Pharmacology, Toxicology and Environmental Health Commons^™

Human Exposure Modeling Using Sheds, Luther Smith, William Graham Glen

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Implementation Of Universal Hplc Analysis For Counterfeit Medication: A Partnership Of Purdue University And The Kilimanjaro School Of Pharmacy, Jordyn Mccord, Michael Mavity, David Wintczak

Purdue Journal of Service-Learning and International Engagement

Jordyn McCord and Michael Mavity are 2016 graduates of both biological engineering and pharmaceutical sciences. David Wintczak is a third-year pharmacy doctoral candidate. Here, in their second article published in PJSL, they describe a weeklong study abroad course at the Kilimanjaro School of Pharmacy in Tanzania, designed to engage students in the implementation of methods for detecting counterfeit medications.

Aneuploidy: A Common And Early Evidence-Based Biomarker For Carcinogens And Reproductive Toxicants., Daniele Mandrioli, Fiorella Belpoggi, Ellen K Silbergeld, Melissa J. Perry

Environmental and Occupational Health Faculty Publications

Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for …

Cotinine Antagonizes The Behavioral Effects Of Nicotine Exposure In The Planarian Girardia Tigrina, Daniel J. Bach, Matthew Tenaglia, Debra L. Baker, Sean Deats, Erica Montgomery, Oné R. Pagán

Biology Faculty Publications

Nicotine is one of the most addictive drugs abused by humans. Our laboratory and others have demonstrated that nicotine decreases motility and induces seizure-like behavior in planarians (pSLM, which are vigorous writhing and bending of the body) in a concentration-dependent manner. Nicotine also induces withdrawal-like behaviors in these worms. Cotinine is the major nicotine metabolite in humans, although it is not the final product of nicotine metabolism. Cotinine is mostly inactive in vertebrate nervous systems and is currently being explored as a molecule which possess most of nicotine’s beneficial effects and few of its undesirable ones. It is not known …

The Eco-Epidemiology Of Pacific Coast Tick Fever In California, Kerry A. Padgett, Denise L. Bonilla, Marina E. Eremeeva, Carol A. Glaser, Robert S. Lane, Charsey Cole Porse, Martin B. Castro, Sharon L. Messenger, Alex Espinosa, Jill Hacker, Anne Kjemtrup, Bonnie Ryan, Jamesina J. Scott, Renjie Hu, Melissa Hardstone Yoshimizu, Gregory A. Dasch, Vicki Kramer

Environmental Health Sciences: Faculty Publications

Rickettsia philipii (type strain “Rickettsia 364D”), the etiologic agent of Pacific Coast tick fever (PCTF), is transmitted to people by the Pacific Coast tick, Dermacentor occidentalis. Following the first confirmed human case of PCTF in 2008, 13 additional human cases have been reported in California, more than half of which were pediatric cases. The most common features of PCTF are the presence of at least one necrotic lesion known as an eschar (100%), fever (85%), and headache (79%); four case-patients required hospitalization and four had multiple eschars. Findings presented here implicate the nymphal or larval stages of D …

How Do The Social Benefits And Costs Of The Patent System Stack Up In Pharmaceuticals?, Daniel J. Gifford

Journal of Intellectual Property Law

This paper explores the workings of the patent system in the context of the generation of new pharmaceutical products. First it identifies the relevant characteristics of the patent system and its relation to the market. The paper concedes that, in general, the patent system is probably the best way of generating new technology, in substantial part because that system uses the market to provide both incentives and rewards. The paper also identifies downsides of this patent/market system: deadweight loss and the unresponsiveness of that patent/market system to the needs of the poor. The paper then explores the social costs and …

Tgf-Β Signaling: New Insights Into Aortic Aneurysms, Sean E. Thatcher

Pharmacology and Nutritional Sciences Faculty Publications

No abstract provided.

An Excitatory Cortical Feedback Loop Gates Retinal Wave Transmission In Rodent Thalamus, Yasunobu Murata, Matthew T. Colonnese

Pharmacology and Physiology Faculty Publications

Spontaneous retinal waves are critical for the development of receptive fields in visual thalamus (LGN) and cortex (VC). Despite a detailed understanding of the circuit specializations in retina that generate waves, whether central circuit specializations also exist to control their propagation through visual pathways of the brain is unknown. Here we identify a developmentally transient, corticothalamic amplification of retinal drive to thalamus as a mechanism for retinal wave transmission in the infant rat brain. During the period of retinal waves, corticothalamic connections excite LGN, rather than driving feedforward inhibition as observed in the adult. This creates an excitatory feedback loop …

Mechanisms Of Comorbidities Associated With The Metabolic Syndrome: Insights From The Jcr:La-Cp Corpulent Rat Strain, Abdoulaye Diane, W David Pierce, Sandra Kelly, Sharon Sokolik, Rebecca Hutcheson, Petra Rocic, Spencer Proctor

NYMC Faculty Publications

Obesity and its metabolic complications have emerged as the epidemic of the new millennia. The use of obese rodent models continues to be a productive component of efforts to understand the concomitant metabolic complications of this disease. In 1978, the JCR:LA-cp rat model was developed with an autosomal recessive corpulent (cp) trait resulting from a premature stop codon in the extracellular domain of the leptin receptor. Rats that are heterozygous for the cp trait are lean-prone, while those that are homozygous (cp/cp) spontaneously display the pathophysiology of obesity as well as a metabolic syndrome (MetS)-like phenotype. Over the years, there …

Reef Fish And Coral Assemblages On Hospital Point And Near Bastimentos Island, Panama, Elaine Shen

Independent Study Project (ISP) Collection

Because worldwide declines coral reef health are of major concern, studying coral reefs through the lens of conservation efforts at local scales is essential for determining and monitoring effective policy measures. In the Bocas del Toro Archipelago, there are conflicts of interest between exploitative rapid tourism development, overfishing practices, and national efforts to conserve the local marine biodiversity. Coral and reef fish species abundance richness, diversity, evenness, and similarity were measured to see how coral and reef fish assemblages changed between protected and unprotected areas. A total of 329 fish and 322.5 square meters of benthos were analyzed using underwater …

Chemical Activation Of A Food Deprivation Signal Extends Lifespan., Mark Lucanic, Theo Garrett, Ivan Yu, Fernando Calahorro, Azar Asadi Shahmirzadi, Aaron Miller, Matthew S Gill, Robert E. Hughes, Lindy Holden-Dye, Gordon J. Lithgow

Natural Sciences and Mathematics | Student Professional Publications

Model organisms subject to dietary restriction (DR) generally live longer. Accompanying this lifespan extension are improvements in overall health, based on multiple metrics. This indicates that pharmacological treatments that mimic the effects of DR could improve health in humans. To find new chemical structures that extend lifespan, we screened 30 000 synthetic, diverse drug-like chemicals in Caenorhabditis elegans and identified several structurally related compounds that acted through DR mechanisms. The most potent of these NP1 impinges upon a food perception pathway by promoting glutamate signaling in the pharynx. This results in the overriding of a GPCR pathway involved in the …

School Siting Near Industrial Chemical Facilities: Findings From The U.S. Chemical Safety Board's Investigation Of The West Fertilizer Explosion., Veronica A Tinney, Jerad M Denton, Lucy Sciallo-Tyler, Jerome A. Paulson

Environmental and Occupational Health Faculty Publications

BACKGROUND: The U.S. Chemical Safety and Hazard Investigation Board (CSB) investigated the April 17, 2013 explosion at the West Fertilizer Company (WFC) that resulted in 15 fatalities, more than 260 injuries and damage to more than 150 buildings. Among these structures were four nearby school buildings cumulatively housing children in grades K-12, a nursing care facility and an apartment complex. The incident occurred during the evening when school was not in session, which reduced the number of injuries.

OBJECTIVES: The goal of this paper is to illustrate the consequences of siting schools near facilities that store or use hazardous chemicals, …

Consumer Product Chemicals In Indoor Dust: A Quantitative Meta-Analysis Of U.S. Studies, Susanna D. Mitro, Robin Dodson, Veena Singla, Gary Adamkiewicz, Angelo F. Elmi, Monica Tilly, Ami R. Zota

Environmental and Occupational Health Faculty Publications

Indoor dust is a reservoir for commercial consumer product chemicals, including many compounds with known or suspected health effects. However, most dust exposure studies measure few chemicals in small samples. We systematically searched the U.S. indoor dust literature on phthalates, replacement flame retardants (RFRs), perfluoroalkyl substances (PFASs), synthetic fragrances, and environmental phenols and estimated pooled geometric means (GMs) and 95% confidence intervals for 45 chemicals measured in ≥3 data sets. In order to rank and contextualize these results, we used the pooled GMs to calculate residential intake from dust ingestion, inhalation, and dermal uptake from air, and then identified hazard …

Pharmacology Of Cannabis, Mandakini Sadhir

Pediatrics Faculty Publications

Cannabis has been used for recreational purposes around the world. It is derived from the plant cannabis sativa which has various other compounds known as cannabinoids. Most common form of cannabis used for recreational purpose is marijuana, which is prepared from dried flowering tops and leaves. The primary psychoactive component is delta 9-tetrahydrocannabinol (δ-9THC), which exerts its physiological and psychological effects through its interaction with CB1 and CB2 receptors. Smoking is the most commonly used method with onset of effects within minutes after inhalation. Oral ingestion of cannabis has varied absorption with delayed onset but longer duration of action. Urine …

Rabbit Control: Bait Stations, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

This factsheet provides information on using bait stations for rabbit control.

Biological control agents such as the myxoma virus (myxomatosis), and rabbit haemorraghic disease virus (RHDV) or rabbit calicivirus disease, will not provide ‘magic bullets’ for reducing the impact of rabbits on agricultural production and the environment. Biological agents are more effective when they form part of an integrated approach to rabbit control. An integrated approach should use all available control options, including biological control, the use of vertebrate pesticides, shooting, and trapping programs. Control programs are most effective when they include the greatest number of properties possible (that is, …

Variability Of Lacustrine Sediment Proxy Responses To Late Holocene Climate Change As Modified By Lake Specific Processes: A Review Of Ecological And Geophysical Processes Across Northern And Eastern Iceland, Mallory Mintz

Independent Study Project (ISP) Collection

Consistenly-deposited lake sediments provide some of the highest resolution records of local and global climates in the past, offering the potential to better understand modern climate change in the context of past climate variability. In relating proxies to their respective climate regimes, the environmental cues that the specific proxies reacted to must be isolated from the general noise of possible local influences. In this investigation, biogenic silica (BSi), total organic carbon (TOC), δ13C values, and carbon: nitrogen ratios were analyzed between lakes through northern Iceland, to review possible complicating factors specific to the use of lacustrine proxies in the interpretation …

Investigating Effects Of Climate Change On Glaciers And Proglacial Landscapes In Southeast Iceland: Fluvioglacial Behavior Of Sólheimajökull And Seljavallajökull, Roberta B.C. Miller

Independent Study Project (ISP) Collection

The Seljavallajökull glacier, part of the Eyjafjallajökull glacier system, and Sólheimajökull, part of the Mýrdalsjökull glacier system, are two glaciers that extend into valleys in the southeast part of Iceland. Due to climate warming, both of these glaciers are part of a melting ice cap. They are located nearby to one another, and Sólheimajökull has been extensively studied for its outwash plain sedimentology, retreat history, pro-glacial geomorphology and has been steadily monitored by the Glaciological Society of Iceland. Seljavallajökull has also been monitored by this group, but it has not been studied for sediment profiles and landscape chronology as Sólheimajökull …

The Importance Of Rivers In Protected Areas: Macroinvertebrate Sampling Reveals The Impact Of Humans And Highways On Water Quality, Marie-Claire Harrison

Independent Study Project (ISP) Collection

The water quality and level of contamination of two rivers in a cloud forest ecosystem in the Mejía region of Ecuador, the Tupí River and the Pilatón River were assessed through benthic macroinvertebrate sampling at various sites along the rivers. Many different biological indices were then used to assess water quality at each site. Pollution in the form of grey water, black water, and petroleum negatively impacted the water quality of the both rivers as they pass through the town of La Esperie. Differences in river structure and size also played a role in determining the prevalence of certain benthic …

La Lluvia Y El Océano Oculto: El Estudio Del Unu Cambio Y Su Relación Con Viracocha En Chinchero / The Rain And The Occult Ocean: The Study Of The Change And Its Relationship With Viracocha In Chinchero, Edgar J. Payano

Independent Study Project (ISP) Collection

Chinchero es una comunidad pequeña donde tradiciones han permanecido, pero a la misma vez el ambiente se está cambiando rápidamente. Una de las actividades más importante de Chinchero es el cultivo seco. El cultivo seco depende de la temporada de lluvias. Mi investigación se trata del unu cambio porque mezclan fuentes de aguas sagradas para atraer lluvia durante sequias. Chinchero siempre ha sufrido de sequias y el unu cambio es un método de prevención desde los tiempos pre-incaicas. Con pocas fuentes de agua en Chinchero, tienen que buscar y utilizar fuentes sagradas afuera de sus inmediaciones. Al otro lado de …

Live And Dead Coral Cover On Three Reefs And Public Perceptions Of Degradation Around Almirante Bay, Bocas Del Toro, Phoebe Thompson

Independent Study Project (ISP) Collection

Almirante Bay is a lagoonal body of water off the western Caribbean coast of Panama. The islands within the bay are popular tourist destinations, drawing visitors from around the world to explore beaches and coral reefs. However, the reefs in Almirante Bay are continually exposed to both natural and anthropogenic stressors, such as temperature inversions, boat pollution, sedimentation from dredging, and chemical runoff from coastal banana plantations. Because the economy of the area is heavily dependent on tourism, this creates an interesting dynamic in that the main source of income (tourism) could be detrimental to a main attraction of the …

Water Resource Change And Management: Implications Of Climate Change And Water Resource Management For Pastoral Herders In Bayan Ulgii, Rachel Ryan

Independent Study Project (ISP) Collection

Mongolia is the 8th most vulnerable country in the world to climate change. The water regime of Mongolia is therefore experiencing intensive change with significant effects in the availability, distribution, and security of water resources. The implications of this change are exacerbated when aligned with poor water resource management, an issue that is prevalent as water regime change challenges current water management systems. These implications specifically affect the vulnerable rural population of Mongolian herders who maintain the practice of nomadic pastoralism. In the western province of Bayan Ulgii, the change in the numerous glaciers and other water resources that are …

Adopters And Non-Adopters Of Low-Cost Household Latrines: A Study Of Corbelled Pit Latrines In 15 Districts Of Malawi., Rochelle Holm, Mavuto Tembo, Dalo Njera, Victor Kasulo, Mphatso Malota, Willy Chipeta, Wales Singini, Joshua Mchenga

Faculty and Staff Scholarship

The Sustainable Development Goals will challenge low- and middle-income settings to look at new approaches for rural sanitation. In 2013, Mzuzu University, in partnership with United Nations Children's Fund (UNICEF) Malawi, started a low-cost latrine program in rural areas using the corbelled latrine design supported by locally owned sustainable businesses. The objective of this work was to trace customers (early household adopters) and non-customers through field observations and interviews in 15 districts of Malawi. The research team spent 193 personnel work days in data collection and found 21 households as adopters in 7 districts. Most respondents had a preference with …

Quantifying The Toxicity Of 1-Methylnaphthalene To The Shallow-Water Coral, Porites Divaricata, For Use In The Target Lipid Model, Nicholas Turner

HCNSO Student Theses and Dissertations

The proximity of coral reefs to coastal urban areas and shipping lanes predisposes corals to petroleum pollution from multiple sources. Previous research has evaluated petroleum toxicity to coral using a variety of methodologies, including monitoring effects of acute and chronic spills, in situ exposures, and ex situ exposures with both adult and larval stage corals. Variability in toxicant, bioassay conditions, species and other methodological disparities among studies prevents comprehensive conclusions regarding the toxicity of hydrocarbons to corals. This research evaluated the 48-hour toxicity of 1-methylnaphthalene to Porites divaricata using a continuous-flow passive dosing system. The range-finding exposure evaluated the dosing …

Rickettsiologist Pavel F. Zdrodovskii: Larger Than Life, And Not Just For His Famous Book, Marina E. Eremeeva, S. N. Shpynov, I. V. Tarasevich

Environmental Health Sciences: Faculty Publications

This article highlights the biography and scientific accomplishments of Pavel F. Zdrodovskii and his contributions to understanding the biology, pathogenesis, treatment, prevention and epidemiology of brucellosis, rickettsioses and many other infectious diseases.

Synthetic And Biological Exploration Of (+)-Boldine - Identification Of Potential Cns Receptor Ligands, Sujay Joseph

Theses and Dissertations

(+)-Boldine, an aporphine alkaloid, is reported to be biologically active at various Central Nervous System(CNS) receptors. However, only a few Structure Activity Relationship(SAR) studies have been conducted using boldine’s aporphine scaffold. A library of novel analogs was synthesized from boldine to understand the effect of bisbenzylation at C2 and C9 positions on the affinity and selectivity at the serotonin receptors.

Molecular Mechanisms Involved In Neurotoxicity Mediated By Hiv Proteins And Drug Abuse, Yu Cai

Theses & Dissertations

While the advancement of highly active antiretroviral therapy (HAART) has transformed the course of HIV/AIDS from a death sentence to a manageable chronic condition, the prevalence of a constellation of neurological disorders collectively termed as HIV-associated neurocognitive disorders (HAND) continues to persist in these patients. HAND is characterized by cognitive dysfunction, depression, impaired memory and/or deficits in motor skills. The underlying factors leading to HAND have been the subject of extensive research and are thought to be associated with HIV infection in the CNS combined with robust immune activation of resident cells of the CNS. In addition, there is a …

Binge Ethanol Exposure Causes Endoplasmic Reticulum Stress, Oxidative Stress And Tissue Injury In The Pancreas, Zhenhua Ren, Xin Wang, Mei Xu, Fanmuyi Yang, Jacqueline A. Frank, Zun-Ji Ke, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Alcohol abuse is associated with both acute and chronic pancreatitis. Repeated episodes of acute pancreatitis or pancreatic injury may result in chronic pancreatitis. We investigated ethanol-induced pancreatic injury using a mouse model of binge ethanol exposure. Male C57BL/6 mice were exposed to ethanol intragastrically (5 g/kg, 25% ethanol w/v) daily for 10 days. Binge ethanol exposure caused pathological changes in pancreas demonstrated by tissue edema, acinar atrophy and moderate fibrosis. Ethanol caused both apoptotic and necrotic cell death which was demonstrated by the increase in active caspase-3, caspase-8, cleaved PARP, cleaved CK-18 and the secretion of high mobility group protein …

Comparative Genomics Of 9 Novel Paenibacillus Larvae Bacteriophages, Casey Stamereilers, Lucy Leblanc, Diane Yost, Penny S. Amy, Philippos K. Tsourkas

Life Sciences Faculty Research

American Foulbrood Disease, caused by the bacterium Paenibacillus larvae, is one of the most destructive diseases of the honeybee, Apis mellifera. Our group recently published the sequences of 9 new phages with the ability to infect and lyse P. larvae. Here, we characterize the genomes of these P. larvae phages, compare them to each other and to other sequenced P. larvae phages, and putatively identify protein function. The phage genomes are 38–45 kb in size and contain 68–86 genes, most of which appear to be unique to P. larvae phages. We classify P. larvae phages into 2 main clusters and …

Drug-Induced Nutrient Depletion, Rodney Richmond

Faculty Research ​and Publications

No abstract provided.

Air Pollution, Pulmonary Oxidative Stress, And The Endothelin System In The Development Of Cardiovascular Injury., Jordan B. Finch

Electronic Theses and Dissertations

The goal of this project was to examine the role of endothelin-1 (ET-1) as a mediator in the pathway between air pollution exposure and the development of vascular injury. A human cohort and male mice (C57BL/6 and ecSOD-Tg) were used to evaluate changes in the ET-1 system in response to exposures of fine particulate matter (PM2.5). Human ET-1 levels were significantly associated with environmental factors and markers of vascular change, but were decreased with increased PM2.5. No association was seen between ET-1 and endothelial progenitor cells (EPCs) except for EPC-4, possibly indicating a regulatory relationship with this specific population. In …