Pharmacology, Toxicology and Environmental Health Commons^™

The Perception Of Emergency Department Physicians Regarding Economic And Regulatory Factors Impacting Management Of Drug Seeking Patients, Sharon Susanne Kelley

USF Tampa Graduate Theses and Dissertations

Abstract

Physicians in the emergency department (ED) are facing a number of unique challenges in the currently changing healthcare and economic climates. Dramatic increases in ED patient volumes have been noted nationwide with visits related to prescription opioid abuse and misuse alone having increased by 111% between 2004 and 2008.

Ironically, several challenges ED physicians are facing arise from regulatory and economic initiatives which were originally designed for the protection of patients. Regulatory requirements to address pain as the fifth vital sign, along with entities utilizing patient satisfaction based reimbursement, have inadvertently created an environment conducive to exploitation by the …

Full Issue: Volume 6, Number 2

The Science Journal of the Lander College of Arts and Sciences

No abstract provided.

Full Issue: Volume 7, Number 1

The Science Journal of the Lander College of Arts and Sciences

No abstract provided.

Anti-Lipase Activity Of Quercus Infectoria G.Olivier Extract, Sirinan Thubthimthed., Sarunya Laovitthayanggoon, Parkpoom Siriarchavatana, Konlawit Chaithongsri, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Antibacterial Activity Of A-Mangostin From The Pericarp Extract Of Garcinia Mangostana L. Against Drug Resistant Bacteria, Griangsak Eumkeb, Sineewan Phitaktim

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Gene Cloning And Expression Of A Triterpene Synthase From Alangium Lamarckii, Nattaon Tansakul, Pimpimon Tansakul, Wanchai De-Eknamkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Investigation On Phytochemical, Antioxidant And Cytotoxic Properties Of Momordica Cochinchinensis (Gac) Fruit Extracted By Supercritical Fluid Carbon Dioxide (Scf-Co2) Method, Prapaipat Klungsupya., Worawan Tiatragoon, Thanchanok Muangman, Jirawat. Eiamwat, Sarunya Laovitthayanggoon, Jeerayu Thongdo-A, Srisak Trangwacharakul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Meloxicam-Loaded Ph Sensitive Polymeric Micelles: Solvents And Entrapment Methods, Thisirak Woraphatphadung, Warayuth Sajomsang, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Stability Evaluation Of A Hair Conditioner Comprising A Mixed Extract From Fruits Of Phyllanthus Emblica And Zanthoxylum Limon Ella, Sitthiphong Soradech, Buppachart Potduang, Itsara Keeta, Wanlapha Saisin, Suchipha Wannaphatchaiyong, Cholticha Niwaspragrit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Pharmacokinetic And Bioequivalence Evaluation Of Two Formulations Of Levocetirizine 5 Mg In Healthy Thai Volunteers, Chutima Jantarat, Thitima Keskanokwong

The Thai Journal of Pharmaceutical Sciences

Pharmacokinetics of levoceterizine have been studied, however, obtained information was only from the Western people. เท addition, the license of this drug formulation was expired few years ago. For approval of this new generic drug, the bioequivalen...

Compulsory Licensing Of Chronic Diseases Pharmaceuticals Thailand, Sakda Thanicul, Matthew Lim Braslow

The Thai Journal of Pharmaceutical Sciences

For pharmaceutical companies, obtaining patent protection for the pharmaceuticals they develop is essential. Patent protection assures that the pharmaceutical company will have a reasonable opportunity to recoup their most likely quite heavy investment in the new drug and allow the company to control the wholesale market price of the drugs. These key intellectual property rights are truly at the heart of the internationally recognized intellectual property regime. For patent right holders in general merchandise, say an innovative paperclip or mousetrap, the absolute right of the patent holder as to the distribution and price is perfectly acceptable. Pharmaceutical patents however, with …

Detection Of Esterase Activity Converting Cytotoxic Renieramycin M To Jorunnamycin A In The Crude Enzyme Of The Nudibranch Jorunna Funebris, Dalad Waropastrakul., Khanit Suwanborirux, Wanchai De-Eknamkul, Taksina Chuanasa

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Use Of Three Thai Indigenous Vegetables As Potential Dietary Fiber Sources For Health Food Product, Jeeravu Thongdon-A., Prapaipat Klungsupya, Thanchanok Muangman, Arkachai Tantrawong, Srisak Trangvacharakul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Theodorakis Studies Effects Of Toxic Chemicals, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

When Substance Abuse And Mental Illness Combine, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Solubility And Dissolution Enhancement Of Quercetin Via Preparation Of Spray Dried Microstructured Solid Dispersions, Ahmed Shawky Mohamed Ghanem, Hany Saleh, Sohair Mostafa El-Shanawany, El-Sayed Ali Ibrahim

The Thai Journal of Pharmaceutical Sciences

Quercetin (QC) is a bioflavonoid characterized with poor water solubility that limits its oral bioavailability and hence its therapeutic applications. เท an attempt to enhance its solubility and dissolution rate, both binary and ternary microstructur...

Bioequivalence Study Of 300 Mg Irbesartan Film-Coated Tablets Preparations In Healthy Thai Volunteers, Porranee Puranajoti, Peerawong Werarak, Burapat Intawong, Jarunee Hongrapipat, Rungrudee Talubsri, Soravee Sangsuriyawong, Temsiri Kuamsuk

The Thai Journal of Pharmaceutical Sciences

Irbesartan, an angiotensin II receptor antagonist, is indicated for the treatment of essential hypertension alone or in combination with other antihypertensive agents. The purpose of this study was to compare the bioavailability of two formulations of ir...

Quantitative Analysis Of Epigallocatechin Gallate In Young And Mature Assam Tea Leaf Extracts, Pattra Ahmadi Pirshahid, Thongchai Hemthanon, Yaowaluk Khamphan, Phatsuda Chueboonmee, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Pilot Study Of Antibacterial And Antiinflammatory Activities Of Indian Gooseberry (Phyllanthus Emblica L. Extract) Against Bacteria Associated With Pitted Keratolysis, Rattanasiri Giwanon., Krittiva Thisayakom, Pongsatom Limsiriwong, Saowaluck Ruengsri, Vichein Kheuynok, Kanchana Sriyam, Marudech Srisom, Darunee Pahusee, Sawai Nakakaew, Natthachest Ketmanee, Sontaya Peungsumrong, Chulerattana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Radical-Scavenging And Cellular Dna Protective Activities Of Active Fractions From Lansivm Domesticum Corr. Fruit, Prapaipat Klungsupya, Nava Suthepakul, Sarunya Laovitthayanggoon, Jeerayu Thongdon-A, Srisak Trangwacharakul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cytotoxic Evaluation Of A Fruit Extract From Zanthoxylum Limonella In Human Dermal Fibroblast Cell Line Using Mtt Assay, Sarunva Laovitthayanggoon., Buppachart Potduang, Natthachest Ketmanee, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Fabrication Of Meloxicam Taste-Masked Oral Fast Disintegrating Tablet By Ion Exchange Resin And Cyclodextrin, Wipada Samprasit, Theerasak Rojanarata, Prasert Akkaramongkolpom, Tanasait Ngawhirunpat, Praneet Opanasopit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Garcinia Mangostana Extract In Liquid Crystal Cream For Topical Delivery System, Napa Bunma, Jirapan Moungjaroen, Prasan Tanguenyongwatana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Formulation Of Ketoprofen Matrix Membrane For Transdermal Delivery Systems, Jirapomehai Suksaeree, Wiwat Pichayakorn, Chaowalit Monton, Apirak Sakunpak, Tun Chusut, Worawan Saingam, Fameera Madaka

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cosmeceutical Development Of Oxyresveratrol From Mahad (Artocarpus Lakoocha Roxb.), Surapol Natakankitkul, Nicha Chareonmuang, Tawan Panyakhong, Worrapon Wangkananon

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Time Kill Study Of The In Vitro Activity Of Tigecycline Against Carbapenem-Resistant Klebsiella Pneumoniae, Maimun Halee, Wanchai Treyaprasert, Pompan Koomanachai, Duangdao Waywa

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Does Nicotine Replacement Therapy Reduce The Withdrawal Symptom Of Craving, Or Urge To Smoke, In Dependent Adult Smokers During Smoking Cessation?, Theresa Dijoseph

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not nicotine replacement therapy reduces the withdrawal symptom of craving, or urge to smoke, in dependent adult smokers during smoking cessation.

STUDY DESIGN: Systematic review of three English language and peer-reviewed randomized-controlled trials published in 2009, 2010, and 2011.

DATA SOURCES: One single-blinded randomized-controlled crossover trial, one double-blinded, placebo controlled, randomized-controlled crossover trial, and one single-blinded, placebo controlled, randomized-controlled crossover trial

OUTCOMES MEASURED: Withdrawal symptoms of craving, irritability, difficulty concentrating, and restlessness were measured on a 100mm visual analog scale (VAS). Adverse effects (AEs) of mouth and …

Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma, Jennifer M. Rothberg

Wayne State University Dissertations

Among the non-cellular microenvironmental factors that contribute to malignancy of solid tumors is an acidic peritumoral pH. The first objective was to determine if an acidic extracellular pH observed in vivo (i.e., pHe 6.8) affects the activity of proteases, such as cathepsin B, that contribute to degradation of collagen IV by tumor cells when grown in biologically relevant three-dimensional cultures. At pHe 6.8 there were increases in pericellular active cysteine cathepsins and in degradation of DQ-collagen IV, which was partially blocked by a cathepsin B inhibitor. Imaging probes for active cysteine cathepsins localized to tumors in vivo. The amount of …

Progress Towards Development Of Multifunctional, Dopamine D2/D3 Receptor Agonists As Symptomatic And Disease-Modifying Therapeutic Agents For Parkinson's Disease, Mark Andrew Johnson

Wayne State University Dissertations

Parkinson¡¯s disease (PD) is a progressive, neurodegenerative disorder that arises primarily through the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), resulting in a diminished level of the neurotransmitter dopamine in the nigrostriatal pathway and ensuing loss of motor function. Common symptoms of PD include resting tremor, muscular rigidity, bradykinesia (slowness and decreased amplitude of movement), along with postural instability and cognitive psychiatric complications. PD affects 1% of the population ¡Ý 65 and is the second most prevalent neurodegenerative disorder next to Alzheimer¡¯s disease (AD). Although the etiology of PD is not yet clear and may be …

Mitochondrial Dna Instability In Cells Lacking Aconitase Correlates With Iron Citrate Toxicity, Muhammad A. Farooq, Tammy M. Pracheil, Zhejun Dong, Fei Xiao, Zhengchang Liu

Biological Sciences Faculty Publications

Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate. aco1 Delta results in mitochondrial DNA (mtDNA) instability. It has been proposed that Aco1 binds to mtDNA and mediates its maintenance. Here we propose an alternative mechanism to account for mtDNA loss in aco1 Delta mutant cells. We found that aco1 Delta activated the RTG pathway, resulting in increased expression of genes encoding citrate synthase. By deleting RTG1, RTG3, or genes encoding citrate synthase, mtDNA instability was prevented in aco1 Delta mutant …