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Articles 3811 - 3840 of 7020

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Rxtx And Micromedex, Shawn Hendrikx, Kelly Hatch Aug 2017

Rxtx And Micromedex, Shawn Hendrikx, Kelly Hatch

Western Libraries Publications

No abstract provided.

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Sphingolipids In Models Of Kidney Disease And Injury., Tess V. Dupre Aug 2017

Sphingolipids In Models Of Kidney Disease And Injury., Tess V. Dupre

Electronic Theses and Dissertations

Acute kidney injury (AKI), resulting from cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves cell death pathways regulated by sphingolipids such as ceramide and glucosylceramide. Results indicate that cisplatin-treated mice had increased levels of ceramide and hexosylceramide. Pre-treatment of mice with inhibitors of ceramide synthesis prevented accumulation of ceramide and hexosylceramide in the renal cortex and attenuated cisplatin-induced AKI. To determine the role of ceramide metabolism to hexosylceramides in kidney injury, we treated mice with an inhibitor of glycosphingolipid synthesis. Inhibition of glycosphingolipid synthesis attenuated the accumulation of the hexosylceramide and exacerbated ceramide accumulation in the …

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Using Neonatal Skin To Study The Developmental Programming Of Aging, Leryn J. Reynolds, Brett J. Dickens, Benjamin B. Green, Carmen J. Marsit, Kevin J. Pearson Aug 2017

Using Neonatal Skin To Study The Developmental Programming Of Aging, Leryn J. Reynolds, Brett J. Dickens, Benjamin B. Green, Carmen J. Marsit, Kevin J. Pearson

Pharmacology and Nutritional Sciences Faculty Publications

Numerous studies have examined how both negative and positive maternal exposures (environmental contaminants, nutrition, exercise, etc.) impact offspring risk for age-associated diseases such as obesity, type 2 diabetes, hypertension, and others. The purpose of this study was to introduce the foreskin as a novel model to examine developmental programming in human neonates, particularly in regard to adipogenesis and insulin receptor signaling, major contributors to age-associated diseases such as obesity and diabetes. Neonatal foreskin was collected following circumcision and primary dermal fibroblasts were isolated to perform adipocyte differentiation and insulin stimulation experiments. Human neonatal foreskin primary fibroblasts take up lipid when …

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Novel Insight Into The Liver-Lung Axis In Alcohol-Enhanced Acute Lung Injury., Lauren G. Poole Aug 2017

Novel Insight Into The Liver-Lung Axis In Alcohol-Enhanced Acute Lung Injury., Lauren G. Poole

Electronic Theses and Dissertations

Background. Individuals who chronically abuse alcohol are almost 4 times more likely to develop Acute Respiratory Distress Syndrome (ARDS), the most severe form of Acute Lung Injury (ALI), but the mechanisms by which alcohol abuse sensitizes the lung to injury are poorly understood. However, the lung appears to share many parallel mechanisms of injury with the liver- a primary target of alcohol abuse. The overarching goal of this dissertation was therefore to expand on established mechanisms of alcohol-induced liver injury to ask innovative questions about mechanisms of alcohol-enhanced acute lung injury, as well as to develop new tools that may …

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Advances In Tumor-Targeted Therapy Using Nanomedicine., Divya Karukonda Aug 2017

Advances In Tumor-Targeted Therapy Using Nanomedicine., Divya Karukonda

Electronic Theses and Dissertations

Despite continuous improvement and significant progress made in diagnostic and therapeutic approaches for cancer, it is still the leading cause of death worldwide. Although conventional chemotherapy has made significant advances in improving patient survival the indiscriminate destruction of normal cells leads to severe side effects and poor clinical outcomes. Thus, there is a need for effective delivery of drugs to the tumor site avoiding normal tissues to reduce toxicity in the rest of the body. For this reason, a novel multidisciplinary field called Nanotechnology has evolved in recent years and advances in this field have contributed to the development of …

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Prevention And Treatment Of Familial Adenomatous Polyposis And Colorectal Cancer By Bilberry-Derived Anthocyanidins., Ashley M. Mudd Aug 2017

Prevention And Treatment Of Familial Adenomatous Polyposis And Colorectal Cancer By Bilberry-Derived Anthocyanidins., Ashley M. Mudd

Electronic Theses and Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths within the United States. Familial adenomatous polyposis (FAP) is an inherited disorder which if left untreated will develop into colon cancer. The family of plant-derived compounds, anthocyanins, show significant therapeutic potential against a variety of diseases, however, they are limited by their instability and poor bioavailability. The goal of my Master’s research project was to determine whether anthocyanidins (non-glycosylated anthocyanins) are more effective than the native anthocyanins, and whether exosomal formulation of anthocyanidins (ExoAnthos) can enhance therapeutic potency compared with free Anthos against both FAP and CRC. The antiproliferative …

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The Comparative Cytotoxicity And Genotoxicity Of Hexavalent Chromium In Humans And Sea Turtles., Rachel M. Speer Aug 2017

The Comparative Cytotoxicity And Genotoxicity Of Hexavalent Chromium In Humans And Sea Turtles., Rachel M. Speer

Electronic Theses and Dissertations

Monitoring the health effects of environmental contaminants can be achieved using sentinel species as models. Leatherback sea turtles (Dermochelys coriacea) are an endangered marine species that may experience prolonged exposures to environmental contaminants including hexavalent chromium [Cr(VI)]. While Cr(VI) has been identified as a known human carcinogen, the health effects in marine species are poorly understood. In this study the cytotoxic and genotoxic effects of particulate and soluble Cr(VI) were assessed in leatherback lung cells and compared to those in human lung cells. Cr(VI) induced a concentration-dependent increase in cytotoxicity and genotoxicity in leatherback lung cells indicating Cr(VI) …

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A Comparison Of Outdoor Bioaerosol And Particulate Measurements In Las Vegas, Tanviben Yogeshkumar Patel Aug 2017

A Comparison Of Outdoor Bioaerosol And Particulate Measurements In Las Vegas, Tanviben Yogeshkumar Patel

UNLV Theses, Dissertations, Professional Papers, and Capstones

The urbanization of the Las Vegas Valley has turned the desert into a green oasis by introducing many non-native plant species, some of which are allergenic. Outdoor bioaerosols consist of microorganisms, pollen, spores, and other agents that could cause infections or affect the health of humans. Studies have suggested that exposure to bioaerosols through inhalation can lead to various human health risks. Typically, one monitoring station is established per city to obtain pollen and mold counts for an entire metropolitan area, and the site may not be representative of community exposures. The objective of this study was to measure and …

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Enemy Exacerbation: Effects Of Predator Stress On Sulfate Lethality In Freshwater Amphipods (Gammarus Minus), Trevor Chapman Aug 2017

Enemy Exacerbation: Effects Of Predator Stress On Sulfate Lethality In Freshwater Amphipods (Gammarus Minus), Trevor Chapman

Electronic Theses and Dissertations

Predator cues can influence how aquatic organisms respond to anthropogenic contaminants. This study examined the effects of predator cues on behavior, metabolic rate, and sulfate (as Na2SO4) toxicity in amphipods (Gammarus minus). Predator cues included alarm cue (macerated conspecifics) and kairomone from mosquitofish (Gambusia affinis). Amphipods decreased activity and increased time in refuge when exposed to alarm cue, and increased time in refuge when exposed to kairomone. While median lethal concentrations (96-h LC50) were not influenced by predator cues, analysis of dose response curves indicated that kairomone exposure increased amphipod …

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Pharmacologic And Genetic Manipulations Of Angiotensin Signaling In Thoracic Aortic Disease Models, Andrew M. Peters Aug 2017

Pharmacologic And Genetic Manipulations Of Angiotensin Signaling In Thoracic Aortic Disease Models, Andrew M. Peters

Dissertations and Theses (Open Access)

Thoracic aortic aneurysms and dissections (TAAD) are a major cause of morbidity and mortality in patients. Many different risk factors have been associated TAAD, but hypertension is the largest risk factor. Subsets of TAAD patients have identifiable syndromic genetic diseases, yet a number of genetic non-syndromic patients have been identified. Infusion of angiotensin II into mouse models causes aortic disease through inflammation and fibrosis. An angiotensin type I receptor (AT1R) blocker (ARB) or an angiotensin converting enzyme (ACE) inhibitor (ACEi) can reverse aortic pathology in some mouse models. I set out to better understand the relationship between angiotensin and TAAD …

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Designing Local Solutions For Emptying Pit Latrines In Low-Income Urban Settlements (Malawi)., W. C. Chipeta, R. H. Holm, J. F. Kamanula, W. E. Mtonga, F. L. De Los Reyes Aug 2017

Designing Local Solutions For Emptying Pit Latrines In Low-Income Urban Settlements (Malawi)., W. C. Chipeta, R. H. Holm, J. F. Kamanula, W. E. Mtonga, F. L. De Los Reyes

Faculty and Staff Scholarship

A lack of effective options in local technology poses challenges when onsite household sanitation facilities are eventually filled to capacity in unplanned settlement areas within Mzuzu City, located in northern Malawi. Vacuum trucks currently dominate the market but focus on emptying septic tanks in the more easily accessible planned settlement areas, rather than servicing the pit latrines common in unplanned settlement areas. As a result, households in the unplanned settlement areas within Mzuzu rely primarily on manual pit emptying (i.e., shoveling by hand) or digging a new pit latrine. These practices have associated health risks and are limited by space …

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Complete Genome Sequence Of Vibrio Gazogenes Atcc 43942, Phani M. Gummadidala, Michael E. Holder, Jacqueline L. O’Brien, Nadim J. Ajami, Joseph F. Petrosino, Chandrani Mitra, Yung Pin Chen, Alan W. Decho, Anindya Chandaa Jul 2017

Complete Genome Sequence Of Vibrio Gazogenes Atcc 43942, Phani M. Gummadidala, Michael E. Holder, Jacqueline L. O’Brien, Nadim J. Ajami, Joseph F. Petrosino, Chandrani Mitra, Yung Pin Chen, Alan W. Decho, Anindya Chandaa

Faculty Publications

Vibrio gazogenes ATCC 43942 has the potential to synthesize a plethora of metabolites which are of clinical and agricultural significance in response to environmental triggers. The complete genomic sequence of Vibrio gazogenes ATCC 43942 is reported herein, contributing to the knowledge base of strains in the Vibrio genus.

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Effect Assessment Of Tio2 Nanoparticles Exposure On Medicago By Monitoring Morphophysiology, Charles Towey Jul 2017

Effect Assessment Of Tio2 Nanoparticles Exposure On Medicago By Monitoring Morphophysiology, Charles Towey

Mahurin Honors College Capstone Experience/Thesis Projects

In recent years titanium dioxide nanoparticles (TiO2NPs) have been ingredients in everything from paints to cosmetics, and even in some kinds of food. This growth in use has resulted in a substantial increase in the amount of titanium released into the environment, which could have detrimental effects on nearby plant and animal life. Currently, the number of studies conducted on the effects of TiO2NPs is quite small, especially when it comes to edible crops. Because of this lack of research data, this study has been designed to assess the effect of TiO2 NPs exposure on …

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Distribution Of Polybrominated Diphenyl Ethers Among Demographic Categories, Giorvanni Merilis Jul 2017

Distribution Of Polybrominated Diphenyl Ethers Among Demographic Categories, Giorvanni Merilis

USF Tampa Graduate Theses and Dissertations

Polybrominated Diphenyl Ethers (PBDEs) are flame retardants widely used within the United States in various products such as plastics, electronics, textiles and furniture. With an increase in production and usage, PBDEs have recently emerged as a contaminant of concern. Due to their chemical structure, PBDEs have the propensity to bioaccumulate in mammals. In fact, elevated PBDE concentrations have been recorded in human breast milk. Due to the potential widespread exposure to PBDEs, this study investigates human blood concentrations of PBDEs generated through the 2003-2004 National Health and Nutrition Examination Survey. Through the use of statistical modeling, a comparison of mean …

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The Impact Weather Has On Nyc Citi Bike Share Company Activity, Mark Martinez Jul 2017

The Impact Weather Has On Nyc Citi Bike Share Company Activity, Mark Martinez

Journal of Environmental and Resource Economics at Colby

This paper seeks to figure out the effect weather has on individuals’ behavior. A more focused approach to determining this effect is seeing how different weather conditions ranging from the temperature, the precipitation, the amount of inches of snowfall and the wind speed effect the ridership of Citi Bikes throughout all four seasons. The approach of this research paper is using data from the National Climatic Data Center that focuses in on the weather found in Manhattan, New York and correlates each of the weather conditions to the total number of trips per day that is provided by the Citi …

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Electricity Demand Due To Policy Change In The U.K., Kevin W. Doherty Jul 2017

Electricity Demand Due To Policy Change In The U.K., Kevin W. Doherty

Journal of Environmental and Resource Economics at Colby

This paper examines United Kingdom Electricity Demand with regards to the Climate Change Act, which was enacted in November of 2008. Through actual demand data obtained from Nationalgrid, a U.K. based gas and electric utility company, this paper seeks to find out if the Climate Change Act has started to achieve its goal of reducing carbon emissions by looking at trends of electricity demand. Burning fossil fuels to produce electricity is a major contributor to global warming in the U.K. and policies enacted do not always live up to their ultimate goals. This paper tests how on track the Climate …

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The Demographic Drivers Of California’S Environmental Voting, Lukas Yasuda Jul 2017

The Demographic Drivers Of California’S Environmental Voting, Lukas Yasuda

Journal of Environmental and Resource Economics at Colby

This study examines the demographics of California’s 53 congressional districts and the relationship with the voting patterns on three environmentally focused propositions in the 2008 and 2010 elections. Previous literature on the topic is mixed as some studies suggest that select attributes are found among environmental voting centers, yet other research describes the relationship as more complex than simple characteristics. Previous literature on the topic is mixed, with some studies suggesting that select attributes are found among environmental vote support hubs, whereas alternative research suggests the problem is more complex than simple characteristics. I collected data on income, education, age, …

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How Individuals React To Smog Alerts In Beijing --Evidence From Beijing Subway Volume, Hanjing Shi Jul 2017

How Individuals React To Smog Alerts In Beijing --Evidence From Beijing Subway Volume, Hanjing Shi

Journal of Environmental and Resource Economics at Colby

This paper is going to find out the impact of smog alerts on individuals’ outdoor activities in Beijing. I use the subway volume to represent the outdoor activities. There are four levels of smog alerts in Beijing – blue, yellow, orange, and, red. The blue one is the lowest, and the red one is the highest. People in Beijing in all do not react to smog alerts in all statistically significant both on working days and weekends. But when combine orange alerts and red alerts together, the results show that people react to severe alerts differently during non-weekend days and …

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The Effects From Public Transportation On Property Values: A Closer Look At Scituate, Hanover, And Norwell, Massachusetts, Alexandra Taylor Perticone, Christine S. Coveney Jul 2017

The Effects From Public Transportation On Property Values: A Closer Look At Scituate, Hanover, And Norwell, Massachusetts, Alexandra Taylor Perticone, Christine S. Coveney

Journal of Environmental and Resource Economics at Colby

Prior studies have expressed the value of location in real estate, but more recent studies have explored the influence that public transportation has had on housing prices. Access to public transportation is understood to increase the value of homes. Easier access to public transportation allows for shorter and more convenient commutes into or within cities. However, other studies have found that proximity to public transportation can also have adverse effects on property values. This paper investigates whether the implementation of the Greenbush Commuter line in Massachusetts in October 2007 increased the housing prices in Scituate, Ma--the furthest town from the …

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Invited Introduction To Jerec, Matthew Kahn Jul 2017

Invited Introduction To Jerec, Matthew Kahn

Journal of Environmental and Resource Economics at Colby

No abstract provided.

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Welcome By The Editor, Nathan W. Chan Jul 2017

Welcome By The Editor, Nathan W. Chan

Journal of Environmental and Resource Economics at Colby

No abstract provided.

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The Mobile Monitoring Of Particulate Matter Through Wearable Sensors And Their Influence On Students' Environmental Attitudes, Joseph M. Abbate Jul 2017

The Mobile Monitoring Of Particulate Matter Through Wearable Sensors And Their Influence On Students' Environmental Attitudes, Joseph M. Abbate

DePaul Discoveries

While we have a comprehensive understanding of air pollutants, and their spatiotemporal characteristics across global, and even regional, scales, we are quite limited in our capacity to monitor neighborhood-scale emissions. The mobile monitoring of air pollution is a growing field, prospectively filling in these gaps while personalizing air quality-based tools and risk assessment. In the present study, we developed wearable sensors for particulate matter (PM); and through a citizen science approach, students of partnering Chicago schools monitored PM concentrations throughout their commutes over a five-day period. While their recorded findings would be used to explore the relationship between PM concentrations …

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The Effects Of Isoprene Emission From Native And Invasive Trees On Local Air Quality, Aarti P. Mistry Jul 2017

The Effects Of Isoprene Emission From Native And Invasive Trees On Local Air Quality, Aarti P. Mistry

DePaul Discoveries

Biogenic volatile organic compounds (BVOC) are the second-most abundant reactive gasses emitted into the atmosphere by the biosphere. Isoprene is a BVOC produced by the process of photosynthesis from vegetation and is emitted from plant leaves. Isoprene is a hydrocarbon that combines with oxides of nitrogen in the atmosphere to create ozone in the troposphere, an air pollutant. Invasive trees alter ecosystems and affect native tree populations. Invasive tree species in the Chicagoland area are outcompeting native tree species and expanding rapidly. The effect of isoprene emissions on air quality is a well-researched area in the atmospheric science community, however, …

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Zebrafish Models In Neuropsychopharmacology And Cns Drug Discovery, Kanza M. Khan, Adam D. Collier, Darya A. Meshalkina, Elana V. Kysil, Sergey L. Khatsko, Tatyana Kolesnikova, Yury Yu Morzherin, Jason E. Warnick, Allan V. Kalueff, David Echevarria Jul 2017

Zebrafish Models In Neuropsychopharmacology And Cns Drug Discovery, Kanza M. Khan, Adam D. Collier, Darya A. Meshalkina, Elana V. Kysil, Sergey L. Khatsko, Tatyana Kolesnikova, Yury Yu Morzherin, Jason E. Warnick, Allan V. Kalueff, David Echevarria

Faculty Publications

Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and …

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Reducing The Burden Of Rural Water Supply Through Greywater Reuse: A Case Study From Northern Malawi., Evan Newcomer, Courtney Boyd, Laban Nyirenda, Emmanuel Opong, Shannon Marquez, Rochelle Holm Jul 2017

Reducing The Burden Of Rural Water Supply Through Greywater Reuse: A Case Study From Northern Malawi., Evan Newcomer, Courtney Boyd, Laban Nyirenda, Emmanuel Opong, Shannon Marquez, Rochelle Holm

Faculty and Staff Scholarship

Greywater reuse has potential for non-potable applications that conserve freshwater resources in water-stressed areas especially in sub-Saharan Africa. The feasibility of reusing greywater for domestic activities in a rural area of Malawi, Africa, was evaluated from microbiological and public acceptance perspectives. Median Escherichia coli concentrations for eight domestic greywater sources (handwashing, laundry, runoff from a tap apron, bathing, cleaning a home/kitchen, cleaning a water collection container, washing plates and soaking vegetables) ranged from 100 to >20, 000 colony forming units (cfu)/100 ml. Twenty-four of 47 greywater samples tested (51%) met the World Health Organization guideline for unrestricted use of greywater …

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Alternative Splicing Promotes Tumour Aggressiveness And Drug Resistance In African American Prostate Cancer., Bi-Dar Wang, Kristin Ceniccola, Sujin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A Freedman, Jacqueline Olender, Stefan Knapp, Travers Ching, Lana Garmire, Vyomesh Patel, Mariano A Garcia-Blanco, Steven R Patierno, Norman H Lee Jun 2017

Alternative Splicing Promotes Tumour Aggressiveness And Drug Resistance In African American Prostate Cancer., Bi-Dar Wang, Kristin Ceniccola, Sujin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A Freedman, Jacqueline Olender, Stefan Knapp, Travers Ching, Lana Garmire, Vyomesh Patel, Mariano A Garcia-Blanco, Steven R Patierno, Norman H Lee

Pharmacology and Physiology Faculty Publications

linical challenges exist in reducing prostate cancer (PCa) disparities. The RNA splicing landscape of PCa across racial populations has not been fully explored as a potential molecular mechanism contributing to race-related tumour aggressiveness. Here, we identify novel genome-wide, race-specific RNA splicing events as critical drivers of PCa aggressiveness and therapeutic resistance in African American (AA) men. AA-enriched splice variants of PIK3CD, FGFR3, TSC2 and RASGRP2 contribute to greater oncogenic potential compared with corresponding European American (EA)-expressing variants. Ectopic overexpression of the newly cloned AA-enriched variant, PIK3CD-S, in EA PCa cell lines enhances AKT/mTOR signalling and increases proliferative …

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Growth And Survival Of Salamanders Exposed To Different Formulations Of Glyphosate-Based Herbicide, Jessica Johnson Jun 2017

Growth And Survival Of Salamanders Exposed To Different Formulations Of Glyphosate-Based Herbicide, Jessica Johnson

Mahurin Honors College Capstone Experience/Thesis Projects

Amphibian populations have been experiencing rapid declines worldwide in the past few decades. There are many proposed causations, including the use of agricultural chemicals such as herbicides. Glyphosate based herbicides are one of the most widely used herbicides. This study looks at the effects of different brands of glyphosate-based herbicides, including those intended for aquatic use, on the survival and growth of axolotl salamander larvae. Out of four brands of glyphosate herbicide (Aquamaster, Aquaneat, Helosate plus, and Roundup Pro), the survival rates of Roundup Pro were the lowest. Most mortality occurred between the 3 mg/L and 6 mg/L concentrations, during …

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The Effects Of Fluoride Ions On Neuromuscular Activity And Regeneration In Dugesia Tigrina, John Williams Jr. Jun 2017

The Effects Of Fluoride Ions On Neuromuscular Activity And Regeneration In Dugesia Tigrina, John Williams Jr.

Georgia Journal of Science

Fluoride ions have been implicated in numerous nervous system pathologies, though the association of these ions with these conditions has been controversial. The purpose of this research is to determine the effects that fluoride ions have on the nervous system development and function in planarians as a simple model for fluoride-nervous system interactions. In the first set of experiments, planarians were exposed to one of four concentrations of sodium fluoride: 0 mM, 1 mM, 1 mM, and 5 mM. In the second set of experiments, planarians were bisected and exposed to 1 mM of NaCl and NaF for regeneration purposes. …

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Investigating A Modern Midwestern Crisis: The Economy And Opioid Overdose Death In Ohio, Anna M. Gagliardo Jun 2017

Investigating A Modern Midwestern Crisis: The Economy And Opioid Overdose Death In Ohio, Anna M. Gagliardo

Undergraduate Economic Review

This paper examines the effect of local economic factors on the amount of opioid overdose deaths across counties in Ohio. Ohio leads the nation in opioid overdose deaths. The data examined spans all 88 counties of Ohio and compares 2009 and 2013 data, relying predominantly on Ohio Department of Health and US Census American Community Survey data. Using two linear regression models, I demonstrate that there is a significant correlation between insured rates and opioid overdose deaths in 2009 as well as a significant correlation between poverty rates and opioid overdose death rates in Ohio in 2013. Additionally, I show …

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Nfatc2 Modulates Microglial Activation In The Aβpp/Ps1 Mouse Model Of Alzheimer's Disease, Gunjan D. Manocha, Atreyi Ghatak, Kendra L. Puig, Susan D. Kraner, Christopher M. Norris, Colin K. Combs Jun 2017

Nfatc2 Modulates Microglial Activation In The Aβpp/Ps1 Mouse Model Of Alzheimer's Disease, Gunjan D. Manocha, Atreyi Ghatak, Kendra L. Puig, Susan D. Kraner, Christopher M. Norris, Colin K. Combs

Pharmacology and Nutritional Sciences Faculty Publications

Alzheimer’s disease (AD) brains are characterized by fibrillar amyloid-β (Aβ) peptide containing plaques and associated reactive microglia. The proinflammatory phenotype of the microglia suggests that they may negatively affect disease course and contribute to behavioral decline. This hypothesis predicts that attenuating microglial activation may provide benefit against disease. Prior work from our laboratory and others has characterized a role for the transcription factor, nuclear factor of activated T cells (NFAT), in regulating microglial phenotype in response to different stimuli, including Aβ peptide. We observed that the NFATc2 isoform was the most highly expressed in murine microglia cultures, and inhibition or …

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