental damage did not occur until 2015. Stakeholders including local residents, Indigenous tribes, Missoula County, and environmental non-profits have advocated for comprehensive site characterization, a timely cleanup, and robust community engagement. While residents and visitors contend with elevated toxins in fish tissue, prompting a 100-mile fish consumption advisory near the Smurfit-Stone Mill, the Environmental Protection Agency is several years away from determining the scope of a reclamation. Community …

New Treatment Modality For Metastatic Cancer By Targeting The Endothelin Type A Receptor (Etar), Elbara Fathelrahman Abdelmoula

Theses

Ambrisentan, an FDA-approved selective antagonist of the Endothelin Type A Receptor (ETAR) for pulmonary arterial hypertension, has shown potential in limiting cancer growth and metastasis. While effective treatment options for melanoma remain elusive, this study investigates the effects of Ambrisentan on invasive, metastatic B16F10 melanoma using a syngeneic mouse model, aiming to assess Ambrisentan’s impact on tumor growth, metastasis, and overall host survival in B16F10 melanoma, along with gaining mechanistic insights into ETAR antagonism. C57Bl/6 mice were divided into two groups, receiving either dH2O or Ambrisentan orally. Treatments commenced prior to tumor implantation and continued post-implantation. Luciferase-expressing B16F10 cells facilitated …

Kvx-053, A Protein Tyrosine Phosphatase 4a3 Inhibitor, Ameliorates Sars-Cov-2 Spike Protein Subunit 1 - Induced Acute Lung Injury In Mice, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, Tierney Day, Betsy Gregory, Elizabeth R. Sharlow, John S. Lazo, John D. Catravas

Bioelectrics Publications

The Acute Respiratory Distress Syndrome (ARDS), often preceded by acute lung injury (ALI), is characterized by the accumulation of inflammatory fluid in the lung alveoli, leaky alveolar epithelium and endothelium, and overexpression of pro-inflammatory cytokines. This progression from ALI to ARDS is a major contributor to the high mortality observed in COVID-19 patients. The Spike protein of SARS-CoV-2 binds to lung ACE2 and, in addition to facilitating viral cell entry, it plays an important role in the development of ALI and ARDS, especially in the later phases of COVID-19 as well as long COVID. Protein tyrosine phosphatase (PTP) 4A3 is …

Aggravated Ulcerative Colitis Via Circnlgn-Mediated Suppression Of Nuclear Actin Polymerization., William W Du, Chi Zhou, Hui Yang, Shuoyang Wen, Yu Chen, Eric X Chen, Xiuwei H. Yang, Feiya Li, Kevin Y Du, Hui Yuan, Ting Ye, Javeria Qadir, Burton B Yang

Pharmacology and Nutritional Sciences Faculty Publications

Colitis is a chronic bowel disease characterized by damage to the lining of the large intestine, with its precise underlying causes remaining incompletely understood. In this study, we provide evidence that circular RNA circNlgn plays a pivotal role in promoting the development of colitis. Colitis patients produce significant higher levels of circNlgn. Transgenic mice expressing circNlgn exhibit heightened susceptibility to colitis development and progression, primarily attributed to the presence of the protein isoform Nlgn173 encoded by circNlgn. Nlgn173 undergoes translocation into cell nuclei, where it interacts with actin, impeding the binding of actin-related protein 2 and 3 (Arp2/3) complex to …

Exposition Professionnelle Des Femmes Aux Substances Chimiques : Amélioration D’Une Matrice Emploi Exposition Existante Pour Fournir Des Estimations Spécifiques Au Sexe : Rapport Abrégé, Vikki Ho, Chelsea Almadin, France Labrèche, Mark Goldberg, Marie-Élise Parent, Jack Siemiatycki, Jérôme Lavoué

Rapports de recherche scientifique

Il est reconnu que les femmes et les hommes ont des profils professionnels différents qui peuvent donc se traduire par des risques de maladie professionnelle différents. Pourtant, la plupart de nos connaissances actuelles sur les maladies professionnelles découlent d'études menées auprès des hommes. Or, les femmes représentent actuellement 48 % de la population active au Québec. La santé des femmes dans l’environnement de travail demeure un domaine sous-étudié et nous sommes particulièrement freinés par le manque de compréhension de l'impact du genre sur l'exposition en milieu de travail. Il a été démontré que l'attribution des tâches et les conditions de …

Occupational Exposures Of Women To Chemical Substances: Improvement Of An Existing Job Exposure Matrix To Provide Sex-Specific Estimations Of Exposure, Vikki Ho, Chelsea Almadin, France Labrèche, Mark Goldberg, Marie-Élise Parent, Jack Siemiatycki, Jérôme Lavoué

Rapports de recherche scientifique

Il est reconnu que les femmes et les hommes ont des profils professionnels différents qui peuvent donc se traduire par des risques de maladie professionnelle différents. Pourtant, la plupart de nos connaissances actuelles sur les maladies professionnelles découlent d'études menées auprès des hommes. Or, les femmes représentent actuellement 48 % de la population active au Québec. La santé des femmes dans l’environnement de travail demeure un domaine sous-étudié et nous sommes particulièrement freinés par le manque de compréhension de l'impact du genre sur l'exposition en milieu de travail. Il a été démontré que l'attribution des tâches et les conditions de …

"It Is More Than A Feeling, It Is A Commitment" : Evaluation Of Empathy Development Using Graphic Novels In A Medical Humanities First-Year Seminar, Susanna Foxworthy Scott, Brittany R. Heer, Alli Leonard

Scholarship and Professional Work

No abstract provided.

(Plant)Ing Traditional Roots: Exploring An Impact Of Environmental Shifts On Traditional Phytotherapy Practices In The Cusco Region Of Perú, Nicole Elizabeth Wilmot

Undergraduate Honors Theses

This thesis investigates the potential outcomes of environmental shifts on plant-based medical practices in the Cusco region of Peru. Located in the Andes mountain range, at a high elevation, the environment varies immensely, specifically in the various types of native plants in the region. Historically, using plants as natural forms of medicine or healthcare has been deeply rooted in many indigenous communities, traditions, and cultures globally. Environmentally, there have been potential changes and shifts in temperature, water, and soil that affect the nutrition and health of plants to maintain their beneficial properties. Due to various factors, adaptations or shifts to …

The Effects Of Alcohol On Crash Avoidance Reaction Time In A Driving Simulator Task In Humans, Aishwarya Vasudevan

Wayne State University Theses

AIM 1: Alcohol-impaired driving continues to be a significant cause of car crash injuries and deaths. The blood alcohol concentration (BAC) cut-off level for drunk driving is 0.08% in Michigan, and is estimated that lowering this cut-off to 0.05%would save 500–800 lives every year in the US alone. We used a portable virtual reality (VR)-based driving simulator to demonstrate the effects of alcohol at BAC concentrations 0.02-0.08%, grouped into 0.01% increments, on driving performance, specifically Crash Avoidance Reaction Time (CART), i.e., the time (in msec) required to initiate a steering avoidance response. We found that BAC concentrations as low as …

High-Throughput Screening Of Fda-Approved Drugs For Protecting Retinal Pigment Epithelial Cells Against Er Stress Induced Cell Death: Implications For Age-Related Macular Degeneration, Shaima Ali Jawarneh

Wayne State University Theses

Purpose: Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population, characterized by the degeneration of the retinal pigment epithelium (RPE). The link between endoplasmic reticulum (ER) stress and AMD is well established, however FDA-approved medications for the treatment of AMD caused by unregulated ER stress are limited and have potential side effects. The purpose of this study was to conduct a comprehensive screening of the FDA-approved drug library in order to identify potential candidates that could be repurposed in order to protect against the degeneration and death of RPE cells due to ER stress.

Methods: …

Lead Bioaccessibility And Commonly Measured Soil Characteristics (Detroit, Mi, Usa) – Phase 1, Sabrina R. Good, Allison R. Harris, Patrick Crouch, Conor T. Gowan, William D. Shuster, Shawn P. Mcelmurry

Open Data at Wayne State

Contaminated urban soil is one of the major contributors to child Pb exposure. To gain a better understanding of Pb risk in urban areas, composite samples were collected from 142 residential, privately owned, parcels in Detroit, Hamtramck, and Highland Park, Michigan, with approval from the property owners. The proximity of soil sampling and former smelter locations were also reported. Sample were collected from areas covered with turf grass. Four samples were collected, one from each cardinal direction (north, south, east, and west), 20 cm from an aluminum tent stake driven into the center of the sampling site. Soils were collected …

Elucidation Of Mismatch Repair Regulation By Abl1: Advantages/Disadvantages Of Tyrosine Kinase Inhibitor Treatment, Hannah Daniels

Theses and Dissertations--Toxicology and Cancer Biology

DNA mismatch repair (MMR) is a critical repair process necessary for not only repairing mispairs incorporated into the DNA during replication, but also for inducing apoptosis in response to certain types of DNA damage. MMR is required for maintaining genomic integrity and due to the importance of this pathway, any impairment of its function can lead to increased mutation frequency, which is well known to be a driving force of cancer development, progression, and resistance. Despite extensive studies involving the proteins involved in the MMR pathway, the regulation of those proteins remains relatively unknown. Regulation of MLH1, a protein necessary …

Braving The Elements: Loss Of Metals From Mardi Gras Beads Due To Handling And Weathering, Thomas O. Carmichael, Ruth H. Carmichael

Gulf and Caribbean Research

The largest Mardi Gras celebrations in the U.S. are found along the Gulf of Mexico coast. With increasing awareness of and concern for environmental and human health risks due to pollution from Mardi Gras celebrations, there is a need for studies to quantify potential harms. We conducted a 2—part study to determine whether use—related handling and weathering of common Mardi Gras beaded necklaces results in loss of potentially harmful metals to the environment at levels of ecological or human health concern. Our data indicate that weathering and use—related handling can cause metals to be shed from the metallic coating of …

What Are The Best Treatment Options For Infantile Cataracts?, Breindy Hecht

The Science Journal of the Lander College of Arts and Sciences

Congenital and infantile cataracts are characterized by opacity of the ocular lens, causing decreased visual acuity and inducing amblyopia. Treatment of pediatric patients is complicated because the eye is still growing during childhood, and the mind-eye connection is developing during this time. Anything that obstructs visual input from the eye to the brain raises risks of permanent visual deficit. Treatment includes immediate cataract extraction; this is sometimes followed by intraocular implantation of an artificial lens. After surgery, treatment continues in the form of occlusive patching therapy, corrective spectacles, or cycloplegic eye drops. Oftentimes, several methods are used simultaneously for maximal …

Full Issue: Volume 17, Number 2, Spring 2024

The Science Journal of the Lander College of Arts and Sciences

Complete .pdf file of Volume 17, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2024.

The Effects Of Electronic Cigarettes On The Oral Cavity, Batsheva Saposh

The Science Journal of the Lander College of Arts and Sciences

Electronic cigarettes, which became available for purchase in the United States in 2007, were initially touted as a harmless aid for smoking cessation. However, recent research into the impact of electronic cigarettes on the human body has shown potential deleterious effects. This paper aims to examine the effects electronic cigarette usage has on the oral cavity. The methods to compile research involved reading through many peer-reviewed articles to analyze the most current information on the topic. The findings indicate several potentially adverse effects on the oral cavity including oral cancer, periodontitis, dental caries, xerostomia, facial fractures, failed dental implants, and …

Sibo And The Effectiveness Of Treatment Via Diet And Medication, Elizabeth C. Hersko

The Science Journal of the Lander College of Arts and Sciences

This study delves into small intestinal bacterial overgrowth (SIBO), exploring its origins, diagnosis, and treatment methods. The research illuminates the complexities of SIBO, a condition characterized by an abnormal surge of bacteria in the small intestine. Factors contributing to SIBO include impaired motility, anatomical abnormalities, and digestive system dysfunctions. Diagnosing SIBO proves challenging due to its nonspecific symptoms which often overlap with other conditions like irritable bowel syndrome (IBS). Various diagnostic approaches, including lactulose breath testing, blood tests, stool analysis, and imaging, aim to identify SIBO and its underlying causes. Treatment involves dietary modifications—such as low FODMAP, biphasic, or fast …

Non-Surgical Treatment Options For Male-Pattern Baldness, Robert Schiffer

The Science Journal of the Lander College of Arts and Sciences

Male pattern baldness affects nearly 50% of the world’s male population. It is associated with physiological conditions such as cardiovascular disease as well as psychological issues with self-image and self-esteem. Although surgical treatments exist, they are associated with risks and complications. Various non-surgical treatment modalities for male pattern baldness are available for patients. Topical and oral formulations of minoxidil, finasteride, and dutasteride can be used, in addition to low level light therapy (LLLT) and platelet rich plasma (PRP) therapy. As many treatment options exist, it may be challenging for patients to decide which to choose. Although there have been few …

Targeting Vs. Modulating: How To Confront Variation In Cystic Fibrosis?, Yechiel Muller

The Science Journal of the Lander College of Arts and Sciences

Cystic fibrosis is a genetic disease with over 2,000 reported mutation varieties. It affects a chloride channel called CFTR, which by the transmembrane transport of chlorine, maintains an apical membrane electrolyte equilibrium in luminal epithelial cells. Its malfunction results in cystic fibrosis which causes excess mucus in various organs and is associated with respiratory complications and salty sweat. Treatment of cystic fibrosis has primarily taken two approaches: a mutation-specific method, targeted at a particular mutation to restore its function, and a mutation-non-specific method, which modulates intracellular barriers to CFTR trafficking or cellular repression of mutant protein function. This paper presents …

Lead Exposure: Neurological Implications, Transmission In Utero, And Treatment, Chana Birnbaum

The Science Journal of the Lander College of Arts and Sciences

Blood lead levels are routinely measured in pediatric clinics due to the well-documented detrimental effects of lead exposure on neurodevelopment and consequently cognition. Reading difficulties, impaired detailed movement, and depressed reaction time are three areas, among others, implicated in lead toxicity (Needleman, 1990). Furthermore, lead toxicity can be of particular concern in pregnant women, as placental transmission is viable (Gundacker & Hengstschläger, 2012, as cited in Sun et al., 2018). Future research investigating the transmission of lead from mother to fetus may provide insight into the timeline of in utero lead transmission and consequently the ability to direct anti-toxicity treatment …

Is Ozempic A Safe Way To Lose Weight?, Elizer Terebelo

The Science Journal of the Lander College of Arts and Sciences

Obesity, as classified by the AHA, is a chronic disorder affecting many people worldwide. Providing treatments for obesity is a multi-million-dollar industry. There are many different types of treatments offered for obesity, ranging from pills to surgeries. Ozempic has been touted as an FDA-approved supplement that can help someone lose weight. These GLP-1 agonists are used to treat type-2 diabetes and have been shown to help patients lose weight. Type-2 diabetes is a chronic illness that can lead to cardiovascular disease, stroke, kidney failure, serious eye disease, neuropathy, and many other diseases. For this reason, most risks that Ozempic would …

Is It Possible For Glp-1ras To Combat Type 2 Diabetes And Its Comorbidities?, Michael Weingarten

The Science Journal of the Lander College of Arts and Sciences

Type 2 Diabetes Mellitus is a prevalent metabolic disorder characterized by insulin resistance and pancreatic beta-cell dysfunction, leading to chronic hyperglycemia and comorbidities such as obesity and cardiovascular disease. Traditional treatments focus on glycemic control, but often fail to address the broader spectrum of related conditions. This study investigates the potential of glucagon-like peptide-1 receptor agonists (GLP-1RAs) to combat type 2 diabetes and its comorbidities through their diverse mechanisms of action. GLP-1RAs not only improve glycemic control by enhancing insulin secretion and inhibiting glucagon release, but also promote weight loss, reduce inflammation, and lower cardiovascular risk. The efficacy of GLP-1RAs …

Muscle Degradation Due To Aging And The Role Of Exercise In Aging Adults, Chava Rosenbaum

The Science Journal of the Lander College of Arts and Sciences

Skeletal muscle contraction is essential for the human body’s movement, balance, and formation. As aging sets in, the skeletal muscular system begins to decay, leading to a decline in muscle strength, reducing strength, and increasing the risk of falling. Studies have found changes in hormone levels and muscle communication are key factors contributing to muscle movement and mass decline. Consequently, different exercise methods have been explored to slow down the rapidly deteriorating muscles and help maintain a healthy, strong muscular system. This paper delves into specific exercise routines proven through studies to be beneficial for the body. While some research …

Is Manual Therapy An Effective Modality Of Physical Therapy?, Caryn Karfunkel

The Science Journal of the Lander College of Arts and Sciences

Physical therapy provides relief to patients with musculoskeletal disorders who experience pain and have difficulty functioning. Manual therapy is one of the therapeutic modalities of physical therapy, and helps treat patients through utilizing human touch and pressure. This paper analyzes studies that aim to understand the reasoning behind manual therapy’s effectiveness as a physical therapy modality, questioning whether its benefits are primarily biomechanical or psychological. The research was conducted by analyzing relevant literature on academic databases on topics such as pain, physical therapy, manual therapy, and human touch. The findings reveal that manual therapy is an effective modality of physical …

Full Issue: Volume 18, Number 1, Fall 2024

The Science Journal of the Lander College of Arts and Sciences

Complete .pdf file of Volume 18, Number 1 of The Science Journal of the Lander College of Arts and Sciences. Published Fall 2024.

Can Immunotherapy Treat Food Allergies?, Baila Klahr

The Science Journal of the Lander College of Arts and Sciences

Food allergies among children are highly prevalent. The elimination diet and fear of allergic reactions cause anxiety in many children and their parents. Immunotherapy stimulates the production of Treg cells which inhibit IgE-mediated allergic reactions. This can successfully desensitize children to their allergens. Subcutaneous immunotherapy can be used for environmental allergens while sublingual or oral immunotherapy should be used for food allergies. There are some risks associated with oral immunotherapy and research is ongoing to study the safety and efficacy of oral immunotherapy.

Overview Of Weight Loss Medications, Malky Mandel

The Science Journal of the Lander College of Arts and Sciences

Obesity is a complex medical condition that is multifactorial in origin. About one-third of adults in the United States are obese, and another third are overweight (Ogden et al., 2007). Obesity is associated with a multitude of comorbidities, such as cardiovascular disease, diabetes mellitus, and osteoarthritis (Lim, Boster, 2023). Additionally, obesity may cause psychological disorders due to social prejudice and discrimination toward obese people (Wadden et al. 2002). Economically, obesity is also a tremendous financial burden (Tremmel et al. 2017). It is estimated that the overall cost of obesity-related illness in the US is nearly $500 billion (Cawley et al., …

The Biobehavioral Effects Of Embryonic Exposure To Neural Inflammation And Oxidative Stress In Zebrafish, Dalton J. Anderson

Honors College Theses

The purpose of this research is to improve understanding of the neurodevelopmental effects of embryonic exposure to elevated inflammation and oxidative stress induced by the antipyretic drug acetaminophen (APAP). Our study was the first to examine the interactive effects of APAP and inflammation in zebrafish embryos and how the treatments affect brain development and larval behavior. Experimental groups of zebrafish larvae were exposed to lipopolysaccharide (LPS) to induce inflammation, APAP, or LPS + APAP and larval behavior was analyzed using Ethovision automated behavioral tracking software. We also measured changes in whole-brain Glycogen Synthase Kinase 3 Beta (GSK3B) and GSK3B phosphorylation, …