Pharmacology, Toxicology and Environmental Health Commons^™

Clinical Importance Of Phenytoin Monitoring To Reduce Phenytoin-Related Toxicity In Saudi Patients With Epilepsy, Ghidaa Alwaf, Hussam Younis, Mohammed Al-Hartani, Alaa H. Falemban, Et.Al.

Saudi Toxicology Journal

Background: Phenytoin toxicity can result from overdose, dosage changes, drug interac-tions, or physiological alterations. Symptoms range from nausea and confusion to severe cases involving coma and seizures, though fatalities are rare. To date, no literature has been found concerning phenytoin monitoring in Saudi epileptic patients. This study is the first to inves-tigate phenytoin monitoring for toxicity prevention, optimal dosing, and adverse effect management in Saudi epileptic patients. Methods: A two-month, randomized, open-label, prospective monitoring study was conducted in Saudi epileptic patients treated with phen-ytoin. The patients (n=40) were subdivided into two groups (monitored and unmonitored) to check the prevalence of …

Artificial Intelligence (Ai) In Pharmacy, Giang Nguyen, Elizabeth Sartschev, John Reyes, Allie Honigford, Marisa Petrunich, Kiley Devoll, Brianna Lu, Joshua Honaker, T'Bony M. Jewell

Pharmacy and Wellness Review

Artificial Intelligence (AI) has transformed the pharmaceutical field by enabling computer software systems to learn and perform human behavior. Specifically, AI has revolutionized chronic diabetes management through continuous glucose monitoring, showcasing its immense potential in healthcare. However, alongside its transformative impact, AI’s increasing role in healthcare has prompted concerns over privacy and its premature integration. Despite these challenges, AI offers limitless opportunities to improve medication management and treatment regimens, driving advancements across various domains. From improving CT imaging to enhancing adenoma detection in colonoscopies and facilitating medication adherence, AI’s impact on healthcare is profound. Furthermore, AI plays a pivotal role …

Exploring Single Cell Microbial Protein As A Sustainable Fishmeal Alternative In Yellowtail Kingfish (Seriola Lalandi) Diets: Impacts On Health And Gut Microbiome, Luke Pilmer, Lindsey Woolley, Alan Lymbery, Chinh Dam, Abigail Elizur, Md Javed Foysal, Gavin Partridge

Fisheries Research Articles

Background

With the global expansion of aquaculture and the increasing demand for fish meal, identifying appropriate and sustainable alternative protein sources for aquafeeds has become essential. Single-cell protein (SCP), derived from methanotrophic bacteria, presents a promising alternative by converting methane into protein, potentially addressing both the need for alternative protein sources and reducing industrial greenhouse gas emissions. This study aimed to evaluate the effects of different levels of SCP inclusion (0%, 25%, 50%, and 75% fish meal replacement) on the health, gene expression, and gut microbiome of yellowtail kingfish (YTK, Seriola lalandi) following a 35-day growth trial.

Results

The …

Developing Sustainable Medical Tourism: A Framework In The Perspective Of Developing Countries, Abel Ansporthy Mamboleo Dr.

Journal of Sustainability and Resilience

This study reviewed the literature to develop the framework for sustainable medical tourism in developing countries. According to the findings, the development of a sustainable tourist destination necessitates the involvement of various stakeholders and adherence to sustainability principles. The framework suggests five essential tasks for sustainable medical tourism development. It contributes to the knowledge of sustainable medical tourism by suggesting the framework for analysing a specific situation for the development of a medical tourist destination. It provides a better understanding of sustainable medical tourism operations by integrating medication, travel, hospitality, and tourism. Moreover, it contributes to the sphere of medical …

An Intensified Cereal Push-Pull System Reduces Pest Infestation And Confers Yield Advantages In High-Value Vegetables, Frank Chidawanyika, Evanson R. Omuse, Lavender O. Agutu, Jimmy O. Pittchar, Dickens Nyagol, Zeyaur R. Khan

All Peer-Reviewed Publications

Crop diversification is associated with ecosystem services that can improve yield. We integrated tomatoes and kales within the cereal push-pull technology (PPT), to form the vegetable integrated push-pull (VIPP), and explored the influence of these cropping systems on pest and disease management, and subsequent yield of the vegetables. Aphids and diamondback moths (DBM), the major pests in kale production, together with grasshoppers were consistently lower in the VIPP plots. Low incidences and damage by leafminers, whiteflies and fruitflies on tomatoes were observed in VIPP plots compared to plots of tomato intercropped with maize (control). The severity of black rot and …

Bayesian Population Pharmacokinetic Modeling Of Ondansetron For Neonatal Opioid Withdrawal Syndrome, Kevin Lam, John Mondick, Gary Peltz, Manhong Wu, Walter Kraft

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Ondansetron is an anti-emetic 5-HT3 receptor antagonist being investigated for treating neonatal opioid withdrawal syndrome (NOWS). Sparse PK data were analyzed from a multicenter, double-blind clinical trial with 98 mother/neonate dyads. Pregnant women with opioid use disorder were randomized to receive either placebo or ondansetron 8 mg intravenously within 4 h of delivery. Neonates born to mothers who were randomized to ondansetron received 0.07 mg/kg orally once every 24 h for up to five doses. Using current PK data, model parameters from a two-compartmental structural model from the literature (i.e., a priori model) were updated with the Metropolis-Hastings Markov-chain Monte …

Development Of The Navigation Guide Evidence-To-Decision Framework For Environmental Health: Version 1.0, Nicholas Chartres, Max T. Aung, Sustan L. Norris, Courtney Cooper, Lia A. Bero, Roger Chou, Devon C. Payne-Sturges, Wendy E. Wagner, Jessica W. Reyes, Lisa M. Askie, Daniel A. Axelrad, Deysi Flores Vigo, Jill E. Johnston, Juleen Lam, Keeve E. Nachman, Eva Rehfuess, Rachel Rothschild, Patrice Sutton, Lauren Zeise, Tracey J. Woodruff

Articles

Environmental exposures, including widespread industrial pollution, impact human health and are amplified in more highly exposed communities. Policy and regulatory frameworks for making decisions and recommendations on interventions to mitigate or prevent exposures tend to narrowly focus on exposure and some health-related data related to risks. Typically, such frameworks do not consider other factors, including essentiality, health equity, and distribution of benefits and costs. Further, decisions and recommendations lack transparency regarding how they were developed. We developed the Navigation Guide Evidence-to-Decision Framework for Environmental Health (E2DFEH) to provide a structured and transparent framework incorporating a range of scientific information and …

Attenuation Of Vitamin E On Haloxyfop-R-Methyl Ester-Induced Hepatic Oxidative Stress In Orally Exposed Rats., Omolara D. Falodun

STEM for Success Resources

No abstract provided.

Molecular Modification Of Queen Bee Acid And 10-Hydroxydecanoic Acid With Specific Tripeptides: Rational Design, Organic Synthesis, And Assessment For Prohealing And Antimicrobial Hydrogel Properties, Song Hong, Sachin B. Baravkar, Yan Lu, Abdul Razak Masoud, Qi Zhao, Weilie Zhou

School of Medicine Faculty Publications

Royal jelly and medical grade honey are traditionally used in treating wounds and infections, although their effectiveness is often variable and insufficient. To overcome their limitations, we created novel amphiphiles by modifying the main reparative and antimicrobial components, queen bee acid (hda) and 10-hydroxyl-decanoic acid (hdaa), through peptide bonding with specific tripeptides. Our molecular design incorporated amphiphile targets as being biocompatible in wound healing, biodegradable, non-toxic, hydrogelable, prohealing, and antimicrobial. The amphiphilic molecules were designed in a hda(hdaa)-aa1-aa2-aa3 structural model with rational selection criteria for each moiety, prepared via Rink/Fmoc-tBu-based solid-phase peptide synthesis, and structurally verified by NMR and LC–MS/MS. …

Local Tissue Damage Treatment Of Snake Venom, Suchitra Khunsap

The Thai Journal of Veterinary Medicine

Local tissue damage caused by snake envenomation was a medical problem that caused morbidity and mortality for more than a decade, with no defined treatment guidelines. Nowadays, antivenom is the primary treatment for snakebite, which substantially reduces systemic venom but not significantly reducing local symptoms. We compiled a list of local damage therapies, including antivenom medication, surgery and skin grafting, small molecule medicines, and alternative therapies. Although each was not approved as a standard treatment, it may be a treatment option for tissue damage caused by snake venom. However, antivenoms and most resistant compounds may not be the best strategy …

Immuno-Bioinformatics Study Of Secondary Metabolites From Watercress Nasturtium Officinale As Immunostimulant In Whiteleg Shrimp Litopenaeus Vannamei By Targeting Peroxinectin And Scavenger Receptor Class B, Qurrota A’Yunin, Muhaimin Rifa’I, Maftuch Maftuch, Yoga Dwi Jatmiko, Muhammad Hermawan Widyananda, Triyanto Triyanto, Muhammad Tegar Handrianto

Karbala International Journal of Modern Science

The viral disease affects the whiteleg shrimp (Litopenaeus vannamei) and causes losses. Immunostimulants are recognized as a more environmentally friendly approach to disease management and antimicrobial properties of aquatic organisms. Watercress (Nasturtium officinale) is an aquatic plant species that contains antioxidant properties that can protect the organism from disease and boost the immune system. Shrimp rely heavily on innate immunity to combat infectious agents due to their absence of adaptive immunity. Peroxinectin and scavenger receptor class B (SRB) play essential roles in the shrimp defense system. This research employs a bioinformatic to assess the immunostimulatory potential …

The Effects Of Improper Waste Disposal On Marine Life: Why Does It Matter And How Can We Prevent It?, Abbey Ward, Ashlee Davis

Posters-at-the-Capitol

Improperly disposed of waste, specifically plastic, can end up in the ocean and negatively impact marine life, and in turn, negatively impact human health. Marine life, such as turtles, have faced serious health consequences and even death from entanglement in abandoned fishing gear and consuming plastics. Larger plastic particles can break down into smaller particles known as microplastics which can harbor harmful substances (such as Bisphenol A and persistent organic pollutants) and can cause several negative health effects when consumed by marine life such as loss of nutrition, starvation, and death. Microplastics have been found in 75% of commercial fish. …

Evaluations Of Hand-Arm Vibration (Hav) Exposure And Related Vascular And Musculoskeletal Heath Effects Among Groundskeeping Workers In Southeastern U.S., Nathan Chen

All ETDs from UAB

Long-term, excessive exposure to hand-arm vibration (HAV) may induce vascular, neurological, and musculoskeletal disorders, collectively known as hand-arm vibration syndrome (HAVS). However, concerns arise when adopting the currently available guidelines and standards to protect workers who regularly use vibrating tools due to the lack of standardized exposure assessment methods for HAV and reliable health indicators for HAVS. The existing exposure-response relationship addressed in ISO 5349-1 was developed based on epidemiological studies predominantly performed in temperate zones. Thus, this dissertation aimed to evaluate the HAV exposure levels and vascular and muscular health effects from vibration exposure among groundskeepers in the southeastern …

Cytotoxic, Genotoxic, And Metabolic Effects Of Dihydroxyacetone In Heart, Liver And Lung Models, Arlet Hernandez

All ETDs from UAB

Dihydroxyacetone (DHA) is a triose sugar found as an active ingredient in sunless tanning products (STPs) and by-product in electronic cigarettes (e-cigarettes). DHA can rapidly be absorbed into cells and tissues and incorporated into several metabolic pathways through its conversion into dihydroxyacetone phosphate (DHAP). Previous studies have shown that DHA promotes cytotoxicity and genotoxicity primarily characterized in skin models. The extent of these effects in systemic models is highly cell-type specific. Here we investigate the cytotoxic, genotoxic, and metabolic effects of DHA across several cell models. First, we investigated the effects of DHA in a metabolically active cell line, hepatocellular …

Influence Of Socio-Demographic Factors And Environmental Justice Issues On Vulnerable Populations Exposed To Pollution, Aishwarya Kaushal

All ETDs from UAB

As climate change intensifies environmental hazards and pollution impacts across the U.S., Alabama’s socio-demographically diverse regions face unique and disproportionate vulnerabilities. This dissertation investigates the intersection of socio-demographic factors, environmental justice, and the disproportionate impact of pollution and flood risks on vulnerable populations in Alabama. The first study assesses the role of elevation and socio-economic factors in influencing susceptibility to flooding in Jefferson County, revealing that low-income and minority groups are more likely to reside in high-risk flood zones. A detailed spatial analysis using 2D flood modeling identifies neighborhoods with high flood exposure, emphasizing the racial and economic disparities that …

Does Digital Screen Exposure Have An Impact On The Ocular Health Of Children And Adolescents?, Hannah Brodt

The Science Journal of the Lander College of Arts and Sciences

The increasing prevalence of digital screens among children and adolescents raises significant concerns regarding their ocular health. This paper reviews current evidence linking screen time to visual health issues, particularly myopia (nearsightedness), dry eye syndrome, and digital eye strain. Through a comprehensive literature review of observational studies, the analysis identifies a strong correlation between excessive screen time and the exacerbation of myopia and dry eye disease, particularly in younger populations. The findings highlight the importance of balanced screen time and suggest that early exposure to screens may significantly increase the risk of developing myopia. Further research is also recommended to …

Which Of The Environmental Aspects Affecting The Gut Microbiome Of The Neonate Has The Largest Lifelong Impact?, Roza Heershzon

The Science Journal of the Lander College of Arts and Sciences

The development of new DNA sequencing techniques has led to new discoveries on the gut microbiome’s critical influence on metabolic processes and immune development. Therefore, understanding the most influential factors in the development of the gut microbiome during early infancy, which impacts the individual’s long-term health, is vital. This paper explores how environmental factors, including delivery method and nutrition, shape the gut microbiome’s devel- opment in early life. In addition, it discusses their long-term health implications. The paper highlights how the mode of delivery significantly affects initial microbial colonization. Vaginal births promote a microbial community that is rich in beneficial …

Risk Factors Of Covid-19 Mortality, Ellie Wolff

The Science Journal of the Lander College of Arts and Sciences

This paper investigates the relationship between key health demographics and COVID-19 mortality while focusing on identifying both physiological and genetic factors that contribute to variations in mortality rates. Specifically, it examines how pre-existing conditions—such as sex, autoimmune disorders, cardiovascular diseases, and obesity—interact with COVID-19 pathophysiology to influence patient outcomes. While previous research has highlighted demographic disparities in hospital mortality rates, this study aims to establish a causal, mechanistic link between these health factors and COVID-19 severity. Methods to extract and analyze data included literature review using existing studies such as peer-reviewed articles and reports from PubMed, CDC, etc. By analyzing …

Investigating Drivers In Phytoplankton Between Lentic And Lotic Ecosystems Within Twelvepole Creek Watershed, Devin Lee Farmer

Theses, Dissertations and Capstones

Harmful Algal Blooms (HABs) threaten aquatic ecosystems, local economies, and water quality. While extensively studied in lakes (lentic systems), their impact on flowing waters (lotic systems) remains underexplored. This study examined algal drivers in both ecosystems within the same watershed, focusing on Beech Fork Lake (lentic) and Twelve Pole Creek (lotic). Key environmental factors, including pH, turbidity, dissolved oxygen, and nutrient levels, were measured using in situ sensors and laboratory analysis. Water samples were analyzed for nitrogen, phosphorus, and algal biomass for comparison to environmental conditions. Phytoplankton was preserved for identification in future research. By comparing these environments, this study …

Improving The Safety Of N,N-Dimethylacetamide As A Potential Treatment For Preterm Birth Using A Vaginal Nanoformulation, Asad Mir

Theses and Dissertations

With no available treatment for preterm birth, the field of reproductive medicine has been repurposing small molecule candidates into vaginal nanoformulations as potential treatments for the condition. The commercial solvent N,N-Dimethylacetamide (DMA) has previously been shown to delay and prevent inflammation-induced preterm birth in a mouse model. A vaginal nanoformulation of DMA loaded into a self-nanoemulsifying drug delivery system (SNEEDS) was studied to see if it can also be efficacious. A side by-side histological comparison was done in the more pertinent tissues of the reproductive tract between the traditional formulation of DMA given intraperitoneally (IP) and the vaginal nanoformulation of …

The Effects Of Exosomes In Lead And Lps Induced Inflammation In Microglia, Yitzchak Lax

Theses and Dissertations

Exosomes are membrane bound subcellular vesicles formed through membrane budding of a cell and play important roles in cell-cell communication. Studies have demonstrated inflammatory changes in various cell types depending on the etiology of the exosomes such as exosomes from cancer cells or exosomes derived from mesenchymal stem cells. The purpose of this study was to determine the inflammatory consequences of exosomes in microglial cells following exposure to lead, lipopolysaccharides (LPS) and lead+LPS. The cultured mouse microglial cells were treated at 0.01 μM, 0.1 μM and 1 μM of lead,- three environmentally relevant levels and LPS was used at 10 …

Spatial Analysis Of Heavy Metal Enrichment In A Historic Appalachian Mining Stream, Eric M. Torres

Research and Creativity Symposium

This study examined the spatial distribution of heavy metals along the Levisa Fork and primary tributaries in Buchanan County, VA and Pike County, KY. Buchanan and Pike Counties have a long history of coal mining, a process known to release heavy metals into surrounding waterways. Exposure to certain heavy metals, such as arsenic and lead, has been known to cause health problems, such as cancer and organ damage. The study looked at concentrations in riverine sediments, surface water and groundwater for As, Al, Cr, Cu, Fe, Li, Mg, Mn, Ni, Pb and Zn. Sediment samples were collected, dried and digested …

Ms Environmental Biology Capstone: Evaluating Environmental Risks And Conflicts In Golf Course Landscapes, Meredith Boos

Regis University Student Publications (comprehensive collection)

1) This review investigates the relationship between pesticide use on golf courses and in agriculture to determine whether the adverse health effects documented in agricultural settings also apply to golf course environments. While the negative health effects from agricultural pesticide use are well established, golf courses use pesticides with greater frequency and intensity, suggesting a potentially higher exposure risk for both workers and players.

2) This study proposes methods to quantify pesticide bioaccumulation on golf courses and adjacent lands. We hypothesize that areas surrounding golf courses will exhibit a spatial gradient of pesticide accumulation, increasing with proximity to treated sites …

Friend And Foe: Tgf-Beta, Its Role In Tumor Development, And An Analysis Of Chung Et Al. (2018), Yosef Sonbolian

The Science Journal of the Lander College of Arts and Sciences

This paper will analyze an important study performed by Chung et al. (2018) regarding transforming growth factor-beta (TGFbeta), which plays an important role in various cellular processes. Paradoxically, TGF-beta plays a different role in the development of cancer at various points. In early-stage tumors, TGF-beta has been known to inhibit cancer growth, but in later stages, it acts as a cancer promoter. Chung et al. (2018) attempted to ascertain the efficaciousness of the drug Sorafenib in suppressing TGF-beta responses, as well as the ways that this drug achieves its goal and the implications that their findings may have for future …

Gene Ontology Enrichment Reveals Pufa-Responsive Functional Themes In The Nucleus Accumbens Of Female Dba/2j Mice, Eman Mahjoub, Jennifer Wolstenholme Ph.D.

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

Validating A Genetic Knockout Of Ninein In A Mouse Model, Jessikah M. Buys, E R. Gnatowski, L Vermuri, A Safeer, L Holmes, M. F. Miles

IRBEH/Spit for Science Publications and Presentations

Ninein (Nin) is a microtubule associated protein that has been previously characterized by the Miles Lab for regulating the anxiety-reducing (anxiolytic) effects of alcohol, which is thought to contribute to development of Alcohol Use Disorder (AUD). Previous studies in the lab have investigated the role of Nin deletion on anxiety and ethanol-related behaviors in a conditional knockout model. The following set of studies seek to validate this genetic model. The model was validated using three main methods: immunofluorescence, qRT-PCR, and gel electrophoresis. In PCR studies, Ninein was significantly reduced in cre-expressing animals compared to controls. Gel Electrophoresis confirmed this reduction …

Effects Of Psychedelics On Acute Nicotine Pharmacological Responses, Aleny Oros, Belle Buzzi, Julian Vaughn, Burhan Buttar, Javier Gonzalez-Maeso, M Imad Damaj

IRBEH/Spit for Science Publications and Presentations

Smoking is a major risk factor for illnesses, such as cancers, cardiovascular diseases and respiratory conditions. In smoking, nicotine activates nicotinic acetylcholine receptors in the brain region. Prolonged use of nicotine will desensitize these specific receptors and cause nicotine dependence, resulting in smokers to experience withdrawal symptoms, such as anhedonia, depression, stress, and craving, leading to relapse.2 As the rate cigarette smoking has declined over the years, it is not significantly entitled by the tremendous increase rate of e-cigarette use. In a previous study being published, life-time use of psychedelics is associated with lower nicotine dependence.1

Psychedelics, specifically psilocybin, which …

Developing Stiripentol Analogs As Potential Ldh Inhibitors For The Treatment Of Glioblastoma, Anshika Y. Jain

Theses and Dissertations

Glioblastoma multiforme (GBM) is a highly proliferative brain tumor that has a 5-year survival rate of ~7 %. Temozolomide (TMZ) is the current standard of care therapeutic for GBM. However, 50% of patients develop resistance to TMZ. Therefore, further investigation for new GBM therapeutics is necessary to overcome this issue of drug resistance. GBM patients are known to overexpress lactate dehydrogenase (LDH), which is inversely correlated with their survival. This key glycolytic enzyme catalyzes the interconversion of pyruvate and lactate and plays an important role in cancer proliferation and invasion. Therefore, we aimed to inhibit LDH for developing therapeutics for …

Occupational Exposures To Chemicals In Dentistry: A Scoping Review, Geneviève Picard, Tisha Prakash, France Labrèche, Sabrina Gravel

Revues de littérature, synthèses de connaissances

The dental workforce comprises a variety of professions, most of which are predominantly occupied by women. Dental workers can be exposed to numerous toxic chemicals such as mercury, methacrylate polymers, and silica. This scoping review aims to synthesize the scientific literature on quantified chemical exposures and to identify research gaps in occupational chemical hazards faced by dental professionals. This review followed the Joanna Briggs Institute approach and PRISMA-ScR guidelines, using three concepts to search PubMed, Embase, and Web of Science: workers, dental care, and chemicals. Studies from high-income countries, published in French or English between 2000 and 2024 and reporting …

Metformin In Overcoming Enzalutamide Resistance In Castration-Resistant Prostate Cancer, Kendall Simpson, Derek B. Allison, Daheng He, Jinpeng Liu, Chi Wang, Xiaoqi Liu

Markey Cancer Center Faculty Publications

Androgen deprivation is the standard treatment for patients with prostate cancer. However, the disease eventually progresses as castration-resistant prostate cancer (CRPC). Enzalutamide, an androgen receptor inhibitor, is a typical drug for treating CRPC and with continuous reliance on the drug, can lead to enzalutamide resistance. This highlights the necessity for developing novel therapeutic targets to combat the gain of resistance. Metformin has been recently investigated for its potential antitumorigenic effects in many cancer types. In this study, we used enzalutamide and metformin in combination to explore the possible rescued efficacy of enzalutamide in the treatment of enzalutamide-resistant CRPC. We first …